| 1 | Thu Apr 1 | at Brewers | L5-6 (10) | 0-1 | .000 | American Family Field · Milwaukee, WI |
| 2 | Sat Apr 3 | at Brewers | W2-0 | 1-1 | .500 | American Family Field · Milwaukee, WI |
| 3 | Sun Apr 4 | at Brewers | W8-2 | 2-1 | .667 | American Family Field · Milwaukee, WI |
| 4 | Mon Apr 5 | at Tigers | W15-6 | 3-1 | .750 | Comerica Park · Detroit, MI |
| 5 | Tue Apr 6 | at Tigers | L3-4 (10) | 3-2 | .600 | Comerica Park · Detroit, MI |
| 6 | Wed Apr 7 | at Tigers | W3-2 | 4-2 | .667 | Comerica Park · Detroit, MI |
| 7 | Thu Apr 8 | vs Mariners | W10-2 | 5-2 | .714 | Target Field · Minneapolis, MN |
| 8 | Sat Apr 10 | vs Mariners | L3-4 (10) | 5-3 | .625 | Target Field · Minneapolis, MN |
| 9 | Sun Apr 11 | vs Mariners | L6-8 | 5-4 | .556 | Target Field · Minneapolis, MN |
| 10 | Tue Apr 13 | vs Red Sox | L2-4 | 5-5 | .500 | Target Field · Minneapolis, MN |
| 11 | Wed Apr 14 | vs Red Sox | L2-3 | 5-6 | .455 | Target Field · Minneapolis, MN |
| 12 | Wed Apr 14 | vs Red Sox | L1-7 | 5-7 | .417 | Target Field · Minneapolis, MN |
| 13 | Thu Apr 15 | vs Red Sox | W4-3 | 6-7 | .462 | Target Field · Minneapolis, MN |
| 14 | Fri Apr 16 | at Angels | L3-10 | 6-8 | .429 | Angel Stadium · Anaheim, CA |
| 15 | Tue Apr 20 | at Athletics | L0-7 | 6-9 | .400 | RingCentral Coliseum · Oakland, CA |
| 16 | Tue Apr 20 | at Athletics | L0-1 | 6-10 | .375 | RingCentral Coliseum · Oakland, CA |
| 17 | Wed Apr 21 | at Athletics | L12-13 (10) | 6-11 | .353 | RingCentral Coliseum · Oakland, CA |
| 18 | Fri Apr 23 | vs Pirates | W2-0 | 7-11 | .389 | Target Field · Minneapolis, MN |
| 19 | Sat Apr 24 | vs Pirates | L2-6 | 7-12 | .368 | Target Field · Minneapolis, MN |
| 20 | Sun Apr 25 | vs Pirates | L2-6 | 7-13 | .350 | Target Field · Minneapolis, MN |
| 21 | Mon Apr 26 | at Guardians | L3-5 (10) | 7-14 | .333 | Progressive Field · Cleveland, OH |
| 22 | Tue Apr 27 | at Guardians | L4-7 | 7-15 | .318 | Progressive Field · Cleveland, OH |
| 23 | Wed Apr 28 | at Guardians | W10-2 | 8-15 | .348 | Progressive Field · Cleveland, OH |
| 24 | Fri Apr 30 | vs Royals | W9-1 | 9-15 | .375 | Target Field · Minneapolis, MN |
| 25 | Sat May 1 | vs Royals | L3-11 | 9-16 | .360 | Target Field · Minneapolis, MN |
| 26 | Sun May 2 | vs Royals | W13-4 | 10-16 | .385 | Target Field · Minneapolis, MN |
| 27 | Mon May 3 | vs Rangers | W6-5 | 11-16 | .407 | Target Field · Minneapolis, MN |
| 28 | Tue May 4 | vs Rangers | L3-6 (10) | 11-17 | .393 | Target Field · Minneapolis, MN |
| 29 | Wed May 5 | vs Rangers | L1-3 | 11-18 | .379 | Target Field · Minneapolis, MN |
| 30 | Thu May 6 | vs Rangers | L3-4 (10) | 11-19 | .367 | Target Field · Minneapolis, MN |
| 31 | Fri May 7 | at Tigers | W7-3 | 12-19 | .387 | Comerica Park · Detroit, MI |
| 32 | Sat May 8 | at Tigers | L3-7 | 12-20 | .375 | Comerica Park · Detroit, MI |
| 33 | Tue May 11 | at White Sox | L3-9 | 12-21 | .364 | Guaranteed Rate Field · Chicago, IL |
| 34 | Wed May 12 | at White Sox | L8-13 | 12-22 | .353 | Guaranteed Rate Field · Chicago, IL |
| 35 | Thu May 13 | at White Sox | L2-4 | 12-23 | .343 | Guaranteed Rate Field · Chicago, IL |
| 36 | Fri May 14 | vs Athletics | L1-6 | 12-24 | .333 | Target Field · Minneapolis, MN |
| 37 | Sat May 15 | vs Athletics | W5-4 | 13-24 | .351 | Target Field · Minneapolis, MN |
| 38 | Sun May 16 | vs Athletics | L6-7 | 13-25 | .342 | Target Field · Minneapolis, MN |
| 39 | Mon May 17 | vs White Sox | L4-16 | 13-26 | .333 | Target Field · Minneapolis, MN |
| 40 | Tue May 18 | vs White Sox | W5-4 | 14-26 | .350 | Target Field · Minneapolis, MN |
| 41 | Wed May 19 | vs White Sox | L1-2 | 14-27 | .341 | Target Field · Minneapolis, MN |
| 42 | Thu May 20 | at Angels | L1-7 | 14-28 | .333 | Angel Stadium · Anaheim, CA |
| 43 | Thu May 20 | at Angels | W6-3 | 15-28 | .349 | Angel Stadium · Anaheim, CA |
| 44 | Fri May 21 | at Guardians | W10-0 | 16-28 | .364 | Progressive Field · Cleveland, OH |
| 45 | Sat May 22 | at Guardians | L3-5 (10) | 16-29 | .356 | Progressive Field · Cleveland, OH |
| 46 | Sun May 23 | at Guardians | W8-5 (10) | 17-29 | .370 | Progressive Field · Cleveland, OH |
| 47 | Mon May 24 | vs Orioles | W8-3 | 18-29 | .383 | Target Field · Minneapolis, MN |
| 48 | Tue May 25 | vs Orioles | W7-4 | 19-29 | .396 | Target Field · Minneapolis, MN |
| 49 | Wed May 26 | vs Orioles | W3-2 | 20-29 | .408 | Target Field · Minneapolis, MN |
| 50 | Fri May 28 | vs Royals | L3-8 | 20-30 | .400 | Target Field · Minneapolis, MN |
| 51 | Sat May 29 | vs Royals | W6-5 | 21-30 | .412 | Target Field · Minneapolis, MN |
| 52 | Sun May 30 | vs Royals | L3-6 | 21-31 | .404 | Target Field · Minneapolis, MN |
| 53 | Mon May 31 | at Orioles | W3-2 (10) | 22-31 | .415 | Camden Yards · Baltimore, MD |
| 54 | Tue Jun 1 | at Orioles | L4-7 | 22-32 | .407 | Camden Yards · Baltimore, MD |
| 55 | Wed Jun 2 | at Orioles | L3-6 | 22-33 | .400 | Camden Yards · Baltimore, MD |
| 56 | Thu Jun 3 | at Royals | L5-6 | 22-34 | .393 | Kauffman Stadium · Kansas City, MO |
| 57 | Fri Jun 4 | at Royals | L5-14 | 22-35 | .386 | Kauffman Stadium · Kansas City, MO |
| 58 | Sat Jun 5 | at Royals | W5-4 | 23-35 | .397 | Kauffman Stadium · Kansas City, MO |
| 59 | Sun Jun 6 | at Royals | W2-1 | 24-35 | .407 | Kauffman Stadium · Kansas City, MO |
| 60 | Tue Jun 8 | vs Yankees | L4-8 | 24-36 | .400 | Target Field · Minneapolis, MN |
| 61 | Wed Jun 9 | vs Yankees | L6-9 | 24-37 | .393 | Target Field · Minneapolis, MN |
| 62 | Thu Jun 10 | vs Yankees | W7-5 | 25-37 | .403 | Target Field · Minneapolis, MN |
| 63 | Fri Jun 11 | vs Astros | L4-6 | 25-38 | .397 | Target Field · Minneapolis, MN |
| 64 | Sat Jun 12 | vs Astros | W5-2 | 26-38 | .406 | Target Field · Minneapolis, MN |
| 65 | Sun Jun 13 | vs Astros | L3-14 | 26-39 | .400 | Target Field · Minneapolis, MN |
| 66 | Mon Jun 14 | at Mariners | L3-4 | 26-40 | .394 | T-Mobile Park · Seattle, WA |
| 67 | Tue Jun 15 | at Mariners | L0-10 | 26-41 | .388 | T-Mobile Park · Seattle, WA |
| 68 | Wed Jun 16 | at Mariners | W7-2 | 27-41 | .397 | T-Mobile Park · Seattle, WA |
| 69 | Fri Jun 18 | at Rangers | W7-5 (10) | 28-41 | .406 | Globe Life Field · Arlington, TX |
| 70 | Sat Jun 19 | at Rangers | W3-2 | 29-41 | .414 | Globe Life Field · Arlington, TX |
| 71 | Sun Jun 20 | at Rangers | W4-2 | 30-41 | .423 | Globe Life Field · Arlington, TX |
| 72 | Mon Jun 21 | vs Reds | W7-5 (12) | 31-41 | .431 | Target Field · Minneapolis, MN |
| 73 | Tue Jun 22 | vs Reds | L7-10 | 31-42 | .425 | Target Field · Minneapolis, MN |
| 74 | Thu Jun 24 | vs Guardians | L1-4 | 31-43 | .419 | Target Field · Minneapolis, MN |
| 75 | Fri Jun 25 | vs Guardians | W8-7 | 32-43 | .427 | Target Field · Minneapolis, MN |
| 76 | Sun Jun 27 | vs Guardians | W8-2 | 33-43 | .434 | Target Field · Minneapolis, MN |
| 77 | Tue Jun 29 | at White Sox | L6-7 | 33-44 | .429 | Guaranteed Rate Field · Chicago, IL |
| 78 | Wed Jun 30 | at White Sox | L3-13 | 33-45 | .423 | Guaranteed Rate Field · Chicago, IL |
| 79 | Thu Jul 1 | at White Sox | L5-8 | 33-46 | .418 | Guaranteed Rate Field · Chicago, IL |
| 80 | Fri Jul 2 | at Royals | L4-7 | 33-47 | .412 | Kauffman Stadium · Kansas City, MO |
| 81 | Sat Jul 3 | at Royals | L3-6 | 33-48 | .407 | Kauffman Stadium · Kansas City, MO |
| 82 | Sun Jul 4 | at Royals | W6-2 | 34-48 | .415 | Kauffman Stadium · Kansas City, MO |
| 83 | Mon Jul 5 | vs White Sox | W8-5 | 35-48 | .422 | Target Field · Minneapolis, MN |
| 84 | Tue Jul 6 | vs White Sox | L1-4 | 35-49 | .417 | Target Field · Minneapolis, MN |
| 85 | Wed Jul 7 | vs White Sox | L1-6 | 35-50 | .412 | Target Field · Minneapolis, MN |
| 86 | Thu Jul 8 | vs Tigers | W5-3 | 36-50 | .419 | Target Field · Minneapolis, MN |
| 87 | Fri Jul 9 | vs Tigers | W4-2 | 37-50 | .425 | Target Field · Minneapolis, MN |
| 88 | Sat Jul 10 | vs Tigers | W9-4 | 38-50 | .432 | Target Field · Minneapolis, MN |
| 89 | Sun Jul 11 | vs Tigers | W12-9 (10) | 39-50 | .438 | Target Field · Minneapolis, MN |
| 90 | Sat Jul 17 | at Tigers | L0-1 | 39-51 | .433 | Comerica Park · Detroit, MI |
| 91 | Sat Jul 17 | at Tigers | L4-5 (8) | 39-52 | .429 | Comerica Park · Detroit, MI |
| 92 | Sun Jul 18 | at Tigers | L0-7 | 39-53 | .424 | Comerica Park · Detroit, MI |
| 93 | Mon Jul 19 | at White Sox | W3-2 (8) | 40-53 | .430 | Guaranteed Rate Field · Chicago, IL |
| 94 | Mon Jul 19 | at White Sox | L3-5 | 40-54 | .426 | Guaranteed Rate Field · Chicago, IL |
| 95 | Tue Jul 20 | at White Sox | L5-9 | 40-55 | .421 | Guaranteed Rate Field · Chicago, IL |
| 96 | Wed Jul 21 | at White Sox | W7-2 | 41-55 | .427 | Guaranteed Rate Field · Chicago, IL |
| 97 | Thu Jul 22 | vs Angels | L2-3 | 41-56 | .423 | Target Field · Minneapolis, MN |
| 98 | Fri Jul 23 | vs Angels | W5-4 | 42-56 | .429 | Target Field · Minneapolis, MN |
| 99 | Sat Jul 24 | vs Angels | L1-2 | 42-57 | .424 | Target Field · Minneapolis, MN |
| 100 | Sun Jul 25 | vs Angels | L2-6 | 42-58 | .420 | Target Field · Minneapolis, MN |
| 101 | Mon Jul 26 | vs Tigers | W6-5 (10) | 43-58 | .426 | Target Field · Minneapolis, MN |
| 102 | Tue Jul 27 | vs Tigers | L5-6 (11) | 43-59 | .422 | Target Field · Minneapolis, MN |
| 103 | Wed Jul 28 | vs Tigers | L14-17 | 43-60 | .417 | Target Field · Minneapolis, MN |
| 104 | Fri Jul 30 | at Cardinals | L1-5 | 43-61 | .413 | Busch Stadium · St. Louis, MO |
| 105 | Sat Jul 31 | at Cardinals | W8-1 | 44-61 | .419 | Busch Stadium · St. Louis, MO |
| 106 | Sun Aug 1 | at Cardinals | L3-7 | 44-62 | .415 | Busch Stadium · St. Louis, MO |
| 107 | Tue Aug 3 | at Reds | W7-5 | 45-62 | .421 | Great American Ball Park · Cincinnati, OH |
| 108 | Wed Aug 4 | at Reds | L5-6 | 45-63 | .417 | Great American Ball Park · Cincinnati, OH |
| 109 | Thu Aug 5 | at Astros | W5-3 | 46-63 | .422 | Minute Maid Park · Houston, TX |
| 110 | Fri Aug 6 | at Astros | W5-4 (11) | 47-63 | .427 | Minute Maid Park · Houston, TX |
| 111 | Sat Aug 7 | at Astros | L0-4 | 47-64 | .423 | Minute Maid Park · Houston, TX |
| 112 | Sun Aug 8 | at Astros | W7-5 | 48-64 | .429 | Minute Maid Park · Houston, TX |
| 113 | Mon Aug 9 | vs White Sox | L1-11 | 48-65 | .425 | Target Field · Minneapolis, MN |
| 114 | Tue Aug 10 | vs White Sox | W4-3 | 49-65 | .430 | Target Field · Minneapolis, MN |
| 115 | Wed Aug 11 | vs White Sox | W1-0 | 50-65 | .435 | Target Field · Minneapolis, MN |
| 116 | Fri Aug 13 | vs Rays | L4-10 | 50-66 | .431 | Target Field · Minneapolis, MN |
| 117 | Sat Aug 14 | vs Rays | W12-0 | 51-66 | .436 | Target Field · Minneapolis, MN |
| 118 | Sun Aug 15 | vs Rays | W5-4 | 52-66 | .441 | Target Field · Minneapolis, MN |
| 119 | Mon Aug 16 | vs Guardians | W5-4 (10) | 53-66 | .445 | Target Field · Minneapolis, MN |
| 120 | Tue Aug 17 | vs Guardians | L1-3 | 53-67 | .442 | Target Field · Minneapolis, MN |
| 121 | Wed Aug 18 | vs Guardians | W8-7 (11) | 54-67 | .446 | Target Field · Minneapolis, MN |
| 122 | Thu Aug 19 | at Yankees | L5-7 | 54-68 | .443 | Yankee Stadium · The Bronx, NY |
| 123 | Fri Aug 20 | at Yankees | L2-10 | 54-69 | .439 | Yankee Stadium · The Bronx, NY |
| 124 | Sat Aug 21 | at Yankees | L1-7 | 54-70 | .435 | Yankee Stadium · The Bronx, NY |
| 125 | Tue Aug 24 | at Red Sox | L9-11 | 54-71 | .432 | Fenway Park · Boston, MA |
| 126 | Wed Aug 25 | at Red Sox | W9-6 (10) | 55-71 | .437 | Fenway Park · Boston, MA |
| 127 | Thu Aug 26 | at Red Sox | L2-12 | 55-72 | .433 | Fenway Park · Boston, MA |
| 128 | Fri Aug 27 | vs Brewers | W2-0 | 56-72 | .438 | Target Field · Minneapolis, MN |
| 129 | Sat Aug 28 | vs Brewers | W6-4 | 57-72 | .442 | Target Field · Minneapolis, MN |
| 130 | Sun Aug 29 | vs Brewers | L2-6 | 57-73 | .438 | Target Field · Minneapolis, MN |
| 131 | Mon Aug 30 | at Tigers | W3-2 | 58-73 | .443 | Comerica Park · Detroit, MI |
| 132 | Tue Aug 31 | vs Cubs | L1-3 | 58-74 | .439 | Target Field · Minneapolis, MN |
| 133 | Wed Sep 1 | vs Cubs | L0-3 | 58-75 | .436 | Target Field · Minneapolis, MN |
| 134 | Fri Sep 3 | at Rays | L3-5 | 58-76 | .433 | Tropicana Field · St. Petersburg, FL |
| 135 | Sat Sep 4 | at Rays | L4-11 | 58-77 | .430 | Tropicana Field · St. Petersburg, FL |
| 136 | Sun Sep 5 | at Rays | W6-5 | 59-77 | .434 | Tropicana Field · St. Petersburg, FL |
| 137 | Mon Sep 6 | at Guardians | W5-2 | 60-77 | .438 | Progressive Field · Cleveland, OH |
| 138 | Tue Sep 7 | at Guardians | W3-0 | 61-77 | .442 | Progressive Field · Cleveland, OH |
| 139 | Wed Sep 8 | at Guardians | W3-0 | 62-77 | .446 | Progressive Field · Cleveland, OH |
| 140 | Thu Sep 9 | at Guardians | L1-4 | 62-78 | .443 | Progressive Field · Cleveland, OH |
| 141 | Fri Sep 10 | vs Royals | L4-6 (11) | 62-79 | .440 | Target Field · Minneapolis, MN |
| 142 | Sat Sep 11 | vs Royals | W9-2 | 63-79 | .444 | Target Field · Minneapolis, MN |
| 143 | Sun Sep 12 | vs Royals | L3-5 | 63-80 | .441 | Target Field · Minneapolis, MN |
| 144 | Mon Sep 13 | at Yankees | L5-6 (10) | 63-81 | .438 | Yankee Stadium · The Bronx, NY |
| 145 | Tue Sep 14 | vs Guardians | L1-3 | 63-82 | .434 | Target Field · Minneapolis, MN |
| 146 | Tue Sep 14 | vs Guardians | W6-3 | 64-82 | .438 | Target Field · Minneapolis, MN |
| 147 | Wed Sep 15 | vs Guardians | L3-12 | 64-83 | .435 | Target Field · Minneapolis, MN |
| 148 | Fri Sep 17 | at Blue Jays | W7-3 | 65-83 | .439 | Rogers Centre · Toronto, ON |
| 149 | Sat Sep 18 | at Blue Jays | L2-6 | 65-84 | .436 | Rogers Centre · Toronto, ON |
| 150 | Sun Sep 19 | at Blue Jays | L3-5 | 65-85 | .433 | Rogers Centre · Toronto, ON |
| 151 | Tue Sep 21 | at Cubs | W9-5 | 66-85 | .437 | Wrigley Field · Chicago, IL |
| 152 | Wed Sep 22 | at Cubs | W5-4 | 67-85 | .441 | Wrigley Field · Chicago, IL |
| 153 | Thu Sep 23 | vs Blue Jays | W7-2 | 68-85 | .444 | Target Field · Minneapolis, MN |
| 154 | Fri Sep 24 | vs Blue Jays | W3-1 | 69-85 | .448 | Target Field · Minneapolis, MN |
| 155 | Sat Sep 25 | vs Blue Jays | L1-6 | 69-86 | .445 | Target Field · Minneapolis, MN |
| 156 | Sun Sep 26 | vs Blue Jays | L2-5 | 69-87 | .442 | Target Field · Minneapolis, MN |
| 157 | Tue Sep 28 | vs Tigers | W3-2 | 70-87 | .446 | Target Field · Minneapolis, MN |
| 158 | Wed Sep 29 | vs Tigers | W5-2 | 71-87 | .449 | Target Field · Minneapolis, MN |
| 159 | Thu Sep 30 | vs Tigers | L7-10 | 71-88 | .447 | Target Field · Minneapolis, MN |
| 160 | Fri Oct 1 | at Royals | L6-11 | 71-89 | .444 | Kauffman Stadium · Kansas City, MO |
| 161 | Sat Oct 2 | at Royals | W4-0 | 72-89 | .447 | Kauffman Stadium · Kansas City, MO |
| 162 | Sun Oct 3 | at Royals | W7-3 | 73-89 | .451 | Kauffman Stadium · Kansas City, MO |