| 1 | Fri Apr 1 | vs Twins | W13-3 | 1-0 | 1.000 | Rogers Centre · Toronto, ON |
| 2 | Sat Apr 2 | vs Twins | W6-1 | 2-0 | 1.000 | Rogers Centre · Toronto, ON |
| 3 | Sun Apr 3 | vs Twins | L3-4 | 2-1 | .667 | Rogers Centre · Toronto, ON |
| 4 | Tue Apr 5 | vs Athletics | W7-6 (10) | 3-1 | .750 | Rogers Centre · Toronto, ON |
| 5 | Wed Apr 6 | vs Athletics | W5-3 | 4-1 | .800 | Rogers Centre · Toronto, ON |
| 6 | Thu Apr 7 | vs Athletics | L1-2 | 4-2 | .667 | Rogers Centre · Toronto, ON |
| 7 | Fri Apr 8 | at Angels | W3-2 | 5-2 | .714 | Angel Stadium · Anaheim, CA |
| 8 | Sat Apr 9 | at Angels | L5-6 (14) | 5-3 | .625 | Angel Stadium · Anaheim, CA |
| 9 | Sun Apr 10 | at Angels | L1-3 | 5-4 | .556 | Angel Stadium · Anaheim, CA |
| 10 | Mon Apr 11 | at Mariners | L7-8 | 5-5 | .500 | T-Mobile Park · Seattle, WA |
| 11 | Tue Apr 12 | at Mariners | L2-3 | 5-6 | .455 | T-Mobile Park · Seattle, WA |
| 12 | Wed Apr 13 | at Mariners | W8-3 | 6-6 | .500 | T-Mobile Park · Seattle, WA |
| 13 | Fri Apr 15 | at Red Sox | W7-6 | 7-6 | .538 | Fenway Park · Boston, MA |
| 14 | Sat Apr 16 | at Red Sox | L1-4 | 7-7 | .500 | Fenway Park · Boston, MA |
| 15 | Sun Apr 17 | at Red Sox | L1-8 | 7-8 | .467 | Fenway Park · Boston, MA |
| 16 | Mon Apr 18 | at Red Sox | L1-9 | 7-9 | .438 | Fenway Park · Boston, MA |
| 17 | Tue Apr 19 | vs Yankees | W6-5 (10) | 8-9 | .471 | Rogers Centre · Toronto, ON |
| 18 | Wed Apr 20 | vs Yankees | L2-6 | 8-10 | .444 | Rogers Centre · Toronto, ON |
| 19 | Fri Apr 22 | vs Rays | W6-4 (11) | 9-10 | .474 | Rogers Centre · Toronto, ON |
| 20 | Sat Apr 23 | vs Rays | L4-6 | 9-11 | .450 | Rogers Centre · Toronto, ON |
| 21 | Sun Apr 24 | vs Rays | L0-2 | 9-12 | .429 | Rogers Centre · Toronto, ON |
| 22 | Mon Apr 25 | at Rangers | W6-4 | 10-12 | .455 | Globe Life Field · Arlington, TX |
| 23 | Tue Apr 26 | at Rangers | W10-3 | 11-12 | .478 | Globe Life Field · Arlington, TX |
| 24 | Wed Apr 27 | at Rangers | L6-7 | 11-13 | .458 | Globe Life Field · Arlington, TX |
| 25 | Thu Apr 28 | at Rangers | W5-2 | 12-13 | .480 | Globe Life Field · Arlington, TX |
| 26 | Fri Apr 29 | at Yankees | W5-3 | 13-13 | .500 | Yankee Stadium · The Bronx, NY |
| 27 | Sat Apr 30 | at Yankees | L4-5 | 13-14 | .481 | Yankee Stadium · The Bronx, NY |
| 28 | Sun May 1 | at Yankees | L2-5 | 13-15 | .464 | Yankee Stadium · The Bronx, NY |
| 29 | Tue May 3 | at Rays | L2-3 | 13-16 | .448 | Tropicana Field · St. Petersburg, FL |
| 30 | Wed May 4 | at Rays | W3-2 | 14-16 | .467 | Tropicana Field · St. Petersburg, FL |
| 31 | Thu May 5 | at Rays | L1-3 | 14-17 | .452 | Tropicana Field · St. Petersburg, FL |
| 32 | Fri May 6 | vs Tigers | W7-4 | 15-17 | .469 | Rogers Centre · Toronto, ON |
| 33 | Sat May 7 | vs Tigers | L0-9 | 15-18 | .455 | Rogers Centre · Toronto, ON |
| 34 | Sun May 8 | vs Tigers | L2-5 | 15-19 | .441 | Rogers Centre · Toronto, ON |
| 35 | Mon May 9 | vs Tigers | L5-10 | 15-20 | .429 | Rogers Centre · Toronto, ON |
| 36 | Tue May 10 | vs Red Sox | W7-6 (10) | 16-20 | .444 | Rogers Centre · Toronto, ON |
| 37 | Wed May 11 | vs Red Sox | W9-3 | 17-20 | .459 | Rogers Centre · Toronto, ON |
| 38 | Fri May 13 | at Twins | W2-0 | 18-20 | .474 | Target Field · Minneapolis, MN |
| 39 | Sat May 14 | at Twins | W9-3 (11) | 19-20 | .487 | Target Field · Minneapolis, MN |
| 40 | Sun May 15 | at Twins | W11-3 | 20-20 | .500 | Target Field · Minneapolis, MN |
| 41 | Mon May 16 | at Tigers | W4-2 | 21-20 | .512 | Comerica Park · Detroit, MI |
| 42 | Wed May 18 | vs Rays | L5-6 | 21-21 | .500 | Rogers Centre · Toronto, ON |
| 43 | Thu May 19 | vs Rays | W3-2 | 22-21 | .512 | Rogers Centre · Toronto, ON |
| 44 | Fri May 20 | vs Astros | L2-5 | 22-22 | .500 | Rogers Centre · Toronto, ON |
| 45 | Sat May 21 | vs Astros | W7-5 | 23-22 | .511 | Rogers Centre · Toronto, ON |
| 46 | Sun May 22 | vs Astros | L2-3 | 23-23 | .500 | Rogers Centre · Toronto, ON |
| 47 | Mon May 23 | at Yankees | W7-3 | 24-23 | .511 | Yankee Stadium · The Bronx, NY |
| 48 | Tue May 24 | at Yankees | L4-5 | 24-24 | .500 | Yankee Stadium · The Bronx, NY |
| 49 | Wed May 25 | at Yankees | L3-7 | 24-25 | .490 | Yankee Stadium · The Bronx, NY |
| 50 | Thu May 26 | vs White Sox | L1-3 | 24-26 | .480 | Rogers Centre · Toronto, ON |
| 51 | Fri May 27 | vs White Sox | W4-2 | 25-26 | .490 | Rogers Centre · Toronto, ON |
| 52 | Sat May 28 | vs White Sox | W9-8 (14) | 26-26 | .500 | Rogers Centre · Toronto, ON |
| 53 | Sun May 29 | vs White Sox | W13-4 | 27-26 | .509 | Rogers Centre · Toronto, ON |
| 54 | Mon May 30 | vs Guardians | W11-1 | 28-26 | .519 | Rogers Centre · Toronto, ON |
| 55 | Tue May 31 | vs Guardians | L3-6 | 28-27 | .509 | Rogers Centre · Toronto, ON |
| 56 | Wed Jun 1 | vs Guardians | L9-13 | 28-28 | .500 | Rogers Centre · Toronto, ON |
| 57 | Fri Jun 3 | at Orioles | W8-4 | 29-28 | .509 | Camden Yards · Baltimore, MD |
| 58 | Sat Jun 4 | at Orioles | L3-5 | 29-29 | .500 | Camden Yards · Baltimore, MD |
| 59 | Sun Jun 5 | at Orioles | W7-4 | 30-29 | .508 | Camden Yards · Baltimore, MD |
| 60 | Mon Jun 6 | at Royals | L2-3 (11) | 30-30 | .500 | Kauffman Stadium · Kansas City, MO |
| 61 | Tue Jun 7 | at Royals | W8-5 | 31-30 | .508 | Kauffman Stadium · Kansas City, MO |
| 62 | Wed Jun 8 | at Royals | W9-8 | 32-30 | .516 | Kauffman Stadium · Kansas City, MO |
| 63 | Thu Jun 9 | at Royals | L2-3 | 32-31 | .508 | Kauffman Stadium · Kansas City, MO |
| 64 | Fri Jun 10 | vs Red Sox | L1-5 | 32-32 | .500 | Rogers Centre · Toronto, ON |
| 65 | Sat Jun 11 | vs Red Sox | L4-16 | 32-33 | .492 | Rogers Centre · Toronto, ON |
| 66 | Sun Jun 12 | vs Red Sox | L1-14 | 32-34 | .485 | Rogers Centre · Toronto, ON |
| 67 | Tue Jun 14 | vs Orioles | W6-5 (11) | 33-34 | .493 | Rogers Centre · Toronto, ON |
| 68 | Wed Jun 15 | vs Orioles | W4-1 | 34-34 | .500 | Rogers Centre · Toronto, ON |
| 69 | Thu Jun 16 | vs Orioles | L3-4 | 34-35 | .493 | Rogers Centre · Toronto, ON |
| 70 | Fri Jun 17 | at Reds | W3-2 | 35-35 | .500 | Great American Ball Park · Cincinnati, OH |
| 71 | Sat Jun 18 | at Reds | W4-0 | 36-35 | .507 | Great American Ball Park · Cincinnati, OH |
| 72 | Sun Jun 19 | at Reds | L1-2 | 36-36 | .500 | Great American Ball Park · Cincinnati, OH |
| 73 | Mon Jun 20 | at Braves | L0-2 | 36-37 | .493 | Truist Park · Cumberland, GA |
| 74 | Tue Jun 21 | at Braves | L1-5 | 36-38 | .486 | Truist Park · Cumberland, GA |
| 75 | Wed Jun 22 | at Braves | L1-5 | 36-39 | .480 | Truist Park · Cumberland, GA |
| 76 | Fri Jun 24 | at Cardinals | W5-4 | 37-39 | .487 | Busch Stadium · St. Louis, MO |
| 77 | Sat Jun 25 | at Cardinals | W6-3 | 38-39 | .494 | Busch Stadium · St. Louis, MO |
| 78 | Sun Jun 26 | at Cardinals | W5-0 | 39-39 | .500 | Busch Stadium · St. Louis, MO |
| 79 | Mon Jun 27 | at Tigers | L2-4 | 39-40 | .494 | Comerica Park · Detroit, MI |
| 80 | Tue Jun 28 | vs Pirates | L6-7 | 39-41 | .487 | Rogers Centre · Toronto, ON |
| 81 | Wed Jun 29 | vs Pirates | W2-1 | 40-41 | .494 | Rogers Centre · Toronto, ON |
| 82 | Thu Jun 30 | vs Pirates | L2-6 | 40-42 | .488 | Rogers Centre · Toronto, ON |
| 83 | Fri Jul 1 | vs Phillies | L6-7 | 40-43 | .482 | Rogers Centre · Toronto, ON |
| 84 | Sat Jul 2 | vs Phillies | L3-5 | 40-44 | .476 | Rogers Centre · Toronto, ON |
| 85 | Sun Jul 3 | vs Phillies | W7-4 | 41-44 | .482 | Rogers Centre · Toronto, ON |
| 86 | Mon Jul 4 | at Red Sox | W9-7 | 42-44 | .488 | Fenway Park · Boston, MA |
| 87 | Tue Jul 5 | at Red Sox | L2-3 | 42-45 | .483 | Fenway Park · Boston, MA |
| 88 | Wed Jul 6 | at Red Sox | L4-6 | 42-46 | .477 | Fenway Park · Boston, MA |
| 89 | Thu Jul 7 | at Guardians | L4-5 | 42-47 | .472 | Progressive Field · Cleveland, OH |
| 90 | Fri Jul 8 | at Guardians | W11-7 | 43-47 | .478 | Progressive Field · Cleveland, OH |
| 91 | Sat Jul 9 | at Guardians | W5-4 (10) | 44-47 | .484 | Progressive Field · Cleveland, OH |
| 92 | Sun Jul 10 | at Guardians | W7-1 | 45-47 | .489 | Progressive Field · Cleveland, OH |
| 93 | Thu Jul 14 | vs Yankees | W16-7 | 46-47 | .495 | Rogers Centre · Toronto, ON |
| 94 | Fri Jul 15 | vs Yankees | W7-1 | 47-47 | .500 | Rogers Centre · Toronto, ON |
| 95 | Sat Jul 16 | vs Yankees | L1-4 | 47-48 | .495 | Rogers Centre · Toronto, ON |
| 96 | Sun Jul 17 | vs Yankees | L2-7 | 47-49 | .490 | Rogers Centre · Toronto, ON |
| 97 | Tue Jul 19 | vs Mariners | W6-5 (14) | 48-49 | .495 | Rogers Centre · Toronto, ON |
| 98 | Wed Jul 20 | vs Mariners | W11-6 | 49-49 | .500 | Rogers Centre · Toronto, ON |
| 99 | Thu Jul 21 | vs Mariners | W7-5 | 50-49 | .505 | Rogers Centre · Toronto, ON |
| 100 | Fri Jul 22 | at Rangers | L2-12 | 50-50 | .500 | Globe Life Field · Arlington, TX |
| 101 | Sat Jul 23 | at Rangers | L4-5 | 50-51 | .495 | Globe Life Field · Arlington, TX |
| 102 | Sun Jul 24 | at Rangers | W3-0 | 51-51 | .500 | Globe Life Field · Arlington, TX |
| 103 | Tue Jul 26 | vs Orioles | L4-12 | 51-52 | .495 | Rogers Centre · Toronto, ON |
| 104 | Wed Jul 27 | vs Orioles | W3-0 | 52-52 | .500 | Rogers Centre · Toronto, ON |
| 105 | Thu Jul 28 | vs Orioles | W8-5 | 53-52 | .505 | Rogers Centre · Toronto, ON |
| 106 | Fri Jul 29 | vs Rangers | W3-2 | 54-52 | .509 | Rogers Centre · Toronto, ON |
| 107 | Sat Jul 30 | vs Rangers | L0-3 | 54-53 | .505 | Rogers Centre · Toronto, ON |
| 108 | Sun Jul 31 | vs Rangers | W7-3 | 55-53 | .509 | Rogers Centre · Toronto, ON |
| 109 | Tue Aug 2 | at Rays | W3-1 | 56-53 | .514 | Tropicana Field · St. Petersburg, FL |
| 110 | Wed Aug 3 | at Rays | L1-9 | 56-54 | .509 | Tropicana Field · St. Petersburg, FL |
| 111 | Thu Aug 4 | at Rays | L6-7 (12) | 56-55 | .505 | Tropicana Field · St. Petersburg, FL |
| 112 | Fri Aug 5 | at Orioles | W5-4 | 57-55 | .509 | Camden Yards · Baltimore, MD |
| 113 | Sat Aug 6 | at Orioles | L2-6 | 57-56 | .504 | Camden Yards · Baltimore, MD |
| 114 | Sun Aug 7 | at Orioles | W7-2 | 58-56 | .509 | Camden Yards · Baltimore, MD |
| 115 | Tue Aug 9 | vs Athletics | L1-4 | 58-57 | .504 | Rogers Centre · Toronto, ON |
| 116 | Wed Aug 10 | vs Athletics | W8-4 | 59-57 | .509 | Rogers Centre · Toronto, ON |
| 117 | Thu Aug 11 | vs Athletics | L3-10 | 59-58 | .504 | Rogers Centre · Toronto, ON |
| 118 | Fri Aug 12 | vs Angels | L1-5 | 59-59 | .500 | Rogers Centre · Toronto, ON |
| 119 | Sat Aug 13 | vs Angels | W11-2 | 60-59 | .504 | Rogers Centre · Toronto, ON |
| 120 | Sun Aug 14 | vs Angels | W5-4 (10) | 61-59 | .508 | Rogers Centre · Toronto, ON |
| 121 | Mon Aug 15 | at Mariners | L5-6 | 61-60 | .504 | T-Mobile Park · Seattle, WA |
| 122 | Tue Aug 16 | at Mariners | W13-7 | 62-60 | .508 | T-Mobile Park · Seattle, WA |
| 123 | Wed Aug 17 | at Mariners | W5-1 | 63-60 | .512 | T-Mobile Park · Seattle, WA |
| 124 | Thu Aug 18 | at Athletics | W7-0 | 64-60 | .516 | RingCentral Coliseum · Oakland, CA |
| 125 | Fri Aug 19 | at Athletics | L0-2 | 64-61 | .512 | RingCentral Coliseum · Oakland, CA |
| 126 | Sat Aug 20 | at Athletics | L1-5 | 64-62 | .508 | RingCentral Coliseum · Oakland, CA |
| 127 | Sun Aug 21 | at Athletics | W1-0 | 65-62 | .512 | RingCentral Coliseum · Oakland, CA |
| 128 | Tue Aug 23 | vs Royals | L4-6 | 65-63 | .508 | Rogers Centre · Toronto, ON |
| 129 | Wed Aug 24 | vs Royals | W4-3 | 66-63 | .512 | Rogers Centre · Toronto, ON |
| 130 | Thu Aug 25 | vs Royals | L6-9 | 66-64 | .508 | Rogers Centre · Toronto, ON |
| 131 | Fri Aug 26 | vs Rays | L1-6 | 66-65 | .504 | Rogers Centre · Toronto, ON |
| 132 | Sat Aug 27 | vs Rays | L5-6 | 66-66 | .500 | Rogers Centre · Toronto, ON |
| 133 | Sun Aug 28 | vs Rays | L0-12 | 66-67 | .496 | Rogers Centre · Toronto, ON |
| 134 | Mon Aug 29 | vs Rays | W7-3 | 67-67 | .500 | Rogers Centre · Toronto, ON |
| 135 | Tue Aug 30 | at Orioles | L5-6 (10) | 67-68 | .496 | Camden Yards · Baltimore, MD |
| 136 | Wed Aug 31 | at Orioles | W13-0 | 68-68 | .500 | Camden Yards · Baltimore, MD |
| 137 | Thu Sep 1 | at Orioles | W8-6 | 69-68 | .504 | Camden Yards · Baltimore, MD |
| 138 | Fri Sep 2 | at Yankees | L2-3 | 69-69 | .500 | Yankee Stadium · The Bronx, NY |
| 139 | Sat Sep 3 | at Yankees | L4-6 | 69-70 | .496 | Yankee Stadium · The Bronx, NY |
| 140 | Sun Sep 4 | at Yankees | L3-9 | 69-71 | .493 | Yankee Stadium · The Bronx, NY |
| 141 | Mon Sep 5 | vs Red Sox | W1-0 (11) | 70-71 | .496 | Rogers Centre · Toronto, ON |
| 142 | Tue Sep 6 | vs Red Sox | L0-14 | 70-72 | .493 | Rogers Centre · Toronto, ON |
| 143 | Wed Sep 7 | vs Red Sox | W11-10 | 71-72 | .497 | Rogers Centre · Toronto, ON |
| 144 | Thu Sep 8 | vs Red Sox | W7-4 | 72-72 | .500 | Rogers Centre · Toronto, ON |
| 145 | Fri Sep 9 | vs Orioles | L0-2 | 72-73 | .497 | Rogers Centre · Toronto, ON |
| 146 | Sat Sep 10 | vs Orioles | W5-4 | 73-73 | .500 | Rogers Centre · Toronto, ON |
| 147 | Sun Sep 11 | vs Orioles | W6-5 | 74-73 | .503 | Rogers Centre · Toronto, ON |
| 148 | Tue Sep 13 | at Red Sox | L6-18 | 74-74 | .500 | Fenway Park · Boston, MA |
| 149 | Wed Sep 14 | at Red Sox | W5-4 | 75-74 | .503 | Fenway Park · Boston, MA |
| 150 | Fri Sep 16 | vs Yankees | W5-4 | 76-74 | .507 | Rogers Centre · Toronto, ON |
| 151 | Sat Sep 17 | vs Yankees | L6-7 | 76-75 | .503 | Rogers Centre · Toronto, ON |
| 152 | Sun Sep 18 | vs Yankees | W3-0 | 77-75 | .507 | Rogers Centre · Toronto, ON |
| 153 | Mon Sep 19 | vs Angels | W3-2 (10) | 78-75 | .510 | Rogers Centre · Toronto, ON |
| 154 | Tue Sep 20 | vs Angels | L6-10 | 78-76 | .506 | Rogers Centre · Toronto, ON |
| 155 | Wed Sep 21 | vs Angels | L2-7 | 78-77 | .503 | Rogers Centre · Toronto, ON |
| 156 | Thu Sep 22 | vs Angels | W4-3 (12) | 79-77 | .506 | Rogers Centre · Toronto, ON |
| 157 | Fri Sep 23 | at Rays | W5-1 | 80-77 | .510 | Tropicana Field · St. Petersburg, FL |
| 158 | Sat Sep 24 | at Rays | L2-6 | 80-78 | .506 | Tropicana Field · St. Petersburg, FL |
| 159 | Sun Sep 25 | at Rays | L2-5 | 80-79 | .503 | Tropicana Field · St. Petersburg, FL |
| 160 | Mon Sep 26 | at White Sox | L3-4 | 80-80 | .500 | Guaranteed Rate Field · Chicago, IL |
| 161 | Tue Sep 27 | at White Sox | L1-2 | 80-81 | .497 | Guaranteed Rate Field · Chicago, IL |
| 162 | Wed Sep 28 | at White Sox | W3-2 | 81-81 | .500 | Guaranteed Rate Field · Chicago, IL |