| 1 | Sat Feb 21 | vs Kansas City | W3-0 | 1-0-0 | 3 PTS | PayPal Park · San Jose, CA |
| 2 | Sat Feb 28 | vsAtlanta | W2-0 | 2-0-0 | 6 PTS | PayPal Park · San Jose, CA |
| 3 | Sat Mar 7 | atPhiladelphia | W1-0 | 3-0-0 | 9 PTS | Subaru Park · Chester, PA |
| 4 | Sun Mar 15 | vsSeattle | L0-1 | 3-0-1 | 9 PTS | PayPal Park · San Jose, CA |
| 5 | Sat Mar 21 | atVancouver | W1-0 | 4-0-1 | 12 PTS | BC Place · Vancouver, BC |
| 6 | Sat Apr 4 | vsSan Diego | W3-0 | 5-0-1 | 15 PTS | PayPal Park · San Jose, CA |
| 7 | Sat Apr 11 | atKansas City | W3-1 | 6-0-1 | 18 PTS | Children's Mercy Park · Kansas City, KS |
| 8 | Sun Apr 19 | atLAFC | W4-1 | 7-0-1 | 21 PTS | BMO Stadium · Los Angeles, CA |
| 9 | Wed Apr 22 | vsAustin | W5-1 | 8-0-1 | 24 PTS | PayPal Park · San Jose, CA |
| 10 | Sat Apr 25 | atSt. Louis | W3-2 | 9-0-1 | 27 PTS | Energizer Park · St. Louis, MO |
| 11 | Sat May 2 | atToronto | D1-1 | 9-1-1 | 28 PTS | BMO Field · Toronto, ON |
| 12 | Sat May 9 | vsVancouver | D1-1 | 9-2-1 | 29 PTS | PayPal Park · San Jose, CA |
| 13 | Wed May 13 | atSeattle | L2-3 | 9-2-2 | 29 PTS | Lumen Field · Seattle, WA |
| 14 | Sat May 16 | vsDallas | L2-3 | 9-2-3 | 29 PTS | PayPal Park · San Jose, CA |
| 15 | Sat May 23 | atPortland | W3-1 | 10-2-3 | 32 PTS | Providence Park · Portland, OR |
| 17 | Wed Jul 22 | vsOrlando | L0-4 | 10-2-4 | 32 PTS | PayPal Park · San Jose, CA |
| 18 | Sat Jul 25 | vsLA Galaxy | D1-1 | 10-3-4 | 33 PTS | PayPal Park · San Jose, CA |
| 19 | Sat Aug 1 | atCincinnati | L2-4 | 10-3-4 | 33 PTS | TQL Stadium · Cincinnati, OH |
| 20 | Sat Aug 15 | vsSt. Louis | L1-3 | 10-3-4 | 33 PTS | PayPal Park · San Jose, CA |
| 21 | Wed Aug 19 | atLA Galaxy | L0-1 | 10-3-4 | 33 PTS | Dignity Health Sports Park · Carson, CA |
| 22 | Sat Aug 22 | vsMinnesota | L1-5 | 10-3-4 | 33 PTS | PayPal Park · San Jose, CA |
| 23 | Sat Aug 29 | atHouston | D0-0 | 10-3-4 | 33 PTS | Shell Energy Stadium · Houston, TX |
