| 1 | Sat Feb 22 | vs Salt Lake | W4-0 | 1-0-0 | 3 PTS | PayPal Park · San Jose, CA |
| 2 | Sat Mar 1 | at Kansas City | W2-1 | 2-0-0 | 6 PTS | Children's Mercy Park · Kansas City, KS |
| 3 | Sat Mar 8 | vs Minnesota | L0-1 | 2-0-1 | 6 PTS | PayPal Park · San Jose, CA |
| 4 | Sat Mar 15 | vs Colorado | L1-2 | 2-0-2 | 6 PTS | PayPal Park · San Jose, CA |
| 5 | Sat Mar 22 | at Charlotte | L1-4 | 2-0-3 | 6 PTS | Bank of America Stadium · Charlotte, NC |
| 6 | Sat Mar 29 | vs Seattle | D1-1 | 2-1-3 | 7 PTS | PayPal Park · San Jose, CA |
| 7 | Sun Apr 6 | vs D.C. United | W6-1 | 3-1-3 | 10 PTS | PayPal Park · San Jose, CA |
| 8 | Sat Apr 12 | at LAFC | L1-2 | 3-1-4 | 10 PTS | BMO Stadium · Los Angeles, CA |
| 9 | Sat Apr 19 | vsKansas City | L3-5 | 3-1-5 | 10 PTS | PayPal Park · San Jose, CA |
| 10 | Sat Apr 26 | at Columbus | L1-2 | 3-1-6 | 10 PTS | Lower.com Field · Columbus, OH |
| 11 | Sat May 3 | vs Portland | W4-1 | 4-1-6 | 13 PTS | PayPal Park · San Jose, CA |
| 12 | Sat May 10 | atColorado | W2-0 | 5-1-6 | 16 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 13 | Wed May 14 | vs Miami | D3-3 | 5-2-6 | 17 PTS | PayPal Park · San Jose, CA |
| 14 | Sat May 17 | at New England | D0-0 | 5-3-6 | 18 PTS | Gillette Stadium · Foxborough, MA |
| 15 | Sat May 24 | vs Houston | D3-3 | 5-4-6 | 19 PTS | PayPal Park · San Jose, CA |
| 16 | Wed May 28 | at LA Galaxy | W1-0 | 6-4-6 | 22 PTS | Dignity Health Sports Park · Carson, CA |
| 17 | Sat May 31 | at St. Louis | L1-2 | 6-4-7 | 22 PTS | Energizer Park · St. Louis, MO |
| 19 | Fri Jun 13 | atPortland | D1-1 | 6-5-7 | 23 PTS | Providence Park · Portland, OR |
| 20 | Wed Jun 25 | at Dallas | W4-2 | 7-5-7 | 26 PTS | Toyota Stadium · Frisco, TX |
| 21 | Sat Jun 28 | vsLA Galaxy | D1-1 | 7-6-7 | 27 PTS | PayPal Park · San Jose, CA |
New York
Vancouver
San Diego
Austin