| 1 | Sat Feb 22 | at St. Louis | D0-0 | 0-1-0 | 1 PTS | Energizer Park · St. Louis, MO |
| 2 | Sat Mar 1 | vsDallas | D3-3 | 0-2-0 | 2 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 3 | Sat Mar 8 | atAustin | W1-0 | 1-2-0 | 5 PTS | Q2 Stadium · Austin, TX |
| 4 | Sat Mar 15 | atSan Jose | W2-1 | 2-2-0 | 8 PTS | PayPal Park · San Jose, CA |
| 5 | Sat Mar 22 | vsPortland | L0-3 | 2-2-1 | 8 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 6 | Sat Mar 29 | vsCharlotte | W2-0 | 3-2-1 | 11 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 7 | Sat Apr 5 | atVancouver | L0-2 | 3-2-2 | 11 PTS | BC Place · Vancouver, BC |
| 8 | Sat Apr 12 | vsSan Diego | W3-2 | 4-2-2 | 14 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 9 | Sat Apr 19 | atHouston | D2-2 | 4-3-2 | 15 PTS | Shell Energy Stadium · Houston, TX |
| 10 | Sat Apr 26 | vsSeattle | D1-1 | 4-4-2 | 16 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 11 | Sat May 3 | atD.C. United | L1-2 | 4-4-3 | 16 PTS | Audi Field · Washington, D.C. |
| 12 | Sat May 10 | vsSan Jose | L0-2 | 4-4-4 | 16 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 13 | Wed May 14 | atSan Diego | L0-2 | 4-4-5 | 16 PTS | Snapdragon Stadium · San Diego, CA |
| 14 | Sat May 17 | vsSalt Lake | W1-0 | 5-4-5 | 19 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 15 | Sat May 24 | vsSt. Louis | W1-0 | 6-4-5 | 22 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 16 | Wed May 28 | atPortland | L1-2 | 6-4-6 | 22 PTS | Providence Park · Portland, OR |
| 18 | Sat Jun 7 | vsAustin | L0-2 | 6-4-7 | 22 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 19 | Sat Jun 14 | vsOrlando | L0-1 | 6-4-8 | 22 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 20 | Wed Jun 25 | vsLA Galaxy | W2-0 | 7-4-8 | 25 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 21 | Sat Jun 28 | atNew England | D3-3 | 7-5-8 | 26 PTS | Gillette Stadium · Foxborough, MA |
| 22 | Fri Jul 4 | vsKansas City | L1-2 | 7-5-9 | 26 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 23 | Wed Jul 9 | atLAFC | L0-3 | 7-5-10 | 26 PTS | BMO Stadium · Los Angeles, CA |
| 24 | Sat Jul 12 | vsVancouver | W3-0 | 8-5-10 | 29 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 25 | Wed Jul 16 | atSeattle | D3-3 | 8-6-10 | 30 PTS | Lumen Field · Seattle, WA |
| 27 | Sat Jul 26 | atPhiladelphia | L1-3 | 8-6-11 | 30 PTS | Subaru Park · Chester, PA |
| 28 | Sun Aug 10 | atMinnesota | W2-1 | 9-6-11 | 33 PTS | Allianz Field · Saint Paul, MN |
| 29 | Sat Aug 16 | vsAtlanta | W3-1 | 10-6-11 | 36 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 30 | Sat Aug 23 | atLA Galaxy | L0-3 | 10-6-12 | 36 PTS | Dignity Health Sports Park · Carson, CA |
| 31 | Sat Aug 30 | atKansas City | L2-4 | 10-6-13 | 36 PTS | Children's Mercy Park · Kansas City, KS |
| 33 | Sat Sep 13 | vsHouston | W2-1 | 11-6-13 | 39 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 35 | Sat Sep 20 | atDallas | L1-3 | 11-6-14 | 39 PTS | Toyota Stadium · Frisco, TX |
| 37 | Sat Sep 27 | vsMinnesota | D1-1 | 11-7-14 | 40 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| 38 | Sat Oct 4 | atSalt Lake | L0-1 | 11-7-15 | 40 PTS | America First Field · Sandy, UT |
| 39 | Sat Oct 18 | vsLAFC | D2-2 | 11-8-15 | 41 PTS | Dick's Sporting Goods Park · Commerce City, CO |
