| 1 | Sat Feb 22 | at LAFC | L0-1 | 0-0-1 | 0 PTS | BMO Stadium · Los Angeles, CA |
| 2 | Sat Mar 1 | vsMontreal | W1-0 | 1-0-1 | 3 PTS | Allianz Field · Saint Paul, MN |
| 3 | Sat Mar 8 | atSan Jose | W1-0 | 2-0-1 | 6 PTS | PayPal Park · San Jose, CA |
| 4 | Sat Mar 15 | atKansas City | D3-3 | 2-1-1 | 7 PTS | Children's Mercy Park · Kansas City, KS |
| 5 | Sat Mar 22 | vsLA Galaxy | D2-2 | 2-2-1 | 8 PTS | Allianz Field · Saint Paul, MN |
| 6 | Sat Mar 29 | vsSalt Lake | W2-0 | 3-2-1 | 11 PTS | Allianz Field · Saint Paul, MN |
| 7 | Sun Apr 6 | atNYCFC | W2-1 | 4-2-1 | 14 PTS | Yankee Stadium · New York City, NY |
| 8 | Sat Apr 12 | atToronto | D0-0 | 4-3-1 | 15 PTS | BMO Field · Toronto, ON |
| 9 | Sat Apr 19 | vsDallas | D0-0 | 4-4-1 | 16 PTS | Allianz Field · Saint Paul, MN |
| 10 | Sun Apr 27 | vsVancouver | L1-3 | 4-4-2 | 16 PTS | Allianz Field · Saint Paul, MN |
| 11 | Sat May 3 | atAustin | W3-0 | 5-4-2 | 19 PTS | Q2 Stadium · Austin, TX |
| 12 | Sat May 10 | vsMiami | W4-1 | 6-4-2 | 22 PTS | Allianz Field · Saint Paul, MN |
| 13 | Wed May 14 | atHouston | L0-2 | 6-4-3 | 22 PTS | Shell Energy Stadium · Houston, TX |
| 14 | Sat May 17 | vsSt. Louis | W3-0 | 7-4-3 | 25 PTS | Allianz Field · Saint Paul, MN |
| 15 | Sat May 24 | vsAustin | D1-1 | 7-5-3 | 26 PTS | Allianz Field · Saint Paul, MN |
| 16 | Wed May 28 | atVancouver | D0-0 | 7-6-3 | 27 PTS | BC Place · Vancouver, BC |
| 17 | Sun Jun 1 | atSeattle | W3-2 | 8-6-3 | 30 PTS | Lumen Field · Seattle, WA |
| 19 | Sat Jun 14 | vsSan Diego | L2-4 | 8-6-4 | 30 PTS | Allianz Field · Saint Paul, MN |
| 20 | Wed Jun 25 | vsHouston | W3-1 | 9-6-4 | 33 PTS | Allianz Field · Saint Paul, MN |
| 21 | Sat Jun 28 | atNew York | D2-2 | 9-7-4 | 34 PTS | Sports Illustrated Stadium · Harrison, NJ |
| 22 | Fri Jul 4 | atDallas | W2-1 | 10-7-4 | 37 PTS | Toyota Stadium · Frisco, TX |
| 24 | Sat Jul 12 | vsSan Jose | W4-1 | 11-7-4 | 40 PTS | Allianz Field · Saint Paul, MN |
| 25 | Wed Jul 16 | vsLAFC | L0-1 | 11-7-5 | 40 PTS | Allianz Field · Saint Paul, MN |
| 26 | Sat Jul 19 | atPortland | D1-1 | 11-8-5 | 41 PTS | Providence Park · Portland, OR |
| 27 | Sat Jul 26 | atSt. Louis | W2-1 | 12-8-5 | 44 PTS | Energizer Park · St. Louis, MO |
| 28 | Sun Aug 10 | vsColorado | L1-2 | 12-8-6 | 44 PTS | Allianz Field · Saint Paul, MN |
| 29 | Sat Aug 16 | vsSeattle | W1-0 | 13-8-6 | 47 PTS | Allianz Field · Saint Paul, MN |
| 30 | Sat Aug 23 | atSalt Lake | W3-1 | 14-8-6 | 50 PTS | America First Field · Sandy, UT |
| 31 | Sat Aug 30 | vsPortland | D1-1 | 14-9-6 | 51 PTS | Allianz Field · Saint Paul, MN |
| 33 | Sat Sep 13 | atSan Diego | W3-1 | 15-9-6 | 54 PTS | Snapdragon Stadium · San Diego, CA |
| 35 | Sat Sep 20 | vsChicago | L0-3 | 15-9-7 | 54 PTS | Allianz Field · Saint Paul, MN |
| 37 | Sat Sep 27 | atColorado | D1-1 | 15-10-7 | 55 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 38 | Sat Oct 4 | vsKansas City | W3-0 | 16-10-7 | 58 PTS | Allianz Field · Saint Paul, MN |
| 39 | Sat Oct 18 | atLA Galaxy | L1-2 | 16-10-8 | 58 PTS | Dignity Health Sports Park · Carson, CA |
