| 1 | Sat Feb 21 | vs Columbus | W3-2 | 1-0-0 | 3 PTS | Providence Park · Portland, OR |
| 2 | Sat Feb 28 | atColorado | L0-2 | 1-0-1 | 3 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 3 | Sat Mar 7 | vsVancouver | L1-4 | 1-0-2 | 3 PTS | Providence Park · Portland, OR |
| 4 | Sat Mar 14 | atHouston | L2-3 | 1-0-3 | 3 PTS | Shell Energy Stadium · Houston, TX |
| 5 | Sun Mar 22 | vsLA Galaxy | D1-1 | 1-1-3 | 4 PTS | Providence Park · Portland, OR |
| 6 | Sat Apr 4 | atVancouver | L2-3 | 1-1-4 | 4 PTS | BC Place · Vancouver, BC |
| 7 | Sat Apr 11 | vsLAFC | W2-1 | 2-1-4 | 7 PTS | Providence Park · Portland, OR |
| 8 | Sat Apr 18 | atMinnesota | L0-2 | 2-1-5 | 7 PTS | Allianz Field · Saint Paul, MN |
| 10 | Sat Apr 25 | atSan Diego | W2-1 | 3-1-5 | 10 PTS | Snapdragon Stadium · San Diego, CA |
| 11 | Sat May 2 | atSalt Lake | L0-2 | 3-1-6 | 10 PTS | America First Field · Sandy, UT |
| 12 | Sat May 9 | vsKansas City | W6-0 | 4-1-6 | 13 PTS | Providence Park · Portland, OR |
| 13 | Wed May 13 | atMontreal | D2-2 | 4-2-6 | 14 PTS | Stade Saputo · Montreal, QC |
| 14 | Sun May 17 | atMiami | L0-2 | 4-2-7 | 14 PTS | Chase Stadium · Fort Lauderdale, FL |
| 15 | Sat May 23 | vsSan Jose | L1-3 | 4-2-8 | 14 PTS | Providence Park · Portland, OR |
| 16 | Thu Jul 16 | atSeattle | W5-1 | 5-2-8 | 17 PTS | Lumen Field · Seattle, WA |
| 17 | Wed Jul 22 | vsDallas | D2-2 | 5-3-8 | 18 PTS | Providence Park · Portland, OR |
| 18 | Sat Jul 25 | vsSalt Lake | W2-1 | 6-3-8 | 21 PTS | Providence Park · Portland, OR |
| 19 | Sat Aug 1 | vsSeattle | W2-1 | 7-3-8 | 24 PTS | Providence Park · Portland, OR |
| 20 | Sun Aug 16 | atChicago | L1-2 | 7-3-9 | 24 PTS | Soldier Field · Chicago, IL |
| 21 | Wed Aug 19 | vsSan Diego | W3-1 | 8-3-9 | 27 PTS | Providence Park · Portland, OR |
| 22 | Sat Aug 22 | atLAFC | D1-1 | 8-4-9 | 28 PTS | BMO Stadium · Los Angeles, CA |
| 23 | Sat Aug 29 | vsAustin | L1-2 | 8-4-10 | 28 PTS | Providence Park · Portland, OR |
| 24 | Sat Sep 5 | vsMinnesota | W5-4 | 9-4-10 | 31 PTS | Providence Park · Portland, OR |
| 25 | Wed Sep 9 | vsSt. Louis | D2-2 | 9-5-10 | 32 PTS | Providence Park · Portland, OR |
| 26 | Sat Sep 12 | atDallas | L1-2 | 9-5-11 | 32 PTS | Toyota Stadium · Frisco, TX |
| 27 | Sat Sep 19 | vsAtlanta | L0-1 | 9-5-11 | 32 PTS | Providence Park · Portland, OR |
| 28 | Sat Sep 26 | atSan Jose | L1-3 | 9-5-11 | 32 PTS | PayPal Park · San Jose, CA |
| 29 | Sat Oct 10 | atKansas City | D3-3 | 9-5-11 | 32 PTS | Children's Mercy Park · Kansas City, KS |
| 30 | Wed Oct 14 | atLA Galaxy | L0-2 | 9-5-11 | 32 PTS | Dignity Health Sports Park · Carson, CA |
