| 1 | Tue Oct 11 | at Rangers | L1-3 | 0-1-0 | 0 PTS | Madison Square Garden · Manhattan, NY |
| 2 | Fri Oct 14 | atJackets | W5-2 | 1-1-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 3 | Sat Oct 15 | atPenguins | L2-6 | 1-2-0 | 2 PTS | PPG Paints Arena · Pittsburgh, PA |
| 4 | Tue Oct 18 | vsFlyers | L2-3 | 1-3-0 | 2 PTS | AMALIE Arena · Tampa, FL |
| 5 | Fri Oct 21 | atPanthers | W3-2 (OT) | 2-3-0 | 4 PTS | Amerant Bank Arena · Sunrise, FL |
| 6 | Sat Oct 22 | vsIslanders | W5-3 | 3-3-0 | 6 PTS | AMALIE Arena · Tampa, FL |
| 7 | Tue Oct 25 | atKings | L2-4 | 3-4-0 | 6 PTS | Crypto.com Arena · Los Angeles, CA |
| 8 | Wed Oct 26 | atDucks | W4-2 | 4-4-0 | 8 PTS | Honda Center · Anaheim, CA |
| 9 | Sat Oct 29 | atSharks | W4-3 | 5-4-0 | 10 PTS | SAP Center · San Jose, CA |
| 10 | Tue Nov 1 | vsSenators | W4-3 | 6-4-0 | 12 PTS | AMALIE Arena · Tampa, FL |
| 11 | Thu Nov 3 | vsHurricanes | L3-4 (SO) | 6-4-1 | 13 PTS | AMALIE Arena · Tampa, FL |
| 12 | Sat Nov 5 | vsSabres | W5-3 | 7-4-1 | 15 PTS | AMALIE Arena · Tampa, FL |
| 13 | Tue Nov 8 | vsOilers | L2-3 | 7-5-1 | 15 PTS | AMALIE Arena · Tampa, FL |
| 14 | Fri Nov 11 | atCapitals | L1-5 | 7-6-1 | 15 PTS | Capital One Arena · Washington, D.C. |
| 15 | Sun Nov 13 | vsCapitals | W6-3 | 8-6-1 | 17 PTS | AMALIE Arena · Tampa, FL |
| 16 | Tue Nov 15 | vsStars | W5-4 (OT) | 9-6-1 | 19 PTS | AMALIE Arena · Tampa, FL |
| 17 | Thu Nov 17 | vsFlames | W4-1 | 10-6-1 | 21 PTS | AMALIE Arena · Tampa, FL |
| 18 | Sat Nov 19 | atPredators | W3-2 (OT) | 11-6-1 | 23 PTS | Bridgestone Arena · Nashville, TN |
| 19 | Mon Nov 21 | vsBruins | L3-5 | 11-7-1 | 23 PTS | AMALIE Arena · Tampa, FL |
| 20 | Fri Nov 25 | vsBlues | W5-2 | 12-7-1 | 25 PTS | AMALIE Arena · Tampa, FL |
| 21 | Mon Nov 28 | atSabres | W6-5 (OT) | 13-7-1 | 27 PTS | KeyBank Center · Buffalo, NY |
| 22 | Tue Nov 29 | atBruins | L1-3 | 13-8-1 | 27 PTS | TD Garden · Boston, MA |
| 23 | Thu Dec 1 | atFlyers | W4-1 | 14-8-1 | 29 PTS | Wells Fargo Center · Philadelphia, PA |
| 24 | Sat Dec 3 | vsMaple Leafs | W4-3 (OT) | 15-8-1 | 31 PTS | AMALIE Arena · Tampa, FL |
| 25 | Tue Dec 6 | vsRed Wings | L2-4 | 15-9-1 | 31 PTS | AMALIE Arena · Tampa, FL |
| 26 | Thu Dec 8 | vsPredators | W5-2 | 16-9-1 | 33 PTS | AMALIE Arena · Tampa, FL |
| 27 | Sat Dec 10 | vsPanthers | W4-1 | 17-9-1 | 35 PTS | AMALIE Arena · Tampa, FL |
| 28 | Tue Dec 13 | vsKraken | W6-2 | 18-9-1 | 37 PTS | AMALIE Arena · Tampa, FL |
| 29 | Thu Dec 15 | vsJackets | W4-1 | 19-9-1 | 39 PTS | AMALIE Arena · Tampa, FL |
| 30 | Sat Dec 17 | atCanadiens | W5-1 | 20-9-1 | 41 PTS | Bell Centre · Montreal, QC |
| 31 | Tue Dec 20 | atMaple Leafs | L1-4 | 20-10-1 | 41 PTS | Scotiabank Arena · Toronto, ON |
| 32 | Wed Dec 21 | atRed Wings | L4-7 | 20-11-1 | 41 PTS | Little Caesars Arena · Detroit, MI |
| 33 | Wed Dec 28 | vsCanadiens | W4-1 | 21-11-1 | 43 PTS | AMALIE Arena · Tampa, FL |
| 34 | Thu Dec 29 | vsRangers | W2-1 (SO) | 22-11-1 | 45 PTS | AMALIE Arena · Tampa, FL |
| 35 | Sat Dec 31 | vsCoyotes | W5-3 | 23-11-1 | 47 PTS | AMALIE Arena · Tampa, FL |
| 36 | Tue Jan 3 | atBlackhawks | W4-1 | 24-11-1 | 49 PTS | United Center · Chicago, IL |
| 37 | Wed Jan 4 | atWild | L1-5 | 24-12-1 | 49 PTS | Xcel Energy Center · St. Paul, MN |
| 38 | Fri Jan 6 | atJets | L2-4 | 24-13-1 | 49 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 39 | Tue Jan 10 | vsJackets | W6-3 | 25-13-1 | 51 PTS | AMALIE Arena · Tampa, FL |
| 40 | Thu Jan 12 | vsCanucks | W5-4 | 26-13-1 | 53 PTS | AMALIE Arena · Tampa, FL |
| 41 | Sat Jan 14 | atBlues | W4-2 | 27-13-1 | 55 PTS | Enterprise Center · St. Louis, MO |
| 42 | Mon Jan 16 | atKraken | W4-1 | 28-13-1 | 57 PTS | Climate Pledge Arena · Seattle, WA |
| 43 | Wed Jan 18 | atCanucks | W5-2 | 29-13-1 | 59 PTS | Rogers Arena · Vancouver, British Columbia |
| 44 | Thu Jan 19 | atOilers | L3-5 | 29-14-1 | 59 PTS | Rogers Place · Edmonton, AB |
| 45 | Sat Jan 21 | atFlames | L3-6 | 29-15-1 | 59 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 46 | Tue Jan 24 | vsWild | W4-2 | 30-15-1 | 61 PTS | AMALIE Arena · Tampa, FL |
| 47 | Thu Jan 26 | vsBruins | W3-2 | 31-15-1 | 63 PTS | AMALIE Arena · Tampa, FL |
| 48 | Sat Jan 28 | vsKings | W5-2 | 32-15-1 | 65 PTS | AMALIE Arena · Tampa, FL |
| 49 | Mon Feb 6 | atPanthers | L1-7 | 32-16-1 | 65 PTS | Amerant Bank Arena · Sunrise, FL |
| 50 | Tue Feb 7 | vsSharks | L3-4 (OT) | 32-16-2 | 66 PTS | AMALIE Arena · Tampa, FL |
| 51 | Thu Feb 9 | vsAvalanche | W5-0 | 33-16-2 | 68 PTS | AMALIE Arena · Tampa, FL |
| 52 | Sat Feb 11 | atStars | W3-1 | 34-16-2 | 70 PTS | American Airlines Center · Dallas, TX |
| 53 | Tue Feb 14 | atAvalanche | W4-3 (SO) | 35-16-2 | 72 PTS | Ball Arena · Denver, CO |
| 54 | Wed Feb 15 | atCoyotes | L0-1 (SO) | 35-16-3 | 73 PTS | Mullett Arena · Tempe, AZ |
| 55 | Sat Feb 18 | atKnights | L4-5 | 35-17-3 | 73 PTS | T-Mobile Arena · Las Vegas, NV |
| 56 | Tue Feb 21 | vsDucks | W6-1 | 36-17-3 | 75 PTS | AMALIE Arena · Tampa, FL |
| 57 | Thu Feb 23 | vsSabres | L5-6 (OT) | 36-17-4 | 76 PTS | AMALIE Arena · Tampa, FL |
| 58 | Sat Feb 25 | atRed Wings | W3-0 | 37-17-4 | 78 PTS | Little Caesars Arena · Detroit, MI |
| 59 | Sun Feb 26 | atPenguins | L3-7 | 37-18-4 | 78 PTS | PPG Paints Arena · Pittsburgh, PA |
| 60 | Tue Feb 28 | vsPanthers | L1-4 | 37-19-4 | 78 PTS | AMALIE Arena · Tampa, FL |
| 61 | Thu Mar 2 | vsPenguins | L4-5 (OT) | 37-19-5 | 79 PTS | AMALIE Arena · Tampa, FL |
| 62 | Sat Mar 4 | atSabres | L3-5 | 37-20-5 | 79 PTS | KeyBank Center · Buffalo, NY |
| 63 | Sun Mar 5 | atHurricanes | L0-6 | 37-21-5 | 79 PTS | PNC Arena · Raleigh, NC |
| 64 | Tue Mar 7 | vsFlyers | W5-2 | 38-21-5 | 81 PTS | AMALIE Arena · Tampa, FL |
| 65 | Thu Mar 9 | vsKnights | L3-4 (OT) | 38-21-6 | 82 PTS | AMALIE Arena · Tampa, FL |
| 66 | Sat Mar 11 | vsBlackhawks | W3-1 | 39-21-6 | 84 PTS | AMALIE Arena · Tampa, FL |
| 67 | Sun Mar 12 | vsJets | L2-3 | 39-22-6 | 84 PTS | AMALIE Arena · Tampa, FL |
| 68 | Tue Mar 14 | atDevils | W4-1 | 40-22-6 | 86 PTS | Prudential Center · Newark, NJ |
| 69 | Thu Mar 16 | atDevils | W4-3 (SO) | 41-22-6 | 88 PTS | Prudential Center · Newark, NJ |
| 70 | Sat Mar 18 | vsCanadiens | W5-3 | 42-22-6 | 90 PTS | AMALIE Arena · Tampa, FL |
| 71 | Sun Mar 19 | vsDevils | L2-5 | 42-23-6 | 90 PTS | AMALIE Arena · Tampa, FL |
| 72 | Tue Mar 21 | atCanadiens | L2-3 | 42-24-6 | 90 PTS | Bell Centre · Montreal, QC |
| 73 | Thu Mar 23 | atSenators | L2-7 | 42-25-6 | 90 PTS | Canadian Tire Centre · Ottawa, ON |
| 74 | Sat Mar 25 | atBruins | L1-2 | 42-26-6 | 90 PTS | TD Garden · Boston, MA |
| 75 | Tue Mar 28 | atHurricanes | W4-0 | 43-26-6 | 92 PTS | PNC Arena · Raleigh, NC |
| 76 | Thu Mar 30 | vsCapitals | W5-1 | 44-26-6 | 94 PTS | AMALIE Arena · Tampa, FL |
| 77 | Sat Apr 1 | vsIslanders | W5-0 | 45-26-6 | 96 PTS | AMALIE Arena · Tampa, FL |
| 78 | Wed Apr 5 | atRangers | L3-6 | 45-27-6 | 96 PTS | Madison Square Garden · Manhattan, NY |
| 79 | Thu Apr 6 | atIslanders | L1-6 | 45-28-6 | 96 PTS | UBS Arena · Elmont, NY |
| 80 | Sat Apr 8 | atSenators | L4-7 | 45-29-6 | 96 PTS | Canadian Tire Centre · Ottawa, ON |
| 81 | Tue Apr 11 | vsMaple Leafs | L3-4 | 45-30-6 | 96 PTS | AMALIE Arena · Tampa, FL |
| 82 | Thu Apr 13 | vsRed Wings | W5-0 | 46-30-6 | 98 PTS | AMALIE Arena · Tampa, FL |
| 1 | Tue Apr 18 | atMaple Leafs | W7-3 | 1-0 | 1.000 | Scotiabank Arena · Toronto, ON |
| 2 | Thu Apr 20 | atMaple Leafs | L2-7 | 1-1 | .500 | Scotiabank Arena · Toronto, ON |
| 3 | Sat Apr 22 | vsMaple Leafs | L3-4 (OT) | 1-2 | .333 | AMALIE Arena · Tampa, FL |
| 4 | Mon Apr 24 | vsMaple Leafs | L4-5 (OT) | 1-3 | .250 | AMALIE Arena · Tampa, FL |
| 5 | Thu Apr 27 | atMaple Leafs | W4-2 | 2-3 | .400 | Scotiabank Arena · Toronto, ON |
| 6 | Sat Apr 29 | vsMaple Leafs | L1-2 (OT) | 2-4 | .333 | AMALIE Arena · Tampa, FL |
