| 1 | Sat Aug 31 | at Wyoming | L31-37 | 0-1 | .000 | Jonah Field at War Memorial Stadium · Laramie, WY |
| 2 | Sat Sep 7 | vsWest Virginia | W38-7 | 1-1 | .500 | Memorial Stadium/Faurot Field · Columbia, MO |
| 3 | Sat Sep 14 | vsSE Missouri St | W50-0 | 2-1 | .667 | Memorial Stadium/Faurot Field · Columbia, MO |
| 4 | Sat Sep 21 | vsSouth Carolina | W34-14 | 3-1 | .750 | Memorial Stadium/Faurot Field · Columbia, MO |
| 5 | Sat Oct 5 | vsTroy | W42-10 | 4-1 | .800 | Memorial Stadium/Faurot Field · Columbia, MO |
| 6 | Sat Oct 12 | vsOle Miss | W38-27 | 5-1 | .833 | Memorial Stadium/Faurot Field · Columbia, MO |
| 7 | Sat Oct 19 | atVanderbilt | L14-21 | 5-2 | .714 | FirstBank Stadium · Nashville, TN |
| 8 | Sat Oct 26 | atKentucky | L7-29 | 5-3 | .625 | Kroger Field · Lexington, KY |
| 9 | Sat Nov 9 | at#6Georgia | L0-27 | 5-4 | .556 | Sanford Stadium · Athens, GA |
| 10 | Sat Nov 16 | vs#11Florida | L6-23 | 5-5 | .500 | Memorial Stadium/Faurot Field · Columbia, MO |
| 11 | Sat Nov 23 | vsTennessee | L20-24 | 5-6 | .455 | Memorial Stadium/Faurot Field · Columbia, MO |
| 12 | Fri Nov 29 | atArkansas | W24-14 | 6-6 | .500 | Razorback Stadium · Fayetteville, AR |
