| 1 | Mon Nov 4 | at Nebraska | L67-87 | 0-1 | .000 | - | B1G+ | Pinnacle Bank Arena · Lincoln, NE |
| 2 | Wed Nov 6 | at #15Creighton | L86-99 | 0-2 | .000 | - | FS2 | CHI Health Center Omaha · Omaha, NE |
| 3 | Sun Nov 10 | vs TBD | W110-60 | 1-2 | .333 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 4 | Fri Nov 15 | at Charleston So | W86-76 | 2-2 | .500 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 5 | Sat Nov 16 | at Tennessee Tech | W83-58 | 3-2 | .600 | - | | Hooper Eblen Center · Cookeville, TN |
| 6 | Mon Nov 18 | at #19Wisconsin | L84-87 | 3-3 | .500 | - | BTN | Kohl Center · Madison, WI |
| 7 | Mon Nov 25 | vs Le Moyne | W97-77 | 4-3 | .571 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 8 | Thu Dec 5 | vs SF Austin | W68-65 | 5-3 | .625 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 9 | Sat Dec 7 | vs Lamar | L52-84 | 5-4 | .556 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 10 | Sat Dec 14 | vsTBD | W72-60 | 6-4 | .600 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 11 | Wed Dec 18 | vs Southern Utah | W78-73 | 7-4 | .636 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 12 | Sat Dec 21 | vsTBD | W106-56 | 8-4 | .667 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 13 | Mon Dec 30 | vsTBD | W88-44 | 9-4 | .692 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 14 | Sat Jan 4 | at New Orleans | W76-64 | 10-4 | .714 | - | ESPN+ | Lakefront Arena · New Orleans, LA |
| 15 | Mon Jan 6 | at SE Louisiana | L75-79 | 10-5 | .667 | - | ESPN+ | University Center (LA) · Hammond, LA |
| 16 | Sat Jan 11 | at Texas A&M-CC | L74-79 | 10-6 | .625 | - | ESPN+ | American Bank Center · Corpus Christi, TX |
| 17 | Mon Jan 13 | vs E Texas A&M | W57-55 | 11-6 | .647 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 18 | Sat Jan 18 | at Hou Christian | L57-66 | 11-7 | .611 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 19 | Mon Jan 20 | at Incarnate Word | W85-78 | 12-7 | .632 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 20 | Sat Jan 25 | vs McNeese | L63-93 | 12-8 | .600 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 21 | Mon Jan 27 | vs Nicholls | L75-82 | 12-9 | .571 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 22 | Sat Feb 1 | vsTexas A&M-CC | W83-73 | 13-9 | .591 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 23 | Mon Feb 3 | at N'Western St | L63-79 | 13-10 | .565 | - | ESPN+ | Prather Coliseum · Natchitoches, LA |
| 24 | Sat Feb 8 | atLamar | L68-70 | 13-11 | .542 | - | ESPN+ | Montagne Center · Beaumont, TX |
| 25 | Mon Feb 10 | atSF Austin | L75-85 | 13-12 | .520 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 26 | Sat Feb 15 | vsHou Christian | W76-52 | 14-12 | .538 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 27 | Mon Feb 17 | vsIncarnate Word | L60-66 | 14-13 | .519 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
