| 1 | Fri Apr 1 | at Blue Jays | L3-13 | 0-1 | .000 | Rogers Centre · Toronto, ON |
| 2 | Sat Apr 2 | at Blue Jays | L1-6 | 0-2 | .000 | Rogers Centre · Toronto, ON |
| 3 | Sun Apr 3 | at Blue Jays | W4-3 | 1-2 | .333 | Rogers Centre · Toronto, ON |
| 4 | Mon Apr 4 | at Yankees | L3-4 | 1-3 | .250 | Yankee Stadium · The Bronx, NY |
| 5 | Tue Apr 5 | at Yankees | W5-4 (10) | 2-3 | .400 | Yankee Stadium · The Bronx, NY |
| 6 | Thu Apr 7 | at Yankees | L3-4 | 2-4 | .333 | Yankee Stadium · The Bronx, NY |
| 7 | Fri Apr 8 | vs Athletics | W2-1 | 3-4 | .429 | Target Field · Minneapolis, MN |
| 8 | Sat Apr 9 | vs Athletics | L0-1 | 3-5 | .375 | Target Field · Minneapolis, MN |
| 9 | Sun Apr 10 | vs Athletics | L3-5 | 3-6 | .333 | Target Field · Minneapolis, MN |
| 10 | Tue Apr 12 | vs Royals | W4-3 (10) | 4-6 | .400 | Target Field · Minneapolis, MN |
| 11 | Wed Apr 13 | vs Royals | L5-10 | 4-7 | .364 | Target Field · Minneapolis, MN |
| 12 | Thu Apr 14 | at Rays | L3-4 (10) | 4-8 | .333 | Tropicana Field · St. Petersburg, FL |
| 13 | Fri Apr 15 | at Rays | L2-5 | 4-9 | .308 | Tropicana Field · St. Petersburg, FL |
| 14 | Sat Apr 16 | at Rays | L3-4 | 4-10 | .286 | Tropicana Field · St. Petersburg, FL |
| 15 | Sun Apr 17 | at Rays | W4-2 | 5-10 | .333 | Tropicana Field · St. Petersburg, FL |
| 16 | Mon Apr 18 | at Orioles | W5-3 | 6-10 | .375 | Camden Yards · Baltimore, MD |
| 17 | Tue Apr 19 | at Orioles | L0-11 | 6-11 | .353 | Camden Yards · Baltimore, MD |
| 18 | Wed Apr 20 | at Orioles | L4-5 | 6-12 | .333 | Camden Yards · Baltimore, MD |
| 19 | Thu Apr 21 | at Orioles | W3-1 | 7-12 | .368 | Camden Yards · Baltimore, MD |
| 20 | Sat Apr 23 | vs Guardians | W10-3 | 8-12 | .400 | Target Field · Minneapolis, MN |
| 21 | Sun Apr 24 | vs Guardians | W4-3 | 9-12 | .429 | Target Field · Minneapolis, MN |
| 22 | Wed Apr 27 | vs Rays | L2-8 | 9-13 | .409 | Target Field · Minneapolis, MN |
| 23 | Thu Apr 28 | vs Rays | L3-15 | 9-14 | .391 | Target Field · Minneapolis, MN |
| 24 | Thu Apr 28 | vs Rays | L1-6 | 9-15 | .375 | Target Field · Minneapolis, MN |
| 25 | Fri Apr 29 | at Royals | L3-4 | 9-16 | .360 | Kauffman Stadium · Kansas City, MO |
| 26 | Sat Apr 30 | at Royals | L2-11 | 9-17 | .346 | Kauffman Stadium · Kansas City, MO |
| 27 | Sun May 1 | at Royals | L3-10 | 9-18 | .333 | Kauffman Stadium · Kansas City, MO |
| 28 | Tue May 3 | at White Sox | W1-0 | 10-18 | .357 | Guaranteed Rate Field · Chicago, IL |
| 29 | Wed May 4 | at White Sox | W3-2 | 11-18 | .379 | Guaranteed Rate Field · Chicago, IL |
| 30 | Fri May 6 | at Red Sox | W9-2 | 12-18 | .400 | Fenway Park · Boston, MA |
| 31 | Sat May 7 | at Red Sox | L0-4 | 12-19 | .387 | Fenway Park · Boston, MA |
| 32 | Sun May 8 | at Red Sox | L5-9 | 12-20 | .375 | Fenway Park · Boston, MA |
| 33 | Mon May 9 | at Red Sox | L1-2 (11) | 12-21 | .364 | Fenway Park · Boston, MA |
| 34 | Tue May 10 | vs Tigers | L2-10 | 12-22 | .353 | Target Field · Minneapolis, MN |
| 35 | Wed May 11 | vs Tigers | L7-9 | 12-23 | .343 | Target Field · Minneapolis, MN |
| 36 | Fri May 13 | vs Blue Jays | L0-2 | 12-24 | .333 | Target Field · Minneapolis, MN |
| 37 | Sat May 14 | vs Blue Jays | L3-9 (11) | 12-25 | .324 | Target Field · Minneapolis, MN |
| 38 | Sun May 15 | vs Blue Jays | L3-11 | 12-26 | .316 | Target Field · Minneapolis, MN |
| 39 | Mon May 16 | at Mariners | L2-5 | 12-27 | .308 | T-Mobile Park · Seattle, WA |
| 40 | Tue May 17 | at Mariners | W2-1 | 13-27 | .325 | T-Mobile Park · Seattle, WA |
| 41 | Wed May 18 | at Athletics | W4-3 (10) | 14-27 | .341 | RingCentral Coliseum · Oakland, CA |
| 42 | Thu May 19 | at Athletics | W11-1 | 15-27 | .357 | RingCentral Coliseum · Oakland, CA |
| 43 | Fri May 20 | at D-backs | L7-8 | 15-28 | .349 | Chase Field · Phoenix, AZ |
| 44 | Sat May 21 | at D-backs | L6-9 | 15-29 | .341 | Chase Field · Phoenix, AZ |
| 45 | Sun May 22 | at D-backs | L2-3 | 15-30 | .333 | Chase Field · Phoenix, AZ |
| 46 | Mon May 23 | vs Mariners | L7-8 (10) | 15-31 | .326 | Target Field · Minneapolis, MN |
| 47 | Tue May 24 | vs Mariners | W4-2 | 16-31 | .340 | Target Field · Minneapolis, MN |
| 48 | Wed May 25 | vs Mariners | L0-3 | 16-32 | .333 | Target Field · Minneapolis, MN |
| 49 | Fri May 27 | vs Angels | L5-6 | 16-33 | .327 | Target Field · Minneapolis, MN |
| 50 | Sat May 28 | vs Angels | W1-0 (10) | 17-33 | .340 | Target Field · Minneapolis, MN |
| 51 | Sun May 29 | vs Angels | L5-6 | 17-34 | .333 | Target Field · Minneapolis, MN |
| 52 | Mon May 30 | at Tigers | L5-6 | 17-35 | .327 | Comerica Park · Detroit, MI |
| 53 | Tue May 31 | at Tigers | L7-8 | 17-36 | .321 | Comerica Park · Detroit, MI |
| 54 | Wed Jun 1 | at Tigers | L2-4 | 17-37 | .315 | Comerica Park · Detroit, MI |
| 55 | Thu Jun 2 | at Royals | W8-2 | 18-37 | .327 | Kauffman Stadium · Kansas City, MO |
| 56 | Fri Jun 3 | at Royals | W5-2 | 19-37 | .339 | Kauffman Stadium · Kansas City, MO |
| 57 | Sat Jun 4 | at Royals | W7-2 | 20-37 | .351 | Kauffman Stadium · Kansas City, MO |
| 58 | Sun Jun 5 | at Royals | W6-0 | 21-37 | .362 | Kauffman Stadium · Kansas City, MO |
| 59 | Mon Jun 6 | at Guardians | W6-4 | 22-37 | .373 | Progressive Field · Cleveland, OH |
| 60 | Tue Jun 7 | at Guardians | L0-1 | 22-38 | .367 | Progressive Field · Cleveland, OH |
| 61 | Wed Jun 8 | at Guardians | W3-2 (10) | 23-38 | .377 | Progressive Field · Cleveland, OH |
| 62 | Thu Jun 9 | vs Rangers | W5-4 | 24-38 | .387 | Target Field · Minneapolis, MN |
| 63 | Fri Jun 10 | vs Rangers | L3-9 | 24-39 | .381 | Target Field · Minneapolis, MN |
| 64 | Sat Jun 11 | vs Rangers | W8-1 | 25-39 | .391 | Target Field · Minneapolis, MN |
| 65 | Sun Jun 12 | vs Rangers | W6-1 | 26-39 | .400 | Target Field · Minneapolis, MN |
| 66 | Wed Jun 15 | vs White Sox | W4-1 | 27-39 | .409 | Target Field · Minneapolis, MN |
| 67 | Thu Jun 16 | vs White Sox | W1-0 | 28-39 | .418 | Target Field · Minneapolis, MN |
| 68 | Fri Jun 17 | vs Padres | W6-5 | 29-39 | .426 | Target Field · Minneapolis, MN |
| 69 | Sat Jun 18 | vs Padres | W1-0 | 30-39 | .435 | Target Field · Minneapolis, MN |
| 70 | Sun Jun 19 | vs Padres | W5-4 | 31-39 | .443 | Target Field · Minneapolis, MN |
| 71 | Tue Jun 21 | at Giants | W9-2 | 32-39 | .451 | Oracle Park · San Francisco, CA |
| 72 | Wed Jun 22 | at Giants | L1-5 | 32-40 | .444 | Oracle Park · San Francisco, CA |
| 73 | Thu Jun 23 | at Giants | L1-2 | 32-41 | .438 | Oracle Park · San Francisco, CA |
| 74 | Fri Jun 24 | at Brewers | L3-4 | 32-42 | .432 | American Family Field · Milwaukee, WI |
| 75 | Sat Jun 25 | at Brewers | L1-11 | 32-43 | .427 | American Family Field · Milwaukee, WI |
| 76 | Sun Jun 26 | at Brewers | L2-6 | 32-44 | .421 | American Family Field · Milwaukee, WI |
| 77 | Mon Jun 27 | vs Dodgers | L0-15 | 32-45 | .416 | Target Field · Minneapolis, MN |
| 78 | Tue Jun 28 | vs Dodgers | W6-4 | 33-45 | .423 | Target Field · Minneapolis, MN |
| 79 | Wed Jun 29 | vs Dodgers | W1-0 | 34-45 | .430 | Target Field · Minneapolis, MN |
| 80 | Fri Jul 1 | vs Brewers | W6-2 | 35-45 | .438 | Target Field · Minneapolis, MN |
| 81 | Sat Jul 2 | vs Brewers | L7-8 | 35-46 | .432 | Target Field · Minneapolis, MN |
| 82 | Sun Jul 3 | vs Brewers | W9-7 | 36-46 | .439 | Target Field · Minneapolis, MN |
| 83 | Mon Jul 4 | vs Rays | W7-0 | 37-46 | .446 | Target Field · Minneapolis, MN |
| 84 | Tue Jul 5 | vs Rays | W3-2 | 38-46 | .452 | Target Field · Minneapolis, MN |
| 85 | Wed Jul 6 | vs Rays | L5-12 | 38-47 | .447 | Target Field · Minneapolis, MN |
| 86 | Thu Jul 7 | at White Sox | W6-2 | 39-47 | .453 | Guaranteed Rate Field · Chicago, IL |
| 87 | Fri Jul 8 | at White Sox | W8-5 | 40-47 | .460 | Guaranteed Rate Field · Chicago, IL |
| 88 | Sat Jul 9 | at White Sox | L3-4 | 40-48 | .455 | Guaranteed Rate Field · Chicago, IL |
| 89 | Sun Jul 10 | at White Sox | W6-3 | 41-48 | .461 | Guaranteed Rate Field · Chicago, IL |
| 90 | Thu Jul 14 | vs Royals | W8-4 | 42-48 | .467 | Target Field · Minneapolis, MN |
| 91 | Fri Jul 15 | vs Royals | L1-2 | 42-49 | .462 | Target Field · Minneapolis, MN |
| 92 | Sat Jul 16 | vs Royals | W4-3 | 43-49 | .467 | Target Field · Minneapolis, MN |
| 93 | Sun Jul 17 | vs Royals | W4-3 | 44-49 | .473 | Target Field · Minneapolis, MN |
| 94 | Mon Jul 18 | vs Guardians | L2-5 | 44-50 | .468 | Target Field · Minneapolis, MN |
| 95 | Mon Jul 18 | vs Guardians | L3-6 | 44-51 | .463 | Target Field · Minneapolis, MN |
| 96 | Tue Jul 19 | vs Guardians | W2-1 | 45-51 | .469 | Target Field · Minneapolis, MN |
| 97 | Wed Jul 20 | vs Guardians | W7-5 | 46-51 | .474 | Target Field · Minneapolis, MN |
| 98 | Thu Jul 21 | vs Tigers | L2-6 | 46-52 | .469 | Target Field · Minneapolis, MN |
| 99 | Fri Jul 22 | vs Tigers | L2-8 | 46-53 | .465 | Target Field · Minneapolis, MN |
| 100 | Sat Jul 23 | vs Tigers | W4-1 | 47-53 | .470 | Target Field · Minneapolis, MN |
| 101 | Sun Jul 24 | vs Tigers | L2-5 | 47-54 | .465 | Target Field · Minneapolis, MN |
| 102 | Mon Jul 25 | at Rangers | L6-20 | 47-55 | .461 | Globe Life Field · Arlington, TX |
| 103 | Tue Jul 26 | at Rangers | W9-8 | 48-55 | .466 | Globe Life Field · Arlington, TX |
| 104 | Wed Jul 27 | at Rangers | W7-2 | 49-55 | .471 | Globe Life Field · Arlington, TX |
| 105 | Thu Jul 28 | at Rangers | L1-4 | 49-56 | .467 | Globe Life Field · Arlington, TX |
| 106 | Fri Jul 29 | at Athletics | W9-5 | 50-56 | .472 | RingCentral Coliseum · Oakland, CA |
| 107 | Sat Jul 30 | at Athletics | L3-8 | 50-57 | .467 | RingCentral Coliseum · Oakland, CA |
| 108 | Sun Jul 31 | at Athletics | L3-7 | 50-58 | .463 | RingCentral Coliseum · Oakland, CA |
| 109 | Tue Aug 2 | at Angels | L1-5 | 50-59 | .459 | Angel Stadium · Anaheim, CA |
| 110 | Wed Aug 3 | at Angels | W11-4 | 51-59 | .464 | Angel Stadium · Anaheim, CA |
| 111 | Thu Aug 4 | at Angels | L1-7 | 51-60 | .459 | Angel Stadium · Anaheim, CA |
| 112 | Fri Aug 5 | vs White Sox | L3-5 | 51-61 | .455 | Target Field · Minneapolis, MN |
| 113 | Sat Aug 6 | vs White Sox | L1-6 | 51-62 | .451 | Target Field · Minneapolis, MN |
| 114 | Sun Aug 7 | vs White Sox | L0-7 | 51-63 | .447 | Target Field · Minneapolis, MN |
| 115 | Mon Aug 8 | vs Red Sox | L6-8 | 51-64 | .443 | Target Field · Minneapolis, MN |
| 116 | Tue Aug 9 | vs Red Sox | L3-4 | 51-65 | .440 | Target Field · Minneapolis, MN |
| 117 | Wed Aug 10 | vs Red Sox | W5-2 | 52-65 | .444 | Target Field · Minneapolis, MN |
| 118 | Fri Aug 12 | at Guardians | L2-3 | 52-66 | .441 | Progressive Field · Cleveland, OH |
| 119 | Sat Aug 13 | at Guardians | L1-3 | 52-67 | .437 | Progressive Field · Cleveland, OH |
| 120 | Mon Aug 15 | at Tigers | W9-6 | 53-67 | .442 | Comerica Park · Detroit, MI |
| 121 | Tue Aug 16 | at Tigers | L1-7 | 53-68 | .438 | Comerica Park · Detroit, MI |
| 122 | Wed Aug 17 | at Tigers | W6-5 | 54-68 | .443 | Comerica Park · Detroit, MI |
| 123 | Thu Aug 18 | vs Yankees | L4-8 | 54-69 | .439 | Target Field · Minneapolis, MN |
| 124 | Fri Aug 19 | vs Yankees | L1-8 | 54-70 | .435 | Target Field · Minneapolis, MN |
| 125 | Sat Aug 20 | vs Yankees | W9-4 | 55-70 | .440 | Target Field · Minneapolis, MN |
| 126 | Sun Aug 21 | vs Yankees | L0-3 | 55-71 | .437 | Target Field · Minneapolis, MN |
| 127 | Mon Aug 22 | vs Orioles | L1-4 | 55-72 | .433 | Target Field · Minneapolis, MN |
| 128 | Tue Aug 23 | vs Orioles | L1-8 | 55-73 | .430 | Target Field · Minneapolis, MN |
| 129 | Wed Aug 24 | vs Orioles | L1-6 | 55-74 | .426 | Target Field · Minneapolis, MN |
| 130 | Thu Aug 25 | vs Orioles | L1-6 | 55-75 | .423 | Target Field · Minneapolis, MN |
| 131 | Fri Aug 26 | vs Tigers | L1-8 | 55-76 | .420 | Target Field · Minneapolis, MN |
| 132 | Sat Aug 27 | vs Tigers | L4-6 | 55-77 | .417 | Target Field · Minneapolis, MN |
| 133 | Sun Aug 28 | vs Tigers | W11-4 | 56-77 | .421 | Target Field · Minneapolis, MN |
| 134 | Mon Aug 29 | at White Sox | L0-3 | 56-78 | .418 | Guaranteed Rate Field · Chicago, IL |
| 135 | Tue Aug 30 | at White Sox | L6-8 | 56-79 | .415 | Guaranteed Rate Field · Chicago, IL |
| 136 | Wed Aug 31 | at White Sox | W7-6 | 57-79 | .419 | Guaranteed Rate Field · Chicago, IL |
| 137 | Fri Sep 2 | at Angels | W13-5 | 58-79 | .423 | Angel Stadium · Anaheim, CA |
| 138 | Sat Sep 3 | at Angels | L6-10 | 58-80 | .420 | Angel Stadium · Anaheim, CA |
| 139 | Sun Sep 4 | at Angels | L1-4 | 58-81 | .417 | Angel Stadium · Anaheim, CA |
| 140 | Mon Sep 5 | vs White Sox | L1-2 | 58-82 | .414 | Target Field · Minneapolis, MN |
| 141 | Mon Sep 5 | vs White Sox | L0-4 | 58-83 | .411 | Target Field · Minneapolis, MN |
| 142 | Tue Sep 6 | vs White Sox | L0-3 | 58-84 | .408 | Target Field · Minneapolis, MN |
| 143 | Wed Sep 7 | vs White Sox | W5-4 | 59-84 | .413 | Target Field · Minneapolis, MN |
| 144 | Fri Sep 9 | at Tigers | L4-8 | 59-85 | .410 | Comerica Park · Detroit, MI |
| 145 | Sat Sep 10 | at Tigers | L2-3 | 59-86 | .407 | Comerica Park · Detroit, MI |
| 146 | Sun Sep 11 | at Tigers | L1-2 | 59-87 | .404 | Comerica Park · Detroit, MI |
| 147 | Tue Sep 13 | at Royals | L0-4 | 59-88 | .401 | Kauffman Stadium · Kansas City, MO |
| 148 | Wed Sep 14 | at Royals | L3-7 | 59-89 | .399 | Kauffman Stadium · Kansas City, MO |
| 149 | Fri Sep 16 | vs Guardians | L6-7 | 59-90 | .396 | Target Field · Minneapolis, MN |
| 150 | Sat Sep 17 | vs Guardians | L4-10 | 59-91 | .393 | Target Field · Minneapolis, MN |
| 151 | Sun Sep 18 | vs Guardians | L5-6 | 59-92 | .391 | Target Field · Minneapolis, MN |
| 152 | Mon Sep 19 | at Yankees | L4-6 | 59-93 | .388 | Yankee Stadium · The Bronx, NY |
| 153 | Tue Sep 20 | vs Mariners | L4-5 | 59-94 | .386 | Target Field · Minneapolis, MN |
| 154 | Wed Sep 21 | vs Mariners | L4-5 | 59-95 | .383 | Target Field · Minneapolis, MN |
| 155 | Thu Sep 22 | vs Mariners | W3-2 | 60-95 | .387 | Target Field · Minneapolis, MN |
| 156 | Fri Sep 23 | at Guardians | L5-6 | 60-96 | .385 | Progressive Field · Cleveland, OH |
| 157 | Sat Sep 24 | at Guardians | L2-8 | 60-97 | .382 | Progressive Field · Cleveland, OH |
| 158 | Sat Sep 24 | at Guardians | L6-7 | 60-98 | .380 | Progressive Field · Cleveland, OH |
| 159 | Sun Sep 25 | at Guardians | W6-4 (10) | 61-98 | .384 | Progressive Field · Cleveland, OH |
| 160 | Mon Sep 26 | vs Royals | L3-7 | 61-99 | .381 | Target Field · Minneapolis, MN |
| 161 | Tue Sep 27 | vs Royals | W7-4 | 62-99 | .385 | Target Field · Minneapolis, MN |
| 162 | Wed Sep 28 | vs Royals | W1-0 | 63-99 | .389 | Target Field · Minneapolis, MN |