| 1 | Sat Feb 21 | vs Atlanta | W2-0 | 1-0-0 | 3 PTS | TQL Stadium · Cincinnati, OH |
| 2 | Sat Feb 28 | atMinnesota | L0-1 | 1-0-1 | 3 PTS | Allianz Field · Saint Paul, MN |
| 3 | Sun Mar 8 | vsToronto | L0-1 | 1-0-2 | 3 PTS | TQL Stadium · Cincinnati, OH |
| 4 | Sun Mar 15 | atNew England | L1-6 | 1-0-3 | 3 PTS | Gillette Stadium · Foxborough, MA |
| 5 | Sun Mar 22 | vsMontreal | W4-3 | 2-0-3 | 6 PTS | TQL Stadium · Cincinnati, OH |
| 6 | Sat Apr 4 | atNew York | L2-4 | 2-0-4 | 6 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 7 | Sat Apr 11 | atToronto | D1-1 | 2-1-4 | 7 PTS | BMO Field · Toronto, ON |
| 8 | Sat Apr 18 | vsChicago | D3-3 | 2-2-4 | 8 PTS | TQL Stadium · Cincinnati, OH |
| 9 | Wed Apr 22 | atNYCFC | D4-4 | 2-3-4 | 9 PTS | Yankee Stadium · New York City, NY |
| 10 | Sat Apr 25 | vsNew York | W2-0 | 3-3-4 | 12 PTS | TQL Stadium · Cincinnati, OH |
| 11 | Sat May 2 | atChicago | W3-2 | 4-3-4 | 15 PTS | Soldier Field · Chicago, IL |
| 12 | Sat May 9 | atCharlotte | D2-2 | 4-4-4 | 16 PTS | Bank of America Stadium · Charlotte, NC |
| 13 | Wed May 13 | vsMiami | L3-5 | 4-4-5 | 16 PTS | TQL Stadium · Cincinnati, OH |
| 14 | Sat May 16 | atSan Diego | D3-3 | 4-5-5 | 17 PTS | Snapdragon Stadium · San Diego, CA |
| 15 | Sat May 23 | vsOrlando | W6-2 | 5-5-5 | 20 PTS | TQL Stadium · Cincinnati, OH |
| 17 | Wed Jul 22 | vsVancouver | W4-3 | 6-5-5 | 23 PTS | TQL Stadium · Cincinnati, OH |
| 18 | Sat Jul 25 | atColumbus | L1-2 | 6-5-6 | 23 PTS | Lower.com Field · Columbus, OH |
| 19 | Sat Aug 1 | vsSan Jose | W4-2 | 7-5-6 | 26 PTS | TQL Stadium · Cincinnati, OH |
| 20 | Sat Aug 15 | atOrlando | D1-1 | 7-6-6 | 27 PTS | Inter&Co Stadium · Orlando, FL |
| 21 | Wed Aug 19 | vsNYCFC | W2-1 | 8-6-6 | 30 PTS | TQL Stadium · Cincinnati, OH |
| 22 | Sat Aug 22 | vsSeattle | D1-1 | 8-7-6 | 31 PTS | TQL Stadium · Cincinnati, OH |
| 23 | Sat Aug 29 | atNashville | L0-4 | 8-7-7 | 31 PTS | GEODIS Park · Nashville, TN |
| 25 | Wed Sep 9 | atPhiladelphia | L0-5 | 8-7-8 | 31 PTS | Subaru Park · Chester, PA |
| 26 | Sat Sep 12 | vsCharlotte | D3-3 | 8-8-8 | 32 PTS | TQL Stadium · Cincinnati, OH |
| 27 | Sat Sep 19 | atHouston | D2-2 | 8-8-8 | 32 PTS | Shell Energy Stadium · Houston, TX |
| 28 | Sat Sep 26 | atMontreal | L1-3 | 8-8-8 | 32 PTS | Stade Saputo · Montreal, QC |
| 29 | Sat Oct 10 | atAtlanta | W3-1 | 8-8-8 | 32 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| 30 | Wed Oct 14 | vsNew England | L2-3 | 8-8-8 | 32 PTS | TQL Stadium · Cincinnati, OH |
