| 4 | Sun Mar 15 | vs Cincinnati | 2:30 PM | 1-0-1 | 3 PTS | Gillette Stadium · Foxborough, MA |
| 5 | Sat Mar 21 | atSt. Louis | 8:30 PM | 0-1-1 | 1 PTS | Energizer Park · St. Louis, MO |
| 6 | Sat Apr 4 | vsMontreal | 4:30 PM | 0-0-2 | 0 PTS | Gillette Stadium · Foxborough, MA |
| 7 | Sat Apr 11 | vsD.C. United | 7:30 PM | 1-0-1 | 3 PTS | Gillette Stadium · Foxborough, MA |
| 8 | Sat Apr 18 | vsColumbus | 7:30 PM | 0-1-1 | 1 PTS | Gillette Stadium · Foxborough, MA |
| 9 | Wed Apr 22 | atAtlanta | 7:45 PM | 0-0-2 | 0 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| 10 | Sat Apr 25 | atMiami | 7:30 PM | 1-0-1 | 3 PTS | Chase Stadium · Fort Lauderdale, FL |
| 11 | Sat May 2 | vsCharlotte | 7:30 PM | 0-1-1 | 1 PTS | Gillette Stadium · Foxborough, MA |
| 12 | Sat May 9 | vsPhiladelphia | 7:30 PM | 0-0-2 | 0 PTS | Gillette Stadium · Foxborough, MA |
| 13 | Wed May 13 | vsNashville | 7:30 PM | 1-1-0 | 4 PTS | Gillette Stadium · Foxborough, MA |
| 14 | Sat May 16 | vsMinnesota | 7:30 PM | 1-1-0 | 4 PTS | Gillette Stadium · Foxborough, MA |
| 15 | Sat May 23 | atCharlotte | 7:30 PM | 0-1-1 | 1 PTS | Bank of America Stadium · Charlotte, NC |
| 17 | Wed Jul 22 | vsToronto | 7:30 PM | 0-0-2 | 0 PTS | Gillette Stadium · Foxborough, MA |
| 18 | Sat Jul 25 | vsAtlanta | 7:30 PM | 0-0-2 | 0 PTS | Gillette Stadium · Foxborough, MA |
| 19 | Sat Aug 1 | atMontreal | 7:30 PM | 0-0-2 | 0 PTS | Stade Saputo · Montreal, QC |
| 20 | Sat Aug 15 | atToronto | 7:30 PM | 0-0-2 | 0 PTS | BMO Field · Toronto, ON |
| 21 | Wed Aug 19 | atD.C. United | 7:30 PM | 1-0-1 | 3 PTS | Audi Field · Washington, D.C. |
| 22 | Sun Aug 23 | vsNYCFC | 4:30 PM | 1-1-0 | 4 PTS | Gillette Stadium · Foxborough, MA |
| 23 | Sat Aug 29 | atColumbus | 7:30 PM | 0-1-1 | 1 PTS | Lower.com Field · Columbus, OH |
| 24 | Sat Sep 5 | atLA Galaxy | 9:30 PM | 1-1-0 | 4 PTS | Dignity Health Sports Park · Carson, CA |
| 25 | Wed Sep 9 | atNYCFC | 7:30 PM | 1-1-0 | 4 PTS | Yankee Stadium · New York City, NY |
| 26 | Sun Sep 13 | atChicago | 6:30 PM | 1-0-1 | 3 PTS | Soldier Field · Chicago, IL |
| 27 | Sat Sep 19 | vsOrlando | 7:30 PM | 0-0-2 | 0 PTS | Gillette Stadium · Foxborough, MA |
| 28 | Sat Sep 26 | atSalt Lake | 9:30 PM | 1-0-1 | 3 PTS | America First Field · Sandy, UT |
| 29 | Sat Oct 10 | vsSeattle | 7:30 PM | 1-0-1 | 3 PTS | Gillette Stadium · Foxborough, MA |
| 30 | Wed Oct 14 | atCincinnati | 7:30 PM | 1-0-1 | 3 PTS | TQL Stadium · Cincinnati, OH |
| 31 | Sat Oct 17 | vsChicago | 7:30 PM | 1-0-1 | 3 PTS | Gillette Stadium · Foxborough, MA |
| 32 | Sat Oct 24 | atPhiladelphia | 7:30 PM | 0-0-2 | 0 PTS | Subaru Park · Chester, PA |
| 33 | Wed Oct 28 | vsNew York | 7:30 PM | 2-0-0 | 6 PTS | Gillette Stadium · Foxborough, MA |
| 34 | Sun Nov 1 | vsMiami | 6:00 PM | 1-0-1 | 3 PTS | Gillette Stadium · Foxborough, MA |
| 35 | Sat Nov 7 | atOrlando | 4:00 PM | 0-0-2 | 0 PTS | Inter&Co Stadium · Orlando, FL |
