| 1 | Thu Mar 29 | at Dodgers | W1-0 | 1-0 | 1.000 | Dodger Stadium · Los Angeles, CA |
| 2 | Fri Mar 30 | at Dodgers | W1-0 | 2-0 | 1.000 | Dodger Stadium · Los Angeles, CA |
| 3 | Sat Mar 31 | at Dodgers | L0-5 | 2-1 | .667 | Dodger Stadium · Los Angeles, CA |
| 4 | Sun Apr 1 | at Dodgers | L0-9 | 2-2 | .500 | Dodger Stadium · Los Angeles, CA |
| 5 | Tue Apr 3 | vs Mariners | L4-6 | 2-3 | .400 | Oracle Park · San Francisco, CA |
| 6 | Wed Apr 4 | vs Mariners | W10-1 | 3-3 | .500 | Oracle Park · San Francisco, CA |
| 7 | Sat Apr 7 | vs Dodgers | W7-5 (14) | 4-3 | .571 | Oracle Park · San Francisco, CA |
| 8 | Sun Apr 8 | vs Dodgers | L1-2 (10) | 4-4 | .500 | Oracle Park · San Francisco, CA |
| 9 | Mon Apr 9 | vs D-backs | L1-2 | 4-5 | .444 | Oracle Park · San Francisco, CA |
| 10 | Tue Apr 10 | vs D-backs | W5-4 | 5-5 | .500 | Oracle Park · San Francisco, CA |
| 11 | Wed Apr 11 | vs D-backs | L3-7 | 5-6 | .455 | Oracle Park · San Francisco, CA |
| 12 | Thu Apr 12 | at Padres | W7-0 | 6-6 | .500 | Petco Park · San Diego, CA |
| 13 | Fri Apr 13 | at Padres | L1-5 | 6-7 | .462 | Petco Park · San Diego, CA |
| 14 | Sat Apr 14 | at Padres | L4-5 | 6-8 | .429 | Petco Park · San Diego, CA |
| 15 | Sun Apr 15 | at Padres | L1-10 | 6-9 | .400 | Petco Park · San Diego, CA |
| 16 | Tue Apr 17 | at D-backs | L0-1 | 6-10 | .375 | Chase Field · Phoenix, AZ |
| 17 | Wed Apr 18 | at D-backs | W4-3 (10) | 7-10 | .412 | Chase Field · Phoenix, AZ |
| 18 | Thu Apr 19 | at D-backs | L1-3 | 7-11 | .389 | Chase Field · Phoenix, AZ |
| 19 | Fri Apr 20 | at Angels | W8-1 | 8-11 | .421 | Angel Stadium · Anaheim, CA |
| 20 | Sat Apr 21 | at Angels | L3-4 | 8-12 | .400 | Angel Stadium · Anaheim, CA |
| 21 | Sun Apr 22 | at Angels | W4-2 | 9-12 | .429 | Angel Stadium · Anaheim, CA |
| 22 | Mon Apr 23 | vs Nationals | W4-2 | 10-12 | .455 | Oracle Park · San Francisco, CA |
| 23 | Tue Apr 24 | vs Nationals | W4-3 | 11-12 | .478 | Oracle Park · San Francisco, CA |
| 24 | Wed Apr 25 | vs Nationals | L2-15 | 11-13 | .458 | Oracle Park · San Francisco, CA |
| 25 | Fri Apr 27 | vs Dodgers | W6-4 | 12-13 | .480 | Oracle Park · San Francisco, CA |
| 26 | Sat Apr 28 | vs Dodgers | L6-15 | 12-14 | .462 | Oracle Park · San Francisco, CA |
| 27 | Sat Apr 28 | vs Dodgers | W8-3 | 13-14 | .481 | Oracle Park · San Francisco, CA |
| 28 | Sun Apr 29 | vs Dodgers | W4-2 | 14-14 | .500 | Oracle Park · San Francisco, CA |
| 29 | Mon Apr 30 | vs Padres | W6-5 | 15-14 | .517 | Oracle Park · San Francisco, CA |
| 30 | Tue May 1 | vs Padres | L2-3 | 15-15 | .500 | Oracle Park · San Francisco, CA |
| 31 | Wed May 2 | vs Padres | W9-4 | 16-15 | .516 | Oracle Park · San Francisco, CA |
| 32 | Fri May 4 | at Braves | W9-4 | 17-15 | .531 | Truist Park · Cumberland, GA |
| 33 | Sat May 5 | at Braves | W11-2 | 18-15 | .545 | Truist Park · Cumberland, GA |
| 34 | Sun May 6 | at Braves | W4-3 | 19-15 | .559 | Truist Park · Cumberland, GA |
| 35 | Mon May 7 | at Phillies | L0-11 | 19-16 | .543 | Citizens Bank Park · Philadelphi, PA |
| 36 | Tue May 8 | at Phillies | L2-4 | 19-17 | .528 | Citizens Bank Park · Philadelphi, PA |
| 37 | Wed May 9 | at Phillies | L3-11 | 19-18 | .514 | Citizens Bank Park · Philadelphi, PA |
| 38 | Thu May 10 | at Phillies | L3-6 | 19-19 | .500 | Citizens Bank Park · Philadelphi, PA |
| 39 | Fri May 11 | at Pirates | L2-11 | 19-20 | .487 | PNC Park · Pittsburgh, PA |
| 40 | Sat May 12 | at Pirates | L5-6 | 19-21 | .475 | PNC Park · Pittsburgh, PA |
| 41 | Sun May 13 | at Pirates | W5-0 | 20-21 | .488 | PNC Park · Pittsburgh, PA |
| 42 | Mon May 14 | vs Reds | W10-7 | 21-21 | .500 | Oracle Park · San Francisco, CA |
| 43 | Tue May 15 | vs Reds | W5-3 | 22-21 | .512 | Oracle Park · San Francisco, CA |
| 44 | Wed May 16 | vs Reds | L3-6 | 22-22 | .500 | Oracle Park · San Francisco, CA |
| 45 | Thu May 17 | vs Rockies | L3-5 (12) | 22-23 | .489 | Oracle Park · San Francisco, CA |
| 46 | Fri May 18 | vs Rockies | L1-6 | 22-24 | .478 | Oracle Park · San Francisco, CA |
| 47 | Sat May 19 | vs Rockies | W9-4 | 23-24 | .489 | Oracle Park · San Francisco, CA |
| 48 | Sun May 20 | vs Rockies | W9-5 | 24-24 | .500 | Oracle Park · San Francisco, CA |
| 49 | Tue May 22 | at Astros | L2-11 | 24-25 | .490 | Minute Maid Park · Houston, TX |
| 50 | Wed May 23 | at Astros | L1-4 | 24-26 | .480 | Minute Maid Park · Houston, TX |
| 51 | Fri May 25 | at Cubs | L2-6 | 24-27 | .471 | Wrigley Field · Chicago, IL |
| 52 | Sat May 26 | at Cubs | W5-4 | 25-27 | .481 | Wrigley Field · Chicago, IL |
| 53 | Sun May 27 | at Cubs | L3-8 | 25-28 | .472 | Wrigley Field · Chicago, IL |
| 54 | Mon May 28 | at Rockies | L5-6 (10) | 25-29 | .463 | Coors Field · Denver, CO |
| 55 | Tue May 29 | at Rockies | L4-11 | 25-30 | .455 | Coors Field · Denver, CO |
| 56 | Wed May 30 | at Rockies | W7-4 | 26-30 | .464 | Coors Field · Denver, CO |
| 57 | Fri Jun 1 | vs Phillies | W4-0 | 27-30 | .474 | Oracle Park · San Francisco, CA |
| 58 | Sat Jun 2 | vs Phillies | W2-0 | 28-30 | .483 | Oracle Park · San Francisco, CA |
| 59 | Sun Jun 3 | vs Phillies | W6-1 | 29-30 | .492 | Oracle Park · San Francisco, CA |
| 60 | Mon Jun 4 | vs D-backs | W10-3 | 30-30 | .500 | Oracle Park · San Francisco, CA |
| 61 | Tue Jun 5 | vs D-backs | L2-3 | 30-31 | .492 | Oracle Park · San Francisco, CA |
| 62 | Wed Jun 6 | vs D-backs | W5-4 (10) | 31-31 | .500 | Oracle Park · San Francisco, CA |
| 63 | Fri Jun 8 | at Nationals | W9-5 | 32-31 | .508 | Nationals Park · Washington, D.C. |
| 64 | Sat Jun 9 | at Nationals | L5-7 | 32-32 | .500 | Nationals Park · Washington, D.C. |
| 65 | Sun Jun 10 | at Nationals | W2-0 | 33-32 | .508 | Nationals Park · Washington, D.C. |
| 66 | Mon Jun 11 | at Marlins | L5-7 | 33-33 | .500 | LoanDepot Park · Miami, FL |
| 67 | Tue Jun 12 | at Marlins | L1-3 | 33-34 | .493 | LoanDepot Park · Miami, FL |
| 68 | Wed Jun 13 | at Marlins | L4-5 | 33-35 | .485 | LoanDepot Park · Miami, FL |
| 69 | Thu Jun 14 | at Marlins | W6-3 (16) | 34-35 | .493 | LoanDepot Park · Miami, FL |
| 70 | Fri Jun 15 | at Dodgers | L2-3 | 34-36 | .486 | Dodger Stadium · Los Angeles, CA |
| 71 | Sat Jun 16 | at Dodgers | L1-3 | 34-37 | .479 | Dodger Stadium · Los Angeles, CA |
| 72 | Sun Jun 17 | at Dodgers | W4-1 | 35-37 | .486 | Dodger Stadium · Los Angeles, CA |
| 73 | Mon Jun 18 | vs Marlins | L4-5 | 35-38 | .479 | Oracle Park · San Francisco, CA |
| 74 | Tue Jun 19 | vs Marlins | W6-3 | 36-38 | .486 | Oracle Park · San Francisco, CA |
| 75 | Wed Jun 20 | vs Marlins | W6-5 | 37-38 | .493 | Oracle Park · San Francisco, CA |
| 76 | Thu Jun 21 | vs Padres | W3-0 | 38-38 | .500 | Oracle Park · San Francisco, CA |
| 77 | Fri Jun 22 | vs Padres | L2-6 | 38-39 | .494 | Oracle Park · San Francisco, CA |
| 78 | Sat Jun 23 | vs Padres | W5-3 | 39-39 | .500 | Oracle Park · San Francisco, CA |
| 79 | Sun Jun 24 | vs Padres | W3-2 (11) | 40-39 | .506 | Oracle Park · San Francisco, CA |
| 80 | Tue Jun 26 | vs Rockies | W3-2 | 41-39 | .512 | Oracle Park · San Francisco, CA |
| 81 | Wed Jun 27 | vs Rockies | W1-0 | 42-39 | .519 | Oracle Park · San Francisco, CA |
| 82 | Thu Jun 28 | vs Rockies | L8-9 | 42-40 | .512 | Oracle Park · San Francisco, CA |
| 83 | Fri Jun 29 | at D-backs | W2-1 | 43-40 | .518 | Chase Field · Phoenix, AZ |
| 84 | Sat Jun 30 | at D-backs | W7-0 | 44-40 | .524 | Chase Field · Phoenix, AZ |
| 85 | Sun Jul 1 | at D-backs | W9-6 | 45-40 | .529 | Chase Field · Phoenix, AZ |
| 86 | Mon Jul 2 | at Rockies | L2-5 | 45-41 | .523 | Coors Field · Denver, CO |
| 87 | Tue Jul 3 | at Rockies | L1-8 | 45-42 | .517 | Coors Field · Denver, CO |
| 88 | Wed Jul 4 | at Rockies | L0-1 | 45-43 | .511 | Coors Field · Denver, CO |
| 89 | Thu Jul 5 | vs Cardinals | L2-11 | 45-44 | .506 | Oracle Park · San Francisco, CA |
| 90 | Fri Jul 6 | vs Cardinals | W3-2 | 46-44 | .511 | Oracle Park · San Francisco, CA |
| 91 | Sat Jul 7 | vs Cardinals | L2-3 | 46-45 | .505 | Oracle Park · San Francisco, CA |
| 92 | Sun Jul 8 | vs Cardinals | W13-8 | 47-45 | .511 | Oracle Park · San Francisco, CA |
| 93 | Mon Jul 9 | vs Cubs | W2-1 (11) | 48-45 | .516 | Oracle Park · San Francisco, CA |
| 94 | Tue Jul 10 | vs Cubs | L0-2 | 48-46 | .511 | Oracle Park · San Francisco, CA |
| 95 | Wed Jul 11 | vs Cubs | W5-4 (13) | 49-46 | .516 | Oracle Park · San Francisco, CA |
| 96 | Fri Jul 13 | vs Athletics | W7-1 | 50-46 | .521 | Oracle Park · San Francisco, CA |
| 97 | Sat Jul 14 | vs Athletics | L3-4 | 50-47 | .515 | Oracle Park · San Francisco, CA |
| 98 | Sun Jul 15 | vs Athletics | L2-6 | 50-48 | .510 | Oracle Park · San Francisco, CA |
| 99 | Fri Jul 20 | at Athletics | W5-1 | 51-48 | .515 | RingCentral Coliseum · Oakland, CA |
| 100 | Sat Jul 21 | at Athletics | L3-4 (11) | 51-49 | .510 | RingCentral Coliseum · Oakland, CA |
| 101 | Sun Jul 22 | at Athletics | L5-6 (10) | 51-50 | .505 | RingCentral Coliseum · Oakland, CA |
| 102 | Tue Jul 24 | at Mariners | W4-3 | 52-50 | .510 | T-Mobile Park · Seattle, WA |
| 103 | Wed Jul 25 | at Mariners | L2-3 | 52-51 | .505 | T-Mobile Park · Seattle, WA |
| 104 | Thu Jul 26 | vs Brewers | L5-7 | 52-52 | .500 | Oracle Park · San Francisco, CA |
| 105 | Fri Jul 27 | vs Brewers | L1-3 | 52-53 | .495 | Oracle Park · San Francisco, CA |
| 106 | Sat Jul 28 | vs Brewers | L1-7 | 52-54 | .491 | Oracle Park · San Francisco, CA |
| 107 | Sun Jul 29 | vs Brewers | W8-5 | 53-54 | .495 | Oracle Park · San Francisco, CA |
| 108 | Mon Jul 30 | at Padres | W5-3 (12) | 54-54 | .500 | Petco Park · San Diego, CA |
| 109 | Tue Jul 31 | at Padres | W3-2 (10) | 55-54 | .505 | Petco Park · San Diego, CA |
| 110 | Thu Aug 2 | at D-backs | W8-1 | 56-54 | .509 | Chase Field · Phoenix, AZ |
| 111 | Fri Aug 3 | at D-backs | L3-6 | 56-55 | .505 | Chase Field · Phoenix, AZ |
| 112 | Sat Aug 4 | at D-backs | L3-9 | 56-56 | .500 | Chase Field · Phoenix, AZ |
| 113 | Sun Aug 5 | at D-backs | W3-2 | 57-56 | .504 | Chase Field · Phoenix, AZ |
| 114 | Mon Aug 6 | vs Astros | L1-3 | 57-57 | .500 | Oracle Park · San Francisco, CA |
| 115 | Tue Aug 7 | vs Astros | L1-2 | 57-58 | .496 | Oracle Park · San Francisco, CA |
| 116 | Thu Aug 9 | vs Pirates | L5-10 | 57-59 | .491 | Oracle Park · San Francisco, CA |
| 117 | Fri Aug 10 | vs Pirates | W13-10 | 58-59 | .496 | Oracle Park · San Francisco, CA |
| 118 | Sat Aug 11 | vs Pirates | L0-4 | 58-60 | .492 | Oracle Park · San Francisco, CA |
| 119 | Sun Aug 12 | vs Pirates | W4-3 | 59-60 | .496 | Oracle Park · San Francisco, CA |
| 120 | Mon Aug 13 | at Dodgers | W5-2 | 60-60 | .500 | Dodger Stadium · Los Angeles, CA |
| 121 | Tue Aug 14 | at Dodgers | W2-1 | 61-60 | .504 | Dodger Stadium · Los Angeles, CA |
| 122 | Wed Aug 15 | at Dodgers | L3-4 (12) | 61-61 | .500 | Dodger Stadium · Los Angeles, CA |
| 123 | Fri Aug 17 | at Reds | L1-2 (11) | 61-62 | .496 | Great American Ball Park · Cincinnati, OH |
| 124 | Sat Aug 18 | at Reds | L1-7 | 61-63 | .492 | Great American Ball Park · Cincinnati, OH |
| 125 | Sun Aug 19 | at Reds | L4-11 | 61-64 | .488 | Great American Ball Park · Cincinnati, OH |
| 126 | Mon Aug 20 | at Mets | W2-1 (13) | 62-64 | .492 | Citi Field · Queens, NY |
| 127 | Tue Aug 21 | at Mets | L3-6 | 62-65 | .488 | Citi Field · Queens, NY |
| 128 | Wed Aug 22 | at Mets | L3-5 | 62-66 | .484 | Citi Field · Queens, NY |
| 129 | Thu Aug 23 | at Mets | W3-1 | 63-66 | .488 | Citi Field · Queens, NY |
| 130 | Fri Aug 24 | vs Rangers | L6-7 (10) | 63-67 | .485 | Oracle Park · San Francisco, CA |
| 131 | Sat Aug 25 | vs Rangers | W5-3 | 64-67 | .489 | Oracle Park · San Francisco, CA |
| 132 | Sun Aug 26 | vs Rangers | W3-1 | 65-67 | .492 | Oracle Park · San Francisco, CA |
| 133 | Mon Aug 27 | vs D-backs | W2-0 | 66-67 | .496 | Oracle Park · San Francisco, CA |
| 134 | Tue Aug 28 | vs D-backs | W1-0 | 67-67 | .500 | Oracle Park · San Francisco, CA |
| 135 | Wed Aug 29 | vs D-backs | L1-3 | 67-68 | .496 | Oracle Park · San Francisco, CA |
| 136 | Fri Aug 31 | vs Mets | W7-0 | 68-68 | .500 | Oracle Park · San Francisco, CA |
| 137 | Sat Sep 1 | vs Mets | L1-2 (11) | 68-69 | .496 | Oracle Park · San Francisco, CA |
| 138 | Sun Sep 2 | vs Mets | L1-4 | 68-70 | .493 | Oracle Park · San Francisco, CA |
| 139 | Mon Sep 3 | at Rockies | L8-9 | 68-71 | .489 | Coors Field · Denver, CO |
| 140 | Tue Sep 4 | at Rockies | L2-6 | 68-72 | .486 | Coors Field · Denver, CO |
| 141 | Wed Sep 5 | at Rockies | L3-5 | 68-73 | .482 | Coors Field · Denver, CO |
| 142 | Fri Sep 7 | at Brewers | L2-4 | 68-74 | .479 | American Family Field · Milwaukee, WI |
| 143 | Sat Sep 8 | at Brewers | L3-4 | 68-75 | .476 | American Family Field · Milwaukee, WI |
| 144 | Sun Sep 9 | at Brewers | L3-6 | 68-76 | .472 | American Family Field · Milwaukee, WI |
| 145 | Mon Sep 10 | vs Braves | L1-4 | 68-77 | .469 | Oracle Park · San Francisco, CA |
| 146 | Tue Sep 11 | vs Braves | L1-4 | 68-78 | .466 | Oracle Park · San Francisco, CA |
| 147 | Wed Sep 12 | vs Braves | L1-2 | 68-79 | .463 | Oracle Park · San Francisco, CA |
| 148 | Fri Sep 14 | vs Rockies | W2-0 | 69-79 | .466 | Oracle Park · San Francisco, CA |
| 149 | Sat Sep 15 | vs Rockies | W3-0 | 70-79 | .470 | Oracle Park · San Francisco, CA |
| 150 | Sun Sep 16 | vs Rockies | L2-3 | 70-80 | .467 | Oracle Park · San Francisco, CA |
| 151 | Mon Sep 17 | at Padres | W4-2 | 71-80 | .470 | Petco Park · San Diego, CA |
| 152 | Tue Sep 18 | at Padres | W5-4 | 72-80 | .474 | Petco Park · San Diego, CA |
| 153 | Wed Sep 19 | at Padres | L4-8 | 72-81 | .471 | Petco Park · San Diego, CA |
| 154 | Fri Sep 21 | at Cardinals | L3-5 | 72-82 | .468 | Busch Stadium · St. Louis, MO |
| 155 | Sat Sep 22 | at Cardinals | L4-5 (10) | 72-83 | .465 | Busch Stadium · St. Louis, MO |
| 156 | Sun Sep 23 | at Cardinals | L2-9 | 72-84 | .462 | Busch Stadium · St. Louis, MO |
| 157 | Mon Sep 24 | vs Padres | L0-5 | 72-85 | .459 | Oracle Park · San Francisco, CA |
| 158 | Tue Sep 25 | vs Padres | W5-4 (12) | 73-85 | .462 | Oracle Park · San Francisco, CA |
| 159 | Wed Sep 26 | vs Padres | L2-3 | 73-86 | .459 | Oracle Park · San Francisco, CA |
| 160 | Fri Sep 28 | vs Dodgers | L1-3 | 73-87 | .456 | Oracle Park · San Francisco, CA |
| 161 | Sat Sep 29 | vs Dodgers | L6-10 | 73-88 | .453 | Oracle Park · San Francisco, CA |
| 162 | Sun Sep 30 | vs Dodgers | L0-15 | 73-89 | .451 | Oracle Park · San Francisco, CA |