| 1 | Sat Feb 21 | at St. Louis | D1-1 | 0-1-0 | 1 PTS | Energizer Park · St. Louis, MO |
| 2 | Sat Feb 28 | atLA Galaxy | L0-3 | 0-1-1 | 1 PTS | Dignity Health Sports Park · Carson, CA |
| 3 | Sat Mar 7 | vsAustin | W3-1 | 1-1-1 | 4 PTS | Bank of America Stadium · Charlotte, NC |
| 4 | Sat Mar 14 | vsMiami | D0-0 | 1-2-1 | 5 PTS | Bank of America Stadium · Charlotte, NC |
| 5 | Sat Mar 21 | vsNew York | W6-1 | 2-2-1 | 8 PTS | Bank of America Stadium · Charlotte, NC |
| 6 | Sat Apr 4 | vsPhiladelphia | W2-1 | 3-2-1 | 11 PTS | Bank of America Stadium · Charlotte, NC |
| 7 | Sat Apr 11 | vsNashville | L1-2 | 3-2-2 | 11 PTS | Bank of America Stadium · Charlotte, NC |
| 8 | Sat Apr 18 | atNYCFC | W2-1 | 4-2-2 | 14 PTS | Yankee Stadium · New York City, NY |
| 9 | Wed Apr 22 | atOrlando | L1-4 | 4-2-3 | 14 PTS | Inter&Co Stadium · Orlando, FL |
| 10 | Sat Apr 25 | atNashville | L2-4 | 4-2-4 | 14 PTS | GEODIS Park · Nashville, TN |
| 11 | Sat May 2 | atNew England | L0-1 | 4-2-5 | 14 PTS | Gillette Stadium · Foxborough, MA |
| 12 | Sat May 9 | vsCincinnati | D2-2 | 4-3-5 | 15 PTS | Bank of America Stadium · Charlotte, NC |
| 13 | Wed May 13 | vsNYCFC | L0-1 | 4-3-6 | 15 PTS | Bank of America Stadium · Charlotte, NC |
| 14 | Sat May 16 | vsToronto | W3-1 | 5-3-6 | 18 PTS | Bank of America Stadium · Charlotte, NC |
| 15 | Sat May 23 | vsNew England | W1-0 | 6-3-6 | 21 PTS | Bank of America Stadium · Charlotte, NC |
| 17 | Wed Jul 22 | vsAtlanta | D2-2 | 6-4-6 | 22 PTS | Bank of America Stadium · Charlotte, NC |
| 18 | Sat Jul 25 | atNew York | W2-0 | 7-4-6 | 25 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 19 | Sat Aug 1 | atChicago | L1-2 | 7-4-7 | 25 PTS | Soldier Field · Chicago, IL |
| 20 | Sat Aug 15 | vsColumbus | W3-1 | 8-4-7 | 28 PTS | Bank of America Stadium · Charlotte, NC |
| 21 | Wed Aug 19 | atToronto | D3-3 | 8-5-7 | 29 PTS | BMO Field · Toronto, ON |
| 22 | Sat Aug 22 | vsD.C. United | W3-1 | 9-5-7 | 32 PTS | Bank of America Stadium · Charlotte, NC |
| 23 | Sat Aug 29 | atAtlanta | W2-0 | 10-5-7 | 35 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| 24 | Sat Sep 5 | vsHouston | D0-0 | 10-6-7 | 36 PTS | Bank of America Stadium · Charlotte, NC |
| 25 | Wed Sep 9 | atMontreal | W2-1 | 11-6-7 | 39 PTS | Stade Saputo · Montreal, QC |
| 26 | Sat Sep 12 | atCincinnati | D3-3 | 11-7-7 | 40 PTS | TQL Stadium · Cincinnati, OH |
| 27 | Sat Sep 19 | atD.C. United | W2-1 | 11-7-7 | 40 PTS | Audi Field · Washington, D.C. |
| 28 | Sat Sep 26 | vsChicago | L0-1 | 11-7-7 | 40 PTS | Bank of America Stadium · Charlotte, NC |
| 29 | Sat Oct 10 | vsDallas | W3-2 | 11-7-7 | 40 PTS | Bank of America Stadium · Charlotte, NC |
