| 1 | Sun Feb 22 | vs Colorado | W2-0 | 1-0-0 | 3 PTS | Lumen Field · Seattle, WA |
| 2 | Sat Feb 28 | atSalt Lake | L1-2 | 1-0-1 | 3 PTS | America First Field · Sandy, UT |
| 3 | Sat Mar 7 | atSt. Louis | W1-0 | 2-0-1 | 6 PTS | Energizer Park · St. Louis, MO |
| 4 | Sun Mar 15 | atSan Jose | W1-0 | 3-0-1 | 9 PTS | PayPal Park · San Jose, CA |
| 5 | Sun Mar 22 | atMinnesota | D0-0 | 3-1-1 | 10 PTS | Allianz Field · Saint Paul, MN |
| 6 | Sat Apr 4 | atHouston | W1-0 | 4-1-1 | 13 PTS | Shell Energy Stadium · Houston, TX |
| 8 | Sat Apr 18 | vsSt. Louis | W4-1 | 5-1-1 | 16 PTS | Lumen Field · Seattle, WA |
| 10 | Sat Apr 25 | vsDallas | W2-1 | 6-1-1 | 19 PTS | Lumen Field · Seattle, WA |
| 11 | Sat May 2 | atKansas City | D1-1 | 6-2-1 | 20 PTS | Children's Mercy Park · Kansas City, KS |
| 12 | Sat May 9 | vsSan Diego | D1-1 | 6-3-1 | 21 PTS | Lumen Field · Seattle, WA |
| 13 | Wed May 13 | vsSan Jose | W3-2 | 7-3-1 | 24 PTS | Lumen Field · Seattle, WA |
| 14 | Sat May 16 | vsLA Galaxy | L0-2 | 7-3-2 | 24 PTS | Lumen Field · Seattle, WA |
| 15 | Sun May 24 | atLAFC | L0-1 | 7-3-3 | 24 PTS | BMO Stadium · Los Angeles, CA |
| 16 | Thu Jul 16 | vsPortland | L1-5 | 7-3-4 | 24 PTS | Lumen Field · Seattle, WA |
| 17 | Wed Jul 22 | atAustin | L1-3 | 7-3-5 | 24 PTS | Q2 Stadium · Austin, TX |
| 18 | Sat Jul 25 | atPhiladelphia | L0-1 | 7-3-6 | 24 PTS | Subaru Park · Chester, PA |
| 19 | Sat Aug 1 | atPortland | L1-2 | 7-3-7 | 24 PTS | Providence Park · Portland, OR |
| 20 | Sun Aug 16 | vsVancouver | L0-2 | 7-3-8 | 24 PTS | Lumen Field · Seattle, WA |
| 21 | Wed Aug 19 | vsAustin | L1-2 | 7-3-9 | 24 PTS | Lumen Field · Seattle, WA |
| 22 | Sat Aug 22 | atCincinnati | D1-1 | 7-4-9 | 25 PTS | TQL Stadium · Cincinnati, OH |
| 23 | Sat Aug 29 | vsChicago | D2-2 | 7-5-9 | 26 PTS | Lumen Field · Seattle, WA |
| 24 | Sat Sep 5 | vsNew York | D0-0 | 7-6-9 | 27 PTS | Lumen Field · Seattle, WA |
| 26 | Sat Sep 12 | atLA Galaxy | D1-1 | 7-7-9 | 28 PTS | Dignity Health Sports Park · Carson, CA |
| 27 | Sat Sep 19 | atColorado | D3-3 | 7-7-9 | 28 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 7 | Wed Sep 23 | vsSalt Lake | W2-0 | 4-1-1 | 13 PTS | Lumen Field · Seattle, WA |
| 28 | Sat Sep 26 | vsMinnesota | W3-1 | 7-7-9 | 28 PTS | Lumen Field · Seattle, WA |
| 25 | Thu Oct 1 | vsKansas City | W2-1 | 7-6-9 | 27 PTS | Lumen Field · Seattle, WA |
| 29 | Sat Oct 10 | atNew England | W3-0 | 7-7-9 | 28 PTS | Gillette Stadium · Foxborough, MA |
| 30 | Wed Oct 14 | atDallas | L0-1 | 7-7-9 | 28 PTS | Toyota Stadium · Frisco, TX |
