| 1 | Sat Feb 21 | vs Charlotte | D1-1 | 0-1-0 | 1 PTS | Energizer Park · St. Louis, MO |
| 2 | Sun Mar 1 | atSan Diego | L0-2 | 0-1-1 | 1 PTS | Snapdragon Stadium · San Diego, CA |
| 3 | Sat Mar 7 | vsSeattle | L0-1 | 0-1-2 | 1 PTS | Energizer Park · St. Louis, MO |
| 4 | Sat Mar 14 | atLAFC | L0-2 | 0-1-3 | 1 PTS | BMO Stadium · Los Angeles, CA |
| 5 | Sat Mar 21 | vsNew England | W3-1 | 1-1-3 | 4 PTS | Energizer Park · St. Louis, MO |
| 6 | Sat Apr 4 | atNYCFC | D1-1 | 1-2-3 | 5 PTS | Yankee Stadium · New York City, NY |
| 7 | Sat Apr 11 | atDallas | D1-1 | 1-3-3 | 6 PTS | Toyota Stadium · Frisco, TX |
| 8 | Sat Apr 18 | atSeattle | L1-4 | 1-3-4 | 6 PTS | Lumen Field · Seattle, WA |
| 10 | Sat Apr 25 | vsSan Jose | L2-3 | 1-3-5 | 6 PTS | Energizer Park · St. Louis, MO |
| 11 | Sun May 3 | atAustin | L0-2 | 1-3-6 | 6 PTS | Q2 Stadium · Austin, TX |
| 12 | Sat May 9 | atColorado | W1-0 | 2-3-6 | 9 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 13 | Wed May 13 | vsLAFC | W2-1 | 3-3-6 | 12 PTS | Energizer Park · St. Louis, MO |
| 14 | Sat May 16 | atD.C. United | D1-1 | 3-4-6 | 13 PTS | Audi Field · Washington, D.C. |
| 15 | Sat May 23 | vsAustin | W3-0 | 4-4-6 | 16 PTS | Energizer Park · St. Louis, MO |
| 16 | Thu Jul 16 | vsKansas City | W3-2 | 5-4-6 | 19 PTS | Energizer Park · St. Louis, MO |
| 17 | Wed Jul 22 | atLA Galaxy | W3-1 | 6-4-6 | 22 PTS | Dignity Health Sports Park · Carson, CA |
| 18 | Sat Jul 25 | vsColorado | W1-0 | 7-4-6 | 25 PTS | Energizer Park · St. Louis, MO |
| 19 | Sat Aug 1 | vsSalt Lake | D1-1 | 7-5-6 | 26 PTS | Energizer Park · St. Louis, MO |
| 20 | Sat Aug 15 | atSan Jose | W3-1 | 8-5-6 | 29 PTS | PayPal Park · San Jose, CA |
| 21 | Wed Aug 19 | atKansas City | D1-1 | 8-6-6 | 30 PTS | Children's Mercy Park · Kansas City, KS |
| 22 | Sat Aug 22 | vsHouston | W2-1 | 9-6-6 | 33 PTS | Energizer Park · St. Louis, MO |
| 23 | Sun Aug 30 | vsDallas | D3-3 | 9-7-6 | 34 PTS | Energizer Park · St. Louis, MO |
| 24 | Sat Sep 5 | atVancouver | W3-1 | 10-7-6 | 37 PTS | BC Place · Vancouver, BC |
| 25 | Wed Sep 9 | atPortland | D2-2 | 10-8-6 | 38 PTS | Providence Park · Portland, OR |
| 26 | Sat Sep 12 | vsMinnesota | W4-2 | 11-8-6 | 41 PTS | Energizer Park · St. Louis, MO |
| 27 | Sat Sep 19 | vsToronto | W3-1 | 11-8-6 | 41 PTS | Energizer Park · St. Louis, MO |
