| 1 | Mon Sep 6 | vs Louisville | W43-24 | +9 | 1-0 | 1.000 | Vaught-Hemingway Stadium · Oxford, MS |
| 2 | Sat Sep 11 | vsAustin Peay | W54-17 | -37 | 2-0 · #20 | 1.000 | Vaught-Hemingway Stadium · Oxford, MS |
| 3 | Sat Sep 18 | vsTulane | W61-21 | -14 | 3-0 · #17 | 1.000 | Vaught-Hemingway Stadium · Oxford, MS |
| 4 | Sat Oct 2 | at1Alabama | L21-42 | +15 | 3-1 · #12 | .750 | Bryant-Denny Stadium · Tuscaloosa, AL |
| 5 | Sat Oct 9 | vs13Arkansas | W52-51 | -5 | 4-1 · #17 | .800 | Vaught-Hemingway Stadium · Oxford, MS |
| 6 | Sat Oct 16 | atTennessee | W31-26 | -1 | 5-1 · #13 | .833 | Neyland Stadium · Knoxville, TN |
| 7 | Sat Oct 23 | vsLSU | W31-17 | -9 | 6-1 | .857 | Vaught-Hemingway Stadium · Oxford, MS |
| 8 | Sat Oct 30 | atAuburn | L20-31 | +3 | 6-2 | .750 | Jordan-Hare Stadium · Auburn, AL |
| 9 | Sat Nov 6 | vsLiberty | W27-14 | -7½ | 7-2 · #16 | .778 | Vaught-Hemingway Stadium · Oxford, MS |
| 10 | Sat Nov 13 | vs11Texas A&M | W29-19 | +1 | 8-2 · #15 | .800 | Vaught-Hemingway Stadium · Oxford, MS |
| 11 | Sat Nov 20 | vsVanderbilt | W31-17 | -36 | 9-2 · #12 | .818 | Vaught-Hemingway Stadium · Oxford, MS |
| 12 | Thu Nov 25 | atMississippi St | W31-21 | +2 | 10-2 · #9 | .833 | Davis Wade Stadium · Starkville, MS |
| BOWLS | Sat Jan 1 | vs7Baylor | L7-21 | -1 | 10-3 · #8 | .769 | Vaught-Hemingway Stadium · Oxford, MS |
