| 3 | Sun Mar 8 | vs Toronto | 7:00 PM | 0-0-2 | 0 PTS | TQL Stadium · Cincinnati, OH |
| 4 | Sun Mar 15 | at New England | 2:30 PM | 0-0-2 | 0 PTS | Gillette Stadium · Foxborough, MA |
| 5 | Sun Mar 22 | vs Montreal | 1:00 PM | 0-0-2 | 0 PTS | TQL Stadium · Cincinnati, OH |
| 6 | Sat Apr 4 | at New York | 7:30 PM | 2-0-0 | 6 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 7 | Sat Apr 11 | at Toronto | 1:00 PM | 0-0-2 | 0 PTS | BMO Field · Toronto, ON |
| 8 | Sat Apr 18 | vs Chicago | 7:30 PM | 1-0-1 | 3 PTS | TQL Stadium · Cincinnati, OH |
| 9 | Wed Apr 22 | at NYCFC | 7:30 PM | 1-1-0 | 4 PTS | Yankee Stadium · New York City, NY |
| 10 | Sat Apr 25 | vs New York | 7:30 PM | 2-0-0 | 6 PTS | TQL Stadium · Cincinnati, OH |
| 11 | Sat May 2 | at Chicago | 8:30 PM | 1-0-1 | 3 PTS | Soldier Field · Chicago, IL |
| 12 | Sat May 9 | at Charlotte | 7:30 PM | 0-1-1 | 1 PTS | Bank of America Stadium · Charlotte, NC |
| 13 | Wed May 13 | vs Miami | 7:30 PM | 1-0-1 | 3 PTS | TQL Stadium · Cincinnati, OH |
| 14 | Sat May 16 | at San Diego | 10:30 PM | 2-0-0 | 6 PTS | Snapdragon Stadium · San Diego, CA |
| 15 | Sat May 23 | vs Orlando | 7:30 PM | 0-0-2 | 0 PTS | TQL Stadium · Cincinnati, OH |
| 17 | Wed Jul 22 | vs Vancouver | 7:30 PM | 2-0-0 | 6 PTS | TQL Stadium · Cincinnati, OH |
| 18 | Sat Jul 25 | at Columbus | 7:00 PM | 0-1-1 | 1 PTS | Lower.com Field · Columbus, OH |
| 19 | Sat Aug 1 | vs San Jose | 7:30 PM | 2-0-0 | 6 PTS | TQL Stadium · Cincinnati, OH |
| 20 | Sat Aug 15 | at Orlando | 7:30 PM | 0-0-2 | 0 PTS | Inter&Co Stadium · Orlando, FL |
| 21 | Wed Aug 19 | vs NYCFC | 7:30 PM | 1-1-0 | 4 PTS | TQL Stadium · Cincinnati, OH |
| 22 | Sat Aug 22 | vs Seattle | 7:30 PM | 1-0-1 | 3 PTS | TQL Stadium · Cincinnati, OH |
| 23 | Sat Aug 29 | at Nashville | 8:30 PM | 1-1-0 | 4 PTS | GEODIS Park · Nashville, TN |
| 24 | Sat Sep 5 | vs D.C. United | 7:30 PM | 1-0-1 | 3 PTS | TQL Stadium · Cincinnati, OH |
| 25 | Wed Sep 9 | at Philadelphia | 7:30 PM | 0-0-2 | 0 PTS | Subaru Park · Chester, PA |
| 26 | Sat Sep 12 | vs Charlotte | 7:30 PM | 0-1-1 | 1 PTS | TQL Stadium · Cincinnati, OH |
| 27 | Sat Sep 19 | at Houston | 8:30 PM | 1-0-1 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 28 | Sat Sep 26 | at Montreal | 7:30 PM | 0-0-2 | 0 PTS | Stade Saputo · Montreal, QC |
| 29 | Sat Oct 10 | at Atlanta | 7:30 PM | 0-0-2 | 0 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| 30 | Wed Oct 14 | vs New England | 7:30 PM | 0-0-2 | 0 PTS | TQL Stadium · Cincinnati, OH |
| 31 | Sun Oct 18 | vs Columbus | 7:00 PM | 0-1-1 | 1 PTS | TQL Stadium · Cincinnati, OH |
| 32 | Sat Oct 24 | at D.C. United | 7:30 PM | 1-0-1 | 3 PTS | Audi Field · Washington, D.C. |
| 33 | Wed Oct 28 | at Miami | 7:30 PM | 1-0-1 | 3 PTS | Chase Stadium · Fort Lauderdale, FL |
| 34 | Sat Oct 31 | vs Philadelphia | 2:00 PM | 0-0-2 | 0 PTS | TQL Stadium · Cincinnati, OH |
| 35 | Sat Nov 7 | vs Nashville | 4:00 PM | 1-1-0 | 4 PTS | TQL Stadium · Cincinnati, OH |