| 1 | Sun Feb 23 | at Portland | W4-1 | 1-0-0 | 3 PTS | Providence Park · Portland, OR |
| 2 | Sun Mar 2 | vs LA Galaxy | W2-1 | 2-0-0 | 6 PTS | BC Place · Vancouver, BC |
| 3 | Sat Mar 8 | vs Montreal | W2-0 | 3-0-0 | 9 PTS | BC Place · Vancouver, BC |
| 4 | Sat Mar 15 | at Dallas | W1-0 | 4-0-0 | 12 PTS | Toyota Stadium · Frisco, TX |
| 5 | Sat Mar 22 | vs Chicago | L1-3 | 4-0-1 | 12 PTS | BC Place · Vancouver, BC |
| 6 | Sat Mar 29 | at Toronto | D0-0 | 4-1-1 | 13 PTS | BMO Field · Toronto, ON |
| 7 | Sat Apr 5 | vs Colorado | W2-0 | 5-1-1 | 16 PTS | BC Place · Vancouver, BC |
| 8 | Sat Apr 12 | vs Austin | W5-1 | 6-1-1 | 19 PTS | BC Place · Vancouver, BC |
| 9 | Sat Apr 19 | at St. Louis | D0-0 | 6-2-1 | 20 PTS | Energizer Park · St. Louis, MO |
| 10 | Sun Apr 27 | at Minnesota | W3-1 | 7-2-1 | 23 PTS | Allianz Field · Saint Paul, MN |
| 11 | Sat May 3 | vs Salt Lake | W2-1 | 8-2-1 | 26 PTS | BC Place · Vancouver, BC |
| 12 | Sun May 11 | vs LAFC | D2-2 | 8-3-1 | 27 PTS | BC Place · Vancouver, BC |
| 14 | Sat May 17 | atAustin | D0-0 | 8-4-1 | 28 PTS | Q2 Stadium · Austin, TX |
| 15 | Sat May 24 | atSalt Lake | W3-2 | 9-4-1 | 31 PTS | America First Field · Sandy, UT |
| 16 | Wed May 28 | vsMinnesota | D0-0 | 9-5-1 | 32 PTS | BC Place · Vancouver, BC |
| 18 | Sun Jun 8 | vs Seattle | W3-0 | 10-5-1 | 35 PTS | BC Place · Vancouver, BC |
| 19 | Sat Jun 14 | at Columbus | L1-2 | 10-5-2 | 35 PTS | Lower.com Field · Columbus, OH |
| 20 | Wed Jun 25 | vs San Diego | L3-5 | 10-5-3 | 35 PTS | BC Place · Vancouver, BC |
| 21 | Sun Jun 29 | atLAFC | W1-0 | 11-5-3 | 38 PTS | BMO Stadium · Los Angeles, CA |
| 22 | Fri Jul 4 | atLA Galaxy | L0-3 | 11-5-4 | 38 PTS | Dignity Health Sports Park · Carson, CA |
| 24 | Sat Jul 12 | atColorado | L0-3 | 11-5-5 | 38 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 25 | Wed Jul 16 | at Houston | W3-0 | 12-5-5 | 41 PTS | Shell Energy Stadium · Houston, TX |
| 26 | Sat Jul 19 | atSan Diego | D1-1 | 12-6-5 | 42 PTS | Snapdragon Stadium · San Diego, CA |
Kansas City
San Jose
Orlando
Philadelphia