| 1 | Sat Feb 22 | vs Toronto | D2-2 | 0-1-0 | 1 PTS | Audi Field · Washington, D.C. |
| 2 | Sat Mar 1 | atChicago | D2-2 | 0-2-0 | 2 PTS | Soldier Field · Chicago, IL |
| 3 | Sat Mar 8 | vsKansas City | W2-1 | 1-2-0 | 5 PTS | Audi Field · Washington, D.C. |
| 4 | Sat Mar 15 | vsMontreal | D0-0 | 1-3-0 | 6 PTS | Audi Field · Washington, D.C. |
| 5 | Sat Mar 22 | atOrlando | L1-4 | 1-3-1 | 6 PTS | Inter&Co Stadium · Orlando, FL |
| 6 | Sat Mar 29 | vsColumbus | L1-2 | 1-3-2 | 6 PTS | Audi Field · Washington, D.C. |
| 7 | Sun Apr 6 | atSan Jose | L1-6 | 1-3-3 | 6 PTS | PayPal Park · San Jose, CA |
| 8 | Sat Apr 12 | vsCincinnati | L0-1 | 1-3-4 | 6 PTS | Audi Field · Washington, D.C. |
| 9 | Sat Apr 19 | atNew York | W2-1 | 2-3-4 | 9 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 10 | Sat Apr 26 | atPhiladelphia | L0-3 | 2-3-5 | 9 PTS | Subaru Park · Chester, PA |
| 11 | Sat May 3 | vsColorado | W2-1 | 3-3-5 | 12 PTS | Audi Field · Washington, D.C. |
| 12 | Sat May 10 | atToronto | L0-2 | 3-3-6 | 12 PTS | BMO Field · Toronto, ON |
| 13 | Wed May 14 | vsNYCFC | D0-0 | 3-4-6 | 13 PTS | Audi Field · Washington, D.C. |
| 14 | Sat May 17 | atNashville | D0-0 | 3-5-6 | 14 PTS | GEODIS Park · Nashville, TN |
| 15 | Sat May 24 | vsNew York | L0-2 | 3-5-7 | 14 PTS | Audi Field · Washington, D.C. |
| 16 | Wed May 28 | vsNew England | D1-1 | 3-6-7 | 15 PTS | Audi Field · Washington, D.C. |
| 17 | Sat May 31 | atCincinnati | W2-1 | 4-6-7 | 18 PTS | TQL Stadium · Cincinnati, OH |
| 18 | Sat Jun 7 | vsChicago | L1-7 | 4-6-8 | 18 PTS | Audi Field · Washington, D.C. |
| 19 | Sat Jun 14 | atSalt Lake | L0-2 | 4-6-9 | 18 PTS | America First Field · Sandy, UT |
| 21 | Sat Jun 28 | vsNashville | L0-1 | 4-6-10 | 18 PTS | Audi Field · Washington, D.C. |
| 22 | Sat Jul 5 | vsAtlanta | D0-0 | 4-7-10 | 19 PTS | Audi Field · Washington, D.C. |
| 24 | Sat Jul 12 | atLA Galaxy | L1-2 | 4-7-11 | 19 PTS | Dignity Health Sports Park · Carson, CA |
| 25 | Wed Jul 16 | atCharlotte | L1-2 | 4-7-12 | 19 PTS | Bank of America Stadium · Charlotte, NC |
| 26 | Sat Jul 19 | atColumbus | L1-2 | 4-7-13 | 19 PTS | Lower.com Field · Columbus, OH |
| 27 | Sat Jul 26 | vsAustin | L2-4 | 4-7-14 | 19 PTS | Audi Field · Washington, D.C. |
| 28 | Sat Aug 9 | atNew England | L0-2 | 4-7-15 | 19 PTS | Gillette Stadium · Foxborough, MA |
| 29 | Sat Aug 16 | atMontreal | D1-1 | 4-8-15 | 20 PTS | Stade Saputo · Montreal, QC |
| 30 | Sat Aug 23 | vsMiami | D1-1 | 4-9-15 | 21 PTS | Audi Field · Washington, D.C. |
| 31 | Sat Aug 30 | atNYCFC | W2-1 | 5-9-15 | 24 PTS | Yankee Stadium · New York City, NY |
| 33 | Sat Sep 13 | vsOrlando | D1-1 | 5-10-15 | 25 PTS | Audi Field · Washington, D.C. |
| 35 | Sat Sep 20 | atMiami | L2-3 | 5-10-16 | 25 PTS | Chase Stadium · Fort Lauderdale, FL |
| 37 | Sat Sep 27 | vsPhiladelphia | L0-6 | 5-10-17 | 25 PTS | Audi Field · Washington, D.C. |
| 38 | Sat Oct 4 | vsCharlotte | L0-1 | 5-10-18 | 25 PTS | Audi Field · Washington, D.C. |
| 39 | Sat Oct 18 | atAtlanta | D1-1 | 5-11-18 | 26 PTS | Mercedes-Benz Stadium · Atlanta, GA |
