| 1 | Sat Aug 31 | at Memphis | L10-15 | +3½ | 0-1 | .000 | Simmons Bank Liberty Stadium · Memphis, TN |
| 2 | Sat Sep 7 | vsArkansas | W31-17 | -5½ | 1-1 | .500 | Vaught-Hemingway Stadium · Oxford, MS |
| 3 | Sat Sep 14 | vsSE Louisiana | W40-29 | -30½ | 2-1 | .667 | Vaught-Hemingway Stadium · Oxford, MS |
| 4 | Sat Sep 21 | vs23California | L20-28 | -3 | 2-2 | .500 | Vaught-Hemingway Stadium · Oxford, MS |
| 5 | Sat Sep 28 | at2Alabama | L31-59 | +38 | 2-3 | .400 | Bryant-Denny Stadium · Tuscaloosa, AL |
| 6 | Sat Oct 5 | vsVanderbilt | W31-6 | -7 | 3-3 | .500 | Vaught-Hemingway Stadium · Oxford, MS |
| 7 | Sat Oct 12 | atMissouri | L27-38 | +12½ | 3-4 | .429 | Memorial Stadium/Faurot Field · Columbia, MO |
| 8 | Sat Oct 19 | vsTexas A&M | L17-24 | +6 | 3-5 | .375 | Vaught-Hemingway Stadium · Oxford, MS |
| 9 | Sat Nov 2 | at11Auburn | L14-20 | +17½ | 3-6 | .333 | Jordan-Hare Stadium · Auburn, AL |
| 10 | Sat Nov 9 | vsNew Mexico St | W41-3 | -28½ | 4-6 | .400 | Vaught-Hemingway Stadium · Oxford, MS |
| 11 | Sat Nov 16 | vs1LSU | L37-58 | +21 | 4-7 | .364 | Vaught-Hemingway Stadium · Oxford, MS |
| 12 | Thu Nov 28 | atMississippi St | L20-21 | -1½ | 4-8 | .333 | Davis Wade Stadium · Starkville, MS |
