| 3 | Sat Mar 7 | at St. Louis | 8:30 PM | 0-1-1 | 1 PTS | Energizer Park · St. Louis, MO |
| 4 | Sun Mar 15 | atSan Jose | 7:00 PM | 2-0-0 | 6 PTS | PayPal Park · San Jose, CA |
| 5 | Sun Mar 22 | atMinnesota | 2:30 PM | 1-1-0 | 4 PTS | Allianz Field · Saint Paul, MN |
| 6 | Sat Apr 4 | atHouston | 8:30 PM | 1-0-1 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 7 | Sun Apr 12 | vsSalt Lake | 9:00 PM | 1-0-1 | 3 PTS | Lumen Field · Seattle, WA |
| 8 | Sat Apr 18 | vsSt. Louis | 9:30 PM | 0-1-1 | 1 PTS | Lumen Field · Seattle, WA |
| 10 | Sat Apr 25 | vsDallas | 10:30 PM | 1-1-0 | 4 PTS | Lumen Field · Seattle, WA |
| 11 | Sat May 2 | atKansas City | 2:30 PM | 0-1-1 | 1 PTS | Children's Mercy Park · Kansas City, KS |
| 12 | Sat May 9 | vsSan Diego | 10:30 PM | 2-0-0 | 6 PTS | Lumen Field · Seattle, WA |
| 13 | Wed May 13 | vsSan Jose | 9:30 PM | 2-0-0 | 6 PTS | Lumen Field · Seattle, WA |
| 14 | Sat May 16 | vsLA Galaxy | 9:00 PM | 1-1-0 | 4 PTS | Lumen Field · Seattle, WA |
| 15 | Sun May 24 | atLAFC | 9:00 PM | 2-0-0 | 6 PTS | BMO Stadium · Los Angeles, CA |
| 16 | Thu Jul 16 | vsPortland | 10:30 PM | 1-0-1 | 3 PTS | Lumen Field · Seattle, WA |
| 17 | Wed Jul 22 | atAustin | 8:30 PM | 1-1-0 | 4 PTS | Q2 Stadium · Austin, TX |
| 18 | Sat Jul 25 | atPhiladelphia | 7:30 PM | 0-0-2 | 0 PTS | Subaru Park · Chester, PA |
| 19 | Sat Aug 1 | atPortland | 10:30 PM | 1-0-1 | 3 PTS | Providence Park · Portland, OR |
| 20 | Sun Aug 16 | vsVancouver | 9:00 PM | 2-0-0 | 6 PTS | Lumen Field · Seattle, WA |
| 21 | Wed Aug 19 | vsAustin | 9:30 PM | 1-1-0 | 4 PTS | Lumen Field · Seattle, WA |
| 22 | Sat Aug 22 | atCincinnati | 7:30 PM | 1-0-1 | 3 PTS | TQL Stadium · Cincinnati, OH |
| 23 | Sat Aug 29 | vsChicago | 4:30 PM | 1-0-1 | 3 PTS | Lumen Field · Seattle, WA |
| 24 | Sat Sep 5 | vsNew York | 8:30 PM | 2-0-0 | 6 PTS | Lumen Field · Seattle, WA |
| 25 | Wed Sep 9 | vsKansas City | 10:30 PM | 0-1-1 | 1 PTS | Lumen Field · Seattle, WA |
| 26 | Sat Sep 12 | atLA Galaxy | 10:30 PM | 1-1-0 | 4 PTS | Dignity Health Sports Park · Carson, CA |
| 27 | Sat Sep 19 | atColorado | 9:30 PM | 1-0-1 | 3 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 28 | Sat Sep 26 | vsMinnesota | 8:30 PM | 1-1-0 | 4 PTS | Lumen Field · Seattle, WA |
| 29 | Sat Oct 10 | atNew England | 7:30 PM | 0-0-2 | 0 PTS | Gillette Stadium · Foxborough, MA |
| 30 | Wed Oct 14 | atDallas | 8:30 PM | 1-1-0 | 4 PTS | Toyota Stadium · Frisco, TX |
| 31 | Sat Oct 17 | vsMontreal | 10:30 PM | 0-0-2 | 0 PTS | Lumen Field · Seattle, WA |
| 32 | Sat Oct 24 | atSan Diego | 10:30 PM | 2-0-0 | 6 PTS | Snapdragon Stadium · San Diego, CA |
| 33 | Wed Oct 28 | vsHouston | 10:30 PM | 1-0-1 | 3 PTS | Lumen Field · Seattle, WA |
| 34 | Sun Nov 1 | atVancouver | 4:30 PM | 2-0-0 | 6 PTS | BC Place · Vancouver, BC |
| 35 | Sat Nov 7 | vsLAFC | 7:00 PM | 2-0-0 | 6 PTS | Lumen Field · Seattle, WA |
