| 1 | Fri Apr 1 | vs Mets | W6-2 | 1-0 | 1.000 | MVP Arena · Albany, NY |
| 2 | Sat Apr 2 | vs Mets | L4-6 (10) | 1-1 | .500 | MVP Arena · Albany, NY |
| 3 | Sun Apr 3 | vs Mets | L2-9 | 1-2 | .333 | MVP Arena · Albany, NY |
| 4 | Tue Apr 5 | vs Nationals | W3-2 (10) | 2-2 | .500 | MVP Arena · Albany, NY |
| 5 | Wed Apr 6 | vs Nationals | W7-4 | 3-2 | .600 | MVP Arena · Albany, NY |
| 6 | Thu Apr 7 | vs Nationals | L3-5 (11) | 3-3 | .500 | MVP Arena · Albany, NY |
| 7 | Fri Apr 8 | at Astros | W4-3 | 4-3 | .571 | Minute Maid Park · Houston, TX |
| 8 | Sat Apr 9 | at Astros | W7-5 | 5-3 | .625 | Minute Maid Park · Houston, TX |
| 9 | Sun Apr 10 | at Astros | L1-7 | 5-4 | .556 | Minute Maid Park · Houston, TX |
| 10 | Tue Apr 12 | at Braves | L0-5 | 5-5 | .500 | Truist Park · Cumberland, GA |
| 11 | Wed Apr 13 | at Braves | W5-1 | 6-5 | .545 | Truist Park · Cumberland, GA |
| 12 | Thu Apr 14 | at Braves | W6-5 | 7-5 | .583 | Truist Park · Cumberland, GA |
| 13 | Fri Apr 15 | at Phillies | W4-3 | 8-5 | .615 | Citizens Bank Park · Philadelphi, PA |
| 14 | Sun Apr 17 | at Phillies | L2-3 | 8-6 | .571 | Citizens Bank Park · Philadelphi, PA |
| 15 | Tue Apr 19 | vs Pirates | W6-0 | 9-6 | .600 | MVP Arena · Albany, NY |
| 16 | Wed Apr 20 | vs Pirates | W6-0 | 10-6 | .625 | MVP Arena · Albany, NY |
| 17 | Thu Apr 21 | vs Pirates | W9-5 | 11-6 | .647 | MVP Arena · Albany, NY |
| 18 | Fri Apr 22 | vs Rockies | W4-1 | 12-6 | .667 | MVP Arena · Albany, NY |
| 19 | Sat Apr 23 | vs Rockies | L1-3 | 12-7 | .632 | MVP Arena · Albany, NY |
| 20 | Sun Apr 24 | vs Rockies | W6-3 | 13-7 | .650 | MVP Arena · Albany, NY |
| 21 | Mon Apr 25 | vs Dodgers | W5-4 | 14-7 | .667 | MVP Arena · Albany, NY |
| 22 | Tue Apr 26 | vs Dodgers | W4-2 | 15-7 | .682 | MVP Arena · Albany, NY |
| 23 | Wed Apr 27 | vs Dodgers | L4-5 (10) | 15-8 | .652 | MVP Arena · Albany, NY |
| 24 | Fri Apr 29 | at Reds | W7-6 | 16-8 | .667 | Great American Ball Park · Cincinnati, OH |
| 25 | Sat Apr 30 | at Reds | L3-4 (10) | 16-9 | .640 | Great American Ball Park · Cincinnati, OH |
| 26 | Sun May 1 | at Reds | W9-5 | 17-9 | .654 | Great American Ball Park · Cincinnati, OH |
| 27 | Mon May 2 | at Cardinals | W6-5 | 18-9 | .667 | Busch Stadium · St. Louis, MO |
| 28 | Tue May 3 | at Cardinals | L5-7 | 18-10 | .643 | Busch Stadium · St. Louis, MO |
| 29 | Wed May 4 | at Cardinals | W8-7 | 19-10 | .655 | Busch Stadium · St. Louis, MO |
| 30 | Thu May 5 | at Cardinals | L3-6 | 19-11 | .633 | Busch Stadium · St. Louis, MO |
| 31 | Fri May 6 | vs Nationals | L2-3 (10) | 19-12 | .613 | MVP Arena · Albany, NY |
| 32 | Sat May 7 | vs Nationals | L2-5 | 19-13 | .594 | MVP Arena · Albany, NY |
| 33 | Sun May 8 | vs Nationals | W8-0 | 20-13 | .606 | MVP Arena · Albany, NY |
| 34 | Mon May 9 | vs Phillies | L4-6 | 20-14 | .588 | MVP Arena · Albany, NY |
| 35 | Tue May 10 | vs Phillies | W2-1 | 21-14 | .600 | MVP Arena · Albany, NY |
| 36 | Wed May 11 | vs Phillies | L3-5 | 21-15 | .583 | MVP Arena · Albany, NY |
| 37 | Fri May 13 | at Nationals | W6-5 (11) | 22-15 | .595 | Nationals Park · Washington, D.C. |
| 38 | Sat May 14 | at Nationals | W1-0 | 23-15 | .605 | Nationals Park · Washington, D.C. |
| 39 | Sun May 15 | at Nationals | L4-8 | 23-16 | .590 | Nationals Park · Washington, D.C. |
| 40 | Mon May 16 | at Mets | W2-1 (11) | 24-16 | .600 | Citi Field · Queens, NY |
| 41 | Wed May 18 | vs Cubs | L5-7 | 24-17 | .585 | MVP Arena · Albany, NY |
| 42 | Thu May 19 | vs Cubs | L1-5 | 24-18 | .571 | MVP Arena · Albany, NY |
| 43 | Fri May 20 | vs Rays | W5-3 | 25-18 | .581 | MVP Arena · Albany, NY |
| 44 | Sat May 21 | vs Rays | W5-3 | 26-18 | .591 | MVP Arena · Albany, NY |
| 45 | Sun May 22 | vs Rays | L0-4 | 26-19 | .578 | MVP Arena · Albany, NY |
| 46 | Tue May 24 | at Giants | W5-1 | 27-19 | .587 | Oracle Park · San Francisco, CA |
| 47 | Wed May 25 | at Giants | W7-6 (12) | 28-19 | .596 | Oracle Park · San Francisco, CA |
| 48 | Thu May 26 | at Giants | W1-0 | 29-19 | .604 | Oracle Park · San Francisco, CA |
| 49 | Fri May 27 | at Dodgers | L2-3 | 29-20 | .592 | Dodger Stadium · Los Angeles, CA |
| 50 | Sat May 28 | at Dodgers | W6-1 | 30-20 | .600 | Dodger Stadium · Los Angeles, CA |
| 51 | Sun May 29 | at Dodgers | L0-8 | 30-21 | .588 | Dodger Stadium · Los Angeles, CA |
| 52 | Mon May 30 | at D-backs | L4-15 | 30-22 | .577 | Chase Field · Phoenix, AZ |
| 53 | Tue May 31 | at D-backs | W5-2 | 31-22 | .585 | Chase Field · Phoenix, AZ |
| 54 | Wed Jun 1 | at D-backs | L5-6 | 31-23 | .574 | Chase Field · Phoenix, AZ |
| 55 | Fri Jun 3 | vs Brewers | L5-6 | 31-24 | .564 | MVP Arena · Albany, NY |
| 56 | Sat Jun 4 | vs Brewers | L2-3 | 31-25 | .554 | MVP Arena · Albany, NY |
| 57 | Sun Jun 5 | vs Brewers | L5-6 (11) | 31-26 | .544 | MVP Arena · Albany, NY |
| 58 | Mon Jun 6 | vs Brewers | L2-7 | 31-27 | .534 | MVP Arena · Albany, NY |
| 59 | Tue Jun 7 | vs Braves | L0-1 | 31-28 | .525 | MVP Arena · Albany, NY |
| 60 | Wed Jun 8 | vs Braves | L2-3 (10) | 31-29 | .517 | MVP Arena · Albany, NY |
| 61 | Thu Jun 9 | vs Braves | L2-3 | 31-30 | .508 | MVP Arena · Albany, NY |
| 62 | Fri Jun 10 | vs D-backs | W6-4 | 32-30 | .516 | MVP Arena · Albany, NY |
| 63 | Sat Jun 11 | vs D-backs | L5-9 | 32-31 | .508 | MVP Arena · Albany, NY |
| 64 | Sun Jun 12 | vs D-backs | L1-5 | 32-32 | .500 | MVP Arena · Albany, NY |
| 65 | Mon Jun 13 | vs D-backs | L9-12 | 32-33 | .492 | MVP Arena · Albany, NY |
| 66 | Tue Jun 14 | at Phillies | L1-9 | 32-34 | .485 | Citizens Bank Park · Philadelphi, PA |
| 67 | Wed Jun 15 | at Phillies | L1-8 | 32-35 | .478 | Citizens Bank Park · Philadelphi, PA |
| 68 | Wed Jun 15 | at Phillies | L4-5 (10) | 32-36 | .471 | Citizens Bank Park · Philadelphi, PA |
| 69 | Thu Jun 16 | at Phillies | L0-3 | 32-37 | .464 | Citizens Bank Park · Philadelphi, PA |
| 70 | Fri Jun 17 | at Rays | L1-5 | 32-38 | .457 | Tropicana Field · St. Petersburg, FL |
| 71 | Sat Jun 18 | at Rays | L4-7 | 32-39 | .451 | Tropicana Field · St. Petersburg, FL |
| 72 | Sun Jun 19 | at Rays | L1-2 | 32-40 | .444 | Tropicana Field · St. Petersburg, FL |
| 73 | Mon Jun 20 | vs Angels | L1-2 | 32-41 | .438 | MVP Arena · Albany, NY |
| 74 | Tue Jun 21 | vs Angels | W5-2 | 33-41 | .446 | MVP Arena · Albany, NY |
| 75 | Wed Jun 22 | vs Angels | L5-6 (10) | 33-42 | .440 | MVP Arena · Albany, NY |
| 76 | Fri Jun 24 | vs Mariners | L1-5 | 33-43 | .434 | T-Mobile Park · Seattle, WA |
| 77 | Sat Jun 25 | vs Mariners | W4-2 | 34-43 | .442 | T-Mobile Park · Seattle, WA |
| 78 | Sun Jun 26 | vs Mariners | L1-2 (10) | 34-44 | .436 | T-Mobile Park · Seattle, WA |
| 79 | Tue Jun 28 | at Athletics | L0-1 | 34-45 | .430 | RingCentral Coliseum · Oakland, CA |
| 80 | Wed Jun 29 | at Athletics | W3-0 | 35-45 | .438 | RingCentral Coliseum · Oakland, CA |
| 81 | Thu Jun 30 | at Athletics | W5-4 | 36-45 | .444 | RingCentral Coliseum · Oakland, CA |
| 82 | Fri Jul 1 | at Rangers | L5-15 | 36-46 | .439 | Globe Life Field · Arlington, TX |
| 83 | Sat Jul 2 | at Rangers | W9-5 | 37-46 | .446 | Globe Life Field · Arlington, TX |
| 84 | Sun Jul 3 | at Rangers | W6-4 | 38-46 | .452 | Globe Life Field · Arlington, TX |
| 85 | Mon Jul 4 | vs Phillies | L0-1 | 38-47 | .447 | MVP Arena · Albany, NY |
| 86 | Tue Jul 5 | vs Phillies | L2-14 | 38-48 | .442 | MVP Arena · Albany, NY |
| 87 | Wed Jul 6 | vs Phillies | W7-6 (10) | 39-48 | .448 | MVP Arena · Albany, NY |
| 88 | Thu Jul 7 | vs Astros | W5-0 | 40-48 | .455 | MVP Arena · Albany, NY |
| 89 | Fri Jul 8 | vs Astros | W6-3 | 41-48 | .461 | MVP Arena · Albany, NY |
| 90 | Sat Jul 9 | vs Astros | W6-1 | 42-48 | .467 | MVP Arena · Albany, NY |
| 91 | Sun Jul 10 | vs Astros | W5-4 | 43-48 | .473 | MVP Arena · Albany, NY |
| 92 | Thu Jul 14 | at Cubs | W6-3 | 44-48 | .478 | Wrigley Field · Chicago, IL |
| 93 | Fri Jul 15 | at Cubs | L1-2 | 44-49 | .473 | Wrigley Field · Chicago, IL |
| 94 | Sat Jul 16 | at Cubs | W13-3 | 45-49 | .479 | Wrigley Field · Chicago, IL |
| 95 | Sun Jul 17 | at Cubs | W7-5 | 46-49 | .484 | Wrigley Field · Chicago, IL |
| 96 | Mon Jul 18 | at Mets | W4-1 | 47-49 | .490 | Citi Field · Queens, NY |
| 97 | Tue Jul 19 | vs Padres | L0-4 | 47-50 | .485 | MVP Arena · Albany, NY |
| 98 | Wed Jul 20 | vs Padres | L3-14 | 47-51 | .480 | MVP Arena · Albany, NY |
| 99 | Thu Jul 21 | vs Padres | L3-5 | 47-52 | .475 | MVP Arena · Albany, NY |
| 100 | Fri Jul 22 | vs Mets | L6-7 | 47-53 | .470 | MVP Arena · Albany, NY |
| 101 | Sat Jul 23 | vs Mets | W8-5 | 48-53 | .475 | MVP Arena · Albany, NY |
| 102 | Sun Jul 24 | vs Mets | W5-4 | 49-53 | .480 | MVP Arena · Albany, NY |
| 103 | Tue Jul 26 | at Nationals | W11-2 | 50-53 | .485 | Nationals Park · Washington, D.C. |
| 104 | Wed Jul 27 | at Nationals | W7-5 | 51-53 | .490 | Nationals Park · Washington, D.C. |
| 105 | Thu Jul 28 | at Nationals | W5-2 | 52-53 | .495 | Nationals Park · Washington, D.C. |
| 106 | Fri Jul 29 | at Braves | L0-5 | 52-54 | .491 | Truist Park · Cumberland, GA |
| 107 | Sat Jul 30 | at Braves | L1-5 | 52-55 | .486 | Truist Park · Cumberland, GA |
| 108 | Sun Jul 31 | at Braves | W3-1 | 53-55 | .491 | Truist Park · Cumberland, GA |
| 109 | Mon Aug 1 | at Mets | W7-3 (10) | 54-55 | .495 | Citi Field · Queens, NY |
| 110 | Tue Aug 2 | at Mets | W4-3 | 55-55 | .500 | Citi Field · Queens, NY |
| 111 | Thu Aug 4 | vs Cardinals | L4-7 | 55-56 | .495 | MVP Arena · Albany, NY |
| 112 | Fri Aug 5 | vs Cardinals | L2-3 | 55-57 | .491 | MVP Arena · Albany, NY |
| 113 | Sat Aug 6 | vs Cardinals | L1-2 | 55-58 | .487 | MVP Arena · Albany, NY |
| 114 | Sun Aug 7 | vs Cardinals | L4-8 | 55-59 | .482 | MVP Arena · Albany, NY |
| 115 | Mon Aug 8 | vs Braves | L5-8 | 55-60 | .478 | MVP Arena · Albany, NY |
| 116 | Tue Aug 9 | vs Braves | L3-4 (11) | 55-61 | .474 | MVP Arena · Albany, NY |
| 117 | Wed Aug 10 | vs Braves | L2-6 | 55-62 | .470 | MVP Arena · Albany, NY |
| 118 | Fri Aug 12 | vs Giants | W2-1 | 56-62 | .475 | MVP Arena · Albany, NY |
| 119 | Sat Aug 13 | vs Giants | L0-3 | 56-63 | .471 | MVP Arena · Albany, NY |
| 120 | Sun Aug 14 | vs Giants | L2-5 | 56-64 | .467 | MVP Arena · Albany, NY |
| 121 | Mon Aug 15 | at Rockies | L4-7 | 56-65 | .463 | Coors Field · Denver, CO |
| 122 | Tue Aug 16 | at Rockies | W6-5 | 57-65 | .467 | Coors Field · Denver, CO |
| 123 | Wed Aug 17 | at Rockies | L5-12 | 57-66 | .463 | Coors Field · Denver, CO |
| 124 | Thu Aug 18 | at Padres | L1-3 | 57-67 | .460 | Petco Park · San Diego, CA |
| 125 | Fri Aug 19 | at Padres | L3-4 | 57-68 | .456 | Petco Park · San Diego, CA |
| 126 | Sat Aug 20 | at Padres | L1-14 | 57-69 | .452 | Petco Park · San Diego, CA |
| 127 | Sun Aug 21 | at Padres | L3-4 | 57-70 | .449 | Petco Park · San Diego, CA |
| 128 | Tue Aug 23 | vs Reds | L6-8 | 57-71 | .445 | MVP Arena · Albany, NY |
| 129 | Wed Aug 24 | vs Reds | W6-5 | 58-71 | .450 | MVP Arena · Albany, NY |
| 130 | Wed Aug 24 | vs Reds | L2-3 | 58-72 | .446 | MVP Arena · Albany, NY |
| 131 | Fri Aug 26 | at Phillies | W6-5 | 59-72 | .450 | Citizens Bank Park · Philadelphi, PA |
| 132 | Mon Aug 29 | at Mets | L1-2 | 59-73 | .447 | Citi Field · Queens, NY |
| 133 | Mon Aug 29 | at Mets | L1-5 | 59-74 | .444 | Citi Field · Queens, NY |
| 134 | Tue Aug 30 | at Mets | W6-0 | 60-74 | .448 | Citi Field · Queens, NY |
| 135 | Wed Aug 31 | at Mets | L2-3 | 60-75 | .444 | Citi Field · Queens, NY |
| 136 | Thu Sep 1 | at Mets | L5-7 | 60-76 | .441 | Citi Field · Queens, NY |
| 137 | Fri Sep 2 | vs Phillies | L3-5 | 60-77 | .438 | MVP Arena · Albany, NY |
| 138 | Sat Sep 3 | vs Phillies | W8-4 | 61-77 | .442 | MVP Arena · Albany, NY |
| 139 | Sun Sep 4 | vs Phillies | W5-4 (14) | 62-77 | .446 | MVP Arena · Albany, NY |
| 140 | Mon Sep 5 | vs Mets | W9-3 | 63-77 | .450 | MVP Arena · Albany, NY |
| 141 | Tue Sep 6 | vs Mets | L4-7 (12) | 63-78 | .447 | MVP Arena · Albany, NY |
| 142 | Wed Sep 7 | vs Mets | L0-1 | 63-79 | .444 | MVP Arena · Albany, NY |
| 143 | Fri Sep 9 | at Pirates | W13-4 | 64-79 | .448 | PNC Park · Pittsburgh, PA |
| 144 | Sat Sep 10 | at Pirates | W3-0 | 65-79 | .451 | PNC Park · Pittsburgh, PA |
| 145 | Sun Sep 11 | at Pirates | W4-1 | 66-79 | .455 | PNC Park · Pittsburgh, PA |
| 146 | Mon Sep 12 | at Braves | W5-4 (12) | 67-79 | .459 | Truist Park · Cumberland, GA |
| 147 | Tue Sep 13 | at Braves | L1-7 | 67-80 | .456 | Truist Park · Cumberland, GA |
| 148 | Wed Sep 14 | at Braves | L1-4 | 67-81 | .453 | Truist Park · Cumberland, GA |
| 149 | Thu Sep 15 | at Phillies | L1-3 | 67-82 | .450 | Citizens Bank Park · Philadelphi, PA |
| 150 | Thu Sep 15 | at Phillies | L1-2 (10) | 67-83 | .447 | Citizens Bank Park · Philadelphi, PA |
| 151 | Fri Sep 16 | at Nationals | W3-0 | 68-83 | .450 | Nationals Park · Washington, D.C. |
| 152 | Sat Sep 17 | at Nationals | W4-1 (13) | 69-83 | .454 | Nationals Park · Washington, D.C. |
| 153 | Sun Sep 18 | at Nationals | L3-4 | 69-84 | .451 | Nationals Park · Washington, D.C. |
| 154 | Mon Sep 19 | vs Braves | W6-5 | 70-84 | .455 | MVP Arena · Albany, NY |
| 155 | Tue Sep 20 | vs Braves | L0-4 | 70-85 | .452 | MVP Arena · Albany, NY |
| 156 | Wed Sep 21 | vs Braves | W4-0 | 71-85 | .455 | MVP Arena · Albany, NY |
| 157 | Fri Sep 23 | at Brewers | L1-4 | 71-86 | .452 | American Family Field · Milwaukee, WI |
| 158 | Sat Sep 24 | at Brewers | L4-6 | 71-87 | .449 | American Family Field · Milwaukee, WI |
| 159 | Sun Sep 25 | at Brewers | L5-9 | 71-88 | .447 | American Family Field · Milwaukee, WI |
| 160 | Mon Sep 26 | vs Nationals | L4-6 | 71-89 | .444 | MVP Arena · Albany, NY |
| 161 | Tue Sep 27 | vs Nationals | W3-2 | 72-89 | .447 | MVP Arena · Albany, NY |
| 162 | Wed Sep 28 | vs Nationals | L1-3 | 72-90 | .444 | MVP Arena · Albany, NY |