| 1 | Thu Mar 30 | vs Mets | L3-5 | 0-1 | .000 | LoanDepot Park · Miami, FL |
| 2 | Fri Mar 31 | vs Mets | W2-1 | 1-1 | .500 | LoanDepot Park · Miami, FL |
| 3 | Sat Apr 1 | vs Mets | L2-6 | 1-2 | .333 | LoanDepot Park · Miami, FL |
| 4 | Sun Apr 2 | vs Mets | L1-5 | 1-3 | .250 | LoanDepot Park · Miami, FL |
| 5 | Mon Apr 3 | vs Twins | L1-11 | 1-4 | .200 | LoanDepot Park · Miami, FL |
| 6 | Tue Apr 4 | vs Twins | W1-0 | 2-4 | .333 | LoanDepot Park · Miami, FL |
| 7 | Wed Apr 5 | vs Twins | W5-2 | 3-4 | .429 | LoanDepot Park · Miami, FL |
| 8 | Fri Apr 7 | at Mets | L3-9 | 3-5 | .375 | Citi Field · Queens, NY |
| 9 | Sat Apr 8 | at Mets | L2-5 | 3-6 | .333 | Citi Field · Queens, NY |
| 10 | Sun Apr 9 | at Mets | W7-2 | 4-6 | .400 | Citi Field · Queens, NY |
| 11 | Mon Apr 10 | at Phillies | L3-15 | 4-7 | .364 | Citizens Bank Park · Philadelphi, PA |
| 12 | Tue Apr 11 | at Phillies | W8-4 | 5-7 | .417 | Citizens Bank Park · Philadelphi, PA |
| 13 | Wed Apr 12 | at Phillies | W3-2 (10) | 6-7 | .462 | Citizens Bank Park · Philadelphi, PA |
| 14 | Fri Apr 14 | vs D-backs | W5-1 | 7-7 | .500 | LoanDepot Park · Miami, FL |
| 15 | Sat Apr 15 | vs D-backs | W3-2 | 8-7 | .533 | LoanDepot Park · Miami, FL |
| 16 | Sun Apr 16 | vs D-backs | L0-5 | 8-8 | .500 | LoanDepot Park · Miami, FL |
| 17 | Mon Apr 17 | vs Giants | W4-3 | 9-8 | .529 | LoanDepot Park · Miami, FL |
| 18 | Tue Apr 18 | vs Giants | W4-2 | 10-8 | .556 | LoanDepot Park · Miami, FL |
| 19 | Wed Apr 19 | vs Giants | L2-5 (11) | 10-9 | .526 | LoanDepot Park · Miami, FL |
| 20 | Sat Apr 22 | at Guardians | W6-1 | 11-9 | .550 | Progressive Field · Cleveland, OH |
| 21 | Sat Apr 22 | at Guardians | W3-2 | 12-9 | .571 | Progressive Field · Cleveland, OH |
| 22 | Sun Apr 23 | at Guardians | L4-7 | 12-10 | .545 | Progressive Field · Cleveland, OH |
| 23 | Mon Apr 24 | at Braves | L0-11 | 12-11 | .522 | Truist Park · Cumberland, GA |
| 24 | Tue Apr 25 | at Braves | L4-7 | 12-12 | .500 | Truist Park · Cumberland, GA |
| 25 | Wed Apr 26 | at Braves | L4-6 | 12-13 | .480 | Truist Park · Cumberland, GA |
| 26 | Thu Apr 27 | at Braves | W5-4 | 13-13 | .500 | Truist Park · Cumberland, GA |
| 27 | Fri Apr 28 | vs Cubs | W3-2 | 14-13 | .519 | LoanDepot Park · Miami, FL |
| 28 | Sat Apr 29 | vs Cubs | W7-6 | 15-13 | .536 | LoanDepot Park · Miami, FL |
| 29 | Sun Apr 30 | vs Cubs | W4-3 | 16-13 | .552 | LoanDepot Park · Miami, FL |
| 30 | Tue May 2 | vs Braves | L0-6 | 16-14 | .533 | LoanDepot Park · Miami, FL |
| 31 | Wed May 3 | vs Braves | L6-14 | 16-15 | .516 | LoanDepot Park · Miami, FL |
| 32 | Thu May 4 | vs Braves | L3-6 | 16-16 | .500 | LoanDepot Park · Miami, FL |
| 33 | Fri May 5 | at Cubs | L1-4 | 16-17 | .485 | Wrigley Field · Chicago, IL |
| 34 | Sat May 6 | at Cubs | L2-4 | 16-18 | .471 | Wrigley Field · Chicago, IL |
| 35 | Sun May 7 | at Cubs | W5-4 (14) | 17-18 | .486 | Wrigley Field · Chicago, IL |
| 36 | Mon May 8 | at D-backs | L2-5 | 17-19 | .472 | Chase Field · Phoenix, AZ |
| 37 | Tue May 9 | at D-backs | W6-2 | 18-19 | .486 | Chase Field · Phoenix, AZ |
| 38 | Wed May 10 | at D-backs | W5-4 | 19-19 | .500 | Chase Field · Phoenix, AZ |
| 39 | Fri May 12 | vs Reds | L4-7 | 19-20 | .487 | LoanDepot Park · Miami, FL |
| 40 | Sat May 13 | vs Reds | L5-6 | 19-21 | .475 | LoanDepot Park · Miami, FL |
| 41 | Sun May 14 | vs Reds | W3-1 | 20-21 | .488 | LoanDepot Park · Miami, FL |
| 42 | Tue May 16 | vs Nationals | W5-4 | 21-21 | .500 | LoanDepot Park · Miami, FL |
| 43 | Wed May 17 | vs Nationals | W4-3 | 22-21 | .512 | LoanDepot Park · Miami, FL |
| 44 | Thu May 18 | vs Nationals | W5-3 | 23-21 | .523 | LoanDepot Park · Miami, FL |
| 45 | Fri May 19 | at Giants | L3-4 | 23-22 | .511 | Oracle Park · San Francisco, CA |
| 46 | Sat May 20 | at Giants | W1-0 | 24-22 | .522 | Oracle Park · San Francisco, CA |
| 47 | Sun May 21 | at Giants | L5-7 | 24-23 | .511 | Oracle Park · San Francisco, CA |
| 48 | Mon May 22 | at Rockies | L3-5 | 24-24 | .500 | Coors Field · Denver, CO |
| 49 | Tue May 23 | at Rockies | L4-5 | 24-25 | .490 | Coors Field · Denver, CO |
| 50 | Wed May 24 | at Rockies | W10-2 | 25-25 | .500 | Coors Field · Denver, CO |
| 51 | Thu May 25 | at Rockies | L6-7 | 25-26 | .490 | Coors Field · Denver, CO |
| 52 | Fri May 26 | at Angels | W6-2 | 26-26 | .500 | Angel Stadium · Anaheim, CA |
| 53 | Sat May 27 | at Angels | W8-5 (10) | 27-26 | .509 | Angel Stadium · Anaheim, CA |
| 54 | Sun May 28 | at Angels | W2-0 | 28-26 | .519 | Angel Stadium · Anaheim, CA |
| 55 | Tue May 30 | vs Padres | L4-9 | 28-27 | .509 | LoanDepot Park · Miami, FL |
| 56 | Wed May 31 | vs Padres | W2-1 | 29-27 | .518 | LoanDepot Park · Miami, FL |
| 57 | Thu Jun 1 | vs Padres | L1-10 | 29-28 | .509 | LoanDepot Park · Miami, FL |
| 58 | Fri Jun 2 | vs Athletics | W4-0 | 30-28 | .517 | LoanDepot Park · Miami, FL |
| 59 | Sat Jun 3 | vs Athletics | W12-1 | 31-28 | .525 | LoanDepot Park · Miami, FL |
| 60 | Sun Jun 4 | vs Athletics | W7-5 | 32-28 | .533 | LoanDepot Park · Miami, FL |
| 61 | Mon Jun 5 | vs Royals | W9-6 | 33-28 | .541 | LoanDepot Park · Miami, FL |
| 62 | Tue Jun 6 | vs Royals | W6-1 | 34-28 | .548 | LoanDepot Park · Miami, FL |
| 63 | Wed Jun 7 | vs Royals | W6-1 | 35-28 | .556 | LoanDepot Park · Miami, FL |
| 64 | Fri Jun 9 | at White Sox | L1-2 | 35-29 | .547 | Guaranteed Rate Field · Chicago, IL |
| 65 | Sat Jun 10 | at White Sox | W5-1 | 36-29 | .554 | Guaranteed Rate Field · Chicago, IL |
| 66 | Sun Jun 11 | at White Sox | W6-5 | 37-29 | .561 | Guaranteed Rate Field · Chicago, IL |
| 67 | Mon Jun 12 | at Mariners | L1-8 | 37-30 | .552 | T-Mobile Park · Seattle, WA |
| 68 | Tue Jun 13 | at Mariners | L3-9 | 37-31 | .544 | T-Mobile Park · Seattle, WA |
| 69 | Wed Jun 14 | at Mariners | W4-1 | 38-31 | .551 | T-Mobile Park · Seattle, WA |
| 70 | Fri Jun 16 | at Nationals | W6-5 | 39-31 | .557 | Nationals Park · Washington, D.C. |
| 71 | Sat Jun 17 | at Nationals | W5-2 | 40-31 | .563 | Nationals Park · Washington, D.C. |
| 72 | Sun Jun 18 | at Nationals | W4-2 | 41-31 | .569 | Nationals Park · Washington, D.C. |
| 73 | Mon Jun 19 | vs Blue Jays | W11-0 | 42-31 | .575 | LoanDepot Park · Miami, FL |
| 74 | Tue Jun 20 | vs Blue Jays | L0-2 | 42-32 | .568 | LoanDepot Park · Miami, FL |
| 75 | Wed Jun 21 | vs Blue Jays | L3-6 | 42-33 | .560 | LoanDepot Park · Miami, FL |
| 76 | Thu Jun 22 | vs Pirates | W6-4 | 43-33 | .566 | LoanDepot Park · Miami, FL |
| 77 | Fri Jun 23 | vs Pirates | L1-3 | 43-34 | .558 | LoanDepot Park · Miami, FL |
| 78 | Sat Jun 24 | vs Pirates | W4-3 (11) | 44-34 | .564 | LoanDepot Park · Miami, FL |
| 79 | Sun Jun 25 | vs Pirates | W2-0 | 45-34 | .570 | LoanDepot Park · Miami, FL |
| 80 | Tue Jun 27 | at Red Sox | W10-1 | 46-34 | .575 | Fenway Park · Boston, MA |
| 81 | Wed Jun 28 | at Red Sox | W6-2 | 47-34 | .580 | Fenway Park · Boston, MA |
| 82 | Thu Jun 29 | at Red Sox | W2-0 | 48-34 | .585 | Fenway Park · Boston, MA |
| 83 | Fri Jun 30 | at Braves | L4-16 | 48-35 | .578 | Truist Park · Cumberland, GA |
| 84 | Sat Jul 1 | at Braves | L0-7 | 48-36 | .571 | Truist Park · Cumberland, GA |
| 85 | Sun Jul 2 | at Braves | L3-6 | 48-37 | .565 | Truist Park · Cumberland, GA |
| 86 | Mon Jul 3 | vs Cardinals | W5-4 | 49-37 | .570 | LoanDepot Park · Miami, FL |
| 87 | Tue Jul 4 | vs Cardinals | W15-2 | 50-37 | .575 | LoanDepot Park · Miami, FL |
| 88 | Wed Jul 5 | vs Cardinals | W10-9 | 51-37 | .580 | LoanDepot Park · Miami, FL |
| 89 | Thu Jul 6 | vs Cardinals | L0-3 | 51-38 | .573 | LoanDepot Park · Miami, FL |
| 90 | Fri Jul 7 | vs Phillies | L3-4 | 51-39 | .567 | LoanDepot Park · Miami, FL |
| 91 | Sat Jul 8 | vs Phillies | W5-3 | 52-39 | .571 | LoanDepot Park · Miami, FL |
| 92 | Sun Jul 9 | vs Phillies | W7-3 | 53-39 | .576 | LoanDepot Park · Miami, FL |
| 93 | Fri Jul 14 | at Orioles | L2-5 | 53-40 | .570 | Camden Yards · Baltimore, MD |
| 94 | Sat Jul 15 | at Orioles | L5-6 | 53-41 | .564 | Camden Yards · Baltimore, MD |
| 95 | Sun Jul 16 | at Orioles | L4-5 | 53-42 | .558 | Camden Yards · Baltimore, MD |
| 96 | Mon Jul 17 | at Cardinals | L4-6 | 53-43 | .552 | Busch Stadium · St. Louis, MO |
| 97 | Tue Jul 18 | at Cardinals | L2-5 (10) | 53-44 | .546 | Busch Stadium · St. Louis, MO |
| 98 | Wed Jul 19 | at Cardinals | L4-6 | 53-45 | .541 | Busch Stadium · St. Louis, MO |
| 99 | Fri Jul 21 | vs Rockies | L1-6 | 53-46 | .535 | LoanDepot Park · Miami, FL |
| 100 | Sat Jul 22 | vs Rockies | L3-4 | 53-47 | .530 | LoanDepot Park · Miami, FL |
| 101 | Sun Jul 23 | vs Rockies | W3-2 (10) | 54-47 | .535 | LoanDepot Park · Miami, FL |
| 102 | Tue Jul 25 | at Rays | L1-4 | 54-48 | .529 | Tropicana Field · St. Petersburg, FL |
| 103 | Wed Jul 26 | at Rays | W7-1 | 55-48 | .534 | Tropicana Field · St. Petersburg, FL |
| 104 | Fri Jul 28 | vs Tigers | W6-5 | 56-48 | .538 | LoanDepot Park · Miami, FL |
| 105 | Sat Jul 29 | vs Tigers | L0-5 | 56-49 | .533 | LoanDepot Park · Miami, FL |
| 106 | Sun Jul 30 | vs Tigers | W8-6 | 57-49 | .538 | LoanDepot Park · Miami, FL |
| 107 | Mon Jul 31 | vs Phillies | L2-4 | 57-50 | .533 | LoanDepot Park · Miami, FL |
| 108 | Tue Aug 1 | vs Phillies | L1-3 | 57-51 | .528 | LoanDepot Park · Miami, FL |
| 109 | Wed Aug 2 | vs Phillies | W9-8 (12) | 58-51 | .532 | LoanDepot Park · Miami, FL |
| 110 | Thu Aug 3 | vs Phillies | L2-4 | 58-52 | .527 | LoanDepot Park · Miami, FL |
| 111 | Fri Aug 4 | at Rangers | L2-6 | 58-53 | .523 | Globe Life Field · Arlington, TX |
| 112 | Sat Aug 5 | at Rangers | L8-9 | 58-54 | .518 | Globe Life Field · Arlington, TX |
| 113 | Sun Aug 6 | at Rangers | L0-6 | 58-55 | .513 | Globe Life Field · Arlington, TX |
| 114 | Mon Aug 7 | at Reds | L2-5 | 58-56 | .509 | Great American Ball Park · Cincinnati, OH |
| 115 | Tue Aug 8 | at Reds | W3-2 | 59-56 | .513 | Great American Ball Park · Cincinnati, OH |
| 116 | Wed Aug 9 | at Reds | W5-4 | 60-56 | .517 | Great American Ball Park · Cincinnati, OH |
| 117 | Fri Aug 11 | vs Yankees | L4-9 | 60-57 | .513 | LoanDepot Park · Miami, FL |
| 118 | Sat Aug 12 | vs Yankees | W3-1 | 61-57 | .517 | LoanDepot Park · Miami, FL |
| 119 | Sun Aug 13 | vs Yankees | W8-7 | 62-57 | .521 | LoanDepot Park · Miami, FL |
| 120 | Mon Aug 14 | vs Astros | W5-1 | 63-57 | .525 | LoanDepot Park · Miami, FL |
| 121 | Tue Aug 15 | vs Astros | L5-6 | 63-58 | .521 | LoanDepot Park · Miami, FL |
| 122 | Wed Aug 16 | vs Astros | L5-12 | 63-59 | .516 | LoanDepot Park · Miami, FL |
| 123 | Fri Aug 18 | at Dodgers | W11-3 | 64-59 | .520 | Dodger Stadium · Los Angeles, CA |
| 124 | Sat Aug 19 | at Dodgers | L1-3 | 64-60 | .516 | Dodger Stadium · Los Angeles, CA |
| 125 | Sat Aug 19 | at Dodgers | L1-3 | 64-61 | .512 | Dodger Stadium · Los Angeles, CA |
| 126 | Mon Aug 21 | at Padres | L2-6 | 64-62 | .508 | Petco Park · San Diego, CA |
| 127 | Tue Aug 22 | at Padres | W3-0 | 65-62 | .512 | Petco Park · San Diego, CA |
| 128 | Wed Aug 23 | at Padres | L0-4 | 65-63 | .508 | Petco Park · San Diego, CA |
| 129 | Fri Aug 25 | vs Nationals | L4-7 | 65-64 | .504 | LoanDepot Park · Miami, FL |
| 130 | Sat Aug 26 | vs Nationals | L2-3 | 65-65 | .500 | LoanDepot Park · Miami, FL |
| 131 | Sun Aug 27 | vs Nationals | W2-1 | 66-65 | .504 | LoanDepot Park · Miami, FL |
| 132 | Tue Aug 29 | vs Rays | L2-11 | 66-66 | .500 | LoanDepot Park · Miami, FL |
| 133 | Wed Aug 30 | vs Rays | L0-3 (10) | 66-67 | .496 | LoanDepot Park · Miami, FL |
| 134 | Thu Aug 31 | at Nationals | W6-1 | 67-67 | .500 | Nationals Park · Washington, D.C. |
| 135 | Fri Sep 1 | at Nationals | W8-5 (11) | 68-67 | .504 | Nationals Park · Washington, D.C. |
| 136 | Sat Sep 2 | at Nationals | W11-5 | 69-67 | .507 | Nationals Park · Washington, D.C. |
| 137 | Sun Sep 3 | at Nationals | W6-4 | 70-67 | .511 | Nationals Park · Washington, D.C. |
| 138 | Tue Sep 5 | vs Dodgers | W6-3 | 71-67 | .514 | LoanDepot Park · Miami, FL |
| 139 | Wed Sep 6 | vs Dodgers | W11-4 | 72-67 | .518 | LoanDepot Park · Miami, FL |
| 140 | Thu Sep 7 | vs Dodgers | L0-10 | 72-68 | .514 | LoanDepot Park · Miami, FL |
| 141 | Fri Sep 8 | at Phillies | W3-2 | 73-68 | .518 | Citizens Bank Park · Philadelphi, PA |
| 142 | Sat Sep 9 | at Phillies | L4-8 | 73-69 | .514 | Citizens Bank Park · Philadelphi, PA |
| 143 | Sun Sep 10 | at Phillies | W5-4 | 74-69 | .517 | Citizens Bank Park · Philadelphi, PA |
| 144 | Mon Sep 11 | at Brewers | L0-12 | 74-70 | .514 | American Family Field · Milwaukee, WI |
| 145 | Tue Sep 12 | at Brewers | L1-3 | 74-71 | .510 | American Family Field · Milwaukee, WI |
| 146 | Wed Sep 13 | at Brewers | W2-0 | 75-71 | .514 | American Family Field · Milwaukee, WI |
| 147 | Thu Sep 14 | at Brewers | L2-4 | 75-72 | .510 | American Family Field · Milwaukee, WI |
| 148 | Fri Sep 15 | vs Braves | W9-6 | 76-72 | .514 | LoanDepot Park · Miami, FL |
| 149 | Sat Sep 16 | vs Braves | W11-5 | 77-72 | .517 | LoanDepot Park · Miami, FL |
| 150 | Sun Sep 17 | vs Braves | W16-2 | 78-72 | .520 | LoanDepot Park · Miami, FL |
| 151 | Mon Sep 18 | vs Mets | L1-2 | 78-73 | .517 | LoanDepot Park · Miami, FL |
| 152 | Tue Sep 19 | vs Mets | W4-3 | 79-73 | .520 | LoanDepot Park · Miami, FL |
| 153 | Wed Sep 20 | vs Mets | L3-8 | 79-74 | .516 | LoanDepot Park · Miami, FL |
| 154 | Fri Sep 22 | vs Brewers | L1-16 | 79-75 | .513 | LoanDepot Park · Miami, FL |
| 155 | Sat Sep 23 | vs Brewers | W5-4 | 80-75 | .516 | LoanDepot Park · Miami, FL |
| 156 | Sun Sep 24 | vs Brewers | W6-1 | 81-75 | .519 | LoanDepot Park · Miami, FL |
| 157 | Wed Sep 27 | at Mets | L2-11 | 81-76 | .516 | Citi Field · Queens, NY |
| 158 | Wed Sep 27 | at Mets | W4-2 | 82-76 | .519 | Citi Field · Queens, NY |
| 159 | Fri Sep 29 | at Pirates | W4-3 | 83-77 | .519 | PNC Park · Pittsburgh, PA |
| 160 | Sat Sep 30 | at Pirates | W7-3 | 84-77 | .522 | PNC Park · Pittsburgh, PA |
| 161 | Sun Oct 1 | at Pirates | L0-3 | 84-78 | .519 | PNC Park · Pittsburgh, PA |
| 162 | Mon Oct 2 | at Mets | L0-1 | 82-77 | .516 | Citi Field · Queens, NY |
| 163 | Tue Oct 3 | at Phillies | L1-4 | 0-1 | .000 | Citizens Bank Park · Philadelphi, PA |
| 164 | Wed Oct 4 | at Phillies | L1-7 | 0-2 | .000 | Citizens Bank Park · Philadelphi, PA |