| 1 | Fri Apr 1 | at Cubs | W6-3 | 1-0 | 1.000 | Wrigley Field · Chicago, IL |
| 2 | Sat Apr 2 | at Cubs | L3-5 | 1-1 | .500 | Wrigley Field · Chicago, IL |
| 3 | Sun Apr 3 | at Cubs | W5-4 | 2-1 | .667 | Wrigley Field · Chicago, IL |
| 4 | Mon Apr 4 | at Cardinals | W4-3 | 3-1 | .750 | Busch Stadium · St. Louis, MO |
| 5 | Tue Apr 5 | at Cardinals | L2-3 | 3-2 | .600 | Busch Stadium · St. Louis, MO |
| 6 | Wed Apr 6 | at Cardinals | W3-1 | 4-2 | .667 | Busch Stadium · St. Louis, MO |
| 7 | Thu Apr 7 | vs Rockies | L1-7 | 4-3 | .571 | PNC Park · Pittsburgh, PA |
| 8 | Fri Apr 8 | vs Rockies | W4-3 (14) | 5-3 | .625 | PNC Park · Pittsburgh, PA |
| 9 | Sat Apr 9 | vs Rockies | L4-6 | 5-4 | .556 | PNC Park · Pittsburgh, PA |
| 10 | Sun Apr 10 | vs Rockies | L5-6 | 5-5 | .500 | PNC Park · Pittsburgh, PA |
| 11 | Wed Apr 13 | vs Brewers | L0-6 | 5-6 | .455 | PNC Park · Pittsburgh, PA |
| 12 | Thu Apr 14 | vs Brewers | L1-4 | 5-7 | .417 | PNC Park · Pittsburgh, PA |
| 13 | Fri Apr 15 | at Reds | W6-1 | 6-7 | .462 | Great American Ball Park · Cincinnati, OH |
| 14 | Sat Apr 16 | at Reds | L2-11 | 6-8 | .429 | Great American Ball Park · Cincinnati, OH |
| 15 | Sun Apr 17 | at Reds | W7-6 | 7-8 | .467 | Great American Ball Park · Cincinnati, OH |
| 16 | Mon Apr 18 | at Reds | W9-3 | 8-8 | .500 | Great American Ball Park · Cincinnati, OH |
| 17 | Tue Apr 19 | at Marlins | L0-6 | 8-9 | .471 | MVP Arena · Albany, NY |
| 18 | Wed Apr 20 | at Marlins | L0-6 | 8-10 | .444 | MVP Arena · Albany, NY |
| 19 | Thu Apr 21 | at Marlins | L5-9 | 8-11 | .421 | MVP Arena · Albany, NY |
| 20 | Sat Apr 23 | vs Nationals | W7-2 | 9-11 | .450 | PNC Park · Pittsburgh, PA |
| 21 | Sun Apr 24 | vs Nationals | L3-6 | 9-12 | .429 | PNC Park · Pittsburgh, PA |
| 22 | Mon Apr 25 | vs Nationals | W4-2 | 10-12 | .455 | PNC Park · Pittsburgh, PA |
| 23 | Tue Apr 26 | vs Giants | L2-3 (10) | 10-13 | .435 | PNC Park · Pittsburgh, PA |
| 24 | Wed Apr 27 | vs Giants | W2-0 | 11-13 | .458 | PNC Park · Pittsburgh, PA |
| 25 | Thu Apr 28 | vs Giants | L2-5 | 11-14 | .440 | PNC Park · Pittsburgh, PA |
| 26 | Fri Apr 29 | at Rockies | W3-0 | 12-14 | .462 | Coors Field · Denver, CO |
| 27 | Sat Apr 30 | at Rockies | L1-4 | 12-15 | .444 | Coors Field · Denver, CO |
| 28 | Sun May 1 | at Rockies | W8-4 | 13-15 | .464 | Coors Field · Denver, CO |
| 29 | Mon May 2 | at Padres | W4-3 | 14-15 | .483 | Petco Park · San Diego, CA |
| 30 | Tue May 3 | at Padres | L5-6 | 14-16 | .467 | Petco Park · San Diego, CA |
| 31 | Wed May 4 | at Padres | W7-4 | 15-16 | .484 | Petco Park · San Diego, CA |
| 32 | Fri May 6 | vs Astros | L2-3 | 15-17 | .469 | PNC Park · Pittsburgh, PA |
| 33 | Sat May 7 | vs Astros | W6-1 | 16-17 | .485 | PNC Park · Pittsburgh, PA |
| 34 | Sun May 8 | vs Astros | W5-4 | 17-17 | .500 | PNC Park · Pittsburgh, PA |
| 35 | Mon May 9 | vs Dodgers | W4-1 | 18-17 | .514 | PNC Park · Pittsburgh, PA |
| 36 | Tue May 10 | vs Dodgers | L3-10 | 18-18 | .500 | PNC Park · Pittsburgh, PA |
| 37 | Wed May 11 | vs Dodgers | L0-2 | 18-19 | .486 | PNC Park · Pittsburgh, PA |
| 38 | Fri May 13 | at Brewers | L2-5 | 18-20 | .474 | American Family Field · Milwaukee, WI |
| 39 | Sat May 14 | at Brewers | L2-8 | 18-21 | .462 | American Family Field · Milwaukee, WI |
| 40 | Sun May 15 | at Brewers | L6-9 | 18-22 | .450 | American Family Field · Milwaukee, WI |
| 41 | Mon May 16 | at Nationals | L2-4 | 18-23 | .439 | Nationals Park · Washington, D.C. |
| 42 | Wed May 18 | at Reds | W5-0 | 19-23 | .452 | Great American Ball Park · Cincinnati, OH |
| 43 | Thu May 19 | at Reds | W5-3 | 20-23 | .465 | Great American Ball Park · Cincinnati, OH |
| 44 | Fri May 20 | vs Tigers | W10-1 | 21-23 | .477 | PNC Park · Pittsburgh, PA |
| 45 | Sat May 21 | vs Tigers | W6-2 | 22-23 | .489 | PNC Park · Pittsburgh, PA |
| 46 | Sun May 22 | vs Tigers | L0-2 | 22-24 | .478 | PNC Park · Pittsburgh, PA |
| 47 | Tue May 24 | vs Braves | L0-2 | 22-25 | .468 | PNC Park · Pittsburgh, PA |
| 48 | Wed May 25 | vs Braves | L2-4 (11) | 22-26 | .458 | PNC Park · Pittsburgh, PA |
| 49 | Fri May 27 | at Cubs | W4-2 | 23-26 | .469 | Wrigley Field · Chicago, IL |
| 50 | Sat May 28 | at Cubs | W10-0 | 24-26 | .480 | Wrigley Field · Chicago, IL |
| 51 | Sun May 29 | at Cubs | L2-3 | 24-27 | .471 | Wrigley Field · Chicago, IL |
| 52 | Mon May 30 | at Mets | L3-7 | 24-28 | .462 | Citi Field · Queens, NY |
| 53 | Tue May 31 | at Mets | W5-1 | 25-28 | .472 | Citi Field · Queens, NY |
| 54 | Wed Jun 1 | at Mets | W9-3 | 26-28 | .481 | Citi Field · Queens, NY |
| 55 | Thu Jun 2 | at Mets | L8-9 | 26-29 | .473 | Citi Field · Queens, NY |
| 56 | Fri Jun 3 | vs Phillies | W2-1 (12) | 27-29 | .482 | PNC Park · Pittsburgh, PA |
| 57 | Sat Jun 4 | vs Phillies | W6-3 | 28-29 | .491 | PNC Park · Pittsburgh, PA |
| 58 | Sun Jun 5 | vs Phillies | L3-7 | 28-30 | .483 | PNC Park · Pittsburgh, PA |
| 59 | Tue Jun 7 | vs D-backs | W8-5 | 29-30 | .492 | PNC Park · Pittsburgh, PA |
| 60 | Wed Jun 8 | vs D-backs | W3-2 (12) | 30-30 | .500 | PNC Park · Pittsburgh, PA |
| 61 | Thu Jun 9 | vs D-backs | L0-2 | 30-31 | .492 | PNC Park · Pittsburgh, PA |
| 62 | Fri Jun 10 | vs Mets | L1-8 | 30-32 | .484 | PNC Park · Pittsburgh, PA |
| 63 | Sat Jun 11 | vs Mets | W3-2 | 31-32 | .492 | PNC Park · Pittsburgh, PA |
| 64 | Sun Jun 12 | vs Mets | L0-7 | 31-33 | .484 | PNC Park · Pittsburgh, PA |
| 65 | Mon Jun 13 | vs Mets | W3-1 | 32-33 | .492 | PNC Park · Pittsburgh, PA |
| 66 | Tue Jun 14 | at Astros | W1-0 | 33-33 | .500 | Minute Maid Park · Houston, TX |
| 67 | Wed Jun 15 | at Astros | W7-3 | 34-33 | .507 | Minute Maid Park · Houston, TX |
| 68 | Thu Jun 16 | at Astros | W5-4 | 35-33 | .515 | Minute Maid Park · Houston, TX |
| 69 | Fri Jun 17 | at Guardians | L1-5 | 35-34 | .507 | Progressive Field · Cleveland, OH |
| 70 | Sat Jun 18 | at Guardians | L1-5 | 35-35 | .500 | Progressive Field · Cleveland, OH |
| 71 | Sun Jun 19 | at Guardians | L2-5 (11) | 35-36 | .493 | Progressive Field · Cleveland, OH |
| 72 | Mon Jun 20 | vs Orioles | L3-8 | 35-37 | .486 | PNC Park · Pittsburgh, PA |
| 73 | Tue Jun 21 | vs Orioles | W9-3 | 36-37 | .493 | PNC Park · Pittsburgh, PA |
| 74 | Wed Jun 22 | vs Orioles | W5-4 | 37-37 | .500 | PNC Park · Pittsburgh, PA |
| 75 | Fri Jun 24 | vs Red Sox | W3-1 | 38-37 | .507 | PNC Park · Pittsburgh, PA |
| 76 | Sat Jun 25 | vs Red Sox | W6-4 | 39-37 | .513 | PNC Park · Pittsburgh, PA |
| 77 | Sun Jun 26 | vs Red Sox | L2-4 | 39-38 | .506 | PNC Park · Pittsburgh, PA |
| 78 | Tue Jun 28 | at Blue Jays | W7-6 | 40-38 | .513 | Rogers Centre · Toronto, ON |
| 79 | Wed Jun 29 | at Blue Jays | L1-2 | 40-39 | .506 | Rogers Centre · Toronto, ON |
| 80 | Thu Jun 30 | at Blue Jays | W6-2 | 41-39 | .512 | Rogers Centre · Toronto, ON |
| 81 | Fri Jul 1 | at Nationals | L1-2 | 41-40 | .506 | Nationals Park · Washington, D.C. |
| 82 | Sat Jul 2 | at Nationals | W5-3 | 42-40 | .512 | Nationals Park · Washington, D.C. |
| 83 | Sat Jul 2 | at Nationals | L3-4 | 42-41 | .506 | Nationals Park · Washington, D.C. |
| 84 | Sun Jul 3 | at Nationals | W10-2 | 43-41 | .512 | Nationals Park · Washington, D.C. |
| 85 | Mon Jul 4 | vs Astros | W5-3 | 44-41 | .518 | PNC Park · Pittsburgh, PA |
| 86 | Tue Jul 5 | vs Astros | W5-1 | 45-41 | .523 | PNC Park · Pittsburgh, PA |
| 87 | Wed Jul 6 | vs Astros | L2-8 | 45-42 | .517 | PNC Park · Pittsburgh, PA |
| 88 | Fri Jul 8 | vs Cubs | W7-4 | 46-42 | .523 | PNC Park · Pittsburgh, PA |
| 89 | Sat Jul 9 | vs Cubs | L3-6 | 46-43 | .517 | PNC Park · Pittsburgh, PA |
| 90 | Sun Jul 10 | vs Cubs | W9-1 | 47-43 | .522 | PNC Park · Pittsburgh, PA |
| 91 | Fri Jul 15 | at Astros | W4-0 | 48-43 | .527 | Minute Maid Park · Houston, TX |
| 92 | Sat Jul 16 | at Astros | L4-6 | 48-44 | .522 | Minute Maid Park · Houston, TX |
| 93 | Sun Jul 17 | at Astros | W7-5 (11) | 49-44 | .527 | Minute Maid Park · Houston, TX |
| 94 | Mon Jul 18 | vs Reds | W2-0 | 50-44 | .532 | PNC Park · Pittsburgh, PA |
| 95 | Tue Jul 19 | vs Reds | W1-0 | 51-44 | .537 | PNC Park · Pittsburgh, PA |
| 96 | Wed Jul 20 | vs Reds | L1-3 | 51-45 | .531 | PNC Park · Pittsburgh, PA |
| 97 | Fri Jul 22 | vs Cardinals | L4-6 | 51-46 | .526 | PNC Park · Pittsburgh, PA |
| 98 | Sat Jul 23 | vs Cardinals | L1-9 | 51-47 | .520 | PNC Park · Pittsburgh, PA |
| 99 | Sun Jul 24 | vs Cardinals | W4-3 (10) | 52-47 | .525 | PNC Park · Pittsburgh, PA |
| 100 | Mon Jul 25 | at Braves | W3-1 | 53-47 | .530 | Truist Park · Cumberland, GA |
| 101 | Tue Jul 26 | at Braves | L3-4 (19) | 53-48 | .525 | Truist Park · Cumberland, GA |
| 102 | Wed Jul 27 | at Braves | L1-2 (10) | 53-49 | .520 | Truist Park · Cumberland, GA |
| 103 | Thu Jul 28 | at Braves | W5-2 | 54-49 | .524 | Truist Park · Cumberland, GA |
| 104 | Fri Jul 29 | at Phillies | L3-10 | 54-50 | .519 | Citizens Bank Park · Philadelphi, PA |
| 105 | Sat Jul 30 | at Phillies | L4-7 | 54-51 | .514 | Citizens Bank Park · Philadelphi, PA |
| 106 | Sun Jul 31 | at Phillies | L5-6 (10) | 54-52 | .509 | Citizens Bank Park · Philadelphi, PA |
| 107 | Mon Aug 1 | vs Cubs | L3-5 | 54-53 | .505 | PNC Park · Pittsburgh, PA |
| 108 | Tue Aug 2 | vs Cubs | L6-11 | 54-54 | .500 | PNC Park · Pittsburgh, PA |
| 109 | Wed Aug 3 | vs Cubs | L0-1 | 54-55 | .495 | PNC Park · Pittsburgh, PA |
| 110 | Thu Aug 4 | vs Cubs | L6-7 | 54-56 | .491 | PNC Park · Pittsburgh, PA |
| 111 | Fri Aug 5 | vs Padres | L5-15 | 54-57 | .486 | PNC Park · Pittsburgh, PA |
| 112 | Sat Aug 6 | vs Padres | L2-13 | 54-58 | .482 | PNC Park · Pittsburgh, PA |
| 113 | Sun Aug 7 | vs Padres | L3-7 | 54-59 | .478 | PNC Park · Pittsburgh, PA |
| 114 | Mon Aug 8 | at Giants | W5-0 | 55-59 | .482 | Oracle Park · San Francisco, CA |
| 115 | Tue Aug 9 | at Giants | L0-6 | 55-60 | .478 | Oracle Park · San Francisco, CA |
| 116 | Wed Aug 10 | at Giants | W9-2 | 56-60 | .483 | Oracle Park · San Francisco, CA |
| 117 | Fri Aug 12 | at Brewers | L2-7 | 56-61 | .479 | American Family Field · Milwaukee, WI |
| 118 | Sat Aug 13 | at Brewers | L0-1 | 56-62 | .475 | American Family Field · Milwaukee, WI |
| 119 | Sun Aug 14 | at Brewers | L1-2 (10) | 56-63 | .471 | American Family Field · Milwaukee, WI |
| 120 | Mon Aug 15 | vs Cardinals | W6-2 | 57-63 | .475 | PNC Park · Pittsburgh, PA |
| 121 | Tue Aug 16 | vs Cardinals | W5-4 (11) | 58-63 | .479 | PNC Park · Pittsburgh, PA |
| 122 | Wed Aug 17 | vs Cardinals | L2-7 | 58-64 | .475 | PNC Park · Pittsburgh, PA |
| 123 | Fri Aug 19 | vs Reds | L8-11 | 58-65 | .472 | PNC Park · Pittsburgh, PA |
| 124 | Sat Aug 20 | vs Reds | W5-3 | 59-65 | .476 | PNC Park · Pittsburgh, PA |
| 125 | Sun Aug 21 | vs Reds | L4-5 | 59-66 | .472 | PNC Park · Pittsburgh, PA |
| 126 | Mon Aug 22 | vs Brewers | L1-8 | 59-67 | .468 | PNC Park · Pittsburgh, PA |
| 127 | Mon Aug 22 | vs Brewers | W9-2 | 60-67 | .472 | PNC Park · Pittsburgh, PA |
| 128 | Tue Aug 23 | vs Brewers | L4-11 | 60-68 | .469 | PNC Park · Pittsburgh, PA |
| 129 | Wed Aug 24 | vs Brewers | W2-0 | 61-68 | .473 | PNC Park · Pittsburgh, PA |
| 130 | Thu Aug 25 | at Cardinals | L4-8 | 61-69 | .469 | Busch Stadium · St. Louis, MO |
| 131 | Fri Aug 26 | at Cardinals | L4-5 | 61-70 | .466 | Busch Stadium · St. Louis, MO |
| 132 | Sat Aug 27 | at Cardinals | W7-0 | 62-70 | .470 | Busch Stadium · St. Louis, MO |
| 133 | Sun Aug 28 | at Cardinals | L4-7 | 62-71 | .466 | Busch Stadium · St. Louis, MO |
| 134 | Mon Aug 29 | at Astros | L4-7 | 62-72 | .463 | Minute Maid Park · Houston, TX |
| 135 | Tue Aug 30 | at Astros | L2-8 | 62-73 | .459 | Minute Maid Park · Houston, TX |
| 136 | Wed Aug 31 | at Astros | L0-2 | 62-74 | .456 | Minute Maid Park · Houston, TX |
| 137 | Thu Sep 1 | vs Dodgers | L4-6 | 62-75 | .453 | PNC Park · Pittsburgh, PA |
| 138 | Fri Sep 2 | at Cubs | W3-1 | 63-75 | .457 | Wrigley Field · Chicago, IL |
| 139 | Sat Sep 3 | at Cubs | W7-5 | 64-75 | .460 | Wrigley Field · Chicago, IL |
| 140 | Sun Sep 4 | at Cubs | L3-6 | 64-76 | .457 | Wrigley Field · Chicago, IL |
| 141 | Mon Sep 5 | vs Astros | W3-1 | 65-76 | .461 | PNC Park · Pittsburgh, PA |
| 142 | Tue Sep 6 | vs Astros | L1-4 | 65-77 | .458 | PNC Park · Pittsburgh, PA |
| 143 | Wed Sep 7 | vs Astros | W5-4 | 66-77 | .462 | PNC Park · Pittsburgh, PA |
| 144 | Fri Sep 9 | vs Marlins | L4-13 | 66-78 | .458 | PNC Park · Pittsburgh, PA |
| 145 | Sat Sep 10 | vs Marlins | L0-3 | 66-79 | .455 | PNC Park · Pittsburgh, PA |
| 146 | Sun Sep 11 | vs Marlins | L1-4 | 66-80 | .452 | PNC Park · Pittsburgh, PA |
| 147 | Mon Sep 12 | vs Cardinals | W6-5 | 67-80 | .456 | PNC Park · Pittsburgh, PA |
| 148 | Tue Sep 13 | vs Cardinals | L4-6 | 67-81 | .453 | PNC Park · Pittsburgh, PA |
| 149 | Wed Sep 14 | vs Cardinals | L2-3 | 67-82 | .450 | PNC Park · Pittsburgh, PA |
| 150 | Thu Sep 15 | at Dodgers | W6-2 | 68-82 | .453 | Dodger Stadium · Los Angeles, CA |
| 151 | Fri Sep 16 | at Dodgers | L2-7 | 68-83 | .450 | Dodger Stadium · Los Angeles, CA |
| 152 | Sat Sep 17 | at Dodgers | L1-6 | 68-84 | .447 | Dodger Stadium · Los Angeles, CA |
| 153 | Sun Sep 18 | at Dodgers | L1-15 | 68-85 | .444 | Dodger Stadium · Los Angeles, CA |
| 154 | Mon Sep 19 | at D-backs | L0-1 | 68-86 | .442 | Chase Field · Phoenix, AZ |
| 155 | Tue Sep 20 | at D-backs | W5-3 | 69-86 | .445 | Chase Field · Phoenix, AZ |
| 156 | Wed Sep 21 | at D-backs | L5-8 | 69-87 | .442 | Chase Field · Phoenix, AZ |
| 157 | Fri Sep 23 | vs Reds | W4-3 | 70-87 | .446 | PNC Park · Pittsburgh, PA |
| 158 | Sat Sep 24 | vs Reds | W4-3 | 71-87 | .449 | PNC Park · Pittsburgh, PA |
| 159 | Sun Sep 25 | vs Reds | L4-5 | 71-88 | .447 | PNC Park · Pittsburgh, PA |
| 160 | Mon Sep 26 | at Brewers | W9-8 | 72-88 | .450 | American Family Field · Milwaukee, WI |
| 161 | Tue Sep 27 | at Brewers | L4-6 | 72-89 | .447 | American Family Field · Milwaukee, WI |
| 162 | Wed Sep 28 | at Brewers | L3-7 | 72-90 | .444 | American Family Field · Milwaukee, WI |