| 1 | Sat Feb 21 | at Portland | L2-3 | 0-0-1 | 0 PTS | Providence Park · Portland, OR |
| 2 | Sat Feb 28 | atKansas City | D2-2 | 0-1-1 | 1 PTS | Children's Mercy Park · Kansas City, KS |
| 3 | Sat Mar 7 | vsChicago | D0-0 | 0-2-1 | 2 PTS | Lower.com Field · Columbus, OH |
| 4 | Sat Mar 14 | vsNashville | L0-1 | 0-2-2 | 2 PTS | Lower.com Field · Columbus, OH |
| 5 | Sat Mar 21 | atToronto | L1-2 | 0-2-3 | 2 PTS | BMO Field · Toronto, ON |
| 6 | Sat Apr 4 | atAtlanta | W3-1 | 1-2-3 | 5 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| 7 | Sun Apr 12 | vsOrlando | D1-1 | 1-3-3 | 6 PTS | Lower.com Field · Columbus, OH |
| 8 | Sat Apr 18 | atNew England | L1-2 | 1-3-4 | 6 PTS | Gillette Stadium · Foxborough, MA |
| 9 | Wed Apr 22 | vsLA Galaxy | W2-1 | 2-3-4 | 9 PTS | Lower.com Field · Columbus, OH |
| 10 | Sat Apr 25 | vsPhiladelphia | W2-0 | 3-3-4 | 12 PTS | Lower.com Field · Columbus, OH |
| 11 | Sat May 2 | vsMinnesota | L2-3 | 3-3-5 | 12 PTS | Lower.com Field · Columbus, OH |
| 12 | Sun May 10 | atNYCFC | L0-3 | 3-3-6 | 12 PTS | Yankee Stadium · New York City, NY |
| 13 | Wed May 13 | atNew York | L2-3 | 3-3-7 | 12 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 14 | Sat May 16 | atPhiladelphia | D1-1 | 3-4-7 | 13 PTS | Subaru Park · Chester, PA |
| 15 | Sun May 24 | vsAtlanta | W2-0 | 4-4-7 | 16 PTS | Lower.com Field · Columbus, OH |
| 17 | Wed Jul 22 | vsNYCFC | L1-2 | 4-4-8 | 16 PTS | Lower.com Field · Columbus, OH |
| 18 | Sat Jul 25 | vsCincinnati | W2-1 | 5-4-8 | 19 PTS | Lower.com Field · Columbus, OH |
| 19 | Sat Aug 1 | atMiami | D2-2 | 5-5-8 | 20 PTS | Chase Stadium · Fort Lauderdale, FL |
| 20 | Sat Aug 15 | atCharlotte | L1-3 | 5-5-9 | 20 PTS | Bank of America Stadium · Charlotte, NC |
| 21 | Wed Aug 19 | vsMontreal | L1-2 | 5-5-10 | 20 PTS | Lower.com Field · Columbus, OH |
| 22 | Sat Aug 22 | atNashville | L2-3 | 5-5-11 | 20 PTS | GEODIS Park · Nashville, TN |
| 23 | Sun Aug 30 | vsNew England | L1-3 | 5-5-12 | 20 PTS | Lower.com Field · Columbus, OH |
| 24 | Sat Sep 5 | vsColorado | W3-0 | 6-5-12 | 23 PTS | Lower.com Field · Columbus, OH |
| 25 | Wed Sep 9 | atD.C. United | L1-2 | 6-5-13 | 23 PTS | Audi Field · Washington, D.C. |
| 26 | Sat Sep 12 | vsNew York | L0-1 | 6-5-14 | 23 PTS | Lower.com Field · Columbus, OH |
| 27 | Sat Sep 19 | atMontreal | W2-0 | 6-5-14 | 23 PTS | Stade Saputo · Montreal, QC |
