| 1 | Sat Feb 21 | vs Salt Lake | W1-0 | 1-0-0 | 3 PTS | BC Place · Vancouver, BC |
| 2 | Sat Feb 28 | vsToronto | W3-0 | 2-0-0 | 6 PTS | BC Place · Vancouver, BC |
| 3 | Sat Mar 7 | atPortland | W4-1 | 3-0-0 | 9 PTS | Providence Park · Portland, OR |
| 4 | Sun Mar 15 | vsMinnesota | W6-0 | 4-0-0 | 12 PTS | BC Place · Vancouver, BC |
| 5 | Sat Mar 21 | vsSan Jose | L0-1 | 4-0-1 | 12 PTS | BC Place · Vancouver, BC |
| 6 | Sat Apr 4 | vsPortland | W3-2 | 5-0-1 | 15 PTS | BC Place · Vancouver, BC |
| 7 | Sat Apr 11 | vsNYCFC | W2-0 | 6-0-1 | 18 PTS | BC Place · Vancouver, BC |
| 8 | Fri Apr 17 | vsKansas City | W3-0 | 7-0-1 | 21 PTS | BC Place · Vancouver, BC |
| 10 | Sat Apr 25 | vsColorado | W3-1 | 8-0-1 | 24 PTS | BC Place · Vancouver, BC |
| 11 | Sat May 2 | atLA Galaxy | D1-1 | 8-1-1 | 25 PTS | Dignity Health Sports Park · Carson, CA |
| 12 | Sat May 9 | atSan Jose | D1-1 | 8-2-1 | 26 PTS | PayPal Park · San Jose, CA |
| 13 | Wed May 13 | atDallas | W3-2 | 9-2-1 | 29 PTS | Toyota Stadium · Frisco, TX |
| 14 | Sat May 16 | atHouston | L0-1 | 9-2-2 | 29 PTS | Shell Energy Stadium · Houston, TX |
| 15 | Sat May 23 | atSan Diego | W4-2 | 10-2-2 | 32 PTS | Snapdragon Stadium · San Diego, CA |
| 17 | Wed Jul 22 | atCincinnati | L3-4 | 10-2-3 | 32 PTS | TQL Stadium · Cincinnati, OH |
| 18 | Sat Jul 25 | atMinnesota | D0-0 | 10-3-3 | 33 PTS | Allianz Field · Saint Paul, MN |
| 19 | Sat Aug 1 | vsLAFC | D1-1 | 10-3-3 | 33 PTS | BC Place · Vancouver, BC |
| 20 | Sun Aug 16 | atSeattle | W2-0 | 10-3-3 | 33 PTS | Lumen Field · Seattle, WA |
| 21 | Wed Aug 19 | vsHouston | L0-1 | 10-3-3 | 33 PTS | BC Place · Vancouver, BC |
| 22 | Sat Aug 22 | vsDallas | W5-0 | 10-3-3 | 33 PTS | BC Place · Vancouver, BC |
| 23 | Sat Aug 29 | atKansas City | W3-0 | 10-3-3 | 33 PTS | Children's Mercy Park · Kansas City, KS |
