| 1 | Tue Nov 5 | at 25VCU | L58-72 | 0-1 | .000 | - | | Stuart C. Siegel Center · Richmond, VA |
| 2 | Fri Nov 8 | atRichmond | L98-100 (OT) | 0-2 | .000 | - | | Robins Center · Richmond, VA |
| 3 | Wed Nov 13 | atMorgan St | W71-65 | 1-2 | .333 | - | | Hill Field House · Baltimore, MD |
| 4 | Sat Nov 16 | vsAmerican | W79-76 | 2-2 | .500 | - | | DeGol Arena · Loretto, PA |
| 5 | Tue Nov 19 | vsDelaware | L64-79 | 2-3 | .400 | - | | DeGol Arena · Loretto, PA |
| 6 | Sat Nov 23 | atFlorida St | L65-80 | 2-4 | .333 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 7 | Sat Nov 30 | atSaint Joseph's | W79-63 | 3-4 | .429 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 8 | Wed Dec 4 | vsLehigh | W77-69 | 4-4 | .500 | - | | DeGol Arena · Loretto, PA |
| 9 | Sat Dec 7 | atUMBC | W63-60 | 5-4 | .556 | - | | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 10 | Tue Dec 17 | vsTBD | W115-66 | 6-4 | .600 | - | | DeGol Arena · Loretto, PA |
| 11 | Sun Dec 22 | atWilliam & Mary | W78-72 | 7-4 | .636 | - | | Kaplan Arena · Williamsburg, VA |
| 12 | Thu Jan 2 | atBryant | L63-67 | 7-5 | .583 | - | | Chace Athletic Center · Smithfield, RI |
| 13 | Sat Jan 4 | atC Connecticut | W93-69 | 8-5 | .615 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 14 | Thu Jan 9 | vsWagner | W80-62 | 9-5 | .643 | - | | DeGol Arena · Loretto, PA |
| 15 | Sat Jan 11 | vsSt Francis BK | W81-80 | 10-5 | .667 | - | | DeGol Arena · Loretto, PA |
| 16 | Wed Jan 15 | atFairleigh | W100-85 | 11-5 | .688 | - | ESPNU | Bogota Savings Bank Center · Teaneck, NJ |
| 17 | Sat Jan 18 | vsSacred Heart | W72-65 | 12-5 | .706 | - | | DeGol Arena · Loretto, PA |
| 18 | Mon Jan 20 | vsMerrimack | L55-72 | 12-6 | .667 | - | | DeGol Arena · Loretto, PA |
| 19 | Thu Jan 23 | atLong Island | L81-86 | 12-7 | .632 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 20 | Sat Jan 25 | atSt Francis BK | L79-86 | 12-8 | .600 | - | | Pope Physical Education Center · Brooklyn, NY |
| 21 | Thu Jan 30 | vsC Connecticut | W84-77 | 13-8 | .619 | - | | DeGol Arena · Loretto, PA |
| 22 | Sat Feb 1 | vsBryant | W84-64 | 14-8 | .636 | - | CBSSN | DeGol Arena · Loretto, PA |
| 23 | Thu Feb 6 | atSacred Heart | W70-68 | 15-8 | .652 | - | | William H. Pitt Center · Fairfield, CT |
| 24 | Sat Feb 8 | atWagner | W85-68 | 16-8 | .667 | - | | Spiro Sports Center · Staten Island, NY |
| 25 | Sat Feb 15 | atMount St Mary | W70-55 | 17-8 | .680 | - | | Knott Arena · Emmitsburg, MD |
| 26 | Tue Feb 18 | vsRobert Morris | W86-71 | 18-8 | .692 | - | | DeGol Arena · Loretto, PA |
| 27 | Sun Feb 23 | vsLong Island | W74-71 | 19-8 | .704 | - | | DeGol Arena · Loretto, PA |
| 28 | Thu Feb 27 | vsMount St Mary | W75-62 | 20-8 | .714 | - | | DeGol Arena · Loretto, PA |
| 29 | Sat Feb 29 | atRobert Morris | L68-78 | 20-9 | .690 | - | | UPMC Events Center · Moon Township, PA |
| 30 | Wed Mar 4 | vsBryant | W87-61 | 21-9 | .700 | - | | DeGol Arena · Loretto, PA |
| 31 | Sat Mar 7 | vsSacred Heart | W84-72 | 22-9 | .710 | - | | DeGol Arena · Loretto, PA |
| 32 | Tue Mar 10 | atRobert Morris | L67-77 | 22-10 | .688 | - | ESPN2 | UPMC Events Center · Moon Township, PA |
