| 1 | Sat Feb 21 | at St. Louis | D1-1 | 0-1-0 | 1 PTS | Energizer Park · St. Louis, MO |
| 2 | Sat Feb 28 | at LA Galaxy | L0-3 | 0-1-1 | 1 PTS | Dignity Health Sports Park · Carson, CA |
| 3 | Sat Mar 7 | vs Austin | W3-1 | 1-1-1 | 4 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 4 | Sat Mar 14 | vs Miami | D0-0 | 1-2-1 | 5 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 5 | Sat Mar 21 | vs New York | W6-1 | 2-2-1 | 8 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 6 | Sat Apr 4 | vs Philadelphia | W2-1 | 3-2-1 | 11 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 7 | Sat Apr 11 | vs Nashville | L1-2 | 3-2-2 | 11 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 8 | Sat Apr 18 | at NYCFC | W2-1 | 4-2-2 | 14 PTS | Yankee Stadium · New York City, NY |
| 9 | Wed Apr 22 | at Orlando | L1-4 | 4-2-3 | 14 PTS | Inter&Co Stadium · Orlando, FL |
| 10 | Sat Apr 25 | at Nashville | L2-4 | 4-2-4 | 14 PTS | GEODIS Park · Nashville, TN |
| 11 | Sat May 2 | at New England | L0-1 | 4-2-5 | 14 PTS | Gillette Stadium · Foxborough, MA |
| 12 | Sat May 9 | vs Cincinnati | D2-2 | 4-3-5 | 15 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 13 | Wed May 13 | vs NYCFC | L0-1 | 4-3-6 | 15 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 14 | Sat May 16 | vs Toronto | W3-1 | 5-3-6 | 18 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 15 | Sat May 23 | vs New England | W1-0 | 6-3-6 | 21 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 17 | Wed Jul 22 | vs Atlanta | D2-2 | 6-4-6 | 22 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 18 | Sat Jul 25 | at New York | W2-0 | 7-4-6 | 25 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 19 | Sat Aug 1 | at Chicago | L1-2 | 7-4-6 | 25 PTS | Soldier Field · Chicago, IL |