| 1 | Sat Feb 21 | at Nashville | L1-4 | 0-0-1 | 0 PTS | GEODIS Park · Nashville, TN |
| 2 | Sat Feb 28 | atNew York | L0-1 | 0-0-2 | 0 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 4 | Sun Mar 15 | vsCincinnati | W6-1 | 1-0-3 | 3 PTS | Gillette Stadium · Foxborough, MA |
| 5 | Sat Mar 21 | atSt. Louis | L1-3 | 1-0-4 | 3 PTS | Energizer Park · St. Louis, MO |
| 6 | Sat Apr 4 | vsMontreal | W3-0 | 2-0-4 | 6 PTS | Gillette Stadium · Foxborough, MA |
| 7 | Sat Apr 11 | vsD.C. United | W1-0 | 3-0-4 | 9 PTS | Gillette Stadium · Foxborough, MA |
| 8 | Sat Apr 18 | vsColumbus | W2-1 | 4-0-4 | 12 PTS | Gillette Stadium · Foxborough, MA |
| 9 | Wed Apr 22 | atAtlanta | W2-1 | 5-0-4 | 15 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| 10 | Sat Apr 25 | atMiami | D1-1 | 5-1-4 | 16 PTS | Chase Stadium · Fort Lauderdale, FL |
| 11 | Sat May 2 | vsCharlotte | W1-0 | 6-1-4 | 19 PTS | Gillette Stadium · Foxborough, MA |
| 12 | Sat May 9 | vsPhiladelphia | W2-1 | 7-1-4 | 22 PTS | Gillette Stadium · Foxborough, MA |
| 13 | Wed May 13 | vsNashville | L0-3 | 7-1-5 | 22 PTS | Gillette Stadium · Foxborough, MA |
| 14 | Sat May 16 | vsMinnesota | W2-1 | 8-1-5 | 25 PTS | Gillette Stadium · Foxborough, MA |
| 15 | Sat May 23 | atCharlotte | L0-1 | 8-1-6 | 25 PTS | Bank of America Stadium · Charlotte, NC |
| 17 | Wed Jul 22 | vsToronto | D0-0 | 8-2-6 | 26 PTS | Gillette Stadium · Foxborough, MA |
| 18 | Sat Jul 25 | vsAtlanta | W4-1 | 9-2-6 | 29 PTS | Gillette Stadium · Foxborough, MA |
| 19 | Sat Aug 1 | atMontreal | D2-2 | 9-3-6 | 30 PTS | Stade Saputo · Montreal, QC |
| 3 | Sat Aug 8 | vsHouston | L0-2 | 0-0-3 | 0 PTS | Gillette Stadium · Foxborough, MA |
| 20 | Sat Aug 15 | atToronto | L1-2 | 9-3-7 | 30 PTS | BMO Field · Toronto, ON |
| 21 | Wed Aug 19 | atD.C. United | W3-0 | 10-3-7 | 33 PTS | Audi Field · Washington, D.C. |
| 22 | Sun Aug 23 | vsNYCFC | D1-1 | 10-4-7 | 34 PTS | Gillette Stadium · Foxborough, MA |
| 23 | Sun Aug 30 | atColumbus | W3-1 | 11-4-7 | 37 PTS | Lower.com Field · Columbus, OH |
| 24 | Sat Sep 5 | atLA Galaxy | L1-2 | 11-4-8 | 37 PTS | Dignity Health Sports Park · Carson, CA |
| 25 | Wed Sep 9 | atNYCFC | W2-1 | 12-4-8 | 40 PTS | Yankee Stadium · New York City, NY |
| 26 | Sun Sep 13 | atChicago | W2-1 | 13-4-8 | 43 PTS | Soldier Field · Chicago, IL |
| 27 | Sat Sep 19 | vsOrlando | W4-2 | 13-4-8 | 43 PTS | Gillette Stadium · Foxborough, MA |
| 28 | Sat Sep 26 | atSalt Lake | L0-3 | 13-4-8 | 43 PTS | America First Field · Sandy, UT |
| 29 | Sat Oct 10 | vsSeattle | L0-3 | 13-4-8 | 43 PTS | Gillette Stadium · Foxborough, MA |
