| 1 | Thu Sep 1 | vs Louisiana Tech | W52-24 | 1-0 | 1.000 | Memorial Stadium/Faurot Field · Columbia, MO |
| 2 | Sat Sep 10 | atKansas St | L12-40 | 1-1 | .500 | Bill Snyder Family Stadium · Manhattan, KS |
| 3 | Sat Sep 17 | vsAbilene Chrstn | W34-17 | 2-1 | .667 | Memorial Stadium/Faurot Field · Columbia, MO |
| 4 | Sat Sep 24 | atAuburn | L14-17 (OT) | 2-2 | .500 | Jordan-Hare Stadium · Auburn, AL |
| 5 | Sat Oct 1 | vs#1Georgia | L22-26 | 2-3 | .400 | Memorial Stadium/Faurot Field · Columbia, MO |
| 6 | Sat Oct 8 | atFlorida | L17-24 | 2-4 | .333 | Ben Hill Griffin Stadium · Gainesville, FL |
| 7 | Sat Oct 22 | vsVanderbilt | W17-14 | 3-4 | .429 | Memorial Stadium/Faurot Field · Columbia, MO |
| 8 | Sat Oct 29 | at#25South Carolina | W23-10 | 4-4 | .500 | Williams-Brice Stadium · Columbia, SC |
| 9 | Sat Nov 5 | vsKentucky | L17-21 | 4-5 | .444 | Memorial Stadium/Faurot Field · Columbia, MO |
| 10 | Sat Nov 12 | at#5Tennessee | L24-66 | 4-6 | .400 | Neyland Stadium · Knoxville, TN |
| 11 | Sat Nov 19 | vsNew Mexico St | W45-14 | 5-6 | .455 | Memorial Stadium/Faurot Field · Columbia, MO |
| 12 | Fri Nov 25 | vsArkansas | W29-27 | 6-6 | .500 | Memorial Stadium/Faurot Field · Columbia, MO |
| BOWLS | Fri Dec 23 | vsWake Forest | L17-27 | 6-7 | .462 | Memorial Stadium/Faurot Field · Columbia, MO |
