| 1 | Sat Feb 22 | vs Colorado | D0-0 | 0-1-0 | 1 PTS | Energizer Park · St. Louis, MO |
| 2 | Sat Mar 1 | at San Diego | D0-0 | 0-2-0 | 2 PTS | Snapdragon Stadium · San Diego, CA |
| 3 | Sun Mar 9 | at LA Galaxy | W3-0 | 1-2-0 | 5 PTS | Dignity Health Sports Park · Carson, CA |
| 4 | Sat Mar 15 | vs Seattle | W1-0 | 2-2-0 | 8 PTS | Energizer Park · St. Louis, MO |
| 5 | Sat Mar 22 | at Philadelphia | L0-1 | 2-2-1 | 8 PTS | Subaru Park · Chester, PA |
| 6 | Sun Mar 30 | vs Austin | L0-1 | 2-2-2 | 8 PTS | Energizer Park · St. Louis, MO |
| 7 | Sat Apr 5 | at Kansas City | L0-2 | 2-2-3 | 8 PTS | Children's Mercy Park · Kansas City, KS |
| 8 | Sun Apr 13 | vs Columbus | L1-2 | 2-2-4 | 8 PTS | Energizer Park · St. Louis, MO |
| 9 | Sat Apr 19 | vs Vancouver | D0-0 | 2-3-4 | 9 PTS | Energizer Park · St. Louis, MO |
| 10 | Sun Apr 27 | at LAFC | D2-2 | 2-4-4 | 10 PTS | BMO Stadium · Los Angeles, CA |
| 11 | Sat May 3 | atSeattle | L1-4 | 2-4-5 | 10 PTS | Lumen Field · Seattle, WA |
| 12 | Sat May 10 | vsSan Diego | L1-2 | 2-4-6 | 10 PTS | Energizer Park · St. Louis, MO |
| 13 | Wed May 14 | vsKansas City | D2-2 | 2-5-6 | 11 PTS | Energizer Park · St. Louis, MO |
| 14 | Sat May 17 | at Minnesota | L0-3 | 2-5-7 | 11 PTS | Allianz Field · Saint Paul, MN |
| 15 | Sat May 24 | atColorado | L0-1 | 2-5-8 | 11 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 17 | Sat May 31 | vs San Jose | W2-1 | 3-5-8 | 14 PTS | Energizer Park · St. Louis, MO |
| 18 | Sun Jun 8 | at Portland | L1-2 | 3-5-9 | 14 PTS | Providence Park · Portland, OR |
| 19 | Sat Jun 14 | vsLA Galaxy | D3-3 | 3-6-9 | 15 PTS | Energizer Park · St. Louis, MO |
| 20 | Wed Jun 25 | vs Orlando | L2-4 | 3-6-10 | 15 PTS | Energizer Park · St. Louis, MO |
| 21 | Sat Jun 28 | at Houston | L0-1 | 3-6-11 | 15 PTS | Shell Energy Stadium · Houston, TX |
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