| 1 | Mon Nov 4 | vs TBD | W81-62 | 1-0 | 1.000 | - | | placeholder · sf, ca |
| 2 | Wed Nov 6 | atNotre Dame | L60-89 | 1-1 | .500 | - | ESPN+ | Purcell Pavilion · South Bend, IN |
| 3 | Sat Nov 9 | atProvidence | L49-76 | 1-2 | .333 | - | FS2 | Amica Mutual Pavilion · Providence, RI |
| 4 | Thu Nov 14 | atRobert Morris | L51-63 | 1-3 | .250 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 5 | Fri Nov 15 | vsNew Orleans | W80-54 | 2-3 | .400 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 6 | Sun Nov 17 | atLindenwood | L74-75 | 2-4 | .333 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 7 | Thu Nov 21 | vsBryant | W67-66 | 3-4 | .429 | - | | placeholder · sf, ca |
| 8 | Mon Nov 25 | vsE Texas A&M | W67-65 | 4-4 | .500 | - | | placeholder · sf, ca |
| 9 | Wed Nov 27 | at#10Marquette | L59-94 | 4-5 | .444 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 10 | Sun Dec 1 | vsQuinnipiac | W88-74 | 5-5 | .500 | - | | placeholder · sf, ca |
| 11 | Wed Dec 11 | vsTBD | W97-53 | 6-5 | .545 | - | | placeholder · sf, ca |
| 12 | Sun Dec 15 | atBoston College | L69-73 | 6-6 | .500 | - | ACC Extra | Silvio O. Conte Forum · Chestnut Hill, MA |
| 13 | Wed Dec 18 | atUMass Lowell | L67-78 | 6-7 | .462 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 14 | Sun Dec 22 | vsNew Hampshire | W90-83 | 7-7 | .500 | - | | placeholder · sf, ca |
| 15 | Sun Dec 29 | atLafayette | W70-65 | 8-7 | .533 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 16 | Fri Jan 3 | atMercyhurst | L69-76 | 8-8 | .500 | - | | Mercyhurst Athletic Center · Erie, PA |
| 17 | Sun Jan 5 | atSt Francis PA | W64-60 | 9-8 | .529 | - | | DeGol Arena · Loretto, PA |
| 18 | Fri Jan 10 | vsLong Island | L60-70 | 9-9 | .500 | - | | placeholder · sf, ca |
| 19 | Sun Jan 12 | atChicago St | W68-52 | 10-9 | .526 | - | | Jones Convocation Center · Chicago, IL |
| 20 | Mon Jan 20 | atLe Moyne | L72-73 | 10-10 | .500 | - | | Ted Grant Court · Syracuse, NY |
| 21 | Fri Jan 24 | vsChicago St | W75-73 | 11-10 | .524 | - | | placeholder · sf, ca |
| 22 | Sun Jan 26 | vsFairleigh | L54-65 | 11-11 | .500 | - | | placeholder · sf, ca |
| 23 | Thu Jan 30 | vsWagner | W73-61 | 12-11 | .522 | - | | placeholder · sf, ca |
| 24 | Sat Feb 1 | vsC Connecticut | L63-71 | 12-12 | .500 | - | | placeholder · sf, ca |
| 25 | Sat Feb 8 | atLong Island | L59-62 | 12-13 | .480 | - | ESPN+ | Steinberg Wellness Center · Brooklyn, NY |
| 26 | Thu Feb 13 | vsSt Francis PA | W79-74 | 13-13 | .500 | - | | placeholder · sf, ca |
| 27 | Sat Feb 15 | vsMercyhurst | W85-73 | 14-13 | .519 | - | ESPN+ | placeholder · sf, ca |
| 28 | Thu Feb 20 | atWagner | L57-63 | 14-14 | .500 | - | | Spiro Sports Center · Staten Island, NY |
| 29 | Sat Feb 22 | atC Connecticut | L41-67 | 14-15 | .483 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 30 | Thu Feb 27 | atFairleigh | L69-82 | 14-16 | .467 | - | | Stratis Arena at the Rothman Center · Teaneck, NJ |
| 31 | Sat Mar 1 | vsLe Moyne | W85-79 | 15-16 | .484 | - | | placeholder · sf, ca |
| 32 | Wed Mar 5 | atFairleigh | L56-71 | 15-17 | .469 | - | | Stratis Arena at the Rothman Center · Teaneck, NJ |
