| 1 | Thu Mar 31 | at Dodgers | L1-2 | 0-1 | .000 | Dodger Stadium · Los Angeles, CA |
| 2 | Fri Apr 1 | at Dodgers | L3-4 | 0-2 | .000 | Dodger Stadium · Los Angeles, CA |
| 3 | Sat Apr 2 | at Dodgers | W10-0 | 1-2 | .333 | Dodger Stadium · Los Angeles, CA |
| 4 | Sun Apr 3 | at Dodgers | L5-7 | 1-3 | .250 | Dodger Stadium · Los Angeles, CA |
| 5 | Tue Apr 5 | at Padres | L1-3 | 1-4 | .200 | Petco Park · San Diego, CA |
| 6 | Wed Apr 6 | at Padres | W8-4 | 2-4 | .333 | Petco Park · San Diego, CA |
| 7 | Fri Apr 8 | vs Cardinals | W5-4 (12) | 3-4 | .429 | Oracle Park · San Francisco, CA |
| 8 | Sat Apr 9 | vs Cardinals | W3-2 | 4-4 | .500 | Oracle Park · San Francisco, CA |
| 9 | Sun Apr 10 | vs Cardinals | L1-6 | 4-5 | .444 | Oracle Park · San Francisco, CA |
| 10 | Mon Apr 11 | vs Dodgers | L1-6 | 4-6 | .400 | Oracle Park · San Francisco, CA |
| 11 | Tue Apr 12 | vs Dodgers | W5-4 | 5-6 | .455 | Oracle Park · San Francisco, CA |
| 12 | Wed Apr 13 | vs Dodgers | W4-3 | 6-6 | .500 | Oracle Park · San Francisco, CA |
| 13 | Fri Apr 15 | at D-backs | W5-2 | 7-6 | .538 | Chase Field · Phoenix, AZ |
| 14 | Sat Apr 16 | at D-backs | W5-3 | 8-6 | .571 | Chase Field · Phoenix, AZ |
| 15 | Sun Apr 17 | at D-backs | L5-6 (12) | 8-7 | .533 | Chase Field · Phoenix, AZ |
| 16 | Mon Apr 18 | at Rockies | W8-1 | 9-7 | .563 | Coors Field · Denver, CO |
| 17 | Tue Apr 19 | at Rockies | W6-3 | 10-7 | .588 | Coors Field · Denver, CO |
| 18 | Wed Apr 20 | at Rockies | L2-10 | 10-8 | .556 | Coors Field · Denver, CO |
| 19 | Fri Apr 22 | vs Braves | L1-4 | 10-9 | .526 | Oracle Park · San Francisco, CA |
| 20 | Sat Apr 23 | vs Braves | L2-5 | 10-10 | .500 | Oracle Park · San Francisco, CA |
| 21 | Sun Apr 24 | vs Braves | L6-9 (10) | 10-11 | .476 | Oracle Park · San Francisco, CA |
| 22 | Tue Apr 26 | at Pirates | W3-2 (10) | 11-11 | .500 | PNC Park · Pittsburgh, PA |
| 23 | Wed Apr 27 | at Pirates | L0-2 | 11-12 | .478 | PNC Park · Pittsburgh, PA |
| 24 | Thu Apr 28 | at Pirates | W5-2 | 12-12 | .500 | PNC Park · Pittsburgh, PA |
| 25 | Fri Apr 29 | at Nationals | L0-3 | 12-13 | .480 | Nationals Park · Washington, D.C. |
| 26 | Sat Apr 30 | at Nationals | W2-1 | 13-13 | .500 | Nationals Park · Washington, D.C. |
| 27 | Sun May 1 | at Nationals | L2-5 | 13-14 | .481 | Nationals Park · Washington, D.C. |
| 28 | Mon May 2 | at Nationals | L0-2 | 13-15 | .464 | Nationals Park · Washington, D.C. |
| 29 | Tue May 3 | at Mets | W7-6 (10) | 14-15 | .483 | Citi Field · Queens, NY |
| 30 | Wed May 4 | at Mets | W2-0 | 15-15 | .500 | Citi Field · Queens, NY |
| 31 | Thu May 5 | at Mets | L2-5 | 15-16 | .484 | Citi Field · Queens, NY |
| 32 | Fri May 6 | vs Rockies | W4-3 | 16-16 | .500 | Oracle Park · San Francisco, CA |
| 33 | Sat May 7 | vs Rockies | W3-2 | 17-16 | .515 | Oracle Park · San Francisco, CA |
| 34 | Sun May 8 | vs Rockies | W3-0 | 18-16 | .529 | Oracle Park · San Francisco, CA |
| 35 | Tue May 10 | vs D-backs | W1-0 | 19-16 | .543 | Oracle Park · San Francisco, CA |
| 36 | Wed May 11 | vs D-backs | W4-3 | 20-16 | .556 | Oracle Park · San Francisco, CA |
| 37 | Thu May 12 | vs D-backs | W3-2 | 21-16 | .568 | Oracle Park · San Francisco, CA |
| 38 | Fri May 13 | at Cubs | L4-11 | 21-17 | .553 | Wrigley Field · Chicago, IL |
| 39 | Sat May 14 | at Cubs | W3-0 | 22-17 | .564 | Wrigley Field · Chicago, IL |
| 40 | Mon May 16 | at Rockies | L4-7 | 22-18 | .550 | Coors Field · Denver, CO |
| 41 | Tue May 17 | at Rockies | L3-5 | 22-19 | .537 | Coors Field · Denver, CO |
| 42 | Wed May 18 | at Dodgers | W8-5 | 23-19 | .548 | Dodger Stadium · Los Angeles, CA |
| 43 | Thu May 19 | at Dodgers | W3-1 | 24-19 | .558 | Dodger Stadium · Los Angeles, CA |
| 44 | Fri May 20 | vs Athletics | W2-1 (10) | 25-19 | .568 | Oracle Park · San Francisco, CA |
| 45 | Sat May 21 | vs Athletics | W3-0 | 26-19 | .578 | Oracle Park · San Francisco, CA |
| 46 | Sun May 22 | vs Athletics | W5-4 (11) | 27-19 | .587 | Oracle Park · San Francisco, CA |
| 47 | Tue May 24 | vs Marlins | L1-5 | 27-20 | .574 | Oracle Park · San Francisco, CA |
| 48 | Wed May 25 | vs Marlins | L6-7 (12) | 27-21 | .563 | Oracle Park · San Francisco, CA |
| 49 | Thu May 26 | vs Marlins | L0-1 | 27-22 | .551 | Oracle Park · San Francisco, CA |
| 50 | Fri May 27 | at Brewers | W5-4 | 28-22 | .560 | American Family Field · Milwaukee, WI |
| 51 | Sat May 28 | at Brewers | L2-3 | 28-23 | .549 | American Family Field · Milwaukee, WI |
| 52 | Sun May 29 | at Brewers | L0-6 | 28-24 | .538 | American Family Field · Milwaukee, WI |
| 53 | Mon May 30 | at Cardinals | W7-3 | 29-24 | .547 | Busch Stadium · St. Louis, MO |
| 54 | Tue May 31 | at Cardinals | L3-4 | 29-25 | .537 | Busch Stadium · St. Louis, MO |
| 55 | Wed Jun 1 | at Cardinals | W7-5 (11) | 30-25 | .545 | Busch Stadium · St. Louis, MO |
| 56 | Thu Jun 2 | at Cardinals | W12-7 | 31-25 | .554 | Busch Stadium · St. Louis, MO |
| 57 | Fri Jun 3 | vs Rockies | W3-1 | 32-25 | .561 | Oracle Park · San Francisco, CA |
| 58 | Sat Jun 4 | vs Rockies | L1-2 | 32-26 | .552 | Oracle Park · San Francisco, CA |
| 59 | Sun Jun 5 | vs Rockies | W2-1 | 33-26 | .559 | Oracle Park · San Francisco, CA |
| 60 | Mon Jun 6 | vs Nationals | W5-4 (13) | 34-26 | .567 | Oracle Park · San Francisco, CA |
| 61 | Tue Jun 7 | vs Nationals | L1-2 | 34-27 | .557 | Oracle Park · San Francisco, CA |
| 62 | Wed Jun 8 | vs Nationals | W3-1 | 35-27 | .565 | Oracle Park · San Francisco, CA |
| 63 | Thu Jun 9 | vs Reds | L0-3 | 35-28 | .556 | Oracle Park · San Francisco, CA |
| 64 | Fri Jun 10 | vs Reds | W3-2 | 36-28 | .563 | Oracle Park · San Francisco, CA |
| 65 | Sat Jun 11 | vs Reds | L2-10 | 36-29 | .554 | Oracle Park · San Francisco, CA |
| 66 | Sun Jun 12 | vs Reds | W4-2 | 37-29 | .561 | Oracle Park · San Francisco, CA |
| 67 | Tue Jun 14 | at D-backs | W6-5 | 38-29 | .567 | Chase Field · Phoenix, AZ |
| 68 | Wed Jun 15 | at D-backs | W5-2 | 39-29 | .574 | Chase Field · Phoenix, AZ |
| 69 | Thu Jun 16 | at D-backs | L2-3 (10) | 39-30 | .565 | Chase Field · Phoenix, AZ |
| 70 | Fri Jun 17 | at Athletics | L2-5 | 39-31 | .557 | RingCentral Coliseum · Oakland, CA |
| 71 | Sat Jun 18 | at Athletics | L2-4 | 39-32 | .549 | RingCentral Coliseum · Oakland, CA |
| 72 | Sun Jun 19 | at Athletics | L1-2 | 39-33 | .542 | RingCentral Coliseum · Oakland, CA |
| 73 | Tue Jun 21 | vs Twins | L2-9 | 39-34 | .534 | Oracle Park · San Francisco, CA |
| 74 | Wed Jun 22 | vs Twins | W5-1 | 40-34 | .541 | Oracle Park · San Francisco, CA |
| 75 | Thu Jun 23 | vs Twins | W2-1 | 41-34 | .547 | Oracle Park · San Francisco, CA |
| 76 | Fri Jun 24 | vs Guardians | W4-3 | 42-34 | .553 | Oracle Park · San Francisco, CA |
| 77 | Sat Jun 25 | vs Guardians | W1-0 | 43-34 | .558 | Oracle Park · San Francisco, CA |
| 78 | Sun Jun 26 | vs Guardians | W3-1 | 44-34 | .564 | Oracle Park · San Francisco, CA |
| 79 | Tue Jun 28 | at Cubs | W13-7 | 45-34 | .570 | Wrigley Field · Chicago, IL |
| 80 | Tue Jun 28 | at Cubs | W6-3 | 46-34 | .575 | Wrigley Field · Chicago, IL |
| 81 | Wed Jun 29 | at Cubs | L1-2 | 46-35 | .568 | Wrigley Field · Chicago, IL |
| 82 | Thu Jun 30 | at Cubs | L2-5 (13) | 46-36 | .561 | Wrigley Field · Chicago, IL |
| 83 | Fri Jul 1 | at Tigers | W4-3 | 47-36 | .566 | Comerica Park · Detroit, MI |
| 84 | Sat Jul 2 | at Tigers | W15-3 | 48-36 | .571 | Comerica Park · Detroit, MI |
| 85 | Sun Jul 3 | at Tigers | L3-6 | 48-37 | .565 | Comerica Park · Detroit, MI |
| 86 | Mon Jul 4 | vs Padres | L3-5 | 48-38 | .558 | Oracle Park · San Francisco, CA |
| 87 | Tue Jul 5 | vs Padres | L3-5 | 48-39 | .552 | Oracle Park · San Francisco, CA |
| 88 | Wed Jul 6 | vs Padres | W6-5 (14) | 49-39 | .557 | Oracle Park · San Francisco, CA |
| 89 | Thu Jul 7 | vs Padres | W2-1 | 50-39 | .562 | Oracle Park · San Francisco, CA |
| 90 | Fri Jul 8 | vs Mets | L2-5 | 50-40 | .556 | Oracle Park · San Francisco, CA |
| 91 | Sat Jul 9 | vs Mets | W3-1 | 51-40 | .560 | Oracle Park · San Francisco, CA |
| 92 | Sun Jul 10 | vs Mets | W4-2 | 52-40 | .565 | Oracle Park · San Francisco, CA |
| 93 | Thu Jul 14 | at Padres | W6-2 (12) | 53-40 | .570 | Petco Park · San Diego, CA |
| 94 | Fri Jul 15 | at Padres | W6-1 | 54-40 | .574 | Petco Park · San Diego, CA |
| 95 | Sat Jul 16 | at Padres | L3-11 | 54-41 | .568 | Petco Park · San Diego, CA |
| 96 | Sun Jul 17 | at Padres | W4-3 (11) | 55-41 | .573 | Petco Park · San Diego, CA |
| 97 | Mon Jul 18 | vs Dodgers | W5-0 | 56-41 | .577 | Oracle Park · San Francisco, CA |
| 98 | Tue Jul 19 | vs Dodgers | W5-3 | 57-41 | .582 | Oracle Park · San Francisco, CA |
| 99 | Wed Jul 20 | vs Dodgers | L0-1 | 57-42 | .576 | Oracle Park · San Francisco, CA |
| 100 | Fri Jul 22 | vs Brewers | L2-4 | 57-43 | .570 | Oracle Park · San Francisco, CA |
| 101 | Sat Jul 23 | vs Brewers | W4-2 | 58-43 | .574 | Oracle Park · San Francisco, CA |
| 102 | Sun Jul 24 | vs Brewers | W2-1 | 59-43 | .578 | Oracle Park · San Francisco, CA |
| 103 | Tue Jul 26 | at Phillies | L2-7 | 59-44 | .573 | Citizens Bank Park · Philadelphi, PA |
| 104 | Wed Jul 27 | at Phillies | W2-1 | 60-44 | .577 | Citizens Bank Park · Philadelphi, PA |
| 105 | Thu Jul 28 | at Phillies | W4-1 | 61-44 | .581 | Citizens Bank Park · Philadelphi, PA |
| 106 | Fri Jul 29 | at Reds | L3-4 (13) | 61-45 | .575 | Great American Ball Park · Cincinnati, OH |
| 107 | Sat Jul 30 | at Reds | L2-7 | 61-46 | .570 | Great American Ball Park · Cincinnati, OH |
| 108 | Sun Jul 31 | at Reds | L0-9 | 61-47 | .565 | Great American Ball Park · Cincinnati, OH |
| 109 | Mon Aug 1 | vs D-backs | L2-5 | 61-48 | .560 | Oracle Park · San Francisco, CA |
| 110 | Tue Aug 2 | vs D-backs | L1-6 | 61-49 | .555 | Oracle Park · San Francisco, CA |
| 111 | Wed Aug 3 | vs D-backs | W8-1 | 62-49 | .559 | Oracle Park · San Francisco, CA |
| 112 | Thu Aug 4 | vs Phillies | L0-3 | 62-50 | .554 | Oracle Park · San Francisco, CA |
| 113 | Fri Aug 5 | vs Phillies | L2-9 | 62-51 | .549 | Oracle Park · San Francisco, CA |
| 114 | Sat Aug 6 | vs Phillies | L1-2 | 62-52 | .544 | Oracle Park · San Francisco, CA |
| 115 | Sun Aug 7 | vs Phillies | W3-1 | 63-52 | .548 | Oracle Park · San Francisco, CA |
| 116 | Mon Aug 8 | vs Pirates | L0-5 | 63-53 | .543 | Oracle Park · San Francisco, CA |
| 117 | Tue Aug 9 | vs Pirates | W6-0 | 64-53 | .547 | Oracle Park · San Francisco, CA |
| 118 | Wed Aug 10 | vs Pirates | L2-9 | 64-54 | .542 | Oracle Park · San Francisco, CA |
| 119 | Fri Aug 12 | at Marlins | L1-2 | 64-55 | .538 | MVP Arena · Albany, NY |
| 120 | Sat Aug 13 | at Marlins | W3-0 | 65-55 | .542 | MVP Arena · Albany, NY |
| 121 | Sun Aug 14 | at Marlins | W5-2 | 66-55 | .545 | MVP Arena · Albany, NY |
| 122 | Mon Aug 15 | at Braves | L4-5 | 66-56 | .541 | Truist Park · Cumberland, GA |
| 123 | Tue Aug 16 | at Braves | L1-2 (11) | 66-57 | .537 | Truist Park · Cumberland, GA |
| 124 | Wed Aug 17 | at Braves | W7-5 | 67-57 | .540 | Truist Park · Cumberland, GA |
| 125 | Thu Aug 18 | at Braves | L0-1 | 67-58 | .536 | Truist Park · Cumberland, GA |
| 126 | Fri Aug 19 | at Astros | L0-6 | 67-59 | .532 | Minute Maid Park · Houston, TX |
| 127 | Sat Aug 20 | at Astros | L5-7 | 67-60 | .528 | Minute Maid Park · Houston, TX |
| 128 | Sun Aug 21 | at Astros | W6-4 (11) | 68-60 | .531 | Minute Maid Park · Houston, TX |
| 129 | Tue Aug 23 | vs Padres | L5-7 | 68-61 | .527 | Oracle Park · San Francisco, CA |
| 130 | Wed Aug 24 | vs Padres | W2-1 | 69-61 | .531 | Oracle Park · San Francisco, CA |
| 131 | Thu Aug 25 | vs Astros | L1-3 | 69-62 | .527 | Oracle Park · San Francisco, CA |
| 132 | Fri Aug 26 | vs Astros | W2-1 | 70-62 | .530 | Oracle Park · San Francisco, CA |
| 133 | Sat Aug 27 | vs Astros | W2-1 (10) | 71-62 | .534 | Oracle Park · San Francisco, CA |
| 134 | Sun Aug 28 | vs Astros | L3-4 (11) | 71-63 | .530 | Oracle Park · San Francisco, CA |
| 135 | Mon Aug 29 | vs Cubs | L0-7 | 71-64 | .526 | Oracle Park · San Francisco, CA |
| 136 | Tue Aug 30 | vs Cubs | L2-5 | 71-65 | .522 | Oracle Park · San Francisco, CA |
| 137 | Wed Aug 31 | vs Cubs | W4-0 | 72-65 | .526 | Oracle Park · San Francisco, CA |
| 138 | Fri Sep 2 | vs D-backs | W6-2 | 73-65 | .529 | Oracle Park · San Francisco, CA |
| 139 | Sat Sep 3 | vs D-backs | L2-7 | 73-66 | .525 | Oracle Park · San Francisco, CA |
| 140 | Sun Sep 4 | vs D-backs | L1-4 | 73-67 | .521 | Oracle Park · San Francisco, CA |
| 141 | Mon Sep 5 | at Padres | W7-2 | 74-67 | .525 | Petco Park · San Diego, CA |
| 142 | Tue Sep 6 | at Padres | W6-4 | 75-67 | .528 | Petco Park · San Diego, CA |
| 143 | Wed Sep 7 | at Padres | L1-3 | 75-68 | .524 | Petco Park · San Diego, CA |
| 144 | Fri Sep 9 | vs Dodgers | L1-2 | 75-69 | .521 | Oracle Park · San Francisco, CA |
| 145 | Sat Sep 10 | vs Dodgers | L0-3 | 75-70 | .517 | Oracle Park · San Francisco, CA |
| 146 | Sun Sep 11 | vs Dodgers | W8-1 | 76-70 | .521 | Oracle Park · San Francisco, CA |
| 147 | Mon Sep 12 | vs Padres | W8-3 | 77-70 | .524 | Oracle Park · San Francisco, CA |
| 148 | Tue Sep 13 | vs Padres | W3-2 (12) | 78-70 | .527 | Oracle Park · San Francisco, CA |
| 149 | Wed Sep 14 | vs Padres | W3-1 | 79-70 | .530 | Oracle Park · San Francisco, CA |
| 150 | Thu Sep 15 | at Rockies | W8-5 | 80-70 | .533 | Coors Field · Denver, CO |
| 151 | Fri Sep 16 | at Rockies | W9-1 | 81-70 | .536 | Coors Field · Denver, CO |
| 152 | Sat Sep 17 | at Rockies | W6-5 | 82-70 | .539 | Coors Field · Denver, CO |
| 153 | Sun Sep 18 | at Rockies | W12-5 | 83-70 | .542 | Coors Field · Denver, CO |
| 154 | Tue Sep 20 | at Dodgers | L1-2 | 83-71 | .539 | Dodger Stadium · Los Angeles, CA |
| 155 | Wed Sep 21 | at Dodgers | W8-5 | 84-71 | .542 | Dodger Stadium · Los Angeles, CA |
| 156 | Thu Sep 22 | at Dodgers | L2-8 | 84-72 | .538 | Dodger Stadium · Los Angeles, CA |
| 157 | Fri Sep 23 | at D-backs | L1-3 | 84-73 | .535 | Chase Field · Phoenix, AZ |
| 158 | Sat Sep 24 | at D-backs | L2-15 | 84-74 | .532 | Chase Field · Phoenix, AZ |
| 159 | Sun Sep 25 | at D-backs | L2-5 | 84-75 | .528 | Chase Field · Phoenix, AZ |
| 160 | Mon Sep 26 | vs Rockies | W3-1 | 85-75 | .531 | Oracle Park · San Francisco, CA |
| 161 | Tue Sep 27 | vs Rockies | W7-0 | 86-75 | .534 | Oracle Park · San Francisco, CA |
| 162 | Wed Sep 28 | vs Rockies | L3-6 | 86-76 | .531 | Oracle Park · San Francisco, CA |