| 1 | Mon Apr 6 | at Yankees | W6-1 | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 2 | Wed Apr 8 | at Yankees | L3-4 | 1-1 | .500 | Yankee Stadium · The Bronx, NY |
| 3 | Thu Apr 9 | at Yankees | W6-3 | 2-1 | .667 | Yankee Stadium · The Bronx, NY |
| 4 | Fri Apr 10 | at Orioles | W12-5 | 3-1 | .750 | Camden Yards · Baltimore, MD |
| 5 | Sat Apr 11 | at Orioles | L1-7 | 3-2 | .600 | Camden Yards · Baltimore, MD |
| 6 | Sun Apr 12 | at Orioles | W10-7 | 4-2 | .667 | Camden Yards · Baltimore, MD |
| 7 | Mon Apr 13 | vs Rays | L1-2 | 4-3 | .571 | Rogers Centre · Toronto, ON |
| 8 | Tue Apr 14 | vs Rays | L2-3 | 4-4 | .500 | Rogers Centre · Toronto, ON |
| 9 | Wed Apr 15 | vs Rays | W12-7 | 5-4 | .556 | Rogers Centre · Toronto, ON |
| 10 | Thu Apr 16 | vs Rays | L2-4 | 5-5 | .500 | Rogers Centre · Toronto, ON |
| 11 | Fri Apr 17 | vs Braves | L7-8 | 5-6 | .455 | Rogers Centre · Toronto, ON |
| 12 | Sat Apr 18 | vs Braves | W6-5 (10) | 6-6 | .500 | Rogers Centre · Toronto, ON |
| 13 | Sun Apr 19 | vs Braves | L2-5 | 6-7 | .462 | Rogers Centre · Toronto, ON |
| 14 | Tue Apr 21 | vs Orioles | W13-6 | 7-7 | .500 | Rogers Centre · Toronto, ON |
| 15 | Wed Apr 22 | vs Orioles | W4-2 | 8-7 | .533 | Rogers Centre · Toronto, ON |
| 16 | Thu Apr 23 | vs Orioles | W7-6 | 9-7 | .563 | Rogers Centre · Toronto, ON |
| 17 | Fri Apr 24 | at Rays | L3-12 | 9-8 | .529 | Tropicana Field · St. Petersburg, FL |
| 18 | Sat Apr 25 | at Rays | L2-4 | 9-9 | .500 | Tropicana Field · St. Petersburg, FL |
| 19 | Sun Apr 26 | at Rays | L1-5 | 9-10 | .474 | Tropicana Field · St. Petersburg, FL |
| 20 | Mon Apr 27 | at Red Sox | L5-6 | 9-11 | .450 | Fenway Park · Boston, MA |
| 21 | Tue Apr 28 | at Red Sox | W11-8 | 10-11 | .476 | Fenway Park · Boston, MA |
| 22 | Wed Apr 29 | at Red Sox | L1-4 | 10-12 | .455 | Fenway Park · Boston, MA |
| 23 | Thu Apr 30 | at Guardians | W5-1 | 11-12 | .478 | Progressive Field · Cleveland, OH |
| 24 | Fri May 1 | at Guardians | L4-9 | 11-13 | .458 | Progressive Field · Cleveland, OH |
| 25 | Sat May 2 | at Guardians | W11-4 | 12-13 | .480 | Progressive Field · Cleveland, OH |
| 26 | Sun May 3 | at Guardians | L7-10 | 12-14 | .462 | Progressive Field · Cleveland, OH |
| 27 | Mon May 4 | vs Yankees | W3-1 | 13-14 | .481 | Rogers Centre · Toronto, ON |
| 28 | Tue May 5 | vs Yankees | L3-6 | 13-15 | .464 | Rogers Centre · Toronto, ON |
| 29 | Wed May 6 | vs Yankees | W5-1 | 14-15 | .483 | Rogers Centre · Toronto, ON |
| 30 | Fri May 8 | vs Red Sox | W7-0 | 15-15 | .500 | Rogers Centre · Toronto, ON |
| 31 | Sat May 9 | vs Red Sox | W7-1 | 16-15 | .516 | Rogers Centre · Toronto, ON |
| 32 | Sun May 10 | vs Red Sox | L3-6 | 16-16 | .500 | Rogers Centre · Toronto, ON |
| 33 | Mon May 11 | at Orioles | L2-5 | 16-17 | .485 | Camden Yards · Baltimore, MD |
| 34 | Tue May 12 | at Orioles | W10-2 | 17-17 | .500 | Camden Yards · Baltimore, MD |
| 35 | Wed May 13 | at Orioles | L1-6 | 17-18 | .486 | Camden Yards · Baltimore, MD |
| 36 | Thu May 14 | at Astros | L4-6 | 17-19 | .472 | Minute Maid Park · Houston, TX |
| 37 | Fri May 15 | at Astros | L4-8 | 17-20 | .459 | Minute Maid Park · Houston, TX |
| 38 | Sat May 16 | at Astros | L5-6 | 17-21 | .447 | Minute Maid Park · Houston, TX |
| 39 | Sun May 17 | at Astros | L2-4 | 17-22 | .436 | Minute Maid Park · Houston, TX |
| 40 | Mon May 18 | vs Angels | W10-6 | 18-22 | .450 | Rogers Centre · Toronto, ON |
| 41 | Tue May 19 | vs Angels | L2-3 | 18-23 | .439 | Rogers Centre · Toronto, ON |
| 42 | Wed May 20 | vs Angels | L3-4 | 18-24 | .429 | Rogers Centre · Toronto, ON |
| 43 | Thu May 21 | vs Angels | W8-4 | 19-24 | .442 | Rogers Centre · Toronto, ON |
| 44 | Fri May 22 | vs Mariners | L3-4 | 19-25 | .432 | Rogers Centre · Toronto, ON |
| 45 | Sat May 23 | vs Mariners | L2-3 | 19-26 | .422 | Rogers Centre · Toronto, ON |
| 46 | Sun May 24 | vs Mariners | W8-2 | 20-26 | .435 | Rogers Centre · Toronto, ON |
| 47 | Mon May 25 | vs White Sox | W6-0 | 21-26 | .447 | Rogers Centre · Toronto, ON |
| 48 | Tue May 26 | vs White Sox | W10-9 | 22-26 | .458 | Rogers Centre · Toronto, ON |
| 49 | Wed May 27 | vs White Sox | L3-5 (10) | 22-27 | .449 | Rogers Centre · Toronto, ON |
| 50 | Fri May 29 | at Twins | W6-4 | 23-27 | .460 | Target Field · Minneapolis, MN |
| 51 | Sat May 30 | at Twins | L2-3 | 23-28 | .451 | Target Field · Minneapolis, MN |
| 52 | Sun May 31 | at Twins | L5-6 | 23-29 | .442 | Target Field · Minneapolis, MN |
| 53 | Tue Jun 2 | at Nationals | L0-2 | 23-30 | .434 | Nationals Park · Washington, D.C. |
| 54 | Tue Jun 2 | at Nationals | W7-3 | 24-30 | .444 | Nationals Park · Washington, D.C. |
| 55 | Wed Jun 3 | at Nationals | W8-0 | 25-30 | .455 | Nationals Park · Washington, D.C. |
| 56 | Fri Jun 5 | vs Astros | W6-2 | 26-30 | .464 | Rogers Centre · Toronto, ON |
| 57 | Sat Jun 6 | vs Astros | W7-2 | 27-30 | .474 | Rogers Centre · Toronto, ON |
| 58 | Sun Jun 7 | vs Astros | W7-6 | 28-30 | .483 | Rogers Centre · Toronto, ON |
| 59 | Mon Jun 8 | vs Marlins | W11-3 | 29-30 | .492 | Rogers Centre · Toronto, ON |
| 60 | Tue Jun 9 | vs Marlins | W4-3 | 30-30 | .500 | Rogers Centre · Toronto, ON |
| 61 | Wed Jun 10 | vs Marlins | W7-2 | 31-30 | .508 | Rogers Centre · Toronto, ON |
| 62 | Fri Jun 12 | at Red Sox | W13-10 | 32-30 | .516 | Fenway Park · Boston, MA |
| 63 | Sat Jun 13 | at Red Sox | W5-4 (11) | 33-30 | .524 | Fenway Park · Boston, MA |
| 64 | Sun Jun 14 | at Red Sox | W13-5 | 34-30 | .531 | Fenway Park · Boston, MA |
| 65 | Mon Jun 15 | at Mets | L3-4 (11) | 34-31 | .523 | Citi Field · Queens, NY |
| 66 | Tue Jun 16 | at Mets | L2-3 | 34-32 | .515 | Citi Field · Queens, NY |
| 67 | Wed Jun 17 | vs Mets | W8-0 | 35-32 | .522 | Rogers Centre · Toronto, ON |
| 68 | Thu Jun 18 | vs Mets | W7-1 | 36-32 | .529 | Rogers Centre · Toronto, ON |
| 69 | Fri Jun 19 | vs Orioles | W5-4 | 37-32 | .536 | Rogers Centre · Toronto, ON |
| 70 | Sat Jun 20 | vs Orioles | L3-5 | 37-33 | .529 | Rogers Centre · Toronto, ON |
| 71 | Sun Jun 21 | vs Orioles | L9-13 | 37-34 | .521 | Rogers Centre · Toronto, ON |
| 72 | Mon Jun 22 | at Rays | W8-5 | 38-34 | .528 | Tropicana Field · St. Petersburg, FL |
| 73 | Tue Jun 23 | at Rays | L3-4 | 38-35 | .521 | Tropicana Field · St. Petersburg, FL |
| 74 | Wed Jun 24 | at Rays | W1-0 (12) | 39-35 | .527 | Tropicana Field · St. Petersburg, FL |
| 75 | Fri Jun 26 | vs Rangers | W12-2 | 40-35 | .533 | Rogers Centre · Toronto, ON |
| 76 | Sat Jun 27 | vs Rangers | L0-4 | 40-36 | .526 | Rogers Centre · Toronto, ON |
| 77 | Sun Jun 28 | vs Rangers | W3-2 | 41-36 | .532 | Rogers Centre · Toronto, ON |
| 78 | Mon Jun 29 | vs Red Sox | L1-3 | 41-37 | .526 | Rogers Centre · Toronto, ON |
| 79 | Tue Jun 30 | vs Red Sox | L3-4 | 41-38 | .519 | Rogers Centre · Toronto, ON |
| 80 | Wed Jul 1 | vs Red Sox | W11-2 | 42-38 | .525 | Rogers Centre · Toronto, ON |
| 81 | Thu Jul 2 | vs Red Sox | L6-12 | 42-39 | .519 | Rogers Centre · Toronto, ON |
| 82 | Fri Jul 3 | at Tigers | L6-8 | 42-40 | .512 | Comerica Park · Detroit, MI |
| 83 | Sat Jul 4 | at Tigers | L3-8 | 42-41 | .506 | Comerica Park · Detroit, MI |
| 84 | Sun Jul 5 | at Tigers | W10-5 | 43-41 | .512 | Comerica Park · Detroit, MI |
| 85 | Mon Jul 6 | at White Sox | L2-4 | 43-42 | .506 | Guaranteed Rate Field · Chicago, IL |
| 86 | Tue Jul 7 | at White Sox | W2-1 | 44-42 | .512 | Guaranteed Rate Field · Chicago, IL |
| 87 | Wed Jul 8 | at White Sox | L6-7 (11) | 44-43 | .506 | Guaranteed Rate Field · Chicago, IL |
| 88 | Thu Jul 9 | at White Sox | L0-2 | 44-44 | .500 | Guaranteed Rate Field · Chicago, IL |
| 89 | Fri Jul 10 | at Royals | L0-3 | 44-45 | .494 | Kauffman Stadium · Kansas City, MO |
| 90 | Sat Jul 11 | at Royals | W6-2 | 45-45 | .500 | Kauffman Stadium · Kansas City, MO |
| 91 | Sun Jul 12 | at Royals | L10-11 | 45-46 | .495 | Kauffman Stadium · Kansas City, MO |
| 92 | Fri Jul 17 | vs Rays | W6-2 | 46-46 | .500 | Rogers Centre · Toronto, ON |
| 93 | Sat Jul 18 | vs Rays | L2-3 | 46-47 | .495 | Rogers Centre · Toronto, ON |
| 94 | Sun Jul 19 | vs Rays | W4-0 | 47-47 | .500 | Rogers Centre · Toronto, ON |
| 95 | Tue Jul 21 | at Athletics | W7-1 | 48-47 | .505 | RingCentral Coliseum · Oakland, CA |
| 96 | Wed Jul 22 | at Athletics | L3-4 (10) | 48-48 | .500 | RingCentral Coliseum · Oakland, CA |
| 97 | Thu Jul 23 | at Athletics | W5-2 | 49-48 | .505 | RingCentral Coliseum · Oakland, CA |
| 98 | Fri Jul 24 | at Mariners | L2-5 | 49-49 | .500 | T-Mobile Park · Seattle, WA |
| 99 | Sat Jul 25 | at Mariners | W8-6 | 50-49 | .505 | T-Mobile Park · Seattle, WA |
| 100 | Sun Jul 26 | at Mariners | L5-6 (10) | 50-50 | .500 | T-Mobile Park · Seattle, WA |
| 101 | Tue Jul 28 | vs Phillies | L2-3 | 50-51 | .495 | Rogers Centre · Toronto, ON |
| 102 | Wed Jul 29 | vs Phillies | W8-2 | 51-51 | .500 | Rogers Centre · Toronto, ON |
| 103 | Thu Jul 30 | vs Royals | W5-2 | 52-51 | .505 | Rogers Centre · Toronto, ON |
| 104 | Fri Jul 31 | vs Royals | W7-6 (11) | 53-51 | .510 | Rogers Centre · Toronto, ON |
| 105 | Sat Aug 1 | vs Royals | L6-7 | 53-52 | .505 | Rogers Centre · Toronto, ON |
| 106 | Sun Aug 2 | vs Royals | W5-2 | 54-52 | .509 | Rogers Centre · Toronto, ON |
| 107 | Mon Aug 3 | vs Twins | W5-1 | 55-52 | .514 | Rogers Centre · Toronto, ON |
| 108 | Tue Aug 4 | vs Twins | W3-1 | 56-52 | .519 | Rogers Centre · Toronto, ON |
| 109 | Wed Aug 5 | vs Twins | W9-7 | 57-52 | .523 | Rogers Centre · Toronto, ON |
| 110 | Thu Aug 6 | vs Twins | W9-3 | 58-52 | .527 | Rogers Centre · Toronto, ON |
| 111 | Fri Aug 7 | at Yankees | W2-1 (10) | 59-52 | .532 | Yankee Stadium · The Bronx, NY |
| 112 | Sat Aug 8 | at Yankees | W6-0 | 60-52 | .536 | Yankee Stadium · The Bronx, NY |
| 113 | Sun Aug 9 | at Yankees | W2-0 | 61-52 | .540 | Yankee Stadium · The Bronx, NY |
| 114 | Tue Aug 11 | vs Athletics | W4-2 | 62-52 | .544 | Rogers Centre · Toronto, ON |
| 115 | Wed Aug 12 | vs Athletics | W10-3 | 63-52 | .548 | Rogers Centre · Toronto, ON |
| 116 | Thu Aug 13 | vs Athletics | W4-2 | 64-52 | .552 | Rogers Centre · Toronto, ON |
| 117 | Fri Aug 14 | vs Yankees | L3-4 | 64-53 | .547 | Rogers Centre · Toronto, ON |
| 118 | Sat Aug 15 | vs Yankees | L1-4 | 64-54 | .542 | Rogers Centre · Toronto, ON |
| 119 | Sun Aug 16 | vs Yankees | W3-1 | 65-54 | .546 | Rogers Centre · Toronto, ON |
| 120 | Tue Aug 18 | at Phillies | W8-5 | 66-54 | .550 | Citizens Bank Park · Philadelphi, PA |
| 121 | Wed Aug 19 | at Phillies | L4-7 | 66-55 | .545 | Citizens Bank Park · Philadelphi, PA |
| 122 | Fri Aug 21 | at Angels | W9-2 | 67-55 | .549 | Angel Stadium · Anaheim, CA |
| 123 | Sat Aug 22 | at Angels | W15-3 | 68-55 | .553 | Angel Stadium · Anaheim, CA |
| 124 | Sun Aug 23 | at Angels | W12-5 | 69-55 | .556 | Angel Stadium · Anaheim, CA |
| 125 | Tue Aug 25 | at Rangers | W6-5 | 70-55 | .560 | Globe Life Field · Arlington, TX |
| 126 | Wed Aug 26 | at Rangers | W12-4 | 71-55 | .563 | Globe Life Field · Arlington, TX |
| 127 | Thu Aug 27 | at Rangers | L1-4 | 71-56 | .559 | Globe Life Field · Arlington, TX |
| 128 | Fri Aug 28 | vs Tigers | W5-3 | 72-56 | .563 | Rogers Centre · Toronto, ON |
| 129 | Sat Aug 29 | vs Tigers | W15-1 | 73-56 | .566 | Rogers Centre · Toronto, ON |
| 130 | Sun Aug 30 | vs Tigers | W9-2 | 74-56 | .569 | Rogers Centre · Toronto, ON |
| 131 | Mon Aug 31 | vs Guardians | L2-4 | 74-57 | .565 | Rogers Centre · Toronto, ON |
| 132 | Tue Sep 1 | vs Guardians | W5-3 (10) | 75-57 | .568 | Rogers Centre · Toronto, ON |
| 133 | Wed Sep 2 | vs Guardians | W5-1 | 76-57 | .571 | Rogers Centre · Toronto, ON |
| 134 | Fri Sep 4 | vs Orioles | L2-10 | 76-58 | .567 | Rogers Centre · Toronto, ON |
| 135 | Sat Sep 5 | vs Orioles | W5-1 | 77-58 | .570 | Rogers Centre · Toronto, ON |
| 136 | Sun Sep 6 | vs Orioles | W10-4 | 78-58 | .574 | Rogers Centre · Toronto, ON |
| 137 | Mon Sep 7 | at Red Sox | L4-11 | 78-59 | .569 | Fenway Park · Boston, MA |
| 138 | Tue Sep 8 | at Red Sox | W5-1 (10) | 79-59 | .572 | Fenway Park · Boston, MA |
| 139 | Wed Sep 9 | at Red Sox | L4-10 | 79-60 | .568 | Fenway Park · Boston, MA |
| 140 | Fri Sep 11 | at Yankees | W11-5 | 80-60 | .571 | Yankee Stadium · The Bronx, NY |
| 141 | Sat Sep 12 | at Yankees | W9-5 (11) | 81-60 | .574 | Yankee Stadium · The Bronx, NY |
| 142 | Sat Sep 12 | at Yankees | W10-7 | 82-60 | .577 | Yankee Stadium · The Bronx, NY |
| 143 | Sun Sep 13 | at Yankees | L0-5 | 82-61 | .573 | Yankee Stadium · The Bronx, NY |
| 144 | Tue Sep 15 | at Braves | L2-3 | 82-62 | .569 | Truist Park · Cumberland, GA |
| 145 | Wed Sep 16 | at Braves | W9-1 | 83-62 | .572 | Truist Park · Cumberland, GA |
| 146 | Thu Sep 17 | at Braves | W5-0 | 84-62 | .575 | Truist Park · Cumberland, GA |
| 147 | Fri Sep 18 | vs Red Sox | W6-1 | 85-62 | .578 | Rogers Centre · Toronto, ON |
| 148 | Sat Sep 19 | vs Red Sox | L6-7 | 85-63 | .574 | Rogers Centre · Toronto, ON |
| 149 | Sun Sep 20 | vs Red Sox | L3-4 | 85-64 | .570 | Rogers Centre · Toronto, ON |
| 150 | Mon Sep 21 | vs Yankees | W4-2 | 86-64 | .573 | Rogers Centre · Toronto, ON |
| 151 | Tue Sep 22 | vs Yankees | L4-6 (10) | 86-65 | .570 | Rogers Centre · Toronto, ON |
| 152 | Wed Sep 23 | vs Yankees | W4-0 | 87-65 | .572 | Rogers Centre · Toronto, ON |
| 153 | Fri Sep 25 | vs Rays | W5-3 | 88-65 | .575 | Rogers Centre · Toronto, ON |
| 154 | Sat Sep 26 | vs Rays | W10-8 | 89-65 | .578 | Rogers Centre · Toronto, ON |
| 155 | Sun Sep 27 | vs Rays | W5-4 | 90-65 | .581 | Rogers Centre · Toronto, ON |
| 156 | Mon Sep 28 | at Orioles | W4-3 | 91-65 | .583 | Camden Yards · Baltimore, MD |
| 157 | Wed Sep 30 | at Orioles | W15-2 | 92-65 | .586 | Camden Yards · Baltimore, MD |
| 158 | Wed Sep 30 | at Orioles | L1-8 | 92-66 | .582 | Camden Yards · Baltimore, MD |
| 159 | Thu Oct 1 | at Orioles | L4-6 | 92-67 | .579 | Camden Yards · Baltimore, MD |
| 160 | Fri Oct 2 | at Rays | W8-4 | 93-67 | .581 | Tropicana Field · St. Petersburg, FL |
| 161 | Sat Oct 3 | at Rays | L3-4 | 93-68 | .578 | Tropicana Field · St. Petersburg, FL |
| 162 | Sun Oct 4 | at Rays | L3-12 | 93-69 | .574 | Tropicana Field · St. Petersburg, FL |
| 163 | Thu Oct 8 | vs Rangers | L3-5 | 0-1 | .000 | Rogers Centre · Toronto, ON |
| 164 | Fri Oct 9 | vs Rangers | L4-6 (14) | 0-2 | .000 | Rogers Centre · Toronto, ON |
| 165 | Sun Oct 11 | at Rangers | W5-1 | 1-2 | .333 | Globe Life Field · Arlington, TX |
| 166 | Mon Oct 12 | at Rangers | W8-4 | 2-2 | .500 | Globe Life Field · Arlington, TX |
| 167 | Wed Oct 14 | vs Rangers | W6-3 | 3-2 | .600 | Rogers Centre · Toronto, ON |
| 168 | Fri Oct 16 | at Royals | L0-5 | 0-1 | .000 | Kauffman Stadium · Kansas City, MO |
| 169 | Sat Oct 17 | at Royals | L3-6 | 0-2 | .000 | Kauffman Stadium · Kansas City, MO |
| 170 | Mon Oct 19 | vs Royals | W11-8 | 1-2 | .333 | Rogers Centre · Toronto, ON |
| 171 | Tue Oct 20 | vs Royals | L2-14 | 1-3 | .250 | Rogers Centre · Toronto, ON |
| 172 | Wed Oct 21 | vs Royals | W7-1 | 2-3 | .400 | Rogers Centre · Toronto, ON |
| 173 | Fri Oct 23 | at Royals | L3-4 | 2-4 | .333 | Kauffman Stadium · Kansas City, MO |