| 1 | Mon Apr 5 | at Astros | W5-2 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 2 | Tue Apr 6 | at Astros | W3-0 | 2-0 | 1.000 | Minute Maid Park · Houston, TX |
| 3 | Wed Apr 7 | at Astros | W10-4 | 3-0 | 1.000 | Minute Maid Park · Houston, TX |
| 4 | Fri Apr 9 | vs Braves | W5-4 (13) | 4-0 | 1.000 | Oracle Park · San Francisco, CA |
| 5 | Sat Apr 10 | vs Braves | L2-7 | 4-1 | .800 | Oracle Park · San Francisco, CA |
| 6 | Sun Apr 11 | vs Braves | W6-3 | 5-1 | .833 | Oracle Park · San Francisco, CA |
| 7 | Mon Apr 12 | vs Pirates | W9-3 | 6-1 | .857 | Oracle Park · San Francisco, CA |
| 8 | Tue Apr 13 | vs Pirates | L5-6 | 6-2 | .750 | Oracle Park · San Francisco, CA |
| 9 | Wed Apr 14 | vs Pirates | W6-0 | 7-2 | .778 | Oracle Park · San Francisco, CA |
| 10 | Fri Apr 16 | at Dodgers | L8-10 | 7-3 | .700 | Dodger Stadium · Los Angeles, CA |
| 11 | Sat Apr 17 | at Dodgers | W9-0 | 8-3 | .727 | Dodger Stadium · Los Angeles, CA |
| 12 | Sun Apr 18 | at Dodgers | L1-2 | 8-4 | .667 | Dodger Stadium · Los Angeles, CA |
| 13 | Mon Apr 19 | at Padres | L2-3 (10) | 8-5 | .615 | Petco Park · San Diego, CA |
| 14 | Tue Apr 20 | at Padres | L0-1 | 8-6 | .571 | Petco Park · San Diego, CA |
| 15 | Wed Apr 21 | at Padres | L2-5 | 8-7 | .533 | Petco Park · San Diego, CA |
| 16 | Fri Apr 23 | vs Cardinals | W4-1 | 9-7 | .563 | Oracle Park · San Francisco, CA |
| 17 | Sat Apr 24 | vs Cardinals | W2-0 | 10-7 | .588 | Oracle Park · San Francisco, CA |
| 18 | Sun Apr 25 | vs Cardinals | L0-2 | 10-8 | .556 | Oracle Park · San Francisco, CA |
| 19 | Mon Apr 26 | vs Phillies | W5-1 | 11-8 | .579 | Oracle Park · San Francisco, CA |
| 20 | Tue Apr 27 | vs Phillies | W6-2 | 12-8 | .600 | Oracle Park · San Francisco, CA |
| 21 | Wed Apr 28 | vs Phillies | L6-7 (11) | 12-9 | .571 | Oracle Park · San Francisco, CA |
| 22 | Fri Apr 30 | vs Rockies | W5-2 | 13-9 | .591 | Oracle Park · San Francisco, CA |
| 23 | Sat May 1 | vs Rockies | W6-1 | 14-9 | .609 | Oracle Park · San Francisco, CA |
| 24 | Sun May 2 | vs Rockies | L1-4 | 14-10 | .583 | Oracle Park · San Francisco, CA |
| 25 | Tue May 4 | at Marlins | W9-6 (12) | 15-10 | .600 | MVP Arena · Albany, NY |
| 26 | Wed May 5 | at Marlins | W3-2 | 16-10 | .615 | MVP Arena · Albany, NY |
| 27 | Thu May 6 | at Marlins | W6-3 | 17-10 | .630 | MVP Arena · Albany, NY |
| 28 | Fri May 7 | at Mets | L4-6 | 17-11 | .607 | Citi Field · Queens, NY |
| 29 | Sat May 8 | at Mets | L4-5 (11) | 17-12 | .586 | Citi Field · Queens, NY |
| 30 | Sun May 9 | at Mets | W6-5 | 18-12 | .600 | Citi Field · Queens, NY |
| 31 | Tue May 11 | vs Padres | L2-3 | 18-13 | .581 | Oracle Park · San Francisco, CA |
| 32 | Wed May 12 | vs Padres | L2-5 | 18-14 | .563 | Oracle Park · San Francisco, CA |
| 33 | Thu May 13 | vs Padres | L0-1 | 18-15 | .545 | Oracle Park · San Francisco, CA |
| 34 | Fri May 14 | vs Astros | W8-2 | 19-15 | .559 | Oracle Park · San Francisco, CA |
| 35 | Sat May 15 | vs Astros | W2-1 | 20-15 | .571 | Oracle Park · San Francisco, CA |
| 36 | Sun May 16 | vs Astros | W4-3 | 21-15 | .583 | Oracle Park · San Francisco, CA |
| 37 | Mon May 17 | at Padres | L1-3 | 21-16 | .568 | Petco Park · San Diego, CA |
| 38 | Tue May 18 | at Padres | W7-6 (12) | 22-16 | .579 | Petco Park · San Diego, CA |
| 39 | Wed May 19 | at D-backs | L1-13 | 22-17 | .564 | Chase Field · Phoenix, AZ |
| 40 | Thu May 20 | at D-backs | L7-8 | 22-18 | .550 | Chase Field · Phoenix, AZ |
| 41 | Fri May 21 | at Athletics | L1-6 | 22-19 | .537 | RingCentral Coliseum · Oakland, CA |
| 42 | Sat May 22 | at Athletics | L0-1 | 22-20 | .524 | RingCentral Coliseum · Oakland, CA |
| 43 | Sun May 23 | at Athletics | L0-3 | 22-21 | .512 | RingCentral Coliseum · Oakland, CA |
| 44 | Tue May 25 | vs Nationals | W4-2 | 23-21 | .523 | Oracle Park · San Francisco, CA |
| 45 | Wed May 26 | vs Nationals | L3-7 | 23-22 | .511 | Oracle Park · San Francisco, CA |
| 46 | Thu May 27 | vs Nationals | W5-4 | 24-22 | .522 | Oracle Park · San Francisco, CA |
| 47 | Fri May 28 | vs D-backs | W5-0 | 25-22 | .532 | Oracle Park · San Francisco, CA |
| 48 | Sat May 29 | vs D-backs | W12-1 | 26-22 | .542 | Oracle Park · San Francisco, CA |
| 49 | Sun May 30 | vs D-backs | W6-5 (10) | 27-22 | .551 | Oracle Park · San Francisco, CA |
| 50 | Mon May 31 | vs Rockies | L0-4 | 27-23 | .540 | Oracle Park · San Francisco, CA |
| 51 | Tue Jun 1 | vs Rockies | L1-2 (11) | 27-24 | .529 | Oracle Park · San Francisco, CA |
| 52 | Wed Jun 2 | vs Rockies | W4-1 | 28-24 | .538 | Oracle Park · San Francisco, CA |
| 53 | Fri Jun 4 | at Pirates | W6-4 | 29-24 | .547 | PNC Park · Pittsburgh, PA |
| 54 | Sat Jun 5 | at Pirates | L3-6 | 29-25 | .537 | PNC Park · Pittsburgh, PA |
| 55 | Sun Jun 6 | at Pirates | W6-5 (10) | 30-25 | .545 | PNC Park · Pittsburgh, PA |
| 56 | Mon Jun 7 | at Reds | W6-5 | 31-25 | .554 | Great American Ball Park · Cincinnati, OH |
| 57 | Tue Jun 8 | at Reds | W3-0 | 32-25 | .561 | Great American Ball Park · Cincinnati, OH |
| 58 | Wed Jun 9 | at Reds | L3-6 | 32-26 | .552 | Great American Ball Park · Cincinnati, OH |
| 59 | Thu Jun 10 | at Reds | L6-7 | 32-27 | .542 | Great American Ball Park · Cincinnati, OH |
| 60 | Fri Jun 11 | vs Athletics | W6-2 | 33-27 | .550 | Oracle Park · San Francisco, CA |
| 61 | Sat Jun 12 | vs Athletics | W5-4 | 34-27 | .557 | Oracle Park · San Francisco, CA |
| 62 | Sun Jun 13 | vs Athletics | W6-2 | 35-27 | .565 | Oracle Park · San Francisco, CA |
| 63 | Mon Jun 14 | vs Orioles | W10-2 | 36-27 | .571 | Oracle Park · San Francisco, CA |
| 64 | Tue Jun 15 | vs Orioles | L1-4 | 36-28 | .563 | Oracle Park · San Francisco, CA |
| 65 | Wed Jun 16 | vs Orioles | W6-3 | 37-28 | .569 | Oracle Park · San Francisco, CA |
| 66 | Fri Jun 18 | at Blue Jays | L2-3 | 37-29 | .561 | Rogers Centre · Toronto, ON |
| 67 | Sat Jun 19 | at Blue Jays | L0-3 | 37-30 | .552 | Rogers Centre · Toronto, ON |
| 68 | Sun Jun 20 | at Blue Jays | W9-6 | 38-30 | .559 | Rogers Centre · Toronto, ON |
| 69 | Tue Jun 22 | at Astros | W3-1 | 39-30 | .565 | Minute Maid Park · Houston, TX |
| 70 | Wed Jun 23 | at Astros | L3-6 | 39-31 | .557 | Minute Maid Park · Houston, TX |
| 71 | Thu Jun 24 | at Astros | L5-7 | 39-32 | .549 | Minute Maid Park · Houston, TX |
| 72 | Fri Jun 25 | vs Red Sox | W5-4 | 40-32 | .556 | Oracle Park · San Francisco, CA |
| 73 | Sat Jun 26 | vs Red Sox | L2-4 | 40-33 | .548 | Oracle Park · San Francisco, CA |
| 74 | Sun Jun 27 | vs Red Sox | L1-5 | 40-34 | .541 | Oracle Park · San Francisco, CA |
| 75 | Mon Jun 28 | vs Dodgers | L2-4 | 40-35 | .533 | Oracle Park · San Francisco, CA |
| 76 | Tue Jun 29 | vs Dodgers | L2-4 | 40-36 | .526 | Oracle Park · San Francisco, CA |
| 77 | Wed Jun 30 | vs Dodgers | L2-8 | 40-37 | .519 | Oracle Park · San Francisco, CA |
| 78 | Thu Jul 1 | at Rockies | L3-7 | 40-38 | .513 | Coors Field · Denver, CO |
| 79 | Fri Jul 2 | at Rockies | L3-6 | 40-39 | .506 | Coors Field · Denver, CO |
| 80 | Sat Jul 3 | at Rockies | W11-8 | 41-39 | .512 | Coors Field · Denver, CO |
| 81 | Sun Jul 4 | at Rockies | L3-4 (15) | 41-40 | .506 | Coors Field · Denver, CO |
| 82 | Mon Jul 5 | at Brewers | W6-1 | 42-40 | .512 | American Family Field · Milwaukee, WI |
| 83 | Tue Jul 6 | at Brewers | W6-1 | 43-40 | .518 | American Family Field · Milwaukee, WI |
| 84 | Wed Jul 7 | at Brewers | W15-2 | 44-40 | .524 | American Family Field · Milwaukee, WI |
| 85 | Thu Jul 8 | at Brewers | W9-3 | 45-40 | .529 | American Family Field · Milwaukee, WI |
| 86 | Fri Jul 9 | at Nationals | L1-8 | 45-41 | .523 | Nationals Park · Washington, D.C. |
| 87 | Sat Jul 10 | at Nationals | W10-5 | 46-41 | .529 | Nationals Park · Washington, D.C. |
| 88 | Sun Jul 11 | at Nationals | W6-2 | 47-41 | .534 | Nationals Park · Washington, D.C. |
| 89 | Thu Jul 15 | vs Mets | W2-0 | 48-41 | .539 | Oracle Park · San Francisco, CA |
| 90 | Fri Jul 16 | vs Mets | W1-0 | 49-41 | .544 | Oracle Park · San Francisco, CA |
| 91 | Sat Jul 17 | vs Mets | W8-4 | 50-41 | .549 | Oracle Park · San Francisco, CA |
| 92 | Sun Jul 18 | vs Mets | L3-4 (10) | 50-42 | .543 | Oracle Park · San Francisco, CA |
| 93 | Mon Jul 19 | at Dodgers | W5-2 | 51-42 | .548 | Dodger Stadium · Los Angeles, CA |
| 94 | Tue Jul 20 | at Dodgers | W7-5 | 52-42 | .553 | Dodger Stadium · Los Angeles, CA |
| 95 | Wed Jul 21 | at Dodgers | L0-2 | 52-43 | .547 | Dodger Stadium · Los Angeles, CA |
| 96 | Thu Jul 22 | at D-backs | W3-0 | 53-43 | .552 | Chase Field · Phoenix, AZ |
| 97 | Fri Jul 23 | at D-backs | W7-4 | 54-43 | .557 | Chase Field · Phoenix, AZ |
| 98 | Sat Jul 24 | at D-backs | W10-4 | 55-43 | .561 | Chase Field · Phoenix, AZ |
| 99 | Sun Jul 25 | at D-backs | W3-2 (10) | 56-43 | .566 | Chase Field · Phoenix, AZ |
| 100 | Mon Jul 26 | vs Marlins | L3-4 | 56-44 | .560 | Oracle Park · San Francisco, CA |
| 101 | Tue Jul 27 | vs Marlins | W6-4 | 57-44 | .564 | Oracle Park · San Francisco, CA |
| 102 | Wed Jul 28 | vs Marlins | W10-9 (10) | 58-44 | .569 | Oracle Park · San Francisco, CA |
| 103 | Thu Jul 29 | vs Marlins | L0-5 | 58-45 | .563 | Oracle Park · San Francisco, CA |
| 104 | Fri Jul 30 | vs Dodgers | W6-5 | 59-45 | .567 | Oracle Park · San Francisco, CA |
| 105 | Sat Jul 31 | vs Dodgers | W2-1 | 60-45 | .571 | Oracle Park · San Francisco, CA |
| 106 | Sun Aug 1 | vs Dodgers | W2-0 | 61-45 | .575 | Oracle Park · San Francisco, CA |
| 107 | Tue Aug 3 | at Rockies | W10-0 | 62-45 | .579 | Coors Field · Denver, CO |
| 108 | Wed Aug 4 | at Rockies | L1-6 | 62-46 | .574 | Coors Field · Denver, CO |
| 109 | Thu Aug 5 | at Braves | L2-3 | 62-47 | .569 | Truist Park · Cumberland, GA |
| 110 | Fri Aug 6 | at Braves | W3-2 (11) | 63-47 | .573 | Truist Park · Cumberland, GA |
| 111 | Sat Aug 7 | at Braves | L0-3 | 63-48 | .568 | Truist Park · Cumberland, GA |
| 112 | Sun Aug 8 | at Braves | L3-6 | 63-49 | .563 | Truist Park · Cumberland, GA |
| 113 | Mon Aug 9 | vs Cubs | W4-3 (11) | 64-49 | .566 | Oracle Park · San Francisco, CA |
| 114 | Tue Aug 10 | vs Cubs | L6-8 | 64-50 | .561 | Oracle Park · San Francisco, CA |
| 115 | Wed Aug 11 | vs Cubs | W5-4 | 65-50 | .565 | Oracle Park · San Francisco, CA |
| 116 | Thu Aug 12 | vs Cubs | W8-7 | 66-50 | .569 | Oracle Park · San Francisco, CA |
| 117 | Fri Aug 13 | vs Padres | L2-3 | 66-51 | .564 | Oracle Park · San Francisco, CA |
| 118 | Sat Aug 14 | vs Padres | W3-2 (11) | 67-51 | .568 | Oracle Park · San Francisco, CA |
| 119 | Sun Aug 15 | vs Padres | L2-8 | 67-52 | .563 | Oracle Park · San Francisco, CA |
| 120 | Tue Aug 17 | at Phillies | L3-9 | 67-53 | .558 | Citizens Bank Park · Philadelphi, PA |
| 121 | Wed Aug 18 | at Phillies | L2-8 | 67-54 | .554 | Citizens Bank Park · Philadelphi, PA |
| 122 | Thu Aug 19 | at Phillies | W5-2 | 68-54 | .557 | Citizens Bank Park · Philadelphi, PA |
| 123 | Fri Aug 20 | at Cardinals | W6-3 | 69-54 | .561 | Busch Stadium · St. Louis, MO |
| 124 | Sat Aug 21 | at Cardinals | L1-5 | 69-55 | .556 | Busch Stadium · St. Louis, MO |
| 125 | Sun Aug 22 | at Cardinals | L0-9 | 69-56 | .552 | Busch Stadium · St. Louis, MO |
| 126 | Mon Aug 23 | vs Reds | W11-2 | 70-56 | .556 | Oracle Park · San Francisco, CA |
| 127 | Tue Aug 24 | vs Reds | W16-5 | 71-56 | .559 | Oracle Park · San Francisco, CA |
| 128 | Wed Aug 25 | vs Reds | L11-12 (12) | 71-57 | .555 | Oracle Park · San Francisco, CA |
| 129 | Fri Aug 27 | vs D-backs | L0-6 | 71-58 | .550 | Oracle Park · San Francisco, CA |
| 130 | Sat Aug 28 | vs D-backs | L3-11 | 71-59 | .546 | Oracle Park · San Francisco, CA |
| 131 | Sun Aug 29 | vs D-backs | W9-7 | 72-59 | .550 | Oracle Park · San Francisco, CA |
| 132 | Mon Aug 30 | vs Rockies | L1-2 | 72-60 | .545 | Oracle Park · San Francisco, CA |
| 133 | Tue Aug 31 | vs Rockies | W5-2 | 73-60 | .549 | Oracle Park · San Francisco, CA |
| 134 | Wed Sep 1 | vs Rockies | W2-1 | 74-60 | .552 | Oracle Park · San Francisco, CA |
| 135 | Fri Sep 3 | at Dodgers | L2-4 | 74-61 | .548 | Dodger Stadium · Los Angeles, CA |
| 136 | Sat Sep 4 | at Dodgers | W5-4 | 75-61 | .551 | Dodger Stadium · Los Angeles, CA |
| 137 | Sun Sep 5 | at Dodgers | W3-0 | 76-61 | .555 | Dodger Stadium · Los Angeles, CA |
| 138 | Mon Sep 6 | at D-backs | W2-0 (11) | 77-61 | .558 | Chase Field · Phoenix, AZ |
| 139 | Tue Sep 7 | at D-backs | W6-3 | 78-61 | .561 | Chase Field · Phoenix, AZ |
| 140 | Wed Sep 8 | at D-backs | L1-3 | 78-62 | .557 | Chase Field · Phoenix, AZ |
| 141 | Thu Sep 9 | at Padres | W7-3 | 79-62 | .560 | Petco Park · San Diego, CA |
| 142 | Fri Sep 10 | at Padres | W1-0 | 80-62 | .563 | Petco Park · San Diego, CA |
| 143 | Sat Sep 11 | at Padres | L0-1 | 80-63 | .559 | Petco Park · San Diego, CA |
| 144 | Sun Sep 12 | at Padres | W6-1 | 81-63 | .563 | Petco Park · San Diego, CA |
| 145 | Tue Sep 14 | vs Dodgers | L0-1 | 81-64 | .559 | Oracle Park · San Francisco, CA |
| 146 | Wed Sep 15 | vs Dodgers | W2-1 | 82-64 | .562 | Oracle Park · San Francisco, CA |
| 147 | Thu Sep 16 | vs Dodgers | W10-2 | 83-64 | .565 | Oracle Park · San Francisco, CA |
| 148 | Fri Sep 17 | vs Brewers | L0-3 | 83-65 | .561 | Oracle Park · San Francisco, CA |
| 149 | Sat Sep 18 | vs Brewers | L1-2 | 83-66 | .557 | Oracle Park · San Francisco, CA |
| 150 | Sun Sep 19 | vs Brewers | W9-2 | 84-66 | .560 | Oracle Park · San Francisco, CA |
| 151 | Tue Sep 21 | at Cubs | W1-0 | 85-66 | .563 | Wrigley Field · Chicago, IL |
| 152 | Wed Sep 22 | at Cubs | L0-2 | 85-67 | .559 | Wrigley Field · Chicago, IL |
| 153 | Thu Sep 23 | at Cubs | W13-0 | 86-67 | .562 | Wrigley Field · Chicago, IL |
| 154 | Fri Sep 24 | at Rockies | W2-1 | 87-67 | .565 | Coors Field · Denver, CO |
| 155 | Sat Sep 25 | at Rockies | L9-10 (10) | 87-68 | .561 | Coors Field · Denver, CO |
| 156 | Sun Sep 26 | at Rockies | W4-2 | 88-68 | .564 | Coors Field · Denver, CO |
| 157 | Tue Sep 28 | vs D-backs | W4-2 | 89-68 | .567 | Oracle Park · San Francisco, CA |
| 158 | Wed Sep 29 | vs D-backs | W3-1 | 90-68 | .570 | Oracle Park · San Francisco, CA |
| 159 | Thu Sep 30 | vs D-backs | W4-1 | 91-68 | .572 | Oracle Park · San Francisco, CA |
| 160 | Fri Oct 1 | vs Padres | L4-6 | 91-69 | .569 | Oracle Park · San Francisco, CA |
| 161 | Sat Oct 2 | vs Padres | L2-4 | 91-70 | .565 | Oracle Park · San Francisco, CA |
| 162 | Sun Oct 3 | vs Padres | W3-0 | 92-70 | .568 | Oracle Park · San Francisco, CA |
| 163 | Thu Oct 7 | vs Braves | W1-0 | 1-0 | 1.000 | Oracle Park · San Francisco, CA |
| 164 | Fri Oct 8 | vs Braves | L4-5 (11) | 1-1 | .500 | Oracle Park · San Francisco, CA |
| 165 | Sun Oct 10 | at Braves | W3-2 | 2-1 | .667 | Truist Park · Cumberland, GA |
| 166 | Mon Oct 11 | at Braves | W3-2 | 3-1 | .750 | Truist Park · Cumberland, GA |
| 167 | Sat Oct 16 | at Phillies | W4-3 | 1-0 | 1.000 | Citizens Bank Park · Philadelphi, PA |
| 168 | Sun Oct 17 | at Phillies | L1-6 | 1-1 | .500 | Citizens Bank Park · Philadelphi, PA |
| 169 | Tue Oct 19 | vs Phillies | W3-0 | 2-1 | .667 | Oracle Park · San Francisco, CA |
| 170 | Wed Oct 20 | vs Phillies | W6-5 | 3-1 | .750 | Oracle Park · San Francisco, CA |
| 171 | Thu Oct 21 | vs Phillies | L2-4 | 3-2 | .600 | Oracle Park · San Francisco, CA |
| 172 | Sat Oct 23 | at Phillies | W3-2 | 4-2 | .667 | Citizens Bank Park · Philadelphi, PA |
| 173 | Wed Oct 27 | vs Rangers | W11-7 | 1-0 | 1.000 | Oracle Park · San Francisco, CA |
| 174 | Thu Oct 28 | vs Rangers | W9-0 | 2-0 | 1.000 | Oracle Park · San Francisco, CA |
| 175 | Sat Oct 30 | at Rangers | L2-4 | 2-1 | .667 | Globe Life Field · Arlington, TX |
| 176 | Sun Oct 31 | at Rangers | W4-0 | 3-1 | .750 | Globe Life Field · Arlington, TX |
| 177 | Mon Nov 1 | at Rangers | W3-1 | 4-1 | .800 | Globe Life Field · Arlington, TX |