| 8 | Sat Apr 18 | vs Columbus | 7:30 PM | 1-3-3 | 6 PTS | Gillette Stadium · Foxborough, MA |
| 9 | Wed Apr 22 | at Atlanta | 7:45 PM | 1-1-5 | 4 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| 10 | Sat Apr 25 | at Miami | 7:30 PM | 3-3-1 | 12 PTS | Chase Stadium · Fort Lauderdale, FL |
| 11 | Sat May 2 | vs Charlotte | 7:30 PM | 3-2-2 | 11 PTS | Gillette Stadium · Foxborough, MA |
| 12 | Sat May 9 | vs Philadelphia | 7:30 PM | 1-0-6 | 3 PTS | Gillette Stadium · Foxborough, MA |
| 13 | Wed May 13 | vs Nashville | 7:30 PM | 5-1-1 | 16 PTS | Gillette Stadium · Foxborough, MA |
| 14 | Sat May 16 | vs Minnesota | 7:30 PM | 3-2-2 | 11 PTS | Gillette Stadium · Foxborough, MA |
| 15 | Sat May 23 | at Charlotte | 7:30 PM | 3-2-2 | 11 PTS | Jerry Richardson Stadium · Charlotte, NC |
| 17 | Wed Jul 22 | vs Toronto | 7:30 PM | 3-2-2 | 11 PTS | Gillette Stadium · Foxborough, MA |
| 18 | Sat Jul 25 | vs Atlanta | 7:30 PM | 1-1-5 | 4 PTS | Gillette Stadium · Foxborough, MA |
| 19 | Sat Aug 1 | at Montreal | 7:30 PM | 1-0-6 | 3 PTS | Stade Saputo · Montreal, QC |
| 3 | Sat Aug 8 | vs Houston | 9:30 PM | 1-0-1 | 3 PTS | Gillette Stadium · Foxborough, MA |
| 20 | Sat Aug 15 | at Toronto | 7:30 PM | 3-2-2 | 11 PTS | BMO Field · Toronto, ON |
| 21 | Wed Aug 19 | at D.C. United | 7:30 PM | 2-1-4 | 7 PTS | Audi Field · Washington, D.C. |
| 22 | Sun Aug 23 | vs NYCFC | 4:30 PM | 3-2-2 | 11 PTS | Gillette Stadium · Foxborough, MA |
| 23 | Sat Aug 29 | at Columbus | 7:30 PM | 1-3-3 | 6 PTS | Lower.com Field · Columbus, OH |
| 24 | Sat Sep 5 | at LA Galaxy | 9:30 PM | 2-2-3 | 8 PTS | Dignity Health Sports Park · Carson, CA |
| 25 | Wed Sep 9 | at NYCFC | 7:30 PM | 3-2-2 | 11 PTS | Yankee Stadium · New York City, NY |
| 26 | Sun Sep 13 | at Chicago | 6:30 PM | 4-1-2 | 13 PTS | Soldier Field · Chicago, IL |
| 27 | Sat Sep 19 | vs Orlando | 7:30 PM | 1-1-5 | 4 PTS | Gillette Stadium · Foxborough, MA |
| 28 | Sat Sep 26 | at Salt Lake | 9:30 PM | 4-1-1 | 13 PTS | America First Field · Sandy, UT |
| 29 | Sat Oct 10 | vs Seattle | 7:30 PM | 4-1-1 | 13 PTS | Gillette Stadium · Foxborough, MA |
| 30 | Wed Oct 14 | at Cincinnati | 7:30 PM | 2-1-4 | 7 PTS | TQL Stadium · Cincinnati, OH |
| 31 | Sat Oct 17 | vs Chicago | 7:30 PM | 4-1-2 | 13 PTS | Gillette Stadium · Foxborough, MA |
| 32 | Sat Oct 24 | at Philadelphia | 7:30 PM | 1-0-6 | 3 PTS | Subaru Park · Chester, PA |
| 33 | Wed Oct 28 | vs New York | 7:30 PM | 3-2-2 | 11 PTS | Gillette Stadium · Foxborough, MA |
| 34 | Sun Nov 1 | vs Miami | 6:00 PM | 3-3-1 | 12 PTS | Gillette Stadium · Foxborough, MA |
| 35 | Sat Nov 7 | at Orlando | 4:00 PM | 1-1-5 | 4 PTS | Inter&Co Stadium · Orlando, FL |