| 4 | Sat Mar 14 | vs Portland | 8:30 PM | 1-0-1 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 5 | Sat Mar 21 | atDallas | 8:30 PM | 1-1-0 | 4 PTS | Toyota Stadium · Frisco, TX |
| 6 | Sat Apr 4 | vsSeattle | 8:30 PM | 1-0-1 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 7 | Sat Apr 11 | atColorado | 9:30 PM | 1-0-1 | 3 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 8 | Sat Apr 18 | atOrlando | 7:30 PM | 0-0-2 | 0 PTS | Inter&Co Stadium · Orlando, FL |
| 9 | Wed Apr 22 | vsSan Diego | 8:30 PM | 2-0-0 | 6 PTS | Shell Energy Stadium · Houston, TX |
| 10 | Sat Apr 25 | atAustin | 8:30 PM | 1-1-0 | 4 PTS | Q2 Stadium · Austin, TX |
| 11 | Sat May 2 | vsColorado | 8:30 PM | 1-0-1 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 12 | Sun May 10 | atLAFC | 9:00 PM | 2-0-0 | 6 PTS | BMO Stadium · Los Angeles, CA |
| 13 | Wed May 13 | atSalt Lake | 9:30 PM | 1-0-1 | 3 PTS | America First Field · Sandy, UT |
| 14 | Sat May 16 | vsVancouver | 8:30 PM | 2-0-0 | 6 PTS | Shell Energy Stadium · Houston, TX |
| 15 | Sat May 23 | atLA Galaxy | 10:30 PM | 1-1-0 | 4 PTS | Dignity Health Sports Park · Carson, CA |
| 17 | Wed Jul 22 | vsD.C. United | 8:30 PM | 1-0-1 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 18 | Sat Jul 25 | vsAustin | 8:30 PM | 1-1-0 | 4 PTS | Shell Energy Stadium · Houston, TX |
| 19 | Sat Aug 1 | atKansas City | 8:30 PM | 0-1-1 | 1 PTS | Children's Mercy Park · Kansas City, KS |
| 20 | Sat Aug 15 | vsLA Galaxy | 8:30 PM | 1-1-0 | 4 PTS | Shell Energy Stadium · Houston, TX |
| 21 | Wed Aug 19 | atVancouver | 10:30 PM | 2-0-0 | 6 PTS | BC Place · Vancouver, BC |
| 22 | Sat Aug 22 | atSt. Louis | 8:30 PM | 0-1-1 | 1 PTS | Energizer Park · St. Louis, MO |
| 23 | Sat Aug 29 | vsSan Jose | 8:30 PM | 2-0-0 | 6 PTS | Shell Energy Stadium · Houston, TX |
| 24 | Sat Sep 5 | atCharlotte | 7:30 PM | 0-1-1 | 1 PTS | Bank of America Stadium · Charlotte, NC |
| 25 | Wed Sep 9 | vsSalt Lake | 8:30 PM | 1-0-1 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 26 | Sat Sep 12 | atSan Jose | 10:30 PM | 2-0-0 | 6 PTS | PayPal Park · San Jose, CA |
| 27 | Sat Sep 19 | vsCincinnati | 8:30 PM | 1-0-1 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 28 | Sat Sep 26 | vsKansas City | 8:30 PM | 0-1-1 | 1 PTS | Shell Energy Stadium · Houston, TX |
| 29 | Sat Oct 10 | atMinnesota | 8:30 PM | 1-1-0 | 4 PTS | Allianz Field · Saint Paul, MN |
| 30 | Wed Oct 14 | atSan Diego | 10:30 PM | 2-0-0 | 6 PTS | Snapdragon Stadium · San Diego, CA |
| 31 | Sat Oct 17 | vsDallas | 8:30 PM | 1-1-0 | 4 PTS | Shell Energy Stadium · Houston, TX |
| 32 | Sat Oct 24 | vsMinnesota | 8:30 PM | 1-1-0 | 4 PTS | Shell Energy Stadium · Houston, TX |
| 33 | Wed Oct 28 | atSeattle | 10:30 PM | 1-0-1 | 3 PTS | Lumen Field · Seattle, WA |
| 34 | Sun Nov 1 | atPortland | 8:00 PM | 1-0-1 | 3 PTS | Providence Park · Portland, OR |
| 35 | Sat Nov 7 | vsSt. Louis | 7:00 PM | 0-1-1 | 1 PTS | Shell Energy Stadium · Houston, TX |
