| 1 | Sat Feb 22 | vs Colorado | D0-0 | 0-1-0 | 1 PTS | Energizer Park · St. Louis, MO |
| 2 | Sat Mar 1 | atSan Diego | D0-0 | 0-2-0 | 2 PTS | Snapdragon Stadium · San Diego, CA |
| 3 | Sun Mar 9 | atLA Galaxy | W3-0 | 1-2-0 | 5 PTS | Dignity Health Sports Park · Carson, CA |
| 4 | Sat Mar 15 | vsSeattle | W1-0 | 2-2-0 | 8 PTS | Energizer Park · St. Louis, MO |
| 5 | Sat Mar 22 | atPhiladelphia | L0-1 | 2-2-1 | 8 PTS | Subaru Park · Chester, PA |
| 6 | Sun Mar 30 | vsAustin | L0-1 | 2-2-2 | 8 PTS | Energizer Park · St. Louis, MO |
| 7 | Sat Apr 5 | atKansas City | L0-2 | 2-2-3 | 8 PTS | Children's Mercy Park · Kansas City, KS |
| 8 | Sun Apr 13 | vsColumbus | L1-2 | 2-2-4 | 8 PTS | Energizer Park · St. Louis, MO |
| 9 | Sat Apr 19 | vsVancouver | D0-0 | 2-3-4 | 9 PTS | Energizer Park · St. Louis, MO |
| 10 | Sun Apr 27 | atLAFC | D2-2 | 2-4-4 | 10 PTS | BMO Stadium · Los Angeles, CA |
| 11 | Sat May 3 | atSeattle | L1-4 | 2-4-5 | 10 PTS | Lumen Field · Seattle, WA |
| 12 | Sat May 10 | vsSan Diego | L1-2 | 2-4-6 | 10 PTS | Energizer Park · St. Louis, MO |
| 13 | Wed May 14 | vsKansas City | D2-2 | 2-5-6 | 11 PTS | Energizer Park · St. Louis, MO |
| 14 | Sat May 17 | atMinnesota | L0-3 | 2-5-7 | 11 PTS | Allianz Field · Saint Paul, MN |
| 15 | Sat May 24 | atColorado | L0-1 | 2-5-8 | 11 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 17 | Sat May 31 | vsSan Jose | W2-1 | 3-5-8 | 14 PTS | Energizer Park · St. Louis, MO |
| 18 | Sun Jun 8 | atPortland | L1-2 | 3-5-9 | 14 PTS | Providence Park · Portland, OR |
| 19 | Sat Jun 14 | vsLA Galaxy | D3-3 | 3-6-9 | 15 PTS | Energizer Park · St. Louis, MO |
| 20 | Wed Jun 25 | vsOrlando | L2-4 | 3-6-10 | 15 PTS | Energizer Park · St. Louis, MO |
| 21 | Sat Jun 28 | atHouston | L0-1 | 3-6-11 | 15 PTS | Shell Energy Stadium · Houston, TX |
| 22 | Sat Jul 5 | atSalt Lake | L2-3 | 3-6-12 | 15 PTS | America First Field · Sandy, UT |
| 24 | Sun Jul 13 | vsPortland | W2-1 | 4-6-12 | 18 PTS | Energizer Park · St. Louis, MO |
| 26 | Sat Jul 19 | atDallas | L0-3 | 4-6-13 | 18 PTS | Toyota Stadium · Frisco, TX |
| 27 | Sat Jul 26 | vsMinnesota | L1-2 | 4-6-14 | 18 PTS | Energizer Park · St. Louis, MO |
| 28 | Sat Aug 9 | vsNashville | W3-1 | 5-6-14 | 21 PTS | Energizer Park · St. Louis, MO |
| 29 | Sat Aug 16 | atChicago | L2-3 | 5-6-15 | 21 PTS | Soldier Field · Chicago, IL |
| 30 | Sat Aug 23 | atVancouver | L2-3 | 5-6-16 | 21 PTS | BC Place · Vancouver, BC |
| 31 | Sat Aug 30 | vsHouston | L2-3 | 5-6-17 | 21 PTS | Energizer Park · St. Louis, MO |
| 32 | Sat Sep 6 | vsDallas | D1-1 | 5-7-17 | 22 PTS | Energizer Park · St. Louis, MO |
| 33 | Sat Sep 13 | atMontreal | W2-0 | 6-7-17 | 25 PTS | Stade Saputo · Montreal, QC |
| 35 | Sat Sep 20 | atSan Jose | W3-1 | 7-7-17 | 28 PTS | PayPal Park · San Jose, CA |
| 37 | Sat Sep 27 | vsLAFC | L0-3 | 7-7-18 | 28 PTS | Energizer Park · St. Louis, MO |
| 38 | Sat Oct 4 | atAustin | W3-1 | 8-7-18 | 31 PTS | Q2 Stadium · Austin, TX |
| 39 | Sat Oct 18 | vsSalt Lake | D2-2 | 8-8-18 | 32 PTS | Energizer Park · St. Louis, MO |
