| 1 | Sat Sep 4 | vs C Michigan | W34-24 | 1-0 | 1.000 | Memorial Stadium/Faurot Field · Columbia, MO |
| 2 | Sat Sep 11 | atKentucky | L28-35 | 1-1 | .500 | Kroger Field · Lexington, KY |
| 3 | Sat Sep 18 | vsSE Missouri St | W59-28 | 2-1 | .667 | Memorial Stadium/Faurot Field · Columbia, MO |
| 4 | Sat Sep 25 | atBoston College | L34-41 (OT) | 2-2 | .500 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| 5 | Sat Oct 2 | vsTennessee | L24-62 | 2-3 | .400 | Memorial Stadium/Faurot Field · Columbia, MO |
| 6 | Sat Oct 9 | vsNorth Texas | W48-35 | 3-3 | .500 | Memorial Stadium/Faurot Field · Columbia, MO |
| 7 | Sat Oct 16 | vs#21Texas A&M | L14-35 | 3-4 | .429 | Memorial Stadium/Faurot Field · Columbia, MO |
| 8 | Sat Oct 30 | atVanderbilt | W37-28 | 4-4 | .500 | FirstBank Stadium · Nashville, TN |
| 9 | Sat Nov 6 | at#1Georgia | L6-43 | 4-5 | .444 | Sanford Stadium · Athens, GA |
| 10 | Sat Nov 13 | vsSouth Carolina | W31-28 | 5-5 | .500 | Memorial Stadium/Faurot Field · Columbia, MO |
| 11 | Sat Nov 20 | vsFlorida | W24-23 (OT) | 6-5 | .545 | Memorial Stadium/Faurot Field · Columbia, MO |
| 12 | Fri Nov 26 | atArkansas | L17-34 | 6-6 | .500 | Razorback Stadium · Fayetteville, AR |
| BOWLS | Wed Dec 22 | atArmy | L22-24 | 6-7 | .462 | Michie Stadium · West Point, NY |
