| 1 | Thu Mar 29 | vs Cubs | L4-8 | 0-1 | .000 | LoanDepot Park · Miami, FL |
| 2 | Fri Mar 30 | vs Cubs | W2-1 (17) | 1-1 | .500 | LoanDepot Park · Miami, FL |
| 3 | Sat Mar 31 | vs Cubs | L6-10 (10) | 1-2 | .333 | LoanDepot Park · Miami, FL |
| 4 | Sun Apr 1 | vs Cubs | W6-0 | 2-2 | .500 | LoanDepot Park · Miami, FL |
| 5 | Mon Apr 2 | vs Red Sox | L3-7 | 2-3 | .400 | LoanDepot Park · Miami, FL |
| 6 | Tue Apr 3 | vs Red Sox | L2-4 (13) | 2-4 | .333 | LoanDepot Park · Miami, FL |
| 7 | Thu Apr 5 | at Phillies | L0-5 | 2-5 | .286 | Citizens Bank Park · Philadelphi, PA |
| 8 | Sat Apr 7 | at Phillies | L1-20 | 2-6 | .250 | Citizens Bank Park · Philadelphi, PA |
| 9 | Sun Apr 8 | at Phillies | W6-3 | 3-6 | .333 | Citizens Bank Park · Philadelphi, PA |
| 10 | Mon Apr 9 | vs Mets | L2-4 | 3-7 | .300 | LoanDepot Park · Miami, FL |
| 11 | Tue Apr 10 | vs Mets | L6-8 | 3-8 | .273 | LoanDepot Park · Miami, FL |
| 12 | Wed Apr 11 | vs Mets | L1-4 | 3-9 | .250 | LoanDepot Park · Miami, FL |
| 13 | Fri Apr 13 | vs Pirates | W7-2 | 4-9 | .308 | LoanDepot Park · Miami, FL |
| 14 | Sat Apr 14 | vs Pirates | L0-1 | 4-10 | .286 | LoanDepot Park · Miami, FL |
| 15 | Sun Apr 15 | vs Pirates | L3-7 | 4-11 | .267 | LoanDepot Park · Miami, FL |
| 16 | Mon Apr 16 | at Yankees | L1-12 | 4-12 | .250 | Yankee Stadium · The Bronx, NY |
| 17 | Tue Apr 17 | at Yankees | W9-1 | 5-12 | .294 | Yankee Stadium · The Bronx, NY |
| 18 | Thu Apr 19 | at Brewers | L3-12 | 5-13 | .278 | American Family Field · Milwaukee, WI |
| 19 | Fri Apr 20 | at Brewers | L0-8 | 5-14 | .263 | American Family Field · Milwaukee, WI |
| 20 | Sat Apr 21 | at Brewers | L5-6 | 5-15 | .250 | American Family Field · Milwaukee, WI |
| 21 | Sun Apr 22 | at Brewers | L2-4 | 5-16 | .238 | American Family Field · Milwaukee, WI |
| 22 | Mon Apr 23 | at Dodgers | L1-2 | 5-17 | .227 | Dodger Stadium · Los Angeles, CA |
| 23 | Tue Apr 24 | at Dodgers | W3-2 | 6-17 | .261 | Dodger Stadium · Los Angeles, CA |
| 24 | Wed Apr 25 | at Dodgers | W8-6 | 7-17 | .292 | Dodger Stadium · Los Angeles, CA |
| 25 | Fri Apr 27 | vs Rockies | L0-1 | 7-18 | .280 | LoanDepot Park · Miami, FL |
| 26 | Sat Apr 28 | vs Rockies | W4-1 | 8-18 | .308 | LoanDepot Park · Miami, FL |
| 27 | Sun Apr 29 | vs Rockies | W3-0 | 9-18 | .333 | LoanDepot Park · Miami, FL |
| 28 | Mon Apr 30 | vs Phillies | W8-4 | 10-18 | .357 | LoanDepot Park · Miami, FL |
| 29 | Tue May 1 | vs Phillies | W2-1 (10) | 11-18 | .379 | LoanDepot Park · Miami, FL |
| 30 | Wed May 2 | vs Phillies | L0-6 | 11-19 | .367 | LoanDepot Park · Miami, FL |
| 31 | Fri May 4 | at Reds | L1-4 | 11-20 | .355 | Great American Ball Park · Cincinnati, OH |
| 32 | Sat May 5 | at Reds | W6-0 | 12-20 | .375 | Great American Ball Park · Cincinnati, OH |
| 33 | Sun May 6 | at Reds | W8-5 | 13-20 | .394 | Great American Ball Park · Cincinnati, OH |
| 34 | Mon May 7 | at Cubs | L2-14 | 13-21 | .382 | Wrigley Field · Chicago, IL |
| 35 | Tue May 8 | at Cubs | L3-4 | 13-22 | .371 | Wrigley Field · Chicago, IL |
| 36 | Wed May 9 | at Cubs | L4-13 | 13-23 | .361 | Wrigley Field · Chicago, IL |
| 37 | Thu May 10 | vs Braves | L2-9 | 13-24 | .351 | LoanDepot Park · Miami, FL |
| 38 | Fri May 11 | vs Braves | W6-3 | 14-24 | .368 | LoanDepot Park · Miami, FL |
| 39 | Sat May 12 | vs Braves | L5-10 | 14-25 | .359 | LoanDepot Park · Miami, FL |
| 40 | Sun May 13 | vs Braves | L3-4 | 14-26 | .350 | LoanDepot Park · Miami, FL |
| 41 | Tue May 15 | vs Dodgers | W4-2 | 15-26 | .366 | LoanDepot Park · Miami, FL |
| 42 | Wed May 16 | vs Dodgers | W6-5 | 16-26 | .381 | LoanDepot Park · Miami, FL |
| 43 | Thu May 17 | vs Dodgers | L0-7 | 16-27 | .372 | LoanDepot Park · Miami, FL |
| 44 | Fri May 18 | at Braves | W2-0 | 17-27 | .386 | Truist Park · Cumberland, GA |
| 45 | Sat May 19 | at Braves | L1-8 | 17-28 | .378 | Truist Park · Cumberland, GA |
| 46 | Sun May 20 | at Braves | L9-10 | 17-29 | .370 | Truist Park · Cumberland, GA |
| 47 | Mon May 21 | at Mets | L0-2 | 17-30 | .362 | Citi Field · Queens, NY |
| 48 | Tue May 22 | at Mets | W5-1 | 18-30 | .375 | Citi Field · Queens, NY |
| 49 | Wed May 23 | at Mets | W2-1 | 19-30 | .388 | Citi Field · Queens, NY |
| 50 | Fri May 25 | vs Nationals | L5-9 | 19-31 | .380 | LoanDepot Park · Miami, FL |
| 51 | Sat May 26 | vs Nationals | L1-4 | 19-32 | .373 | LoanDepot Park · Miami, FL |
| 52 | Sun May 27 | vs Nationals | L2-5 | 19-33 | .365 | LoanDepot Park · Miami, FL |
| 53 | Mon May 28 | at Padres | W7-2 | 20-33 | .377 | Petco Park · San Diego, CA |
| 54 | Tue May 29 | at Padres | L5-9 | 20-34 | .370 | Petco Park · San Diego, CA |
| 55 | Wed May 30 | at Padres | L2-3 | 20-35 | .364 | Petco Park · San Diego, CA |
| 56 | Thu May 31 | at Padres | L3-8 | 20-36 | .357 | Petco Park · San Diego, CA |
| 57 | Fri Jun 1 | at D-backs | L1-9 | 20-37 | .351 | Chase Field · Phoenix, AZ |
| 58 | Sat Jun 2 | at D-backs | L2-6 | 20-38 | .345 | Chase Field · Phoenix, AZ |
| 59 | Sun Jun 3 | at D-backs | L1-6 | 20-39 | .339 | Chase Field · Phoenix, AZ |
| 60 | Tue Jun 5 | at Cardinals | W7-4 | 21-39 | .350 | Busch Stadium · St. Louis, MO |
| 61 | Wed Jun 6 | at Cardinals | W11-3 | 22-39 | .361 | Busch Stadium · St. Louis, MO |
| 62 | Thu Jun 7 | at Cardinals | L1-4 | 22-40 | .355 | Busch Stadium · St. Louis, MO |
| 63 | Fri Jun 8 | vs Padres | W4-0 | 23-40 | .365 | LoanDepot Park · Miami, FL |
| 64 | Sat Jun 9 | vs Padres | L4-5 | 23-41 | .359 | LoanDepot Park · Miami, FL |
| 65 | Sun Jun 10 | vs Padres | L1-3 | 23-42 | .354 | LoanDepot Park · Miami, FL |
| 66 | Mon Jun 11 | vs Giants | W7-5 | 24-42 | .364 | LoanDepot Park · Miami, FL |
| 67 | Tue Jun 12 | vs Giants | W3-1 | 25-42 | .373 | LoanDepot Park · Miami, FL |
| 68 | Wed Jun 13 | vs Giants | W5-4 | 26-42 | .382 | LoanDepot Park · Miami, FL |
| 69 | Thu Jun 14 | vs Giants | L3-6 (16) | 26-43 | .377 | LoanDepot Park · Miami, FL |
| 70 | Fri Jun 15 | at Orioles | W2-0 | 27-43 | .386 | Camden Yards · Baltimore, MD |
| 71 | Sat Jun 16 | at Orioles | W5-4 | 28-43 | .394 | Camden Yards · Baltimore, MD |
| 72 | Sun Jun 17 | at Orioles | L4-10 | 28-44 | .389 | Camden Yards · Baltimore, MD |
| 73 | Mon Jun 18 | at Giants | W5-4 | 29-44 | .397 | Oracle Park · San Francisco, CA |
| 74 | Tue Jun 19 | at Giants | L3-6 | 29-45 | .392 | Oracle Park · San Francisco, CA |
| 75 | Wed Jun 20 | at Giants | L5-6 | 29-46 | .387 | Oracle Park · San Francisco, CA |
| 76 | Fri Jun 22 | at Rockies | L3-11 | 29-47 | .382 | Coors Field · Denver, CO |
| 77 | Sat Jun 23 | at Rockies | W6-2 | 30-47 | .390 | Coors Field · Denver, CO |
| 78 | Sun Jun 24 | at Rockies | W8-5 | 31-47 | .397 | Coors Field · Denver, CO |
| 79 | Mon Jun 25 | vs D-backs | W9-5 | 32-47 | .405 | LoanDepot Park · Miami, FL |
| 80 | Tue Jun 26 | vs D-backs | L3-5 | 32-48 | .400 | LoanDepot Park · Miami, FL |
| 81 | Wed Jun 27 | vs D-backs | L1-2 | 32-49 | .395 | LoanDepot Park · Miami, FL |
| 82 | Thu Jun 28 | vs D-backs | L0-4 | 32-50 | .390 | LoanDepot Park · Miami, FL |
| 83 | Fri Jun 29 | vs Mets | W8-2 | 33-50 | .398 | LoanDepot Park · Miami, FL |
| 84 | Sat Jun 30 | vs Mets | W5-2 | 34-50 | .405 | LoanDepot Park · Miami, FL |
| 85 | Sun Jul 1 | vs Mets | L2-5 | 34-51 | .400 | LoanDepot Park · Miami, FL |
| 86 | Mon Jul 2 | vs Rays | W3-2 (10) | 35-51 | .407 | LoanDepot Park · Miami, FL |
| 87 | Tue Jul 3 | vs Rays | L6-9 (16) | 35-52 | .402 | LoanDepot Park · Miami, FL |
| 88 | Wed Jul 4 | vs Rays | W3-0 | 36-52 | .409 | LoanDepot Park · Miami, FL |
| 89 | Thu Jul 5 | at Nationals | L12-14 | 36-53 | .404 | Nationals Park · Washington, D.C. |
| 90 | Fri Jul 6 | at Nationals | L2-3 | 36-54 | .400 | Nationals Park · Washington, D.C. |
| 91 | Sat Jul 7 | at Nationals | L4-18 | 36-55 | .396 | Nationals Park · Washington, D.C. |
| 92 | Sun Jul 8 | at Nationals | W10-2 | 37-55 | .402 | Nationals Park · Washington, D.C. |
| 93 | Mon Jul 9 | vs Brewers | W4-3 (10) | 38-55 | .409 | LoanDepot Park · Miami, FL |
| 94 | Tue Jul 10 | vs Brewers | L4-8 | 38-56 | .404 | LoanDepot Park · Miami, FL |
| 95 | Wed Jul 11 | vs Brewers | W5-4 (12) | 39-56 | .411 | LoanDepot Park · Miami, FL |
| 96 | Fri Jul 13 | vs Phillies | L0-2 | 39-57 | .406 | LoanDepot Park · Miami, FL |
| 97 | Sat Jul 14 | vs Phillies | W2-0 | 40-57 | .412 | LoanDepot Park · Miami, FL |
| 98 | Sun Jul 15 | vs Phillies | W10-5 | 41-57 | .418 | LoanDepot Park · Miami, FL |
| 99 | Fri Jul 20 | at Rays | W6-5 | 42-57 | .424 | Tropicana Field · St. Petersburg, FL |
| 100 | Sat Jul 21 | at Rays | W3-2 | 43-57 | .430 | Tropicana Field · St. Petersburg, FL |
| 101 | Sun Jul 22 | at Rays | L4-6 | 43-58 | .426 | Tropicana Field · St. Petersburg, FL |
| 102 | Mon Jul 23 | vs Braves | L1-12 | 43-59 | .422 | LoanDepot Park · Miami, FL |
| 103 | Tue Jul 24 | vs Braves | W9-3 | 44-59 | .427 | LoanDepot Park · Miami, FL |
| 104 | Thu Jul 26 | vs Nationals | L3-10 | 44-60 | .423 | LoanDepot Park · Miami, FL |
| 105 | Fri Jul 27 | vs Nationals | L1-9 | 44-61 | .419 | LoanDepot Park · Miami, FL |
| 106 | Sat Jul 28 | vs Nationals | W2-1 (10) | 45-61 | .425 | LoanDepot Park · Miami, FL |
| 107 | Sun Jul 29 | vs Nationals | W5-0 | 46-61 | .430 | LoanDepot Park · Miami, FL |
| 108 | Mon Jul 30 | at Braves | L3-5 | 46-62 | .426 | Truist Park · Cumberland, GA |
| 109 | Tue Jul 31 | at Braves | L6-11 | 46-63 | .422 | Truist Park · Cumberland, GA |
| 110 | Thu Aug 2 | at Phillies | L2-5 | 46-64 | .418 | Citizens Bank Park · Philadelphi, PA |
| 111 | Fri Aug 3 | at Phillies | L1-5 | 46-65 | .414 | Citizens Bank Park · Philadelphi, PA |
| 112 | Sat Aug 4 | at Phillies | L3-8 | 46-66 | .411 | Citizens Bank Park · Philadelphi, PA |
| 113 | Sun Aug 5 | at Phillies | L3-5 | 46-67 | .407 | Citizens Bank Park · Philadelphi, PA |
| 114 | Mon Aug 6 | vs Cardinals | W2-1 | 47-67 | .412 | LoanDepot Park · Miami, FL |
| 115 | Tue Aug 7 | vs Cardinals | L2-3 | 47-68 | .409 | LoanDepot Park · Miami, FL |
| 116 | Wed Aug 8 | vs Cardinals | L1-7 | 47-69 | .405 | LoanDepot Park · Miami, FL |
| 117 | Fri Aug 10 | vs Mets | L2-6 | 47-70 | .402 | LoanDepot Park · Miami, FL |
| 118 | Sat Aug 11 | vs Mets | W4-3 (11) | 48-70 | .407 | LoanDepot Park · Miami, FL |
| 119 | Sun Aug 12 | vs Mets | L3-4 | 48-71 | .403 | LoanDepot Park · Miami, FL |
| 120 | Mon Aug 13 | at Braves | L1-9 | 48-72 | .400 | Truist Park · Cumberland, GA |
| 121 | Mon Aug 13 | at Braves | L1-6 | 48-73 | .397 | Truist Park · Cumberland, GA |
| 122 | Tue Aug 14 | at Braves | L6-10 | 48-74 | .393 | Truist Park · Cumberland, GA |
| 123 | Wed Aug 15 | at Braves | L2-5 | 48-75 | .390 | Truist Park · Cumberland, GA |
| 124 | Fri Aug 17 | at Nationals | L2-8 | 48-76 | .387 | Nationals Park · Washington, D.C. |
| 125 | Sat Aug 18 | at Nationals | W7-5 (10) | 49-76 | .392 | Nationals Park · Washington, D.C. |
| 126 | Sun Aug 19 | at Nationals | W12-1 | 50-76 | .397 | Nationals Park · Washington, D.C. |
| 127 | Tue Aug 21 | vs Yankees | L1-2 (12) | 50-77 | .394 | LoanDepot Park · Miami, FL |
| 128 | Wed Aug 22 | vs Yankees | W9-3 | 51-77 | .398 | LoanDepot Park · Miami, FL |
| 129 | Thu Aug 23 | vs Braves | L0-5 | 51-78 | .395 | LoanDepot Park · Miami, FL |
| 130 | Fri Aug 24 | vs Braves | W1-0 | 52-78 | .400 | LoanDepot Park · Miami, FL |
| 131 | Sat Aug 25 | vs Braves | W3-1 | 53-78 | .405 | LoanDepot Park · Miami, FL |
| 132 | Sun Aug 26 | vs Braves | L0-4 | 53-79 | .402 | LoanDepot Park · Miami, FL |
| 133 | Tue Aug 28 | at Red Sox | L7-8 | 53-80 | .398 | Fenway Park · Boston, MA |
| 134 | Wed Aug 29 | at Red Sox | L6-14 | 53-81 | .396 | Fenway Park · Boston, MA |
| 135 | Fri Aug 31 | vs Blue Jays | L5-6 | 53-82 | .393 | LoanDepot Park · Miami, FL |
| 136 | Sat Sep 1 | vs Blue Jays | W6-3 | 54-82 | .397 | LoanDepot Park · Miami, FL |
| 137 | Sun Sep 2 | vs Blue Jays | L1-6 | 54-83 | .394 | LoanDepot Park · Miami, FL |
| 138 | Mon Sep 3 | vs Phillies | W3-1 | 55-83 | .399 | LoanDepot Park · Miami, FL |
| 139 | Tue Sep 4 | vs Phillies | L4-9 | 55-84 | .396 | LoanDepot Park · Miami, FL |
| 140 | Wed Sep 5 | vs Phillies | W2-1 | 56-84 | .400 | LoanDepot Park · Miami, FL |
| 141 | Fri Sep 7 | at Pirates | L3-5 | 56-85 | .397 | PNC Park · Pittsburgh, PA |
| 142 | Sat Sep 8 | at Pirates | L1-5 | 56-86 | .394 | PNC Park · Pittsburgh, PA |
| 144 | Tue Sep 11 | at Mets | W5-3 | 57-86 | .399 | Citi Field · Queens, NY |
| 145 | Wed Sep 12 | at Mets | L0-13 | 57-87 | .396 | Citi Field · Queens, NY |
| 146 | Thu Sep 13 | at Mets | L3-4 | 57-88 | .393 | Citi Field · Queens, NY |
| 147 | Thu Sep 13 | at Mets | L2-5 | 57-89 | .390 | Citi Field · Queens, NY |
| 148 | Fri Sep 14 | at Phillies | L2-14 | 57-90 | .388 | Citizens Bank Park · Philadelphi, PA |
| 149 | Sat Sep 15 | at Phillies | L4-5 | 57-91 | .385 | Citizens Bank Park · Philadelphi, PA |
| 150 | Sun Sep 16 | at Phillies | W6-4 | 58-91 | .389 | Citizens Bank Park · Philadelphi, PA |
| 151 | Mon Sep 17 | vs Nationals | W8-5 | 59-91 | .393 | LoanDepot Park · Miami, FL |
| 152 | Tue Sep 18 | vs Nationals | L2-4 | 59-92 | .391 | LoanDepot Park · Miami, FL |
| 153 | Thu Sep 20 | vs Reds | L2-4 | 59-93 | .388 | LoanDepot Park · Miami, FL |
| 154 | Fri Sep 21 | vs Reds | W1-0 (10) | 60-93 | .392 | LoanDepot Park · Miami, FL |
| 155 | Sat Sep 22 | vs Reds | W5-1 | 61-93 | .396 | LoanDepot Park · Miami, FL |
| 156 | Sun Sep 23 | vs Reds | W6-0 | 62-93 | .400 | LoanDepot Park · Miami, FL |
| 157 | Mon Sep 24 | at Nationals | L3-7 | 62-94 | .397 | Nationals Park · Washington, D.C. |
| 158 | Tue Sep 25 | at Nationals | L4-9 | 62-95 | .395 | Nationals Park · Washington, D.C. |
| 159 | Wed Sep 26 | at Nationals | L3-9 | 62-96 | .392 | Nationals Park · Washington, D.C. |
| 160 | Fri Sep 28 | at Mets | W8-1 | 63-96 | .396 | Citi Field · Queens, NY |
| 161 | Sat Sep 29 | at Mets | L0-1 (13) | 63-97 | .394 | Citi Field · Queens, NY |
| 162 | Sun Sep 30 | at Mets | L0-1 | 63-98 | .391 | Citi Field · Queens, NY |