| 1 | Sun Apr 2 | at D-backs | L5-6 | 0-1 | .000 | Chase Field · Phoenix, AZ |
| 2 | Tue Apr 4 | at D-backs | W8-4 | 1-1 | .500 | Chase Field · Phoenix, AZ |
| 3 | Wed Apr 5 | at D-backs | L6-8 | 1-2 | .333 | Chase Field · Phoenix, AZ |
| 4 | Thu Apr 6 | at D-backs | L3-9 | 1-3 | .250 | Chase Field · Phoenix, AZ |
| 5 | Fri Apr 7 | at Padres | L6-7 | 1-4 | .200 | Petco Park · San Diego, CA |
| 6 | Sat Apr 8 | at Padres | L1-2 | 1-5 | .167 | Petco Park · San Diego, CA |
| 7 | Sun Apr 9 | at Padres | W5-3 | 2-5 | .286 | Petco Park · San Diego, CA |
| 8 | Mon Apr 10 | vs D-backs | W4-1 | 3-5 | .375 | Oracle Park · San Francisco, CA |
| 9 | Tue Apr 11 | vs D-backs | L3-4 | 3-6 | .333 | Oracle Park · San Francisco, CA |
| 10 | Wed Apr 12 | vs D-backs | W6-2 | 4-6 | .400 | Oracle Park · San Francisco, CA |
| 11 | Thu Apr 13 | vs Rockies | L1-3 | 4-7 | .364 | Oracle Park · San Francisco, CA |
| 12 | Fri Apr 14 | vs Rockies | W8-2 | 5-7 | .417 | Oracle Park · San Francisco, CA |
| 13 | Sat Apr 15 | vs Rockies | L0-5 | 5-8 | .385 | Oracle Park · San Francisco, CA |
| 14 | Sun Apr 16 | vs Rockies | L3-4 | 5-9 | .357 | Oracle Park · San Francisco, CA |
| 15 | Tue Apr 18 | at Royals | W2-1 (11) | 6-9 | .400 | Kauffman Stadium · Kansas City, MO |
| 16 | Wed Apr 19 | at Royals | L0-2 | 6-10 | .375 | Kauffman Stadium · Kansas City, MO |
| 17 | Fri Apr 21 | at Rockies | L5-6 | 6-11 | .353 | Coors Field · Denver, CO |
| 18 | Sat Apr 22 | at Rockies | L3-12 | 6-12 | .333 | Coors Field · Denver, CO |
| 19 | Sun Apr 23 | at Rockies | L0-8 | 6-13 | .316 | Coors Field · Denver, CO |
| 20 | Mon Apr 24 | vs Dodgers | W2-1 | 7-13 | .350 | Oracle Park · San Francisco, CA |
| 21 | Tue Apr 25 | vs Dodgers | L1-2 | 7-14 | .333 | Oracle Park · San Francisco, CA |
| 22 | Wed Apr 26 | vs Dodgers | W4-3 (10) | 8-14 | .364 | Oracle Park · San Francisco, CA |
| 23 | Thu Apr 27 | vs Dodgers | L1-5 (10) | 8-15 | .348 | Oracle Park · San Francisco, CA |
| 24 | Fri Apr 28 | vs Padres | W4-3 | 9-15 | .375 | Oracle Park · San Francisco, CA |
| 25 | Sat Apr 29 | vs Padres | L4-12 | 9-16 | .360 | Oracle Park · San Francisco, CA |
| 26 | Sun Apr 30 | vs Padres | L2-5 (12) | 9-17 | .346 | Oracle Park · San Francisco, CA |
| 27 | Mon May 1 | at Dodgers | W4-3 | 10-17 | .370 | Dodger Stadium · Los Angeles, CA |
| 28 | Tue May 2 | at Dodgers | L5-13 | 10-18 | .357 | Dodger Stadium · Los Angeles, CA |
| 29 | Wed May 3 | at Dodgers | W4-1 (11) | 11-18 | .379 | Dodger Stadium · Los Angeles, CA |
| 30 | Fri May 5 | at Reds | L3-13 | 11-19 | .367 | Great American Ball Park · Cincinnati, OH |
| 31 | Sat May 6 | at Reds | L2-14 | 11-20 | .355 | Great American Ball Park · Cincinnati, OH |
| 32 | Sun May 7 | at Reds | L0-4 | 11-21 | .344 | Great American Ball Park · Cincinnati, OH |
| 33 | Mon May 8 | at Mets | L3-4 | 11-22 | .333 | Citi Field · Queens, NY |
| 34 | Tue May 9 | at Mets | L1-6 | 11-23 | .324 | Citi Field · Queens, NY |
| 35 | Wed May 10 | at Mets | W6-5 | 12-23 | .343 | Citi Field · Queens, NY |
| 36 | Thu May 11 | vs Reds | L2-3 | 12-24 | .333 | Oracle Park · San Francisco, CA |
| 37 | Fri May 12 | vs Reds | W3-2 (17) | 13-24 | .351 | Oracle Park · San Francisco, CA |
| 38 | Sat May 13 | vs Reds | W3-1 | 14-24 | .368 | Oracle Park · San Francisco, CA |
| 39 | Sun May 14 | vs Reds | W8-3 | 15-24 | .385 | Oracle Park · San Francisco, CA |
| 40 | Mon May 15 | vs Dodgers | W8-4 | 16-24 | .400 | Oracle Park · San Francisco, CA |
| 41 | Tue May 16 | vs Dodgers | W2-1 | 17-24 | .415 | Oracle Park · San Francisco, CA |
| 42 | Wed May 17 | vs Dodgers | L1-6 | 17-25 | .405 | Oracle Park · San Francisco, CA |
| 43 | Fri May 19 | at Cardinals | W6-5 | 18-25 | .419 | Busch Stadium · St. Louis, MO |
| 44 | Sat May 20 | at Cardinals | W3-1 (13) | 19-25 | .432 | Busch Stadium · St. Louis, MO |
| 45 | Sun May 21 | at Cardinals | L3-8 | 19-26 | .422 | Busch Stadium · St. Louis, MO |
| 46 | Mon May 22 | at Cubs | W6-4 | 20-26 | .435 | Wrigley Field · Chicago, IL |
| 47 | Tue May 23 | at Cubs | L1-4 | 20-27 | .426 | Wrigley Field · Chicago, IL |
| 48 | Wed May 24 | at Cubs | L4-5 | 20-28 | .417 | Wrigley Field · Chicago, IL |
| 49 | Thu May 25 | at Cubs | L1-5 | 20-29 | .408 | Wrigley Field · Chicago, IL |
| 50 | Fri May 26 | vs Braves | L0-2 | 20-30 | .400 | Oracle Park · San Francisco, CA |
| 51 | Sat May 27 | vs Braves | W6-3 | 21-30 | .412 | Oracle Park · San Francisco, CA |
| 52 | Sun May 28 | vs Braves | W7-1 | 22-30 | .423 | Oracle Park · San Francisco, CA |
| 53 | Mon May 29 | vs Nationals | L0-3 | 22-31 | .415 | Oracle Park · San Francisco, CA |
| 54 | Tue May 30 | vs Nationals | L3-6 | 22-32 | .407 | Oracle Park · San Francisco, CA |
| 55 | Wed May 31 | vs Nationals | L1-3 | 22-33 | .400 | Oracle Park · San Francisco, CA |
| 56 | Fri Jun 2 | at Phillies | W10-0 | 23-33 | .411 | Citizens Bank Park · Philadelphi, PA |
| 57 | Sat Jun 3 | at Phillies | L3-5 | 23-34 | .404 | Citizens Bank Park · Philadelphi, PA |
| 58 | Sun Jun 4 | at Phillies | L7-9 | 23-35 | .397 | Citizens Bank Park · Philadelphi, PA |
| 59 | Mon Jun 5 | at Brewers | W7-2 | 24-35 | .407 | American Family Field · Milwaukee, WI |
| 60 | Tue Jun 6 | at Brewers | L2-5 | 24-36 | .400 | American Family Field · Milwaukee, WI |
| 61 | Wed Jun 7 | at Brewers | L3-6 | 24-37 | .393 | American Family Field · Milwaukee, WI |
| 62 | Thu Jun 8 | at Brewers | W9-5 (10) | 25-37 | .403 | American Family Field · Milwaukee, WI |
| 63 | Fri Jun 9 | vs Twins | L0-4 | 25-38 | .397 | Oracle Park · San Francisco, CA |
| 64 | Sat Jun 10 | vs Twins | L2-3 | 25-39 | .391 | Oracle Park · San Francisco, CA |
| 65 | Sun Jun 11 | vs Twins | W13-8 | 26-39 | .400 | Oracle Park · San Francisco, CA |
| 66 | Tue Jun 13 | vs Royals | L1-8 | 26-40 | .394 | Oracle Park · San Francisco, CA |
| 67 | Wed Jun 14 | vs Royals | L2-7 | 26-41 | .388 | Oracle Park · San Francisco, CA |
| 68 | Thu Jun 15 | at Rockies | L9-10 | 26-42 | .382 | Coors Field · Denver, CO |
| 69 | Fri Jun 16 | at Rockies | L8-10 | 26-43 | .377 | Coors Field · Denver, CO |
| 70 | Sat Jun 17 | at Rockies | L1-5 | 26-44 | .371 | Coors Field · Denver, CO |
| 71 | Sun Jun 18 | at Rockies | L5-7 | 26-45 | .366 | Coors Field · Denver, CO |
| 72 | Mon Jun 19 | at Braves | L0-9 | 26-46 | .361 | Truist Park · Cumberland, GA |
| 73 | Tue Jun 20 | at Braves | W6-3 | 27-46 | .370 | Truist Park · Cumberland, GA |
| 74 | Wed Jun 21 | at Braves | L3-5 (11) | 27-47 | .365 | Truist Park · Cumberland, GA |
| 75 | Thu Jun 22 | at Braves | L11-12 | 27-48 | .360 | Truist Park · Cumberland, GA |
| 76 | Fri Jun 23 | vs Mets | L4-11 | 27-49 | .355 | Oracle Park · San Francisco, CA |
| 77 | Sat Jun 24 | vs Mets | L2-5 | 27-50 | .351 | Oracle Park · San Francisco, CA |
| 78 | Sun Jun 25 | vs Mets | L2-8 | 27-51 | .346 | Oracle Park · San Francisco, CA |
| 79 | Mon Jun 26 | vs Rockies | W9-2 | 28-51 | .354 | Oracle Park · San Francisco, CA |
| 80 | Tue Jun 27 | vs Rockies | W4-3 (14) | 29-51 | .362 | Oracle Park · San Francisco, CA |
| 81 | Wed Jun 28 | vs Rockies | W5-3 | 30-51 | .370 | Oracle Park · San Francisco, CA |
| 82 | Fri Jun 30 | at Pirates | W13-5 | 31-51 | .378 | PNC Park · Pittsburgh, PA |
| 83 | Sat Jul 1 | at Pirates | W2-1 (11) | 32-51 | .386 | PNC Park · Pittsburgh, PA |
| 84 | Sun Jul 2 | at Pirates | W5-3 | 33-51 | .393 | PNC Park · Pittsburgh, PA |
| 85 | Tue Jul 4 | at Tigers | L3-5 | 33-52 | .388 | Comerica Park · Detroit, MI |
| 86 | Wed Jul 5 | at Tigers | W5-4 | 34-52 | .395 | Comerica Park · Detroit, MI |
| 87 | Thu Jul 6 | at Tigers | L2-6 | 34-53 | .391 | Comerica Park · Detroit, MI |
| 88 | Fri Jul 7 | vs Marlins | L1-6 | 34-54 | .386 | Oracle Park · San Francisco, CA |
| 89 | Sat Jul 8 | vs Marlins | L4-5 | 34-55 | .382 | Oracle Park · San Francisco, CA |
| 90 | Sun Jul 9 | vs Marlins | L8-10 (11) | 34-56 | .378 | Oracle Park · San Francisco, CA |
| 91 | Fri Jul 14 | at Padres | W5-4 | 35-56 | .385 | Petco Park · San Diego, CA |
| 92 | Sat Jul 15 | at Padres | L3-5 | 35-57 | .380 | Petco Park · San Diego, CA |
| 93 | Sun Jul 16 | at Padres | L1-7 | 35-58 | .376 | Petco Park · San Diego, CA |
| 94 | Mon Jul 17 | vs Guardians | L3-5 | 35-59 | .372 | Oracle Park · San Francisco, CA |
| 95 | Tue Jul 18 | vs Guardians | W2-1 (10) | 36-59 | .379 | Oracle Park · San Francisco, CA |
| 96 | Wed Jul 19 | vs Guardians | W5-4 | 37-59 | .385 | Oracle Park · San Francisco, CA |
| 97 | Thu Jul 20 | vs Padres | L2-5 | 37-60 | .381 | Oracle Park · San Francisco, CA |
| 98 | Fri Jul 21 | vs Padres | L9-12 (11) | 37-61 | .378 | Oracle Park · San Francisco, CA |
| 99 | Sat Jul 22 | vs Padres | W5-4 (12) | 38-61 | .384 | Oracle Park · San Francisco, CA |
| 100 | Sun Jul 23 | vs Padres | L2-5 | 38-62 | .380 | Oracle Park · San Francisco, CA |
| 101 | Mon Jul 24 | vs Pirates | L3-10 | 38-63 | .376 | Oracle Park · San Francisco, CA |
| 102 | Tue Jul 25 | vs Pirates | W11-3 | 39-63 | .382 | Oracle Park · San Francisco, CA |
| 103 | Wed Jul 26 | vs Pirates | W2-1 | 40-63 | .388 | Oracle Park · San Francisco, CA |
| 104 | Fri Jul 28 | at Dodgers | L4-6 | 40-64 | .385 | Dodger Stadium · Los Angeles, CA |
| 105 | Sat Jul 29 | at Dodgers | L1-2 | 40-65 | .381 | Dodger Stadium · Los Angeles, CA |
| 106 | Sun Jul 30 | at Dodgers | L2-3 (11) | 40-66 | .377 | Dodger Stadium · Los Angeles, CA |
| 107 | Mon Jul 31 | at Athletics | L5-8 | 40-67 | .374 | RingCentral Coliseum · Oakland, CA |
| 108 | Tue Aug 1 | at Athletics | W10-4 | 41-67 | .380 | RingCentral Coliseum · Oakland, CA |
| 109 | Wed Aug 2 | vs Athletics | L1-6 | 41-68 | .376 | Oracle Park · San Francisco, CA |
| 110 | Thu Aug 3 | vs Athletics | W11-2 | 42-68 | .382 | Oracle Park · San Francisco, CA |
| 111 | Fri Aug 4 | vs D-backs | L1-2 | 42-69 | .378 | Oracle Park · San Francisco, CA |
| 112 | Sat Aug 5 | vs D-backs | W5-4 (10) | 43-69 | .384 | Oracle Park · San Francisco, CA |
| 113 | Sun Aug 6 | vs D-backs | W6-3 | 44-69 | .389 | Oracle Park · San Francisco, CA |
| 114 | Mon Aug 7 | vs Cubs | L3-5 | 44-70 | .386 | Oracle Park · San Francisco, CA |
| 115 | Tue Aug 8 | vs Cubs | W6-3 | 45-70 | .391 | Oracle Park · San Francisco, CA |
| 116 | Wed Aug 9 | vs Cubs | W3-1 | 46-70 | .397 | Oracle Park · San Francisco, CA |
| 117 | Sat Aug 12 | at Nationals | L1-3 | 46-71 | .393 | Nationals Park · Washington, D.C. |
| 118 | Sun Aug 13 | at Nationals | W4-2 | 47-71 | .398 | Nationals Park · Washington, D.C. |
| 119 | Sun Aug 13 | at Nationals | L2-6 (11) | 47-72 | .395 | Nationals Park · Washington, D.C. |
| 120 | Mon Aug 14 | at Marlins | L3-8 | 47-73 | .392 | LoanDepot Park · Miami, FL |
| 121 | Tue Aug 15 | at Marlins | W9-4 | 48-73 | .397 | LoanDepot Park · Miami, FL |
| 122 | Wed Aug 16 | at Marlins | L1-8 | 48-74 | .393 | LoanDepot Park · Miami, FL |
| 123 | Thu Aug 17 | vs Phillies | W5-4 | 49-74 | .398 | Oracle Park · San Francisco, CA |
| 124 | Fri Aug 18 | vs Phillies | W10-2 | 50-74 | .403 | Oracle Park · San Francisco, CA |
| 125 | Sat Aug 19 | vs Phillies | L9-12 | 50-75 | .400 | Oracle Park · San Francisco, CA |
| 126 | Sun Aug 20 | vs Phillies | L2-5 | 50-76 | .397 | Oracle Park · San Francisco, CA |
| 127 | Mon Aug 21 | vs Brewers | W2-0 | 51-76 | .402 | Oracle Park · San Francisco, CA |
| 128 | Tue Aug 22 | vs Brewers | L3-4 | 51-77 | .398 | Oracle Park · San Francisco, CA |
| 129 | Wed Aug 23 | vs Brewers | W4-2 | 52-77 | .403 | Oracle Park · San Francisco, CA |
| 130 | Fri Aug 25 | at D-backs | L3-4 | 52-78 | .400 | Chase Field · Phoenix, AZ |
| 131 | Sat Aug 26 | at D-backs | L1-2 | 52-79 | .397 | Chase Field · Phoenix, AZ |
| 132 | Sun Aug 27 | at D-backs | L0-11 | 52-80 | .394 | Chase Field · Phoenix, AZ |
| 133 | Mon Aug 28 | at Padres | W3-0 | 53-80 | .398 | Petco Park · San Diego, CA |
| 134 | Tue Aug 29 | at Padres | L3-6 | 53-81 | .396 | Petco Park · San Diego, CA |
| 135 | Wed Aug 30 | at Padres | L0-5 | 53-82 | .393 | Petco Park · San Diego, CA |
| 136 | Thu Aug 31 | vs Cardinals | L2-5 | 53-83 | .390 | Oracle Park · San Francisco, CA |
| 137 | Fri Sep 1 | vs Cardinals | L6-11 | 53-84 | .387 | Oracle Park · San Francisco, CA |
| 138 | Sat Sep 2 | vs Cardinals | W2-1 (10) | 54-84 | .391 | Oracle Park · San Francisco, CA |
| 139 | Sun Sep 3 | vs Cardinals | L3-7 | 54-85 | .388 | Oracle Park · San Francisco, CA |
| 140 | Mon Sep 4 | at Rockies | L3-4 | 54-86 | .386 | Coors Field · Denver, CO |
| 141 | Tue Sep 5 | at Rockies | L6-9 | 54-87 | .383 | Coors Field · Denver, CO |
| 142 | Wed Sep 6 | at Rockies | W11-3 | 55-87 | .387 | Coors Field · Denver, CO |
| 143 | Fri Sep 8 | at White Sox | W9-2 | 56-87 | .392 | Guaranteed Rate Field · Chicago, IL |
| 144 | Sat Sep 9 | at White Sox | L1-13 | 56-88 | .389 | Guaranteed Rate Field · Chicago, IL |
| 145 | Sun Sep 10 | at White Sox | L1-8 | 56-89 | .386 | Guaranteed Rate Field · Chicago, IL |
| 146 | Mon Sep 11 | vs Dodgers | W8-6 | 57-89 | .390 | Oracle Park · San Francisco, CA |
| 147 | Tue Sep 12 | vs Dodgers | L3-5 | 57-90 | .388 | Oracle Park · San Francisco, CA |
| 148 | Wed Sep 13 | vs Dodgers | L1-4 | 57-91 | .385 | Oracle Park · San Francisco, CA |
| 149 | Fri Sep 15 | vs D-backs | L2-3 | 57-92 | .383 | Oracle Park · San Francisco, CA |
| 150 | Sat Sep 16 | vs D-backs | L0-2 | 57-93 | .380 | Oracle Park · San Francisco, CA |
| 151 | Sun Sep 17 | vs D-backs | W7-2 | 58-93 | .384 | Oracle Park · San Francisco, CA |
| 152 | Tue Sep 19 | vs Rockies | W4-3 | 59-93 | .388 | Oracle Park · San Francisco, CA |
| 153 | Wed Sep 20 | vs Rockies | W4-0 | 60-93 | .392 | Oracle Park · San Francisco, CA |
| 154 | Fri Sep 22 | at Dodgers | L2-4 | 60-94 | .390 | Dodger Stadium · Los Angeles, CA |
| 155 | Sat Sep 23 | at Dodgers | W2-1 | 61-94 | .394 | Dodger Stadium · Los Angeles, CA |
| 156 | Sun Sep 24 | at Dodgers | L1-3 | 61-95 | .391 | Dodger Stadium · Los Angeles, CA |
| 157 | Mon Sep 25 | at D-backs | W9-2 | 62-95 | .395 | Chase Field · Phoenix, AZ |
| 158 | Tue Sep 26 | at D-backs | L4-11 | 62-96 | .392 | Chase Field · Phoenix, AZ |
| 159 | Wed Sep 27 | at D-backs | L3-4 | 62-97 | .390 | Chase Field · Phoenix, AZ |
| 160 | Fri Sep 29 | vs Padres | W8-0 | 63-97 | .394 | Oracle Park · San Francisco, CA |
| 161 | Sat Sep 30 | vs Padres | L2-3 | 63-98 | .391 | Oracle Park · San Francisco, CA |
| 162 | Sun Oct 1 | vs Padres | W5-4 | 64-98 | .395 | Oracle Park · San Francisco, CA |