| 1 | Mon Nov 4 | at Dayton | L57-87 | 0-1 | .000 | - | ESPN+ | UD Arena · Dayton, OH |
| 2 | Fri Nov 8 | atClemson | L62-88 | 0-2 | .000 | - | ESPN+ | Littlejohn Coliseum · Clemson, SC |
| 3 | Sun Nov 10 | atCampbell | W65-64 | 1-2 | .333 | - | FloSports | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 4 | Tue Nov 12 | atPenn State | L62-92 | 1-3 | .250 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 5 | Sat Nov 16 | atMount St Mary | L58-66 | 1-4 | .200 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 6 | Wed Nov 20 | vsTBD | W96-57 | 2-4 | .333 | - | | DeGol Arena · Loretto, PA |
| 7 | Sat Nov 23 | atGeorgetown | L65-82 | 2-5 | .286 | - | FS2 | Capital One Arena · Washington, D.C. |
| 8 | Tue Nov 26 | vsLehigh | W88-78 | 3-5 | .375 | - | | DeGol Arena · Loretto, PA |
| 9 | Sun Dec 1 | vsRadford | L70-79 | 3-6 | .333 | - | | DeGol Arena · Loretto, PA |
| 10 | Wed Dec 4 | vsTBD | W107-55 | 4-6 | .400 | - | | DeGol Arena · Loretto, PA |
| 11 | Sat Dec 14 | atNiagara | L66-69 | 4-7 | .364 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 12 | Tue Dec 17 | atMaryland | L57-111 | 4-8 | .333 | - | BTN | XFINITY Center · College Park, MD |
| 13 | Thu Dec 19 | vsTBD | W104-47 | 5-8 | .385 | - | | DeGol Arena · Loretto, PA |
| 14 | Sat Dec 21 | atRobert Morris | L77-90 | 5-9 | .357 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 15 | Fri Jan 3 | vsC Connecticut | L59-74 | 5-10 | .333 | - | | DeGol Arena · Loretto, PA |
| 16 | Sun Jan 5 | vsStonehill | L60-64 | 5-11 | .313 | - | | DeGol Arena · Loretto, PA |
| 17 | Fri Jan 10 | vsMercyhurst | W73-59 | 6-11 | .353 | - | | DeGol Arena · Loretto, PA |
| 18 | Sun Jan 12 | atFairleigh | W75-71 | 7-11 | .389 | - | | Bogota Savings Bank Center · Teaneck, NJ |
| 19 | Sat Jan 18 | atLong Island | L51-64 | 7-12 | .368 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 20 | Mon Jan 20 | atWagner | L68-70 (2OT) | 7-13 | .350 | - | | Spiro Sports Center · Staten Island, NY |
| 21 | Fri Jan 24 | vsLong Island | W74-64 | 8-13 | .381 | - | | DeGol Arena · Loretto, PA |
| 22 | Sun Jan 26 | vsWagner | L66-68 | 8-14 | .364 | - | | DeGol Arena · Loretto, PA |
| 23 | Thu Jan 30 | atMercyhurst | L58-62 | 8-15 | .348 | - | | Mercyhurst Athletic Center · Erie, PA |
| 24 | Thu Feb 6 | vsLe Moyne | W86-78 | 9-15 | .375 | - | | DeGol Arena · Loretto, PA |
| 25 | Sat Feb 8 | atChicago St | W81-69 | 10-15 | .400 | - | ESPN+ | Jones Convocation Center · Chicago, IL |
| 26 | Thu Feb 13 | atStonehill | L74-79 | 10-16 | .385 | - | | placeholder · sf, ca |
| 27 | Sat Feb 15 | atC Connecticut | L67-83 | 10-17 | .370 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 28 | Thu Feb 20 | atLe Moyne | W81-76 (OT) | 11-17 | .393 | - | | Ted Grant Court · Syracuse, NY |
| 29 | Sat Feb 22 | vsFairleigh | W85-80 (OT) | 12-17 | .414 | - | | DeGol Arena · Loretto, PA |
| 30 | Sat Mar 1 | vsChicago St | W80-71 (OT) | 13-17 | .433 | - | | DeGol Arena · Loretto, PA |
| 31 | Wed Mar 5 | vsWagner | W58-55 | 14-17 | .452 | - | | DeGol Arena · Loretto, PA |
| 32 | Sat Mar 8 | atLong Island | W71-68 | 15-17 | .469 | - | ESPN+ | Steinberg Wellness Center · Brooklyn, NY |
| 33 | Tue Mar 11 | atC Connecticut | W46-43 | 16-17 | .485 | - | ESPN2 | William H. Detrick Gymnasium · New Britain, CT |
| 34 | Tue Mar 18 | at16Alabama St | L68-70 | 16-18 | .471 | #16 | truTV | UD Arena · Dayton, OH |
