| 1 | Mon Nov 3 | at Oklahoma | L66-102 | - | 0-1 | .000 | - | | Lloyd Noble Center · Norman, OK |
| 2 | Thu Nov 6 | atTCU | L63-104 | - | 0-2 | .000 | - | TNT | Schollmaier Arena · Fort Worth, TX |
| 3 | Tue Nov 11 | vsMount St Mary | L66-74 | - | 0-3 | .000 | - | | DeGol Arena · Loretto, PA |
| 4 | Tue Nov 18 | atLehigh | L62-79 | - | 0-4 | .000 | - | ESPN+ | Stabler Arena · Bethlehem, PA |
| 5 | Mon Nov 24 | atBelmont | L57-94 | - | 0-5 | .000 | - | | Alico Arena · Fort Myers, FL |
| 6 | Wed Nov 26 | atTroy | L64-74 | +21½ | 0-6 | .000 | - | | Alico Arena · Fort Myers, FL |
| 7 | Sat Nov 29 | vsTBD | W85-60 | - | 1-6 | .143 | - | | DeGol Arena · Loretto, PA |
| 8 | Mon Dec 1 | atXavier | L74-96 | +27½ | 1-7 | .125 | - | truTV | Cintas Center · Cincinnati, OH |
| 9 | Wed Dec 3 | vsTBD | W100-41 | - | 2-7 | .222 | - | | DeGol Arena · Loretto, PA |
| 10 | Sun Dec 7 | atRadford | L56-89 | +13½ | 2-8 | .200 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 11 | Sun Dec 14 | atTemple | L67-95 | +20½ | 2-9 | .182 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 12 | Wed Dec 17 | at23Florida | L61-102 | +44½ | 2-10 | .167 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 13 | Sat Dec 20 | vsRobert Morris | L70-79 | +13½ | 2-11 | .154 | - | | DeGol Arena · Loretto, PA |
| 14 | Fri Jan 2 | vsLe Moyne | L58-84 | +5½ | 2-12 | .143 | - | | DeGol Arena · Loretto, PA |
| 15 | Sun Jan 4 | vsFairleigh | W85-82 | +2½ | 3-12 | .200 | - | | DeGol Arena · Loretto, PA |
| 16 | Thu Jan 8 | atWagner | W71-69 | +7½ | 4-12 | .250 | - | | Spiro Sports Center · Staten Island, NY |
| 17 | Sat Jan 10 | atLong Island | L63-67 | +15½ | 4-13 | .235 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 18 | Sat Jan 17 | vsC Connecticut | L90-98 | +6½ | 4-14 | .222 | - | | DeGol Arena · Loretto, PA |
| 19 | Mon Jan 19 | vsStonehill | W63-61 | -1½ | 5-14 | .263 | - | | DeGol Arena · Loretto, PA |
| 20 | Fri Jan 23 | vsChicago St | W81-60 | -3½ | 6-14 | .300 | - | | DeGol Arena · Loretto, PA |
| 21 | Sun Jan 25 | atNew Haven | PPD | - | 7-24 | .226 | - | | Jeffery P. Hazell Athletics Center |
| 22 | Sat Jan 31 | vsNew Haven | L69-81 | -1½ | 6-15 | .286 | - | | DeGol Arena · Loretto, PA |
| 23 | Thu Feb 5 | atMercyhurst | L89-98 (OT) | +6½ | 6-16 | .273 | - | ESPN+ | Mercyhurst Athletic Center · Erie, PA |
| 24 | Sat Feb 7 | atLe Moyne | L84-86 | +7½ | 6-17 | .261 | - | | Ted Grant Court · Syracuse, NY |
| 25 | Mon Feb 9 | atChicago St | L75-80 | +3½ | 6-18 | .250 | - | | Jones Convocation Center · Chicago, IL |
| 26 | Thu Feb 12 | atFairleigh | L59-66 | +7½ | 6-19 | .240 | - | | Bogota Savings Bank Center · Teaneck, NJ |
| 27 | Sat Feb 14 | vsMercyhurst | L79-94 | +2½ | 6-20 | .231 | - | | DeGol Arena · Loretto, PA |
| 28 | Thu Feb 19 | vsLong Island | L89-91 | +9½ | 6-21 | .222 | - | | DeGol Arena · Loretto, PA |
| 29 | Sat Feb 21 | vsWagner | L56-65 | +1½ | 6-22 | .214 | - | | DeGol Arena · Loretto, PA |
| 30 | Tue Feb 24 | atNew Haven | W73-67 | +6½ | 7-22 | .241 | - | | Jeffery P. Hazell Athletics Center |
| 31 | Thu Feb 26 | atStonehill | L77-103 | +4½ | 7-23 | .233 | - | | placeholder · sf, ca |
| 32 | Sat Feb 28 | atC Connecticut | L64-69 | +8½ | 7-24 | .226 | - | | William H. Detrick Gymnasium · New Britain, CT |
