| 1 | Thu Mar 30 | at Cardinals | W10-9 | 1-0 | 1.000 | Busch Stadium · St. Louis, MO |
| 2 | Sat Apr 1 | at Cardinals | L1-4 | 1-1 | .500 | Busch Stadium · St. Louis, MO |
| 3 | Sun Apr 2 | at Cardinals | L4-9 | 1-2 | .333 | Busch Stadium · St. Louis, MO |
| 4 | Mon Apr 3 | at Royals | L5-9 | 1-3 | .250 | Kauffman Stadium · Kansas City, MO |
| 5 | Tue Apr 4 | at Royals | W4-1 | 2-3 | .400 | Kauffman Stadium · Kansas City, MO |
| 6 | Wed Apr 5 | at Royals | W3-0 | 3-3 | .500 | Kauffman Stadium · Kansas City, MO |
| 7 | Thu Apr 6 | at Royals | W6-3 | 4-3 | .571 | Kauffman Stadium · Kansas City, MO |
| 8 | Fri Apr 7 | at Angels | W4-3 | 5-3 | .625 | Angel Stadium · Anaheim, CA |
| 9 | Sat Apr 8 | at Angels | L5-9 | 5-4 | .556 | Angel Stadium · Anaheim, CA |
| 10 | Sun Apr 9 | at Angels | W12-11 (10) | 6-4 | .600 | Angel Stadium · Anaheim, CA |
| 11 | Tue Apr 11 | vs Tigers | W9-3 | 7-4 | .636 | Rogers Centre · Toronto, ON |
| 12 | Wed Apr 12 | vs Tigers | W4-3 (10) | 8-4 | .667 | Rogers Centre · Toronto, ON |
| 13 | Thu Apr 13 | vs Tigers | L1-3 | 8-5 | .615 | Rogers Centre · Toronto, ON |
| 14 | Fri Apr 14 | vs Rays | W6-3 | 9-5 | .643 | Rogers Centre · Toronto, ON |
| 15 | Sat Apr 15 | vs Rays | W5-2 | 10-5 | .667 | Rogers Centre · Toronto, ON |
| 16 | Sun Apr 16 | vs Rays | L1-8 | 10-6 | .625 | Rogers Centre · Toronto, ON |
| 17 | Mon Apr 17 | at Astros | L2-9 | 10-7 | .588 | Minute Maid Park · Houston, TX |
| 18 | Tue Apr 18 | at Astros | W4-2 | 11-7 | .611 | Minute Maid Park · Houston, TX |
| 19 | Wed Apr 19 | at Astros | L1-8 | 11-8 | .579 | Minute Maid Park · Houston, TX |
| 20 | Fri Apr 21 | at Yankees | W6-1 | 12-8 | .600 | Yankee Stadium · The Bronx, NY |
| 21 | Sat Apr 22 | at Yankees | L2-3 | 12-9 | .571 | Yankee Stadium · The Bronx, NY |
| 22 | Sun Apr 23 | at Yankees | W5-1 | 13-9 | .591 | Yankee Stadium · The Bronx, NY |
| 23 | Mon Apr 24 | vs White Sox | W5-2 | 14-9 | .609 | Rogers Centre · Toronto, ON |
| 24 | Tue Apr 25 | vs White Sox | W7-0 | 15-9 | .625 | Rogers Centre · Toronto, ON |
| 25 | Wed Apr 26 | vs White Sox | W8-0 | 16-9 | .640 | Rogers Centre · Toronto, ON |
| 26 | Fri Apr 28 | vs Mariners | W3-2 | 17-9 | .654 | Rogers Centre · Toronto, ON |
| 27 | Sat Apr 29 | vs Mariners | W1-0 (10) | 18-9 | .667 | Rogers Centre · Toronto, ON |
| 28 | Sun Apr 30 | vs Mariners | L8-10 (10) | 18-10 | .643 | Rogers Centre · Toronto, ON |
| 29 | Mon May 1 | at Red Sox | L5-6 | 18-11 | .621 | Fenway Park · Boston, MA |
| 30 | Tue May 2 | at Red Sox | L6-7 | 18-12 | .600 | Fenway Park · Boston, MA |
| 31 | Wed May 3 | at Red Sox | L3-8 | 18-13 | .581 | Fenway Park · Boston, MA |
| 32 | Thu May 4 | at Red Sox | L5-11 | 18-14 | .563 | Fenway Park · Boston, MA |
| 33 | Fri May 5 | at Pirates | W4-0 | 19-14 | .576 | PNC Park · Pittsburgh, PA |
| 34 | Sat May 6 | at Pirates | W8-2 | 20-14 | .588 | PNC Park · Pittsburgh, PA |
| 35 | Sun May 7 | at Pirates | W10-1 | 21-14 | .600 | PNC Park · Pittsburgh, PA |
| 36 | Tue May 9 | at Phillies | L4-8 | 21-15 | .583 | Citizens Bank Park · Philadelphi, PA |
| 37 | Wed May 10 | at Phillies | L1-2 (10) | 21-16 | .568 | Citizens Bank Park · Philadelphi, PA |
| 38 | Fri May 12 | vs Braves | W3-0 | 22-16 | .579 | Rogers Centre · Toronto, ON |
| 39 | Sat May 13 | vs Braves | W5-2 | 23-16 | .590 | Rogers Centre · Toronto, ON |
| 40 | Sun May 14 | vs Braves | W6-5 | 24-16 | .600 | Rogers Centre · Toronto, ON |
| 41 | Mon May 15 | vs Yankees | L4-7 | 24-17 | .585 | Rogers Centre · Toronto, ON |
| 42 | Tue May 16 | vs Yankees | L3-6 | 24-18 | .571 | Rogers Centre · Toronto, ON |
| 43 | Wed May 17 | vs Yankees | W3-0 (10) | 25-18 | .581 | Rogers Centre · Toronto, ON |
| 44 | Thu May 18 | vs Yankees | L2-4 | 25-19 | .568 | Rogers Centre · Toronto, ON |
| 45 | Fri May 19 | vs Orioles | L2-6 | 25-20 | .556 | Rogers Centre · Toronto, ON |
| 46 | Sat May 20 | vs Orioles | L5-6 (10) | 25-21 | .543 | Rogers Centre · Toronto, ON |
| 47 | Sun May 21 | vs Orioles | L3-8 (11) | 25-22 | .532 | Rogers Centre · Toronto, ON |
| 48 | Mon May 22 | at Rays | L4-6 | 25-23 | .521 | Tropicana Field · St. Petersburg, FL |
| 49 | Tue May 23 | at Rays | W20-1 | 26-23 | .531 | Tropicana Field · St. Petersburg, FL |
| 50 | Wed May 24 | at Rays | L3-7 | 26-24 | .520 | Tropicana Field · St. Petersburg, FL |
| 51 | Thu May 25 | at Rays | L3-6 | 26-25 | .510 | Tropicana Field · St. Petersburg, FL |
| 52 | Fri May 26 | at Twins | W3-1 | 27-25 | .519 | Target Field · Minneapolis, MN |
| 53 | Sat May 27 | at Twins | L7-9 | 27-26 | .509 | Target Field · Minneapolis, MN |
| 54 | Sun May 28 | at Twins | W3-0 | 28-26 | .519 | Target Field · Minneapolis, MN |
| 55 | Tue May 30 | vs Brewers | W7-2 | 29-26 | .527 | Rogers Centre · Toronto, ON |
| 56 | Wed May 31 | vs Brewers | L2-4 | 29-27 | .518 | Rogers Centre · Toronto, ON |
| 57 | Thu Jun 1 | vs Brewers | W3-1 | 30-27 | .526 | Rogers Centre · Toronto, ON |
| 58 | Fri Jun 2 | at Mets | W3-0 | 31-27 | .534 | Citi Field · Queens, NY |
| 59 | Sat Jun 3 | at Mets | W2-1 | 32-27 | .542 | Citi Field · Queens, NY |
| 60 | Sun Jun 4 | at Mets | W6-4 | 33-27 | .550 | Citi Field · Queens, NY |
| 61 | Mon Jun 5 | vs Astros | L4-11 | 33-28 | .541 | Rogers Centre · Toronto, ON |
| 62 | Tue Jun 6 | vs Astros | W5-1 | 34-28 | .548 | Rogers Centre · Toronto, ON |
| 63 | Wed Jun 7 | vs Astros | W3-2 | 35-28 | .556 | Rogers Centre · Toronto, ON |
| 64 | Thu Jun 8 | vs Astros | W3-2 | 36-28 | .563 | Rogers Centre · Toronto, ON |
| 65 | Fri Jun 9 | vs Twins | L2-3 (10) | 36-29 | .554 | Rogers Centre · Toronto, ON |
| 66 | Sat Jun 10 | vs Twins | L4-9 | 36-30 | .545 | Rogers Centre · Toronto, ON |
| 67 | Sun Jun 11 | vs Twins | W7-6 | 37-30 | .552 | Rogers Centre · Toronto, ON |
| 68 | Tue Jun 13 | at Orioles | L6-11 | 37-31 | .544 | Camden Yards · Baltimore, MD |
| 69 | Wed Jun 14 | at Orioles | W3-1 | 38-31 | .551 | Camden Yards · Baltimore, MD |
| 70 | Thu Jun 15 | at Orioles | L2-4 | 38-32 | .543 | Camden Yards · Baltimore, MD |
| 71 | Fri Jun 16 | at Rangers | W2-1 | 39-32 | .549 | Globe Life Field · Arlington, TX |
| 72 | Sat Jun 17 | at Rangers | L2-4 | 39-33 | .542 | Globe Life Field · Arlington, TX |
| 73 | Sun Jun 18 | at Rangers | L7-11 | 39-34 | .534 | Globe Life Field · Arlington, TX |
| 74 | Mon Jun 19 | at Marlins | L0-11 | 39-35 | .527 | LoanDepot Park · Miami, FL |
| 75 | Tue Jun 20 | at Marlins | W2-0 | 40-35 | .533 | LoanDepot Park · Miami, FL |
| 76 | Wed Jun 21 | at Marlins | W6-3 | 41-35 | .539 | LoanDepot Park · Miami, FL |
| 77 | Fri Jun 23 | vs Athletics | L4-5 | 41-36 | .532 | Rogers Centre · Toronto, ON |
| 78 | Sat Jun 24 | vs Athletics | W7-3 | 42-36 | .538 | Rogers Centre · Toronto, ON |
| 79 | Sun Jun 25 | vs Athletics | W12-1 | 43-36 | .544 | Rogers Centre · Toronto, ON |
| 80 | Tue Jun 27 | vs Giants | L0-3 | 43-37 | .537 | Rogers Centre · Toronto, ON |
| 81 | Wed Jun 28 | vs Giants | W6-1 | 44-37 | .543 | Rogers Centre · Toronto, ON |
| 82 | Thu Jun 29 | vs Giants | W2-1 | 45-37 | .549 | Rogers Centre · Toronto, ON |
| 83 | Fri Jun 30 | vs Red Sox | L0-5 | 45-38 | .542 | Rogers Centre · Toronto, ON |
| 84 | Sat Jul 1 | vs Red Sox | L6-7 | 45-39 | .536 | Rogers Centre · Toronto, ON |
| 85 | Sun Jul 2 | vs Red Sox | L4-5 | 45-40 | .529 | Rogers Centre · Toronto, ON |
| 86 | Tue Jul 4 | at White Sox | W4-3 | 46-40 | .535 | Guaranteed Rate Field · Chicago, IL |
| 87 | Thu Jul 6 | at White Sox | W6-2 (11) | 47-40 | .540 | Guaranteed Rate Field · Chicago, IL |
| 88 | Thu Jul 6 | at White Sox | W5-4 | 48-40 | .545 | Guaranteed Rate Field · Chicago, IL |
| 89 | Fri Jul 7 | at Tigers | W12-2 | 49-40 | .551 | Comerica Park · Detroit, MI |
| 90 | Sat Jul 8 | at Tigers | L0-2 | 49-41 | .544 | Comerica Park · Detroit, MI |
| 91 | Sun Jul 9 | at Tigers | W4-3 (10) | 50-41 | .549 | Comerica Park · Detroit, MI |
| 92 | Fri Jul 14 | vs D-backs | W7-2 | 51-41 | .554 | Rogers Centre · Toronto, ON |
| 93 | Sat Jul 15 | vs D-backs | W5-2 | 52-41 | .559 | Rogers Centre · Toronto, ON |
| 94 | Sun Jul 16 | vs D-backs | W7-5 | 53-41 | .564 | Rogers Centre · Toronto, ON |
| 95 | Tue Jul 18 | vs Padres | L1-9 | 53-42 | .558 | Rogers Centre · Toronto, ON |
| 96 | Wed Jul 19 | vs Padres | L0-2 | 53-43 | .552 | Rogers Centre · Toronto, ON |
| 97 | Thu Jul 20 | vs Padres | W4-0 | 54-43 | .557 | Rogers Centre · Toronto, ON |
| 98 | Fri Jul 21 | at Mariners | L2-3 | 54-44 | .551 | T-Mobile Park · Seattle, WA |
| 99 | Sat Jul 22 | at Mariners | L8-9 | 54-45 | .545 | T-Mobile Park · Seattle, WA |
| 100 | Sun Jul 23 | at Mariners | W4-3 | 55-45 | .550 | T-Mobile Park · Seattle, WA |
| 101 | Mon Jul 24 | at Dodgers | W6-3 (11) | 56-45 | .554 | Dodger Stadium · Los Angeles, CA |
| 102 | Tue Jul 25 | at Dodgers | L7-8 (10) | 56-46 | .549 | Dodger Stadium · Los Angeles, CA |
| 103 | Wed Jul 26 | at Dodgers | W8-1 | 57-46 | .553 | Dodger Stadium · Los Angeles, CA |
| 104 | Fri Jul 28 | vs Angels | W4-1 | 58-46 | .558 | Rogers Centre · Toronto, ON |
| 105 | Sat Jul 29 | vs Angels | W6-1 | 59-46 | .562 | Rogers Centre · Toronto, ON |
| 106 | Sun Jul 30 | vs Angels | L2-3 (10) | 59-47 | .557 | Rogers Centre · Toronto, ON |
| 107 | Mon Jul 31 | vs Orioles | L2-4 | 59-48 | .551 | Rogers Centre · Toronto, ON |
| 108 | Tue Aug 1 | vs Orioles | L3-13 | 59-49 | .546 | Rogers Centre · Toronto, ON |
| 109 | Wed Aug 2 | vs Orioles | W4-1 | 60-49 | .550 | Rogers Centre · Toronto, ON |
| 110 | Thu Aug 3 | vs Orioles | L1-6 | 60-50 | .545 | Rogers Centre · Toronto, ON |
| 111 | Fri Aug 4 | at Red Sox | W7-3 | 61-50 | .550 | Fenway Park · Boston, MA |
| 112 | Sat Aug 5 | at Red Sox | W5-4 | 62-50 | .554 | Fenway Park · Boston, MA |
| 113 | Sun Aug 6 | at Red Sox | W13-1 | 63-50 | .558 | Fenway Park · Boston, MA |
| 114 | Mon Aug 7 | at Guardians | W3-1 | 64-50 | .561 | Progressive Field · Cleveland, OH |
| 115 | Tue Aug 8 | at Guardians | L0-1 | 64-51 | .557 | Progressive Field · Cleveland, OH |
| 116 | Wed Aug 9 | at Guardians | W1-0 | 65-51 | .560 | Progressive Field · Cleveland, OH |
| 117 | Thu Aug 10 | at Guardians | L3-4 | 65-52 | .556 | Progressive Field · Cleveland, OH |
| 118 | Fri Aug 11 | vs Cubs | L2-6 | 65-53 | .551 | Rogers Centre · Toronto, ON |
| 119 | Sat Aug 12 | vs Cubs | L4-5 | 65-54 | .546 | Rogers Centre · Toronto, ON |
| 120 | Sun Aug 13 | vs Cubs | W11-4 | 66-54 | .550 | Rogers Centre · Toronto, ON |
| 121 | Tue Aug 15 | vs Phillies | W2-1 | 67-54 | .554 | Rogers Centre · Toronto, ON |
| 122 | Wed Aug 16 | vs Phillies | L4-9 | 67-55 | .549 | Rogers Centre · Toronto, ON |
| 123 | Fri Aug 18 | at Reds | L0-1 | 67-56 | .545 | Great American Ball Park · Cincinnati, OH |
| 124 | Sat Aug 19 | at Reds | W4-3 | 68-56 | .548 | Great American Ball Park · Cincinnati, OH |
| 125 | Sun Aug 20 | at Reds | W10-3 | 69-56 | .552 | Great American Ball Park · Cincinnati, OH |
| 126 | Tue Aug 22 | at Orioles | W6-3 (10) | 70-56 | .556 | Camden Yards · Baltimore, MD |
| 127 | Wed Aug 23 | at Orioles | L0-7 | 70-57 | .551 | Camden Yards · Baltimore, MD |
| 128 | Thu Aug 24 | at Orioles | L3-5 | 70-58 | .547 | Camden Yards · Baltimore, MD |
| 129 | Fri Aug 25 | vs Guardians | L2-5 | 70-59 | .543 | Rogers Centre · Toronto, ON |
| 130 | Sat Aug 26 | vs Guardians | W8-3 | 71-59 | .546 | Rogers Centre · Toronto, ON |
| 131 | Sun Aug 27 | vs Guardians | L7-10 (11) | 71-60 | .542 | Rogers Centre · Toronto, ON |
| 132 | Mon Aug 28 | vs Nationals | W6-3 | 72-60 | .545 | Rogers Centre · Toronto, ON |
| 133 | Tue Aug 29 | vs Nationals | L4-5 | 72-61 | .541 | Rogers Centre · Toronto, ON |
| 134 | Wed Aug 30 | vs Nationals | W7-0 | 73-61 | .545 | Rogers Centre · Toronto, ON |
| 135 | Fri Sep 1 | at Rockies | W13-9 | 74-61 | .548 | Coors Field · Denver, CO |
| 136 | Sat Sep 2 | at Rockies | L7-8 | 74-62 | .544 | Coors Field · Denver, CO |
| 137 | Sun Sep 3 | at Rockies | W7-5 | 75-62 | .547 | Coors Field · Denver, CO |
| 138 | Mon Sep 4 | at Athletics | W6-5 (10) | 76-62 | .551 | RingCentral Coliseum · Oakland, CA |
| 139 | Tue Sep 5 | at Athletics | W7-1 | 77-62 | .554 | RingCentral Coliseum · Oakland, CA |
| 140 | Wed Sep 6 | at Athletics | L2-5 | 77-63 | .550 | RingCentral Coliseum · Oakland, CA |
| 141 | Fri Sep 8 | vs Royals | W5-4 | 78-63 | .553 | Rogers Centre · Toronto, ON |
| 142 | Sat Sep 9 | vs Royals | W5-1 | 79-63 | .556 | Rogers Centre · Toronto, ON |
| 143 | Sun Sep 10 | vs Royals | W5-2 | 80-63 | .559 | Rogers Centre · Toronto, ON |
| 144 | Mon Sep 11 | vs Rangers | L4-10 | 80-64 | .556 | Rogers Centre · Toronto, ON |
| 145 | Tue Sep 12 | vs Rangers | L3-6 | 80-65 | .552 | Rogers Centre · Toronto, ON |
| 146 | Wed Sep 13 | vs Rangers | L0-10 | 80-66 | .548 | Rogers Centre · Toronto, ON |
| 147 | Thu Sep 14 | vs Rangers | L2-9 | 80-67 | .544 | Rogers Centre · Toronto, ON |
| 148 | Fri Sep 15 | vs Red Sox | W3-0 | 81-67 | .547 | Rogers Centre · Toronto, ON |
| 149 | Sat Sep 16 | vs Red Sox | W4-3 (13) | 82-67 | .550 | Rogers Centre · Toronto, ON |
| 150 | Sun Sep 17 | vs Red Sox | W3-2 | 83-67 | .553 | Rogers Centre · Toronto, ON |
| 151 | Tue Sep 19 | at Yankees | W7-1 | 84-67 | .556 | Yankee Stadium · The Bronx, NY |
| 152 | Wed Sep 20 | at Yankees | W6-1 | 85-67 | .559 | Yankee Stadium · The Bronx, NY |
| 153 | Thu Sep 21 | at Yankees | L3-5 | 85-68 | .556 | Yankee Stadium · The Bronx, NY |
| 154 | Fri Sep 22 | at Rays | W6-2 | 86-68 | .558 | Tropicana Field · St. Petersburg, FL |
| 155 | Sat Sep 23 | at Rays | L6-7 | 86-69 | .555 | Tropicana Field · St. Petersburg, FL |
| 156 | Sun Sep 24 | at Rays | W9-5 | 87-69 | .558 | Tropicana Field · St. Petersburg, FL |
| 157 | Tue Sep 26 | vs Yankees | L0-2 | 87-70 | .554 | Rogers Centre · Toronto, ON |
| 158 | Wed Sep 27 | vs Yankees | L0-6 | 87-71 | .551 | Rogers Centre · Toronto, ON |
| 159 | Thu Sep 28 | vs Yankees | W6-0 | 88-71 | .553 | Rogers Centre · Toronto, ON |
| 160 | Fri Sep 29 | vs Rays | W11-4 | 89-71 | .556 | Rogers Centre · Toronto, ON |
| 161 | Sat Sep 30 | vs Rays | L5-7 (10) | 89-72 | .553 | Rogers Centre · Toronto, ON |
| 162 | Sun Oct 1 | vs Rays | L8-12 | 89-73 | .549 | Rogers Centre · Toronto, ON |
| 163 | Tue Oct 3 | at Twins | L1-3 | 0-1 | .000 | Target Field · Minneapolis, MN |
| 164 | Wed Oct 4 | at Twins | L0-2 | 0-2 | .000 | Target Field · Minneapolis, MN |