| 1 | Sat Feb 21 | vs Chicago | W2-1 | 1-0-0 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 2 | Sat Feb 28 | vsLAFC | L0-2 | 1-0-1 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 4 | Sat Mar 14 | vsPortland | W3-2 | 3-0-1 | 9 PTS | Shell Energy Stadium · Houston, TX |
| 5 | Sat Mar 21 | atDallas | L3-4 | 3-0-2 | 9 PTS | Toyota Stadium · Frisco, TX |
| 6 | Sat Apr 4 | vsSeattle | L0-1 | 3-0-3 | 9 PTS | Shell Energy Stadium · Houston, TX |
| 7 | Sat Apr 11 | atColorado | L2-6 | 3-0-4 | 9 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 8 | Sat Apr 18 | atOrlando | W1-0 | 4-0-4 | 12 PTS | Inter&Co Stadium · Orlando, FL |
| 9 | Wed Apr 22 | vsSan Diego | W1-0 | 5-0-4 | 15 PTS | Shell Energy Stadium · Houston, TX |
| 10 | Sat Apr 25 | atAustin | L0-2 | 5-0-5 | 15 PTS | Q2 Stadium · Austin, TX |
| 11 | Sat May 2 | vsColorado | W1-0 | 6-0-5 | 18 PTS | Shell Energy Stadium · Houston, TX |
| 12 | Sun May 10 | atLAFC | W4-1 | 7-0-5 | 21 PTS | BMO Stadium · Los Angeles, CA |
| 13 | Wed May 13 | atSalt Lake | L0-3 | 7-0-6 | 21 PTS | America First Field · Sandy, UT |
| 14 | Sat May 16 | vsVancouver | W1-0 | 8-0-6 | 24 PTS | Shell Energy Stadium · Houston, TX |
| 15 | Sat May 23 | atLA Galaxy | D1-1 | 8-1-6 | 25 PTS | Dignity Health Sports Park · Carson, CA |
| 17 | Wed Jul 22 | vsD.C. United | D1-1 | 8-2-6 | 26 PTS | Shell Energy Stadium · Houston, TX |
| 18 | Sat Jul 25 | vsAustin | W3-0 | 9-2-6 | 29 PTS | Shell Energy Stadium · Houston, TX |
| 19 | Sat Aug 1 | atKansas City | W2-0 | 10-2-6 | 32 PTS | Children's Mercy Park · Kansas City, KS |
| 3 | Sat Aug 8 | atNew England | W2-0 | 2-0-1 | 6 PTS | Gillette Stadium · Foxborough, MA |
| 20 | Sat Aug 15 | vsLA Galaxy | W1-0 | 11-2-6 | 35 PTS | Shell Energy Stadium · Houston, TX |
| 21 | Wed Aug 19 | atVancouver | W1-0 | 12-2-6 | 38 PTS | BC Place · Vancouver, BC |
| 22 | Sat Aug 22 | atSt. Louis | L1-2 | 12-2-7 | 38 PTS | Energizer Park · St. Louis, MO |
| 23 | Sat Aug 29 | vsSan Jose | D0-0 | 12-3-7 | 39 PTS | Shell Energy Stadium · Houston, TX |
| 24 | Sat Sep 5 | atCharlotte | D0-0 | 12-4-7 | 40 PTS | Bank of America Stadium · Charlotte, NC |
| 25 | Wed Sep 9 | vsSalt Lake | W2-1 | 13-4-7 | 43 PTS | Shell Energy Stadium · Houston, TX |
| 26 | Sat Sep 12 | atSan Jose | L0-1 | 13-4-8 | 43 PTS | PayPal Park · San Jose, CA |
| 27 | Sat Sep 19 | vsCincinnati | D2-2 | 13-4-8 | 43 PTS | Shell Energy Stadium · Houston, TX |
| 28 | Sat Sep 26 | vsKansas City | L0-2 | 13-4-8 | 43 PTS | Shell Energy Stadium · Houston, TX |
| 29 | Sat Oct 10 | atMinnesota | D2-2 | 13-4-8 | 43 PTS | Allianz Field · Saint Paul, MN |
| 30 | Wed Oct 14 | atSan Diego | D3-3 | 13-4-8 | 43 PTS | Snapdragon Stadium · San Diego, CA |
