| 1 | Sat Feb 22 | at Miami | D2-2 | 0-1-0 | 1 PTS | Chase Stadium · Fort Lauderdale, FL |
| 2 | Sat Mar 1 | atLAFC | L0-1 | 0-1-1 | 1 PTS | BMO Stadium · Los Angeles, CA |
| 3 | Sat Mar 8 | vsOrlando | W2-1 | 1-1-1 | 4 PTS | Yankee Stadium · New York City, NY |
| 4 | Sat Mar 15 | vsNew England | W2-1 | 2-1-1 | 7 PTS | Yankee Stadium · New York City, NY |
| 5 | Sat Mar 22 | atColumbus | D0-0 | 2-2-1 | 8 PTS | Lower.com Field · Columbus, OH |
| 6 | Sat Mar 29 | atAtlanta | L3-4 | 2-2-2 | 8 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| 7 | Sun Apr 6 | vsMinnesota | L1-2 | 2-2-3 | 8 PTS | Yankee Stadium · New York City, NY |
| 8 | Sat Apr 12 | vsPhiladelphia | W1-0 | 3-2-3 | 11 PTS | Yankee Stadium · New York City, NY |
| 9 | Sat Apr 19 | atNew England | L0-2 | 3-2-4 | 11 PTS | Gillette Stadium · Foxborough, MA |
| 10 | Sat Apr 26 | atToronto | W1-0 | 4-2-4 | 14 PTS | BMO Field · Toronto, ON |
| 11 | Sun May 4 | vsCincinnati | W1-0 | 5-2-4 | 17 PTS | Yankee Stadium · New York City, NY |
| 12 | Sat May 10 | vsMontreal | L0-1 | 5-2-5 | 17 PTS | Yankee Stadium · New York City, NY |
| 13 | Wed May 14 | atD.C. United | D0-0 | 5-3-5 | 18 PTS | Audi Field · Washington, D.C. |
| 14 | Sat May 17 | vsNew York | W2-0 | 6-3-5 | 21 PTS | Yankee Stadium · New York City, NY |
| 15 | Sun May 25 | vsChicago | W3-1 | 7-3-5 | 24 PTS | Yankee Stadium · New York City, NY |
| 16 | Wed May 28 | vsHouston | L0-3 | 7-3-6 | 24 PTS | Yankee Stadium · New York City, NY |
| 17 | Sat May 31 | atNashville | D2-2 | 7-4-6 | 25 PTS | GEODIS Park · Nashville, TN |
| 19 | Thu Jun 12 | vsAtlanta | W4-0 | 8-4-6 | 28 PTS | Yankee Stadium · New York City, NY |
| 21 | Sat Jun 28 | atMontreal | L0-1 | 8-4-7 | 28 PTS | Stade Saputo · Montreal, QC |
| 22 | Thu Jul 3 | vsToronto | W3-1 | 9-4-7 | 31 PTS | Yankee Stadium · New York City, NY |
| 24 | Sat Jul 12 | atCharlotte | L0-2 | 9-4-8 | 31 PTS | Bank of America Stadium · Charlotte, NC |
| 25 | Wed Jul 16 | atOrlando | W2-1 | 10-4-8 | 34 PTS | Inter&Co Stadium · Orlando, FL |
| 26 | Sat Jul 19 | atKansas City | D1-1 | 10-5-8 | 35 PTS | Children's Mercy Park · Kansas City, KS |
| 27 | Fri Jul 25 | atDallas | W4-3 | 11-5-8 | 38 PTS | Toyota Stadium · Frisco, TX |
| 29 | Sun Aug 17 | vsNashville | W2-1 | 12-5-8 | 41 PTS | Yankee Stadium · New York City, NY |
| 30 | Sat Aug 23 | atCincinnati | W1-0 | 13-5-8 | 44 PTS | TQL Stadium · Cincinnati, OH |
| 31 | Sat Aug 30 | vsD.C. United | L1-2 | 13-5-9 | 44 PTS | Yankee Stadium · New York City, NY |
| 33 | Sat Sep 13 | atChicago | W3-1 | 14-5-9 | 47 PTS | Soldier Field · Chicago, IL |
| 35 | Wed Sep 17 | vsColumbus | W3-2 | 16-5-9 | 53 PTS | Yankee Stadium · New York City, NY |
| 35 | Sat Sep 20 | vsCharlotte | W2-0 | 16-5-9 | 53 PTS | Yankee Stadium · New York City, NY |
| 36 | Wed Sep 24 | vsMiami | L0-4 | 16-5-10 | 53 PTS | Yankee Stadium · New York City, NY |
| 37 | Sat Sep 27 | atNew York | W3-2 | 17-5-10 | 56 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 38 | Sat Oct 4 | atPhiladelphia | L0-1 | 17-5-11 | 56 PTS | Subaru Park · Chester, PA |
| 39 | Sat Oct 18 | vsSeattle | L1-2 | 17-5-12 | 56 PTS | Yankee Stadium · New York City, NY |
| 39 | Tue Oct 28 | atCharlotte | W1-0 | 17-5-12 | 56 PTS | Bank of America Stadium · Charlotte, NC |
| 39 | Sat Nov 1 | vsCharlotte | D0-0 | 17-5-12 | 56 PTS | Yankee Stadium · New York City, NY |
| 39 | Fri Nov 7 | atCharlotte | W3-1 | 17-5-12 | 56 PTS | Bank of America Stadium · Charlotte, NC |
