| 1 | Sat Sep 4 | vs 17Indiana | W34-6 | 1-0 · #18 | 1.000 | Kinnick Stadium · Iowa City, IA |
| 2 | Sat Sep 11 | at9Iowa State | W27-17 | 2-0 · #10 | 1.000 | Jack Trice Stadium · Ames, IA |
| 3 | Sat Sep 18 | vsKent State | W30-7 | 3-0 | 1.000 | Kinnick Stadium · Iowa City, IA |
| 4 | Sat Sep 25 | vsColorado St | W24-14 | 4-0 · #5 | 1.000 | Kinnick Stadium · Iowa City, IA |
| 5 | Fri Oct 1 | atMaryland | W51-14 | 5-0 · #5 | 1.000 | SECU Stadium · College Park, MD |
| 6 | Sat Oct 9 | vs4Penn State | W23-20 | 6-0 · #3 | 1.000 | Kinnick Stadium · Iowa City, IA |
| 7 | Sat Oct 16 | vsPurdue | L7-24 | 6-1 · #2 | .857 | Kinnick Stadium · Iowa City, IA |
| 8 | Sat Oct 30 | atWisconsin | L7-27 | 6-2 · #9 | .750 | Camp Randall Stadium · Madison, WI |
| 9 | Sat Nov 6 | atNorthwestern | W17-12 | 7-2 · #22 | .778 | Ryan Field · Evanston, IL |
| 10 | Sat Nov 13 | vsMinnesota | W27-22 | 8-2 · #20 | .800 | Kinnick Stadium · Iowa City, IA |
| 11 | Sat Nov 20 | vsIllinois | W33-23 | 9-2 · #17 | .818 | Kinnick Stadium · Iowa City, IA |
| 12 | Fri Nov 26 | atNebraska | W28-21 | 10-2 · #16 | .833 | Memorial Stadium · Lincoln, NE |
| 13 | Sat Dec 4 | vs2Michigan | L3-42 | 10-3 · #13 | .769 | Kinnick Stadium · Iowa City, IA |
| BOWLS | Sat Jan 1 | at22Kentucky | L17-20 | 10-4 · #15 | .714 | Kroger Field · Lexington, KY |
