| 1 | Wed Jan 13 | vs Blackhawks | W5-1 | 1-0-0 | 2 PTS | AMALIE Arena · Tampa, FL |
| 2 | Fri Jan 15 | vsBlackhawks | W5-2 | 2-0-0 | 4 PTS | AMALIE Arena · Tampa, FL |
| 3 | Thu Jan 21 | atJackets | W3-2 (OT) | 3-0-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 4 | Sat Jan 23 | atJackets | L2-5 | 3-1-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 5 | Thu Jan 28 | atHurricanes | L0-1 (OT) | 3-1-1 | 7 PTS | PNC Arena · Raleigh, NC |
| 6 | Sat Jan 30 | vsPredators | W4-3 | 4-1-1 | 9 PTS | AMALIE Arena · Tampa, FL |
| 7 | Mon Feb 1 | vsPredators | W5-2 | 5-1-1 | 11 PTS | AMALIE Arena · Tampa, FL |
| 8 | Wed Feb 3 | vsRed Wings | W5-1 | 6-1-1 | 13 PTS | AMALIE Arena · Tampa, FL |
| 9 | Fri Feb 5 | vsRed Wings | W3-1 | 7-1-1 | 15 PTS | AMALIE Arena · Tampa, FL |
| 10 | Mon Feb 8 | atPredators | W4-1 | 8-1-1 | 17 PTS | Bridgestone Arena · Nashville, TN |
| 11 | Tue Feb 9 | atPredators | W6-1 | 9-1-1 | 19 PTS | Bridgestone Arena · Nashville, TN |
| 12 | Thu Feb 11 | atPanthers | L2-5 | 9-2-1 | 19 PTS | Amerant Bank Arena · Sunrise, FL |
| 13 | Sat Feb 13 | atPanthers | W6-1 | 10-2-1 | 21 PTS | Amerant Bank Arena · Sunrise, FL |
| 14 | Mon Feb 15 | vsPanthers | L4-6 | 10-3-1 | 21 PTS | AMALIE Arena · Tampa, FL |
| 15 | Sat Feb 20 | atHurricanes | L0-4 | 10-4-1 | 21 PTS | PNC Arena · Raleigh, NC |
| 16 | Mon Feb 22 | atHurricanes | W4-2 | 11-4-1 | 23 PTS | PNC Arena · Raleigh, NC |
| 17 | Wed Feb 24 | vsHurricanes | W3-0 | 12-4-1 | 25 PTS | AMALIE Arena · Tampa, FL |
| 18 | Thu Feb 25 | vsHurricanes | W3-1 | 13-4-1 | 27 PTS | AMALIE Arena · Tampa, FL |
| 19 | Sat Feb 27 | vsStars | W5-0 | 14-4-1 | 29 PTS | AMALIE Arena · Tampa, FL |
| 20 | Tue Mar 2 | atStars | W2-0 | 15-4-1 | 31 PTS | American Airlines Center · Dallas, TX |
| 21 | Thu Mar 4 | atBlackhawks | W3-2 (OT) | 16-4-1 | 33 PTS | United Center · Chicago, IL |
| 22 | Fri Mar 5 | atBlackhawks | L3-4 (SO) | 16-4-2 | 34 PTS | United Center · Chicago, IL |
| 23 | Sun Mar 7 | atBlackhawks | W6-3 | 17-4-2 | 36 PTS | United Center · Chicago, IL |
| 24 | Tue Mar 9 | atRed Wings | W4-3 (OT) | 18-4-2 | 38 PTS | Little Caesars Arena · Detroit, MI |
| 25 | Thu Mar 11 | atRed Wings | L4-6 | 18-5-2 | 38 PTS | Little Caesars Arena · Detroit, MI |
| 26 | Sat Mar 13 | vsPredators | W6-3 | 19-5-2 | 40 PTS | AMALIE Arena · Tampa, FL |
| 27 | Mon Mar 15 | vsPredators | L1-4 | 19-6-2 | 40 PTS | AMALIE Arena · Tampa, FL |
| 28 | Tue Mar 16 | atStars | W4-3 (SO) | 20-6-2 | 42 PTS | American Airlines Center · Dallas, TX |
| 29 | Thu Mar 18 | vsBlackhawks | W4-2 | 21-6-2 | 44 PTS | AMALIE Arena · Tampa, FL |
| 30 | Sat Mar 20 | vsBlackhawks | W4-1 | 22-6-2 | 46 PTS | AMALIE Arena · Tampa, FL |
| 31 | Sun Mar 21 | vsPanthers | W5-3 | 23-6-2 | 48 PTS | AMALIE Arena · Tampa, FL |
| 32 | Tue Mar 23 | atStars | W2-1 | 24-6-2 | 50 PTS | American Airlines Center · Dallas, TX |
| 33 | Thu Mar 25 | atStars | L3-4 | 24-7-2 | 50 PTS | American Airlines Center · Dallas, TX |
| 34 | Sat Mar 27 | atHurricanes | L3-4 | 24-8-2 | 50 PTS | PNC Arena · Raleigh, NC |
| 35 | Tue Mar 30 | vsJackets | L1-3 | 24-9-2 | 50 PTS | AMALIE Arena · Tampa, FL |
| 36 | Thu Apr 1 | vsJackets | W3-2 | 25-9-2 | 52 PTS | AMALIE Arena · Tampa, FL |
| 37 | Sat Apr 3 | vsRed Wings | W2-1 | 26-9-2 | 54 PTS | AMALIE Arena · Tampa, FL |
| 38 | Sun Apr 4 | vsRed Wings | L1-5 | 26-10-2 | 54 PTS | AMALIE Arena · Tampa, FL |
| 39 | Tue Apr 6 | atJackets | L2-4 | 26-11-2 | 54 PTS | Nationwide Arena · Columbus, OH |
| 40 | Thu Apr 8 | atJackets | W6-4 | 27-11-2 | 56 PTS | Nationwide Arena · Columbus, OH |
| 41 | Sat Apr 10 | atPredators | W3-0 | 28-11-2 | 58 PTS | Bridgestone Arena · Nashville, TN |
| 42 | Tue Apr 13 | atPredators | L2-7 | 28-12-2 | 58 PTS | Bridgestone Arena · Nashville, TN |
| 43 | Thu Apr 15 | vsPanthers | W3-2 (OT) | 29-12-2 | 60 PTS | AMALIE Arena · Tampa, FL |
| 44 | Sat Apr 17 | vsPanthers | L3-5 | 29-13-2 | 60 PTS | AMALIE Arena · Tampa, FL |
| 45 | Mon Apr 19 | vsHurricanes | W3-2 (OT) | 30-13-2 | 62 PTS | AMALIE Arena · Tampa, FL |
| 46 | Tue Apr 20 | vsHurricanes | L1-4 | 30-14-2 | 62 PTS | AMALIE Arena · Tampa, FL |
| 47 | Thu Apr 22 | vsJackets | W3-1 | 31-14-2 | 64 PTS | AMALIE Arena · Tampa, FL |
| 48 | Sun Apr 25 | vsJackets | W4-3 (OT) | 32-14-2 | 66 PTS | AMALIE Arena · Tampa, FL |
| 49 | Tue Apr 27 | atBlackhawks | W7-4 | 33-14-2 | 68 PTS | United Center · Chicago, IL |
| 50 | Thu Apr 29 | vsStars | W3-0 | 34-14-2 | 70 PTS | AMALIE Arena · Tampa, FL |
| 51 | Sat May 1 | atRed Wings | L0-1 (SO) | 34-14-3 | 71 PTS | Little Caesars Arena · Detroit, MI |
| 52 | Sun May 2 | atRed Wings | W2-1 | 35-14-3 | 73 PTS | Little Caesars Arena · Detroit, MI |
| 53 | Wed May 5 | vsStars | W6-2 | 36-14-3 | 75 PTS | AMALIE Arena · Tampa, FL |
| 54 | Fri May 7 | vsStars | L2-5 | 36-15-3 | 75 PTS | AMALIE Arena · Tampa, FL |
| 55 | Sat May 8 | atPanthers | L1-5 | 36-16-3 | 75 PTS | Amerant Bank Arena · Sunrise, FL |
| 56 | Mon May 10 | atPanthers | L0-4 | 36-17-3 | 75 PTS | Amerant Bank Arena · Sunrise, FL |
| 1 | Sun May 16 | atPanthers | W5-4 | 1-0 | 1.000 | Amerant Bank Arena · Sunrise, FL |
| 2 | Tue May 18 | atPanthers | W3-1 | 2-0 | 1.000 | Amerant Bank Arena · Sunrise, FL |
| 3 | Thu May 20 | vsPanthers | L5-6 (OT) | 2-1 | .667 | AMALIE Arena · Tampa, FL |
| 4 | Sat May 22 | vsPanthers | W6-2 | 3-1 | .750 | AMALIE Arena · Tampa, FL |
| 5 | Mon May 24 | atPanthers | L1-4 | 3-2 | .600 | Amerant Bank Arena · Sunrise, FL |
| 6 | Wed May 26 | vsPanthers | W4-0 | 4-2 | .667 | AMALIE Arena · Tampa, FL |
| 1 | Sun May 30 | atHurricanes | W2-1 | 1-0 | 1.000 | PNC Arena · Raleigh, NC |
| 2 | Tue Jun 1 | atHurricanes | W2-1 | 2-0 | 1.000 | PNC Arena · Raleigh, NC |
| 3 | Thu Jun 3 | vsHurricanes | L2-3 (OT) | 2-1 | .667 | AMALIE Arena · Tampa, FL |
| 4 | Sat Jun 5 | vsHurricanes | W6-4 | 3-1 | .750 | AMALIE Arena · Tampa, FL |
| 5 | Tue Jun 8 | atHurricanes | W2-0 | 4-1 | .800 | PNC Arena · Raleigh, NC |
| 1 | Sun Jun 13 | vsIslanders | L1-2 | 0-1 | .000 | AMALIE Arena · Tampa, FL |
| 2 | Tue Jun 15 | vsIslanders | W4-2 | 1-1 | .500 | AMALIE Arena · Tampa, FL |
| 3 | Thu Jun 17 | atIslanders | W2-1 | 2-1 | .667 | UBS Arena · Elmont, NY |
| 4 | Sat Jun 19 | atIslanders | L2-3 | 2-2 | .500 | UBS Arena · Elmont, NY |
| 5 | Mon Jun 21 | vsIslanders | W8-0 | 3-2 | .600 | AMALIE Arena · Tampa, FL |
| 6 | Wed Jun 23 | atIslanders | L2-3 (OT) | 3-3 | .500 | UBS Arena · Elmont, NY |
| 7 | Fri Jun 25 | vsIslanders | W1-0 | 4-3 | .571 | AMALIE Arena · Tampa, FL |
| 1 | Mon Jun 28 | vsCanadiens | W5-1 | 1-0 | 1.000 | AMALIE Arena · Tampa, FL |
| 2 | Wed Jun 30 | vsCanadiens | W3-1 | 2-0 | 1.000 | AMALIE Arena · Tampa, FL |
| 3 | Fri Jul 2 | atCanadiens | W6-3 | 3-0 | 1.000 | Bell Centre · Montreal, QC |
| 4 | Mon Jul 5 | atCanadiens | L2-3 (OT) | 3-1 | .750 | Bell Centre · Montreal, QC |
| 5 | Wed Jul 7 | vsCanadiens | W1-0 | 4-1 | .800 | AMALIE Arena · Tampa, FL |
