| 1 | Sat Feb 21 | vs New England | W4-1 | 1-0-0 | 3 PTS | GEODIS Park · Nashville, TN |
| 2 | Sat Feb 28 | atDallas | D0-0 | 1-1-0 | 4 PTS | Toyota Stadium · Frisco, TX |
| 3 | Sat Mar 7 | vsMinnesota | W3-1 | 2-1-0 | 7 PTS | GEODIS Park · Nashville, TN |
| 4 | Sat Mar 14 | atColumbus | W1-0 | 3-1-0 | 10 PTS | Lower.com Field · Columbus, OH |
| 5 | Sat Mar 21 | vsOrlando | W5-0 | 4-1-0 | 13 PTS | GEODIS Park · Nashville, TN |
| 6 | Sat Apr 4 | atChicago | L0-1 | 4-1-1 | 13 PTS | Soldier Field · Chicago, IL |
| 7 | Sat Apr 11 | atCharlotte | W2-1 | 5-1-1 | 16 PTS | Bank of America Stadium · Charlotte, NC |
| 8 | Sat Apr 18 | atAtlanta | W2-0 | 6-1-1 | 19 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| 10 | Sat Apr 25 | vsCharlotte | W4-2 | 7-1-1 | 22 PTS | GEODIS Park · Nashville, TN |
| 11 | Sat May 2 | atPhiladelphia | D0-0 | 7-2-1 | 23 PTS | Subaru Park · Chester, PA |
| 12 | Sat May 9 | vsD.C. United | D2-2 | 7-3-1 | 24 PTS | GEODIS Park · Nashville, TN |
| 13 | Wed May 13 | atNew England | W3-0 | 8-3-1 | 27 PTS | Gillette Stadium · Foxborough, MA |
| 14 | Sun May 17 | vsLAFC | W3-2 | 9-3-1 | 30 PTS | GEODIS Park · Nashville, TN |
| 15 | Sat May 23 | vsNYCFC | W2-1 | 10-3-1 | 33 PTS | GEODIS Park · Nashville, TN |
| 16 | Fri Jul 17 | vsAtlanta | W1-0 | 11-3-1 | 36 PTS | GEODIS Park · Nashville, TN |
| 17 | Wed Jul 22 | vsMontreal | W1-0 | 12-3-1 | 39 PTS | GEODIS Park · Nashville, TN |
| 18 | Sat Jul 25 | atOrlando | L0-1 | 12-3-2 | 39 PTS | Inter&Co Stadium · Orlando, FL |
| 19 | Sat Aug 1 | atD.C. United | D2-2 | 12-4-2 | 40 PTS | Audi Field · Washington, D.C. |
| 20 | Sat Aug 15 | vsMiami | W4-1 | 13-4-2 | 43 PTS | GEODIS Park · Nashville, TN |
| 21 | Wed Aug 19 | atNew York | W1-0 | 14-4-2 | 46 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 22 | Sat Aug 22 | vsColumbus | W3-2 | 15-4-2 | 49 PTS | GEODIS Park · Nashville, TN |
| 23 | Sat Aug 29 | vsCincinnati | W4-0 | 16-4-2 | 52 PTS | GEODIS Park · Nashville, TN |
| 24 | Fri Sep 4 | atNYCFC | D0-0 | 16-5-2 | 53 PTS | Yankee Stadium · New York City, NY |
| 25 | Wed Sep 9 | atToronto | L1-2 | 16-5-3 | 53 PTS | BMO Field · Toronto, ON |
| 26 | Sat Sep 12 | atMiami | D2-2 | 16-6-3 | 54 PTS | Chase Stadium · Fort Lauderdale, FL |
| 27 | Sat Sep 19 | vsChicago | W3-0 | 16-6-3 | 54 PTS | GEODIS Park · Nashville, TN |
| 28 | Sat Sep 26 | vsToronto | W2-0 | 16-6-3 | 54 PTS | GEODIS Park · Nashville, TN |
| 29 | Sat Oct 10 | atAustin | W4-1 | 16-6-3 | 54 PTS | Q2 Stadium · Austin, TX |
