| 6 | Sat Apr 4 | at San Jose | 10:30 PM | 4-0-1 | 12 PTS | PayPal Park · San Jose, CA |
| 7 | Sat Apr 11 | vsMinnesota | 10:30 PM | 1-2-2 | 5 PTS | Snapdragon Stadium · San Diego, CA |
| 8 | Sat Apr 18 | atSalt Lake | 9:30 PM | 3-1-1 | 10 PTS | America First Field · Sandy, UT |
| 9 | Wed Apr 22 | atHouston | 8:30 PM | 2-0-2 | 6 PTS | Shell Energy Stadium · Houston, TX |
| 10 | Sat Apr 25 | vsPortland | 9:30 PM | 1-1-3 | 4 PTS | Snapdragon Stadium · San Diego, CA |
| 11 | Sat May 2 | vsLAFC | 9:30 PM | 4-1-0 | 13 PTS | Snapdragon Stadium · San Diego, CA |
| 12 | Sat May 9 | atSeattle | 10:30 PM | 3-1-1 | 10 PTS | Costello Athletic Center · Lowell, MA |
| 13 | Wed May 13 | vsAustin | 9:30 PM | 1-2-2 | 5 PTS | Snapdragon Stadium · San Diego, CA |
| 14 | Sat May 16 | vsCincinnati | 9:30 PM | 2-0-3 | 6 PTS | Snapdragon Stadium · San Diego, CA |
| 15 | Sat May 23 | vsVancouver | 9:30 PM | 4-0-1 | 12 PTS | Snapdragon Stadium · San Diego, CA |
| 17 | Wed Jul 22 | atColorado | 9:30 PM | 3-0-2 | 9 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 18 | Sat Jul 25 | vsDallas | 9:30 PM | 2-2-1 | 8 PTS | Snapdragon Stadium · San Diego, CA |
| 19 | Sat Aug 1 | atMinnesota | 8:30 PM | 1-2-2 | 5 PTS | Allianz Field · Saint Paul, MN |
| 20 | Sat Aug 15 | atLAFC | 10:30 PM | 4-1-0 | 13 PTS | BMO Stadium · Los Angeles, CA |
| 21 | Wed Aug 19 | atPortland | 10:30 PM | 1-1-3 | 4 PTS | Providence Park · Portland, OR |
| 22 | Sat Aug 22 | vsColorado | 10:30 PM | 3-0-2 | 9 PTS | Snapdragon Stadium · San Diego, CA |
| 23 | Sat Aug 29 | vsLA Galaxy | 10:30 PM | 1-2-2 | 5 PTS | Snapdragon Stadium · San Diego, CA |
| 24 | Sat Sep 5 | atOrlando | 7:30 PM | 1-0-4 | 3 PTS | Inter&Co Stadium · Orlando, FL |
| 25 | Wed Sep 9 | vsSan Jose | 10:30 PM | 4-0-1 | 12 PTS | Snapdragon Stadium · San Diego, CA |
| 26 | Sun Sep 13 | vsPhiladelphia | 9:00 PM | 0-0-5 | 0 PTS | Snapdragon Stadium · San Diego, CA |
| 27 | Sun Sep 20 | atMiami | 7:00 PM | 3-1-1 | 10 PTS | Chase Stadium · Fort Lauderdale, FL |
| 28 | Sat Sep 26 | atAustin | 8:30 PM | 1-2-2 | 5 PTS | Q2 Stadium · Austin, TX |
| 29 | Sat Oct 10 | atNew York | 7:30 PM | 2-1-2 | 7 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 30 | Wed Oct 14 | vsHouston | 10:30 PM | 2-0-2 | 6 PTS | Snapdragon Stadium · San Diego, CA |
| 31 | Sat Oct 17 | atLA Galaxy | 10:30 PM | 1-2-2 | 5 PTS | Dignity Health Sports Park · Carson, CA |
| 32 | Sat Oct 24 | vsSeattle | 10:30 PM | 3-1-1 | 10 PTS | Snapdragon Stadium · San Diego, CA |
| 33 | Wed Oct 28 | atVancouver | 10:30 PM | 4-0-1 | 12 PTS | BC Place · Vancouver, BC |
| 34 | Sun Nov 1 | atSt. Louis | 3:00 PM | 1-1-3 | 4 PTS | Energizer Park · St. Louis, MO |
| 35 | Sat Nov 7 | vsKansas City | 7:00 PM | 1-1-3 | 4 PTS | Snapdragon Stadium · San Diego, CA |
