| Sat Nov 9 | vs NYCFC | L0-0 (5-6) | 1-0-3 | 6 PTS | TQL Stadium · Cincinnati, OH |
| Sat Nov 2 | atNYCFC | L1-3 | 2-0-1 | 7 PTS | Yankee Stadium · New York City, NY |
| Mon Oct 28 | vsNYCFC | W1-0 | 0-0-2 | 2 PTS | TQL Stadium · Cincinnati, OH |
| Sat Oct 19 | at Philadelphia | W2-1 | 17-11-5 | 56 PTS | Subaru Park · Chester, PA |
| Sat Oct 5 | vs Orlando | L1-3 | 17-11-5 | 56 PTS | TQL Stadium · Cincinnati, OH |
| Wed Oct 2 | atNYCFC | L2-3 | 17-11-5 | 56 PTS | Red Bull Arena · Harrison, NJ |
| Sat Sep 28 | vs LAFC | L1-2 | 17-10-5 | 56 PTS | TQL Stadium · Cincinnati, OH |
| Sat Sep 21 | at Nashville | D2-2 | 17-8-6 | 57 PTS | GEODIS Park · Nashville, TN |
| Wed Sep 18 | at Minnesota | W2-1 | 18-8-4 | 58 PTS | Allianz Field · Saint Paul, MN |
| Sat Sep 14 | vs Columbus | D0-0 | 16-8-5 | 53 PTS | TQL Stadium · Cincinnati, OH |
| Sat Aug 31 | vs Montreal | W4-1 | 17-8-3 | 54 PTS | TQL Stadium · Cincinnati, OH |
| Sat Aug 24 | at Miami | L0-2 | 15-9-3 | 48 PTS | DRV PNK Stadium · Fort Lauderdale, FL |
| Sat Jul 20 | at New York | L1-3 | 15-8-3 | 48 PTS | Red Bull Arena · Harrison, NJ |
| Wed Jul 17 | vs Chicago | L0-1 | 15-7-3 | 48 PTS | TQL Stadium · Cincinnati, OH |
| Sat Jul 13 | vs Charlotte | L1-3 | 15-6-3 | 48 PTS | TQL Stadium · Cincinnati, OH |
| Sat Jul 6 | vsMiami | W6-1 | 16-4-3 | 51 PTS | TQL Stadium · Cincinnati, OH |
| Wed Jul 3 | at D.C. United | W3-2 | 15-4-3 | 48 PTS | Audi Field · Washington, D.C. |
| Sat Jun 29 | at Dallas | W1-0 | 14-4-3 | 45 PTS | Toyota Stadium · Frisco, TX |
| Sat Jun 22 | vs New England | L1-2 | 12-5-3 | 39 PTS | TQL Stadium · Cincinnati, OH |
| Wed Jun 19 | vsPhiladelphia | W4-3 | 13-3-3 | 42 PTS | TQL Stadium · Cincinnati, OH |
| Sat Jun 15 | at San Jose | W4-2 | 12-3-3 | 39 PTS | PayPal Park · San Jose, CA |
| Wed May 29 | vsNashville | L0-2 | 10-4-3 | 33 PTS | TQL Stadium · Cincinnati, OH |
| Sat May 25 | at Toronto | W4-3 | 11-2-3 | 36 PTS | BMO Field · Toronto, ON |
| Sat May 18 | vs St. Louis | W3-1 | 10-2-3 | 33 PTS | TQL Stadium · Cincinnati, OH |
| Wed May 15 | vs Atlanta | W1-0 | 9-2-3 | 30 PTS | TQL Stadium · Cincinnati, OH |
| Sat May 11 | atColumbus | W2-1 | 8-2-3 | 27 PTS | Lower.com Field · Columbus, OH |
| Sat May 4 | atOrlando | W1-0 | 7-2-3 | 24 PTS | Exploria Stadium · Orlando, FL |
| Sat Apr 27 | vs Colorado | W2-1 | 6-2-3 | 21 PTS | TQL Stadium · Cincinnati, OH |
| Sat Apr 20 | atAtlanta | W2-1 | 5-2-3 | 18 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| Sat Apr 13 | atMontreal | L1-2 | 3-3-3 | 12 PTS | Stade Saputo · Montreal, QC |
| Sat Apr 6 | vsNew York | L1-2 | 3-2-3 | 12 PTS | TQL Stadium · Cincinnati, OH |
| Sat Mar 30 | atCharlotte | D1-1 | 3-0-4 | 13 PTS | Bank of America Stadium · Charlotte, NC |
| Sat Mar 23 | vsNYCFC | W1-0 | 4-0-2 | 14 PTS | TQL Stadium · Cincinnati, OH |
| Sun Mar 17 | atNew England | W2-1 | 3-0-2 | 11 PTS | Gillette Stadium · Foxborough, MA |
| Sun Mar 10 | vsD.C. United | D0-0 | 1-0-3 | 6 PTS | TQL Stadium · Cincinnati, OH |
| Sat Mar 2 | atChicago | W2-1 | 2-0-1 | 7 PTS | Soldier Field · Chicago, IL |
| Sun Feb 25 | vsToronto | D0-0 | 0-0-2 | 2 PTS | TQL Stadium · Cincinnati, OH |
