| 1 | Mon Apr 3 | vs Royals | W7-1 | 1-0 | 1.000 | Target Field · Minneapolis, MN |
| 2 | Wed Apr 5 | vs Royals | W9-1 | 2-0 | 1.000 | Target Field · Minneapolis, MN |
| 3 | Thu Apr 6 | vs Royals | W5-3 | 3-0 | 1.000 | Target Field · Minneapolis, MN |
| 4 | Fri Apr 7 | at White Sox | W3-1 | 4-0 | 1.000 | Guaranteed Rate Field · Chicago, IL |
| 5 | Sat Apr 8 | at White Sox | L2-6 | 4-1 | .800 | Guaranteed Rate Field · Chicago, IL |
| 6 | Sun Apr 9 | at White Sox | W4-1 | 5-1 | .833 | Guaranteed Rate Field · Chicago, IL |
| 7 | Tue Apr 11 | at Tigers | L1-2 | 5-2 | .714 | Comerica Park · Detroit, MI |
| 8 | Wed Apr 12 | at Tigers | L3-5 | 5-3 | .625 | Comerica Park · Detroit, MI |
| 9 | Thu Apr 13 | at Tigers | W11-5 | 6-3 | .667 | Comerica Park · Detroit, MI |
| 10 | Fri Apr 14 | vs White Sox | L1-2 | 6-4 | .600 | Target Field · Minneapolis, MN |
| 11 | Sat Apr 15 | vs White Sox | W6-0 | 7-4 | .636 | Target Field · Minneapolis, MN |
| 12 | Sun Apr 16 | vs White Sox | L1-3 (10) | 7-5 | .583 | Target Field · Minneapolis, MN |
| 13 | Mon Apr 17 | vs Guardians | L1-3 | 7-6 | .538 | Target Field · Minneapolis, MN |
| 14 | Tue Apr 18 | vs Guardians | L4-11 | 7-7 | .500 | Target Field · Minneapolis, MN |
| 15 | Thu Apr 20 | vs Guardians | L2-6 | 7-8 | .467 | Target Field · Minneapolis, MN |
| 16 | Fri Apr 21 | vs Tigers | W6-3 | 8-8 | .500 | Target Field · Minneapolis, MN |
| 17 | Sat Apr 22 | vs Tigers | L4-5 | 8-9 | .471 | Target Field · Minneapolis, MN |
| 18 | Sun Apr 23 | vs Tigers | L4-13 | 8-10 | .444 | Target Field · Minneapolis, MN |
| 19 | Mon Apr 24 | at Rangers | W3-2 | 9-10 | .474 | Globe Life Field · Arlington, TX |
| 20 | Tue Apr 25 | at Rangers | W8-1 | 10-10 | .500 | Globe Life Field · Arlington, TX |
| 21 | Wed Apr 26 | at Rangers | L3-14 | 10-11 | .476 | Globe Life Field · Arlington, TX |
| 22 | Fri Apr 28 | at Royals | W6-4 | 11-11 | .500 | Kauffman Stadium · Kansas City, MO |
| 23 | Sun Apr 30 | at Royals | W7-5 | 12-11 | .522 | Kauffman Stadium · Kansas City, MO |
| 24 | Tue May 2 | vs Athletics | W9-1 | 13-11 | .542 | Target Field · Minneapolis, MN |
| 25 | Wed May 3 | vs Athletics | W7-4 | 14-11 | .560 | Target Field · Minneapolis, MN |
| 26 | Thu May 4 | vs Athletics | L5-8 | 14-12 | .538 | Target Field · Minneapolis, MN |
| 27 | Fri May 5 | vs Red Sox | W4-3 | 15-12 | .556 | Target Field · Minneapolis, MN |
| 28 | Sat May 6 | vs Red Sox | L1-11 | 15-13 | .536 | Target Field · Minneapolis, MN |
| 29 | Sun May 7 | vs Red Sox | L6-17 | 15-14 | .517 | Target Field · Minneapolis, MN |
| 30 | Tue May 9 | at White Sox | W7-2 | 16-14 | .533 | Guaranteed Rate Field · Chicago, IL |
| 31 | Thu May 11 | at White Sox | W7-6 | 17-14 | .548 | Guaranteed Rate Field · Chicago, IL |
| 32 | Fri May 12 | at Guardians | W1-0 | 18-14 | .563 | Progressive Field · Cleveland, OH |
| 33 | Sat May 13 | at Guardians | W4-1 | 19-14 | .576 | Progressive Field · Cleveland, OH |
| 34 | Sun May 14 | at Guardians | L3-8 | 19-15 | .559 | Progressive Field · Cleveland, OH |
| 35 | Tue May 16 | vs Rockies | L3-7 | 19-16 | .543 | Target Field · Minneapolis, MN |
| 36 | Thu May 18 | vs Rockies | L1-5 | 19-17 | .528 | Target Field · Minneapolis, MN |
| 37 | Thu May 18 | vs Rockies | W2-0 | 20-17 | .541 | Target Field · Minneapolis, MN |
| 38 | Fri May 19 | vs Royals | W4-3 (10) | 21-17 | .553 | Target Field · Minneapolis, MN |
| 39 | Sun May 21 | vs Royals | L4-6 | 21-18 | .538 | Target Field · Minneapolis, MN |
| 40 | Sun May 21 | vs Royals | W8-4 | 22-18 | .550 | Target Field · Minneapolis, MN |
| 41 | Mon May 22 | at Orioles | W14-7 | 23-18 | .561 | Camden Yards · Baltimore, MD |
| 42 | Tue May 23 | at Orioles | W2-0 | 24-18 | .571 | Camden Yards · Baltimore, MD |
| 43 | Wed May 24 | at Orioles | W4-3 | 25-18 | .581 | Camden Yards · Baltimore, MD |
| 44 | Fri May 26 | vs Rays | L2-5 | 25-19 | .568 | Target Field · Minneapolis, MN |
| 45 | Sat May 27 | vs Rays | W5-3 | 26-19 | .578 | Target Field · Minneapolis, MN |
| 46 | Sun May 28 | vs Rays | L6-8 (15) | 26-20 | .565 | Target Field · Minneapolis, MN |
| 47 | Mon May 29 | vs Astros | L8-16 | 26-21 | .553 | Target Field · Minneapolis, MN |
| 48 | Tue May 30 | vs Astros | L2-7 | 26-22 | .542 | Target Field · Minneapolis, MN |
| 49 | Wed May 31 | vs Astros | L6-17 | 26-23 | .531 | Target Field · Minneapolis, MN |
| 50 | Thu Jun 1 | at Angels | W4-2 | 27-23 | .540 | Angel Stadium · Anaheim, CA |
| 51 | Fri Jun 2 | at Angels | W11-5 | 28-23 | .549 | Angel Stadium · Anaheim, CA |
| 52 | Sat Jun 3 | at Angels | L2-7 | 28-24 | .538 | Angel Stadium · Anaheim, CA |
| 53 | Sun Jun 4 | at Angels | W3-2 | 29-24 | .547 | Angel Stadium · Anaheim, CA |
| 54 | Tue Jun 6 | at Mariners | L3-12 | 29-25 | .537 | T-Mobile Park · Seattle, WA |
| 55 | Wed Jun 7 | at Mariners | L5-6 | 29-26 | .527 | T-Mobile Park · Seattle, WA |
| 56 | Thu Jun 8 | at Mariners | W2-1 | 30-26 | .536 | T-Mobile Park · Seattle, WA |
| 57 | Fri Jun 9 | at Giants | W4-0 | 31-26 | .544 | Oracle Park · San Francisco, CA |
| 58 | Sat Jun 10 | at Giants | W3-2 | 32-26 | .552 | Oracle Park · San Francisco, CA |
| 59 | Sun Jun 11 | at Giants | L8-13 | 32-27 | .542 | Oracle Park · San Francisco, CA |
| 60 | Mon Jun 12 | vs Mariners | L3-14 | 32-28 | .533 | Target Field · Minneapolis, MN |
| 61 | Tue Jun 13 | vs Mariners | W20-7 | 33-28 | .541 | Target Field · Minneapolis, MN |
| 62 | Wed Jun 14 | vs Mariners | L4-6 | 33-29 | .532 | Target Field · Minneapolis, MN |
| 63 | Thu Jun 15 | vs Mariners | W6-2 | 34-29 | .540 | Target Field · Minneapolis, MN |
| 64 | Fri Jun 16 | vs Guardians | L1-8 | 34-30 | .531 | Target Field · Minneapolis, MN |
| 65 | Sat Jun 17 | vs Guardians | L3-9 | 34-31 | .523 | Target Field · Minneapolis, MN |
| 66 | Sat Jun 17 | vs Guardians | L2-6 | 34-32 | .515 | Target Field · Minneapolis, MN |
| 67 | Sun Jun 18 | vs Guardians | L2-5 | 34-33 | .507 | Target Field · Minneapolis, MN |
| 68 | Tue Jun 20 | vs White Sox | W9-7 | 35-33 | .515 | Target Field · Minneapolis, MN |
| 69 | Wed Jun 21 | vs White Sox | W4-2 | 36-33 | .522 | Target Field · Minneapolis, MN |
| 70 | Thu Jun 22 | vs White Sox | L0-9 | 36-34 | .514 | Target Field · Minneapolis, MN |
| 71 | Fri Jun 23 | at Guardians | W5-0 | 37-34 | .521 | Progressive Field · Cleveland, OH |
| 72 | Sat Jun 24 | at Guardians | W4-2 | 38-34 | .528 | Progressive Field · Cleveland, OH |
| 73 | Sun Jun 25 | at Guardians | W4-0 | 39-34 | .534 | Progressive Field · Cleveland, OH |
| 74 | Mon Jun 26 | at Red Sox | L1-4 | 39-35 | .527 | Fenway Park · Boston, MA |
| 75 | Tue Jun 27 | at Red Sox | L2-9 | 39-36 | .520 | Fenway Park · Boston, MA |
| 76 | Wed Jun 28 | at Red Sox | W4-1 | 40-36 | .526 | Fenway Park · Boston, MA |
| 77 | Thu Jun 29 | at Red Sox | L3-6 | 40-37 | .519 | Fenway Park · Boston, MA |
| 78 | Fri Jun 30 | at Royals | L1-8 | 40-38 | .513 | Kauffman Stadium · Kansas City, MO |
| 79 | Sat Jul 1 | at Royals | L6-11 | 40-39 | .506 | Kauffman Stadium · Kansas City, MO |
| 80 | Sat Jul 1 | at Royals | W10-5 | 41-39 | .512 | Kauffman Stadium · Kansas City, MO |
| 81 | Sun Jul 2 | at Royals | L2-6 | 41-40 | .506 | Kauffman Stadium · Kansas City, MO |
| 82 | Mon Jul 3 | vs Angels | W9-5 | 42-40 | .512 | Target Field · Minneapolis, MN |
| 83 | Tue Jul 4 | vs Angels | W5-4 | 43-40 | .518 | Target Field · Minneapolis, MN |
| 84 | Wed Jul 5 | vs Angels | L1-2 | 43-41 | .512 | Target Field · Minneapolis, MN |
| 85 | Thu Jul 6 | vs Orioles | W6-4 | 44-41 | .518 | Target Field · Minneapolis, MN |
| 86 | Fri Jul 7 | vs Orioles | W9-6 | 45-41 | .523 | Target Field · Minneapolis, MN |
| 87 | Sat Jul 8 | vs Orioles | L1-5 | 45-42 | .517 | Target Field · Minneapolis, MN |
| 88 | Sun Jul 9 | vs Orioles | L5-11 | 45-43 | .511 | Target Field · Minneapolis, MN |
| 89 | Fri Jul 14 | at Astros | L5-10 | 45-44 | .506 | Minute Maid Park · Houston, TX |
| 90 | Sat Jul 15 | at Astros | W4-2 | 46-44 | .511 | Minute Maid Park · Houston, TX |
| 91 | Sun Jul 16 | at Astros | L3-5 | 46-45 | .505 | Minute Maid Park · Houston, TX |
| 92 | Mon Jul 17 | vs Yankees | W4-2 | 47-45 | .511 | Target Field · Minneapolis, MN |
| 93 | Tue Jul 18 | vs Yankees | L3-6 | 47-46 | .505 | Target Field · Minneapolis, MN |
| 94 | Wed Jul 19 | vs Yankees | W6-1 | 48-46 | .511 | Target Field · Minneapolis, MN |
| 95 | Fri Jul 21 | vs Tigers | L3-6 | 48-47 | .505 | Target Field · Minneapolis, MN |
| 96 | Sat Jul 22 | vs Tigers | W6-5 | 49-47 | .510 | Target Field · Minneapolis, MN |
| 97 | Sun Jul 23 | vs Tigers | L6-9 | 49-48 | .505 | Target Field · Minneapolis, MN |
| 98 | Mon Jul 24 | at Dodgers | L4-6 | 49-49 | .500 | Dodger Stadium · Los Angeles, CA |
| 99 | Tue Jul 25 | at Dodgers | L2-6 | 49-50 | .495 | Dodger Stadium · Los Angeles, CA |
| 100 | Wed Jul 26 | at Dodgers | L5-6 | 49-51 | .490 | Dodger Stadium · Los Angeles, CA |
| 101 | Fri Jul 28 | at Athletics | W6-3 | 50-51 | .495 | RingCentral Coliseum · Oakland, CA |
| 102 | Sat Jul 29 | at Athletics | L4-5 | 50-52 | .490 | RingCentral Coliseum · Oakland, CA |
| 103 | Sun Jul 30 | at Athletics | L5-6 (12) | 50-53 | .485 | RingCentral Coliseum · Oakland, CA |
| 104 | Tue Aug 1 | at Padres | L0-3 | 50-54 | .481 | Petco Park · San Diego, CA |
| 105 | Wed Aug 2 | at Padres | W5-2 | 51-54 | .486 | Petco Park · San Diego, CA |
| 106 | Thu Aug 3 | vs Rangers | L1-4 | 51-55 | .481 | Target Field · Minneapolis, MN |
| 107 | Fri Aug 4 | vs Rangers | W8-4 | 52-55 | .486 | Target Field · Minneapolis, MN |
| 108 | Sat Aug 5 | vs Rangers | L1-4 | 52-56 | .481 | Target Field · Minneapolis, MN |
| 109 | Sun Aug 6 | vs Rangers | W6-5 | 53-56 | .486 | Target Field · Minneapolis, MN |
| 110 | Mon Aug 7 | vs Brewers | W5-4 | 54-56 | .491 | Target Field · Minneapolis, MN |
| 111 | Tue Aug 8 | vs Brewers | W11-4 | 55-56 | .495 | Target Field · Minneapolis, MN |
| 112 | Wed Aug 9 | at Brewers | W4-0 | 56-56 | .500 | American Family Field · Milwaukee, WI |
| 113 | Thu Aug 10 | at Brewers | W7-2 | 57-56 | .504 | American Family Field · Milwaukee, WI |
| 114 | Fri Aug 11 | at Tigers | W9-4 | 58-56 | .509 | Comerica Park · Detroit, MI |
| 115 | Sat Aug 12 | at Tigers | L11-12 | 58-57 | .504 | Comerica Park · Detroit, MI |
| 116 | Sun Aug 13 | at Tigers | W6-4 | 59-57 | .509 | Comerica Park · Detroit, MI |
| 117 | Tue Aug 15 | vs Guardians | L1-8 | 59-58 | .504 | Target Field · Minneapolis, MN |
| 118 | Thu Aug 17 | vs Guardians | L3-9 | 59-59 | .500 | Target Field · Minneapolis, MN |
| 119 | Thu Aug 17 | vs Guardians | W4-2 | 60-59 | .504 | Target Field · Minneapolis, MN |
| 120 | Fri Aug 18 | vs D-backs | W10-3 | 61-59 | .508 | Target Field · Minneapolis, MN |
| 121 | Sat Aug 19 | vs D-backs | W5-0 | 62-59 | .512 | Target Field · Minneapolis, MN |
| 122 | Sun Aug 20 | vs D-backs | W12-5 | 63-59 | .516 | Target Field · Minneapolis, MN |
| 123 | Mon Aug 21 | at White Sox | L6-7 | 63-60 | .512 | Guaranteed Rate Field · Chicago, IL |
| 124 | Mon Aug 21 | at White Sox | W10-2 | 64-60 | .516 | Guaranteed Rate Field · Chicago, IL |
| 125 | Tue Aug 22 | at White Sox | W4-1 | 65-60 | .520 | Guaranteed Rate Field · Chicago, IL |
| 126 | Wed Aug 23 | at White Sox | L3-4 | 65-61 | .516 | Guaranteed Rate Field · Chicago, IL |
| 127 | Thu Aug 24 | at White Sox | L1-5 | 65-62 | .512 | Guaranteed Rate Field · Chicago, IL |
| 128 | Fri Aug 25 | at Blue Jays | W6-1 | 66-62 | .516 | Rogers Centre · Toronto, ON |
| 129 | Sat Aug 26 | at Blue Jays | L9-10 | 66-63 | .512 | Rogers Centre · Toronto, ON |
| 130 | Sun Aug 27 | at Blue Jays | W7-2 | 67-63 | .515 | Rogers Centre · Toronto, ON |
| 131 | Tue Aug 29 | vs White Sox | W6-4 | 68-63 | .519 | Target Field · Minneapolis, MN |
| 132 | Wed Aug 30 | vs White Sox | W11-1 | 69-63 | .523 | Target Field · Minneapolis, MN |
| 133 | Thu Aug 31 | vs White Sox | W5-4 | 70-63 | .526 | Target Field · Minneapolis, MN |
| 134 | Fri Sep 1 | vs Royals | L6-7 | 70-64 | .522 | Target Field · Minneapolis, MN |
| 135 | Sat Sep 2 | vs Royals | W17-0 | 71-64 | .526 | Target Field · Minneapolis, MN |
| 136 | Sun Sep 3 | vs Royals | L4-5 | 71-65 | .522 | Target Field · Minneapolis, MN |
| 137 | Mon Sep 4 | at Rays | L4-11 | 71-66 | .518 | Tropicana Field · St. Petersburg, FL |
| 138 | Tue Sep 5 | at Rays | L1-2 | 71-67 | .514 | Tropicana Field · St. Petersburg, FL |
| 139 | Wed Sep 6 | at Rays | W10-6 | 72-67 | .518 | Tropicana Field · St. Petersburg, FL |
| 140 | Thu Sep 7 | at Royals | W4-2 | 73-67 | .521 | Kauffman Stadium · Kansas City, MO |
| 141 | Fri Sep 8 | at Royals | W8-5 | 74-67 | .525 | Kauffman Stadium · Kansas City, MO |
| 142 | Sat Sep 9 | at Royals | L2-5 | 74-68 | .521 | Kauffman Stadium · Kansas City, MO |
| 143 | Sun Sep 10 | at Royals | L3-11 | 74-69 | .517 | Kauffman Stadium · Kansas City, MO |
| 144 | Tue Sep 12 | vs Padres | W16-0 | 75-69 | .521 | Target Field · Minneapolis, MN |
| 145 | Wed Sep 13 | vs Padres | W3-1 (10) | 76-69 | .524 | Target Field · Minneapolis, MN |
| 146 | Thu Sep 14 | vs Blue Jays | W3-2 (10) | 77-69 | .527 | Target Field · Minneapolis, MN |
| 147 | Fri Sep 15 | vs Blue Jays | L3-4 | 77-70 | .524 | Target Field · Minneapolis, MN |
| 148 | Sat Sep 16 | vs Blue Jays | L2-7 | 77-71 | .520 | Target Field · Minneapolis, MN |
| 149 | Sun Sep 17 | vs Blue Jays | W13-7 | 78-71 | .523 | Target Field · Minneapolis, MN |
| 150 | Mon Sep 18 | at Yankees | L1-2 | 78-72 | .520 | Yankee Stadium · The Bronx, NY |
| 151 | Tue Sep 19 | at Yankees | L2-5 | 78-73 | .517 | Yankee Stadium · The Bronx, NY |
| 152 | Wed Sep 20 | at Yankees | L3-11 | 78-74 | .513 | Yankee Stadium · The Bronx, NY |
| 153 | Thu Sep 21 | at Tigers | W12-1 | 79-74 | .516 | Comerica Park · Detroit, MI |
| 154 | Fri Sep 22 | at Tigers | W7-3 | 80-74 | .519 | Comerica Park · Detroit, MI |
| 155 | Sat Sep 23 | at Tigers | W10-4 | 81-74 | .523 | Comerica Park · Detroit, MI |
| 156 | Sun Sep 24 | at Tigers | W10-4 | 82-74 | .526 | Comerica Park · Detroit, MI |
| 157 | Tue Sep 26 | at Guardians | W8-6 | 83-74 | .529 | Progressive Field · Cleveland, OH |
| 158 | Wed Sep 27 | at Guardians | L2-4 | 83-75 | .525 | Progressive Field · Cleveland, OH |
| 159 | Thu Sep 28 | at Guardians | L2-5 | 83-76 | .522 | Progressive Field · Cleveland, OH |
| 160 | Fri Sep 29 | vs Tigers | W6-3 | 84-76 | .525 | Target Field · Minneapolis, MN |
| 161 | Sat Sep 30 | vs Tigers | L2-3 | 84-77 | .522 | Target Field · Minneapolis, MN |
| 162 | Sun Oct 1 | vs Tigers | W5-1 | 85-77 | .525 | Target Field · Minneapolis, MN |
| 163 | Tue Oct 3 | at Yankees | L4-8 | 0-1 | .000 | Yankee Stadium · The Bronx, NY |