| 1 | Sat Feb 21 | vs Montreal | W5-0 | 1-0-0 | 3 PTS | Snapdragon Stadium · San Diego, CA |
| 2 | Sun Mar 1 | vsSt. Louis | W2-0 | 2-0-0 | 6 PTS | Snapdragon Stadium · San Diego, CA |
| 3 | Sat Mar 7 | atKansas City | W1-0 | 3-0-0 | 9 PTS | Children's Mercy Park · Kansas City, KS |
| 4 | Sat Mar 14 | atDallas | D3-3 | 3-1-0 | 10 PTS | Toyota Stadium · Frisco, TX |
| 5 | Sun Mar 22 | vsSalt Lake | D2-2 | 3-2-0 | 11 PTS | Snapdragon Stadium · San Diego, CA |
| 6 | Sat Apr 4 | atSan Jose | L0-3 | 3-2-1 | 11 PTS | PayPal Park · San Jose, CA |
| 7 | Sat Apr 11 | vsMinnesota | L1-2 | 3-2-2 | 11 PTS | Snapdragon Stadium · San Diego, CA |
| 8 | Sat Apr 18 | atSalt Lake | L2-4 | 3-2-3 | 11 PTS | America First Field · Sandy, UT |
| 9 | Wed Apr 22 | atHouston | L0-1 | 3-2-4 | 11 PTS | Shell Energy Stadium · Houston, TX |
| 10 | Sat Apr 25 | vsPortland | L1-2 | 3-2-5 | 11 PTS | Snapdragon Stadium · San Diego, CA |
| 11 | Sat May 2 | vsLAFC | D2-2 | 3-3-5 | 12 PTS | Snapdragon Stadium · San Diego, CA |
| 12 | Sat May 9 | atSeattle | D1-1 | 3-4-5 | 13 PTS | Lumen Field · Seattle, WA |
| 13 | Wed May 13 | vsAustin | W5-0 | 4-4-5 | 16 PTS | Snapdragon Stadium · San Diego, CA |
| 14 | Sat May 16 | vsCincinnati | D3-3 | 4-5-5 | 17 PTS | Snapdragon Stadium · San Diego, CA |
| 15 | Sat May 23 | vsVancouver | L2-4 | 4-5-6 | 17 PTS | Snapdragon Stadium · San Diego, CA |
| 17 | Wed Jul 22 | atColorado | L0-1 | 4-5-7 | 17 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 18 | Sat Jul 25 | vsDallas | W1-0 | 5-5-7 | 20 PTS | Snapdragon Stadium · San Diego, CA |
| 19 | Sat Aug 1 | atMinnesota | D1-1 | 5-6-7 | 21 PTS | Allianz Field · Saint Paul, MN |
| 20 | Sat Aug 15 | atLAFC | W1-0 | 6-6-7 | 24 PTS | BMO Stadium · Los Angeles, CA |
| 21 | Wed Aug 19 | atPortland | L1-3 | 6-6-8 | 24 PTS | Providence Park · Portland, OR |
| 22 | Sat Aug 22 | vsColorado | W3-0 | 7-6-8 | 27 PTS | Snapdragon Stadium · San Diego, CA |
| 23 | Sat Aug 29 | vsLA Galaxy | W3-1 | 8-6-8 | 30 PTS | Snapdragon Stadium · San Diego, CA |
| 24 | Sat Sep 5 | atOrlando | L0-1 | 8-6-9 | 30 PTS | Inter&Co Stadium · Orlando, FL |
| 25 | Wed Sep 9 | vsSan Jose | L2-3 | 8-6-10 | 30 PTS | Snapdragon Stadium · San Diego, CA |
| 26 | Sun Sep 13 | vsPhiladelphia | L0-5 | 8-6-11 | 30 PTS | Snapdragon Stadium · San Diego, CA |
| 27 | Sun Sep 20 | atMiami | D2-2 | 8-6-11 | 30 PTS | Chase Stadium · Fort Lauderdale, FL |
