| 1 | Sat Aug 30 | vs Georgia St | W63-7 | - | 1-0 · #21 | 1.000 | Vaught-Hemingway Stadium · Oxford, MS |
| 2 | Sat Sep 6 | atKentucky | W30-23 | - | 2-0 · #20 | 1.000 | Kroger Field · Lexington, KY |
| 3 | Sat Sep 13 | vsArkansas | W41-35 | - | 3-0 · #17 | 1.000 | Vaught-Hemingway Stadium · Oxford, MS |
| 4 | Sat Sep 20 | vsTulane | W45-10 | - | 4-0 · #13 | 1.000 | Vaught-Hemingway Stadium · Oxford, MS |
| 5 | Sat Sep 27 | vs4LSU | W24-19 | - | 5-0 · #13 | 1.000 | Vaught-Hemingway Stadium · Oxford, MS |
| 6 | Sat Oct 11 | vsWashington St | W24-21 | - | 6-0 · #4 | 1.000 | Vaught-Hemingway Stadium · Oxford, MS |
| 7 | Sat Oct 18 | at9Georgia | L35-43 | - | 6-1 · #5 | .857 | Sanford Stadium · Athens, GA |
| 8 | Sat Oct 25 | at13Oklahoma | W34-26 | - | 7-1 · #8 | .875 | Memorial Stadium · Norman, OK |
| 9 | Sat Nov 1 | vsSouth Carolina | W30-14 | - | 8-1 · #7 | .889 | Vaught-Hemingway Stadium · Oxford, MS |
| 10 | Sat Nov 8 | vsThe Citadel | W49-0 | - | 9-1 · #6 | .900 | Vaught-Hemingway Stadium · Oxford, MS |
| 11 | Sat Nov 15 | vsFlorida | W34-24 | - | 10-1 · #7 | .909 | Vaught-Hemingway Stadium · Oxford, MS |
| 12 | Fri Nov 28 | atMississippi St | W38-19 | -7½ | 11-1 · #7 | .917 | Davis Wade Stadium · Starkville, MS |
| CFP | Sat Dec 20 | vs11Tulane | W41-10 | -16½ | 12-1 · #6 | .923 | Vaught-Hemingway Stadium · Oxford, MS |
| CFP | Thu Jan 1 | at3Georgia | W39-34 | +6 | 13-1 · #6 | .929 | Sanford Stadium · Athens, GA |
| CFP | Thu Jan 8 | vs10Miami | L27-31 | +3 | 13-2 · #6 | .867 | Vaught-Hemingway Stadium · Oxford, MS |
