| 1 | Mon Apr 3 | at Orioles | L2-3 (11) | 0-1 | .000 | Camden Yards · Baltimore, MD |
| 2 | Wed Apr 5 | at Orioles | L1-3 | 0-2 | .000 | Camden Yards · Baltimore, MD |
| 3 | Thu Apr 6 | at Rays | W5-2 | 1-2 | .333 | Tropicana Field · St. Petersburg, FL |
| 4 | Fri Apr 7 | at Rays | L8-10 | 1-3 | .250 | Tropicana Field · St. Petersburg, FL |
| 5 | Sat Apr 8 | at Rays | L2-3 (11) | 1-4 | .200 | Tropicana Field · St. Petersburg, FL |
| 6 | Sun Apr 9 | at Rays | L2-7 | 1-5 | .167 | Tropicana Field · St. Petersburg, FL |
| 7 | Tue Apr 11 | vs Brewers | L3-4 | 1-6 | .143 | Rogers Centre · Toronto, ON |
| 8 | Wed Apr 12 | vs Brewers | L0-2 | 1-7 | .125 | Rogers Centre · Toronto, ON |
| 9 | Thu Apr 13 | vs Orioles | L1-2 | 1-8 | .111 | Rogers Centre · Toronto, ON |
| 10 | Fri Apr 14 | vs Orioles | L4-6 | 1-9 | .100 | Rogers Centre · Toronto, ON |
| 11 | Sat Apr 15 | vs Orioles | W2-1 | 2-9 | .182 | Rogers Centre · Toronto, ON |
| 12 | Sun Apr 16 | vs Orioles | L4-11 | 2-10 | .167 | Rogers Centre · Toronto, ON |
| 13 | Tue Apr 18 | vs Red Sox | L7-8 | 2-11 | .154 | Rogers Centre · Toronto, ON |
| 14 | Wed Apr 19 | vs Red Sox | W3-0 | 3-11 | .214 | Rogers Centre · Toronto, ON |
| 15 | Thu Apr 20 | vs Red Sox | L1-4 (10) | 3-12 | .200 | Rogers Centre · Toronto, ON |
| 16 | Fri Apr 21 | at Angels | W8-7 (13) | 4-12 | .250 | Angel Stadium · Anaheim, CA |
| 17 | Sat Apr 22 | at Angels | L4-5 | 4-13 | .235 | Angel Stadium · Anaheim, CA |
| 18 | Sun Apr 23 | at Angels | W6-2 | 5-13 | .278 | Angel Stadium · Anaheim, CA |
| 19 | Mon Apr 24 | at Angels | L1-2 | 5-14 | .263 | Angel Stadium · Anaheim, CA |
| 20 | Tue Apr 25 | at Cardinals | W6-5 (11) | 6-14 | .300 | Busch Stadium · St. Louis, MO |
| 21 | Thu Apr 27 | at Cardinals | L4-8 (11) | 6-15 | .286 | Busch Stadium · St. Louis, MO |
| 22 | Thu Apr 27 | at Cardinals | L4-6 | 6-16 | .273 | Busch Stadium · St. Louis, MO |
| 23 | Fri Apr 28 | vs Rays | L4-7 | 6-17 | .261 | Rogers Centre · Toronto, ON |
| 24 | Sat Apr 29 | vs Rays | W4-1 | 7-17 | .292 | Rogers Centre · Toronto, ON |
| 25 | Sun Apr 30 | vs Rays | W3-1 | 8-17 | .320 | Rogers Centre · Toronto, ON |
| 26 | Mon May 1 | at Yankees | W7-1 | 9-17 | .346 | Yankee Stadium · The Bronx, NY |
| 27 | Tue May 2 | at Yankees | L5-11 | 9-18 | .333 | Yankee Stadium · The Bronx, NY |
| 28 | Wed May 3 | at Yankees | L6-8 | 9-19 | .321 | Yankee Stadium · The Bronx, NY |
| 29 | Fri May 5 | at Rays | W8-4 | 10-19 | .345 | Tropicana Field · St. Petersburg, FL |
| 30 | Sat May 6 | at Rays | L1-6 | 10-20 | .333 | Tropicana Field · St. Petersburg, FL |
| 31 | Sun May 7 | at Rays | W2-1 | 11-20 | .355 | Tropicana Field · St. Petersburg, FL |
| 32 | Mon May 8 | vs Guardians | W4-2 | 12-20 | .375 | Rogers Centre · Toronto, ON |
| 33 | Tue May 9 | vs Guardians | L0-6 | 12-21 | .364 | Rogers Centre · Toronto, ON |
| 34 | Wed May 10 | vs Guardians | W8-7 | 13-21 | .382 | Rogers Centre · Toronto, ON |
| 35 | Thu May 11 | vs Mariners | W7-2 | 14-21 | .400 | Rogers Centre · Toronto, ON |
| 36 | Fri May 12 | vs Mariners | W4-0 | 15-21 | .417 | Rogers Centre · Toronto, ON |
| 37 | Sat May 13 | vs Mariners | W7-2 | 16-21 | .432 | Rogers Centre · Toronto, ON |
| 38 | Sun May 14 | vs Mariners | W3-2 | 17-21 | .447 | Rogers Centre · Toronto, ON |
| 39 | Mon May 15 | vs Braves | L6-10 | 17-22 | .436 | Rogers Centre · Toronto, ON |
| 40 | Tue May 16 | vs Braves | L5-9 | 17-23 | .425 | Rogers Centre · Toronto, ON |
| 41 | Wed May 17 | at Braves | L4-8 | 17-24 | .415 | Truist Park · Cumberland, GA |
| 42 | Thu May 18 | at Braves | W9-0 | 18-24 | .429 | Truist Park · Cumberland, GA |
| 43 | Fri May 19 | at Orioles | L3-5 (10) | 18-25 | .419 | Camden Yards · Baltimore, MD |
| 44 | Sat May 20 | at Orioles | L5-7 | 18-26 | .409 | Camden Yards · Baltimore, MD |
| 45 | Sun May 21 | at Orioles | W3-1 | 19-26 | .422 | Camden Yards · Baltimore, MD |
| 46 | Tue May 23 | at Brewers | W4-3 | 20-26 | .435 | American Family Field · Milwaukee, WI |
| 47 | Wed May 24 | at Brewers | W8-4 | 21-26 | .447 | American Family Field · Milwaukee, WI |
| 48 | Fri May 26 | vs Rangers | W7-6 | 22-26 | .458 | Rogers Centre · Toronto, ON |
| 49 | Sat May 27 | vs Rangers | W3-1 | 23-26 | .469 | Rogers Centre · Toronto, ON |
| 50 | Sun May 28 | vs Rangers | L1-3 | 23-27 | .460 | Rogers Centre · Toronto, ON |
| 51 | Mon May 29 | vs Reds | W17-2 | 24-27 | .471 | Rogers Centre · Toronto, ON |
| 52 | Tue May 30 | vs Reds | W6-4 | 25-27 | .481 | Rogers Centre · Toronto, ON |
| 53 | Wed May 31 | vs Reds | W5-4 | 26-27 | .491 | Rogers Centre · Toronto, ON |
| 54 | Thu Jun 1 | vs Yankees | L2-12 | 26-28 | .481 | Rogers Centre · Toronto, ON |
| 55 | Fri Jun 2 | vs Yankees | W7-5 | 27-28 | .491 | Rogers Centre · Toronto, ON |
| 56 | Sat Jun 3 | vs Yankees | L0-7 | 27-29 | .482 | Rogers Centre · Toronto, ON |
| 57 | Sun Jun 4 | vs Yankees | W3-2 | 28-29 | .491 | Rogers Centre · Toronto, ON |
| 58 | Mon Jun 5 | at Athletics | L3-5 | 28-30 | .483 | RingCentral Coliseum · Oakland, CA |
| 59 | Tue Jun 6 | at Athletics | L1-4 | 28-31 | .475 | RingCentral Coliseum · Oakland, CA |
| 60 | Wed Jun 7 | at Athletics | W7-5 (10) | 29-31 | .483 | RingCentral Coliseum · Oakland, CA |
| 61 | Fri Jun 9 | at Mariners | L2-4 | 29-32 | .475 | T-Mobile Park · Seattle, WA |
| 62 | Sat Jun 10 | at Mariners | W4-2 | 30-32 | .484 | T-Mobile Park · Seattle, WA |
| 63 | Sun Jun 11 | at Mariners | W4-0 | 31-32 | .492 | T-Mobile Park · Seattle, WA |
| 64 | Tue Jun 13 | vs Rays | L1-8 | 31-33 | .484 | Rogers Centre · Toronto, ON |
| 65 | Wed Jun 14 | vs Rays | W7-6 | 32-33 | .492 | Rogers Centre · Toronto, ON |
| 66 | Fri Jun 16 | vs White Sox | L4-11 | 32-34 | .485 | Rogers Centre · Toronto, ON |
| 67 | Sat Jun 17 | vs White Sox | L2-5 | 32-35 | .478 | Rogers Centre · Toronto, ON |
| 68 | Sun Jun 18 | vs White Sox | W7-3 | 33-35 | .485 | Rogers Centre · Toronto, ON |
| 69 | Mon Jun 19 | at Rangers | W7-6 | 34-35 | .493 | Globe Life Field · Arlington, TX |
| 70 | Tue Jun 20 | at Rangers | L1-6 | 34-36 | .486 | Globe Life Field · Arlington, TX |
| 71 | Wed Jun 21 | at Rangers | W7-5 | 35-36 | .493 | Globe Life Field · Arlington, TX |
| 72 | Thu Jun 22 | at Rangers | L4-11 | 35-37 | .486 | Globe Life Field · Arlington, TX |
| 73 | Fri Jun 23 | at Royals | L4-5 | 35-38 | .479 | Kauffman Stadium · Kansas City, MO |
| 74 | Sat Jun 24 | at Royals | L2-3 | 35-39 | .473 | Kauffman Stadium · Kansas City, MO |
| 75 | Sun Jun 25 | at Royals | W8-2 | 36-39 | .480 | Kauffman Stadium · Kansas City, MO |
| 76 | Tue Jun 27 | vs Orioles | L1-3 | 36-40 | .474 | Rogers Centre · Toronto, ON |
| 77 | Wed Jun 28 | vs Orioles | W4-0 | 37-40 | .481 | Rogers Centre · Toronto, ON |
| 78 | Thu Jun 29 | vs Orioles | L0-2 | 37-41 | .474 | Rogers Centre · Toronto, ON |
| 79 | Fri Jun 30 | vs Red Sox | L4-7 (11) | 37-42 | .468 | Rogers Centre · Toronto, ON |
| 80 | Sat Jul 1 | vs Red Sox | L1-7 | 37-43 | .463 | Rogers Centre · Toronto, ON |
| 81 | Sun Jul 2 | vs Red Sox | L1-15 | 37-44 | .457 | Rogers Centre · Toronto, ON |
| 82 | Mon Jul 3 | at Yankees | L3-6 | 37-45 | .451 | Yankee Stadium · The Bronx, NY |
| 83 | Tue Jul 4 | at Yankees | W4-1 | 38-45 | .458 | Yankee Stadium · The Bronx, NY |
| 84 | Wed Jul 5 | at Yankees | W7-6 | 39-45 | .464 | Yankee Stadium · The Bronx, NY |
| 85 | Thu Jul 6 | vs Astros | W7-4 | 40-45 | .471 | Rogers Centre · Toronto, ON |
| 86 | Fri Jul 7 | vs Astros | L2-12 | 40-46 | .465 | Rogers Centre · Toronto, ON |
| 87 | Sat Jul 8 | vs Astros | W7-2 | 41-46 | .471 | Rogers Centre · Toronto, ON |
| 88 | Sun Jul 9 | vs Astros | L1-19 | 41-47 | .466 | Rogers Centre · Toronto, ON |
| 89 | Fri Jul 14 | at Tigers | W7-2 | 42-47 | .472 | Comerica Park · Detroit, MI |
| 90 | Sat Jul 15 | at Tigers | L1-11 | 42-48 | .467 | Comerica Park · Detroit, MI |
| 91 | Sun Jul 16 | at Tigers | L5-6 (11) | 42-49 | .462 | Comerica Park · Detroit, MI |
| 92 | Mon Jul 17 | at Red Sox | W4-3 | 43-49 | .467 | Fenway Park · Boston, MA |
| 93 | Tue Jul 18 | at Red Sox | L4-5 (15) | 43-50 | .462 | Fenway Park · Boston, MA |
| 94 | Wed Jul 19 | at Red Sox | L1-5 | 43-51 | .457 | Fenway Park · Boston, MA |
| 95 | Thu Jul 20 | at Red Sox | W8-6 | 44-51 | .463 | Fenway Park · Boston, MA |
| 96 | Fri Jul 21 | at Guardians | L3-13 | 44-52 | .458 | Progressive Field · Cleveland, OH |
| 97 | Sat Jul 22 | at Guardians | L1-2 (10) | 44-53 | .454 | Progressive Field · Cleveland, OH |
| 98 | Sun Jul 23 | at Guardians | L1-8 | 44-54 | .449 | Progressive Field · Cleveland, OH |
| 99 | Mon Jul 24 | vs Athletics | W4-2 | 45-54 | .455 | Rogers Centre · Toronto, ON |
| 100 | Tue Jul 25 | vs Athletics | W4-1 | 46-54 | .460 | Rogers Centre · Toronto, ON |
| 101 | Wed Jul 26 | vs Athletics | W3-2 | 47-54 | .465 | Rogers Centre · Toronto, ON |
| 102 | Thu Jul 27 | vs Athletics | W8-4 (10) | 48-54 | .471 | Rogers Centre · Toronto, ON |
| 103 | Fri Jul 28 | vs Angels | L2-7 | 48-55 | .466 | Rogers Centre · Toronto, ON |
| 104 | Sat Jul 29 | vs Angels | L5-6 | 48-56 | .462 | Rogers Centre · Toronto, ON |
| 105 | Sun Jul 30 | vs Angels | W11-10 | 49-56 | .467 | Rogers Centre · Toronto, ON |
| 106 | Mon Jul 31 | at White Sox | L6-7 | 49-57 | .462 | Guaranteed Rate Field · Chicago, IL |
| 107 | Tue Aug 1 | at White Sox | W8-4 | 50-57 | .467 | Guaranteed Rate Field · Chicago, IL |
| 108 | Wed Aug 2 | at White Sox | W5-1 | 51-57 | .472 | Guaranteed Rate Field · Chicago, IL |
| 109 | Fri Aug 4 | at Astros | L7-16 | 51-58 | .468 | Minute Maid Park · Houston, TX |
| 110 | Sat Aug 5 | at Astros | W4-3 (10) | 52-58 | .473 | Minute Maid Park · Houston, TX |
| 111 | Sun Aug 6 | at Astros | L6-7 | 52-59 | .468 | Minute Maid Park · Houston, TX |
| 112 | Tue Aug 8 | vs Yankees | W4-2 | 53-59 | .473 | Rogers Centre · Toronto, ON |
| 113 | Wed Aug 9 | vs Yankees | L5-11 | 53-60 | .469 | Rogers Centre · Toronto, ON |
| 114 | Thu Aug 10 | vs Yankees | W4-0 | 54-60 | .474 | Rogers Centre · Toronto, ON |
| 115 | Fri Aug 11 | vs Pirates | L2-4 | 54-61 | .470 | Rogers Centre · Toronto, ON |
| 116 | Sat Aug 12 | vs Pirates | W7-2 | 55-61 | .474 | Rogers Centre · Toronto, ON |
| 117 | Sun Aug 13 | vs Pirates | W7-1 | 56-61 | .479 | Rogers Centre · Toronto, ON |
| 118 | Mon Aug 14 | vs Rays | W2-1 | 57-61 | .483 | Rogers Centre · Toronto, ON |
| 119 | Tue Aug 15 | vs Rays | L4-6 | 57-62 | .479 | Rogers Centre · Toronto, ON |
| 120 | Wed Aug 16 | vs Rays | W3-2 | 58-62 | .483 | Rogers Centre · Toronto, ON |
| 121 | Thu Aug 17 | vs Rays | W5-3 | 59-62 | .488 | Rogers Centre · Toronto, ON |
| 122 | Fri Aug 18 | at Cubs | L4-7 | 59-63 | .484 | Wrigley Field · Chicago, IL |
| 123 | Sat Aug 19 | at Cubs | L3-4 | 59-64 | .480 | Wrigley Field · Chicago, IL |
| 124 | Sun Aug 20 | at Cubs | L5-6 (10) | 59-65 | .476 | Wrigley Field · Chicago, IL |
| 125 | Tue Aug 22 | at Rays | L5-6 | 59-66 | .472 | Tropicana Field · St. Petersburg, FL |
| 126 | Wed Aug 23 | at Rays | W7-6 | 60-66 | .476 | Tropicana Field · St. Petersburg, FL |
| 127 | Thu Aug 24 | at Rays | L0-2 | 60-67 | .472 | Tropicana Field · St. Petersburg, FL |
| 128 | Fri Aug 25 | vs Twins | L1-6 | 60-68 | .469 | Rogers Centre · Toronto, ON |
| 129 | Sat Aug 26 | vs Twins | W10-9 | 61-68 | .473 | Rogers Centre · Toronto, ON |
| 130 | Sun Aug 27 | vs Twins | L2-7 | 61-69 | .469 | Rogers Centre · Toronto, ON |
| 131 | Mon Aug 28 | vs Red Sox | L5-6 | 61-70 | .466 | Rogers Centre · Toronto, ON |
| 132 | Tue Aug 29 | vs Red Sox | L0-3 | 61-71 | .462 | Rogers Centre · Toronto, ON |
| 133 | Wed Aug 30 | vs Red Sox | L1-7 | 61-72 | .459 | Rogers Centre · Toronto, ON |
| 134 | Thu Aug 31 | at Orioles | W11-8 | 62-72 | .463 | Camden Yards · Baltimore, MD |
| 135 | Fri Sep 1 | at Orioles | L0-1 (13) | 62-73 | .459 | Camden Yards · Baltimore, MD |
| 136 | Sat Sep 2 | at Orioles | W7-2 | 63-73 | .463 | Camden Yards · Baltimore, MD |
| 137 | Sun Sep 3 | at Orioles | L4-5 (12) | 63-74 | .460 | Camden Yards · Baltimore, MD |
| 138 | Mon Sep 4 | at Red Sox | W10-4 | 64-74 | .464 | Fenway Park · Boston, MA |
| 139 | Tue Sep 5 | at Red Sox | L2-3 (19) | 64-75 | .460 | Fenway Park · Boston, MA |
| 140 | Wed Sep 6 | at Red Sox | L1-6 | 64-76 | .457 | Fenway Park · Boston, MA |
| 141 | Fri Sep 8 | vs Tigers | L4-5 | 64-77 | .454 | Rogers Centre · Toronto, ON |
| 142 | Sat Sep 9 | vs Tigers | W5-4 | 65-77 | .458 | Rogers Centre · Toronto, ON |
| 143 | Sun Sep 10 | vs Tigers | W8-2 | 66-77 | .462 | Rogers Centre · Toronto, ON |
| 144 | Mon Sep 11 | vs Orioles | W4-3 | 67-77 | .465 | Rogers Centre · Toronto, ON |
| 145 | Tue Sep 12 | vs Orioles | W3-2 | 68-77 | .469 | Rogers Centre · Toronto, ON |
| 146 | Wed Sep 13 | vs Orioles | L1-2 | 68-78 | .466 | Rogers Centre · Toronto, ON |
| 147 | Thu Sep 14 | at Twins | L2-3 (10) | 68-79 | .463 | Target Field · Minneapolis, MN |
| 148 | Fri Sep 15 | at Twins | W4-3 | 69-79 | .466 | Target Field · Minneapolis, MN |
| 149 | Sat Sep 16 | at Twins | W7-2 | 70-79 | .470 | Target Field · Minneapolis, MN |
| 150 | Sun Sep 17 | at Twins | L7-13 | 70-80 | .467 | Target Field · Minneapolis, MN |
| 151 | Tue Sep 19 | vs Royals | W5-2 | 71-80 | .470 | Rogers Centre · Toronto, ON |
| 152 | Wed Sep 20 | vs Royals | L5-15 | 71-81 | .467 | Rogers Centre · Toronto, ON |
| 153 | Thu Sep 21 | vs Royals | L0-1 | 71-82 | .464 | Rogers Centre · Toronto, ON |
| 154 | Fri Sep 22 | vs Yankees | W8-1 | 72-82 | .468 | Rogers Centre · Toronto, ON |
| 155 | Sat Sep 23 | vs Yankees | L1-5 | 72-83 | .465 | Rogers Centre · Toronto, ON |
| 156 | Sun Sep 24 | vs Yankees | W9-5 | 73-83 | .468 | Rogers Centre · Toronto, ON |
| 157 | Mon Sep 25 | at Red Sox | W6-4 | 74-83 | .471 | Fenway Park · Boston, MA |
| 158 | Tue Sep 26 | at Red Sox | W9-4 | 75-83 | .475 | Fenway Park · Boston, MA |
| 159 | Wed Sep 27 | at Red Sox | L7-10 | 75-84 | .472 | Fenway Park · Boston, MA |
| 160 | Fri Sep 29 | at Yankees | L0-4 | 75-85 | .469 | Yankee Stadium · The Bronx, NY |
| 161 | Sat Sep 30 | at Yankees | L1-2 | 75-86 | .466 | Yankee Stadium · The Bronx, NY |
| 162 | Sun Oct 1 | at Yankees | W2-1 | 76-86 | .469 | Yankee Stadium · The Bronx, NY |