| 1 | Mon Nov 3 | at Baylor | L81-96 | 0-1 | .000 | - | ESPN+ | Ferrell Center · Waco, TX |
| 2 | Sat Nov 8 | atSouthern Utah | W95-72 | 1-1 | .500 | - | ESPN+ | America First Events Center · Cedar City, UT |
| 3 | Tue Nov 11 | atBoise St | L65-85 | 1-2 | .333 | - | | ExtraMile Arena · Boise, ID |
| 4 | Mon Nov 17 | vsTBD | W110-53 | 2-2 | .500 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 5 | Sat Nov 22 | atMissouri St | L67-74 | 2-3 | .400 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 6 | Mon Nov 24 | at13Illinois | L73-87 | 2-4 | .333 | - | BTN | State Farm Center · Champaign, IL |
| 7 | Wed Dec 3 | atSF Austin | L60-73 | 2-5 | .286 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 8 | Sun Dec 7 | vsAustin Peay | W63-50 | 3-5 | .375 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 9 | Thu Dec 11 | vsUT Arlington | L50-58 | 3-6 | .333 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 10 | Tue Dec 16 | atLamar | W83-72 | 4-6 | .400 | - | ESPN+ | Montagne Center · Beaumont, TX |
| 11 | Sat Dec 20 | vsTBD | W109-51 | 5-6 | .455 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 12 | Mon Dec 29 | vsNew Orleans | L69-85 | 5-7 | .417 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 13 | Wed Dec 31 | vsNicholls | L69-71 | 5-8 | .385 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 14 | Sat Jan 3 | vsTexas A&M-CC | L59-63 | 5-9 | .357 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 15 | Mon Jan 5 | vsIncarnate Word | W80-67 | 6-9 | .400 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 16 | Sat Jan 10 | atE Texas A&M | L69-77 | 6-10 | .375 | - | ESPN+ | The Field House · Commerce, TX |
| 17 | Mon Jan 12 | atN'Western St | L63-64 | 6-11 | .353 | - | ESPN+ | Prather Coliseum · Natchitoches, LA |
| 18 | Sat Jan 17 | vsMcNeese | W79-76 | 7-11 | .389 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 19 | Mon Jan 19 | vsSE Louisiana | W68-65 | 8-11 | .421 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 20 | Sat Jan 24 | atHou Christian | W68-51 | 9-11 | .450 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 21 | Mon Jan 26 | atTexas A&M-CC | W64-55 | 10-11 | .476 | - | ESPN+ | American Bank Center · Corpus Christi, TX |
| 22 | Sat Jan 31 | atIncarnate Word | W106-93 | 11-11 | .500 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 23 | Mon Feb 2 | vsHou Christian | W74-57 | 12-11 | .522 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 24 | Sat Feb 7 | atNew Orleans | W95-76 | 13-11 | .542 | - | ESPN+ | Lakefront Arena · New Orleans, LA |
| 25 | Mon Feb 9 | atNicholls | W92-72 | 14-11 | .560 | - | ESPN+ | David R. Stopher Gymnasium · Thibodaux, LA |
| 26 | Sat Feb 14 | vsSF Austin | L57-66 | 14-12 | .538 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 27 | Mon Feb 16 | vsLamar | W70-65 | 15-12 | .556 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 28 | Sat Feb 21 | atSE Louisiana | W96-75 | 16-12 | .571 | - | ESPN+ | University Center (LA) · Hammond, LA |
| 29 | Mon Feb 23 | atMcNeese | L68-75 | 16-13 | .552 | - | ESPN+ | Legacy Center · Lake Charles, LA |
| 30 | Sat Feb 28 | vsE Texas A&M | W63-55 | 17-13 | .567 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
