| 1 | Sat Feb 22 | vs Minnesota | W1-0 | 1-0-0 | 3 PTS | BMO Stadium · Los Angeles, CA |
| 2 | Sat Mar 1 | vsNYCFC | W1-0 | 2-0-0 | 6 PTS | BMO Stadium · Los Angeles, CA |
| 3 | Sat Mar 8 | atSeattle | L2-5 | 2-0-1 | 6 PTS | Lumen Field · Seattle, WA |
| 4 | Sat Mar 15 | vsAustin | L0-1 | 2-0-2 | 6 PTS | BMO Stadium · Los Angeles, CA |
| 5 | Sat Mar 22 | atKansas City | W2-0 | 3-0-2 | 9 PTS | Children's Mercy Park · Kansas City, KS |
| 6 | Sat Mar 29 | atSan Diego | L2-3 | 3-0-3 | 9 PTS | Snapdragon Stadium · San Diego, CA |
| 7 | Sat Apr 5 | atHouston | L0-1 | 3-0-4 | 9 PTS | Shell Energy Stadium · Houston, TX |
| 8 | Sat Apr 12 | vsSan Jose | W2-1 | 4-0-4 | 12 PTS | BMO Stadium · Los Angeles, CA |
| 9 | Sat Apr 19 | atPortland | D3-3 | 4-1-4 | 13 PTS | Providence Park · Portland, OR |
| 10 | Sun Apr 27 | vsSt. Louis | D2-2 | 4-2-4 | 14 PTS | BMO Stadium · Los Angeles, CA |
| 11 | Sat May 3 | vsHouston | W2-0 | 5-2-4 | 17 PTS | BMO Stadium · Los Angeles, CA |
| 12 | Sun May 11 | atVancouver | D2-2 | 5-3-4 | 18 PTS | BC Place · Vancouver, BC |
| 13 | Wed May 14 | vsSeattle | W4-0 | 6-3-4 | 21 PTS | BMO Stadium · Los Angeles, CA |
| 14 | Sun May 18 | atLA Galaxy | D2-2 | 6-4-4 | 22 PTS | Dignity Health Sports Park · Carson, CA |
| 15 | Sat May 24 | atMontreal | D2-2 | 6-5-4 | 23 PTS | Stade Saputo · Montreal, QC |
| 18 | Sun Jun 8 | vsKansas City | W3-1 | 7-5-4 | 26 PTS | BMO Stadium · Los Angeles, CA |
| 21 | Sun Jun 29 | vsVancouver | L0-1 | 7-5-5 | 26 PTS | BMO Stadium · Los Angeles, CA |
| 23 | Wed Jul 9 | vsColorado | W3-0 | 8-5-5 | 29 PTS | BMO Stadium · Los Angeles, CA |
| 24 | Sat Jul 12 | vsDallas | W2-0 | 9-5-5 | 32 PTS | BMO Stadium · Los Angeles, CA |
| 25 | Wed Jul 16 | atMinnesota | W1-0 | 10-5-5 | 35 PTS | Allianz Field · Saint Paul, MN |
| 26 | Sat Jul 19 | vsLA Galaxy | D3-3 | 10-6-5 | 36 PTS | BMO Stadium · Los Angeles, CA |
| 27 | Fri Jul 25 | vsPortland | L0-1 | 10-6-6 | 36 PTS | BMO Stadium · Los Angeles, CA |
| 28 | Sat Aug 9 | atChicago | D2-2 | 10-7-6 | 37 PTS | Soldier Field · Chicago, IL |
| 29 | Sat Aug 16 | atNew England | W2-0 | 11-7-6 | 40 PTS | Gillette Stadium · Foxborough, MA |
| 30 | Sat Aug 23 | atDallas | D1-1 | 11-8-6 | 41 PTS | Toyota Stadium · Frisco, TX |
| 31 | Sun Aug 31 | vsSan Diego | L1-2 | 11-8-7 | 41 PTS | BMO Stadium · Los Angeles, CA |
| 33 | Sat Sep 13 | atSan Jose | W4-2 | 12-8-7 | 44 PTS | PayPal Park · San Jose, CA |
| 35 | Wed Sep 17 | atSalt Lake | W4-1 | 14-8-7 | 50 PTS | America First Field · Sandy, UT |
| 35 | Sun Sep 21 | vsSalt Lake | W4-1 | 14-8-7 | 50 PTS | BMO Stadium · Los Angeles, CA |
| 37 | Sat Sep 27 | atSt. Louis | W3-0 | 15-8-7 | 53 PTS | Energizer Park · St. Louis, MO |
| 38 | Sun Oct 5 | vsAtlanta | W1-0 | 17-8-7 | 59 PTS | BMO Stadium · Los Angeles, CA |
| 38 | Wed Oct 8 | vsToronto | W2-0 | 17-8-7 | 59 PTS | BMO Stadium · Los Angeles, CA |
| 39 | Sun Oct 12 | atAustin | L0-1 | 17-9-8 | 60 PTS | Q2 Stadium · Austin, TX |
| 39 | Sat Oct 18 | atColorado | D2-2 | 17-9-8 | 60 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 39 | Wed Oct 29 | vsAustin | W2-1 | 17-9-8 | 60 PTS | BMO Stadium · Los Angeles, CA |
| 39 | Sun Nov 2 | atAustin | W4-1 | 17-9-8 | 60 PTS | Q2 Stadium · Austin, TX |
