| 1 | Thu Mar 28 | at Royals | W4-1 | 1-0 | 1.000 | Kauffman Stadium · Kansas City, MO |
| 2 | Sat Mar 30 | at Royals | W5-1 | 2-0 | 1.000 | Kauffman Stadium · Kansas City, MO |
| 3 | Sun Mar 31 | at Royals | L0-11 | 2-1 | .667 | Kauffman Stadium · Kansas City, MO |
| 4 | Tue Apr 2 | at Brewers | L2-3 | 2-2 | .500 | American Family Field · Milwaukee, WI |
| 5 | Wed Apr 3 | at Brewers | W7-3 | 3-2 | .600 | American Family Field · Milwaukee, WI |
| 6 | Thu Apr 4 | vs Guardians | L2-4 | 3-3 | .500 | Target Field · Minneapolis, MN |
| 7 | Sat Apr 6 | vs Guardians | L1-3 | 3-4 | .429 | Target Field · Minneapolis, MN |
| 8 | Mon Apr 8 | vs Dodgers | L2-4 | 3-5 | .375 | Target Field · Minneapolis, MN |
| 9 | Tue Apr 9 | vs Dodgers | L3-6 | 3-6 | .333 | Target Field · Minneapolis, MN |
| 10 | Wed Apr 10 | vs Dodgers | W3-2 | 4-6 | .400 | Target Field · Minneapolis, MN |
| 11 | Fri Apr 12 | at Tigers | L2-8 | 4-7 | .364 | Comerica Park · Detroit, MI |
| 12 | Sat Apr 13 | at Tigers | W11-5 (12) | 5-7 | .417 | Comerica Park · Detroit, MI |
| 13 | Sat Apr 13 | at Tigers | W4-1 | 6-7 | .462 | Comerica Park · Detroit, MI |
| 14 | Sun Apr 14 | at Tigers | L3-4 | 6-8 | .429 | Comerica Park · Detroit, MI |
| 15 | Mon Apr 15 | at Orioles | L4-7 | 6-9 | .400 | Camden Yards · Baltimore, MD |
| 16 | Tue Apr 16 | at Orioles | L3-11 | 6-10 | .375 | Camden Yards · Baltimore, MD |
| 17 | Wed Apr 17 | at Orioles | L2-4 | 6-11 | .353 | Camden Yards · Baltimore, MD |
| 18 | Fri Apr 19 | vs Tigers | L4-5 | 6-12 | .333 | Target Field · Minneapolis, MN |
| 19 | Sat Apr 20 | vs Tigers | W4-3 | 7-12 | .368 | Target Field · Minneapolis, MN |
| 20 | Sun Apr 21 | vs Tigers | L1-6 | 7-13 | .350 | Target Field · Minneapolis, MN |
| 21 | Mon Apr 22 | vs White Sox | W7-0 | 8-13 | .381 | Target Field · Minneapolis, MN |
| 22 | Tue Apr 23 | vs White Sox | W6-5 | 9-13 | .409 | Target Field · Minneapolis, MN |
| 23 | Wed Apr 24 | vs White Sox | W6-3 | 10-13 | .435 | Target Field · Minneapolis, MN |
| 24 | Thu Apr 25 | vs White Sox | W6-3 | 11-13 | .458 | Target Field · Minneapolis, MN |
| 25 | Fri Apr 26 | at Angels | W5-3 | 12-13 | .480 | Angel Stadium · Anaheim, CA |
| 26 | Sat Apr 27 | at Angels | W16-5 | 13-13 | .500 | Angel Stadium · Anaheim, CA |
| 27 | Sun Apr 28 | at Angels | W11-5 | 14-13 | .519 | Angel Stadium · Anaheim, CA |
| 28 | Mon Apr 29 | at White Sox | W3-2 | 15-13 | .536 | Guaranteed Rate Field · Chicago, IL |
| 29 | Tue Apr 30 | at White Sox | W6-5 | 16-13 | .552 | Guaranteed Rate Field · Chicago, IL |
| 30 | Wed May 1 | at White Sox | W10-5 | 17-13 | .567 | Guaranteed Rate Field · Chicago, IL |
| 31 | Fri May 3 | vs Red Sox | W5-2 | 18-13 | .581 | Target Field · Minneapolis, MN |
| 32 | Sat May 4 | vs Red Sox | W3-1 | 19-13 | .594 | Target Field · Minneapolis, MN |
| 33 | Sun May 5 | vs Red Sox | L2-9 | 19-14 | .576 | Target Field · Minneapolis, MN |
| 34 | Mon May 6 | vs Mariners | W3-1 | 20-14 | .588 | Target Field · Minneapolis, MN |
| 35 | Tue May 7 | vs Mariners | L6-10 | 20-15 | .571 | Target Field · Minneapolis, MN |
| 36 | Wed May 8 | vs Mariners | W6-3 | 21-15 | .583 | Target Field · Minneapolis, MN |
| 37 | Thu May 9 | vs Mariners | W11-1 | 22-15 | .595 | Target Field · Minneapolis, MN |
| 38 | Fri May 10 | at Blue Jays | W3-2 | 23-15 | .605 | Rogers Centre · Toronto, ON |
| 39 | Sat May 11 | at Blue Jays | L8-10 | 23-16 | .590 | Rogers Centre · Toronto, ON |
| 40 | Sun May 12 | at Blue Jays | W5-1 | 24-16 | .600 | Rogers Centre · Toronto, ON |
| 41 | Tue May 14 | vs Yankees | L1-5 | 24-17 | .585 | Target Field · Minneapolis, MN |
| 42 | Wed May 15 | vs Yankees | L0-4 | 24-18 | .571 | Target Field · Minneapolis, MN |
| 43 | Thu May 16 | vs Yankees | L0-5 | 24-19 | .558 | Target Field · Minneapolis, MN |
| 44 | Fri May 17 | at Guardians | L2-3 | 24-20 | .545 | Progressive Field · Cleveland, OH |
| 45 | Sat May 18 | at Guardians | L4-11 | 24-21 | .533 | Progressive Field · Cleveland, OH |
| 46 | Sun May 19 | at Guardians | L2-5 | 24-22 | .522 | Progressive Field · Cleveland, OH |
| 47 | Mon May 20 | at Nationals | L3-12 | 24-23 | .511 | Nationals Park · Washington, D.C. |
| 48 | Tue May 21 | at Nationals | W10-0 | 25-23 | .521 | Nationals Park · Washington, D.C. |
| 49 | Wed May 22 | at Nationals | W3-2 | 26-23 | .531 | Nationals Park · Washington, D.C. |
| 50 | Fri May 24 | vs Rangers | W3-2 | 27-23 | .540 | Target Field · Minneapolis, MN |
| 51 | Sat May 25 | vs Rangers | W5-3 | 28-23 | .549 | Target Field · Minneapolis, MN |
| 52 | Sun May 26 | vs Rangers | L2-6 | 28-24 | .538 | Target Field · Minneapolis, MN |
| 53 | Mon May 27 | vs Royals | W6-5 | 29-24 | .547 | Target Field · Minneapolis, MN |
| 54 | Tue May 28 | vs Royals | W4-2 | 30-24 | .556 | Target Field · Minneapolis, MN |
| 55 | Wed May 29 | vs Royals | L1-6 | 30-25 | .545 | Target Field · Minneapolis, MN |
| 56 | Thu May 30 | vs Royals | W7-6 | 31-25 | .554 | Target Field · Minneapolis, MN |
| 57 | Fri May 31 | at Astros | W6-1 | 32-25 | .561 | Minute Maid Park · Houston, TX |
| 58 | Sat Jun 1 | at Astros | L2-5 | 32-26 | .552 | Minute Maid Park · Houston, TX |
| 59 | Sun Jun 2 | at Astros | W4-3 | 33-26 | .559 | Minute Maid Park · Houston, TX |
| 60 | Tue Jun 4 | at Yankees | L1-5 | 33-27 | .550 | Yankee Stadium · The Bronx, NY |
| 61 | Wed Jun 5 | at Yankees | L5-9 | 33-28 | .541 | Yankee Stadium · The Bronx, NY |
| 62 | Thu Jun 6 | at Yankees | L5-8 | 33-29 | .532 | Yankee Stadium · The Bronx, NY |
| 63 | Fri Jun 7 | at Pirates | L0-3 | 33-30 | .524 | PNC Park · Pittsburgh, PA |
| 64 | Sat Jun 8 | at Pirates | L0-4 | 33-31 | .516 | PNC Park · Pittsburgh, PA |
| 65 | Sun Jun 9 | at Pirates | W11-5 (10) | 34-31 | .523 | PNC Park · Pittsburgh, PA |
| 66 | Mon Jun 10 | vs Rockies | W5-0 | 35-31 | .530 | Target Field · Minneapolis, MN |
| 67 | Tue Jun 11 | vs Rockies | L4-5 | 35-32 | .522 | Target Field · Minneapolis, MN |
| 68 | Wed Jun 12 | vs Rockies | W17-9 | 36-32 | .529 | Target Field · Minneapolis, MN |
| 69 | Thu Jun 13 | vs Athletics | W6-2 | 37-32 | .536 | Target Field · Minneapolis, MN |
| 70 | Fri Jun 14 | vs Athletics | W6-5 (10) | 38-32 | .543 | Target Field · Minneapolis, MN |
| 71 | Sun Jun 16 | vs Athletics | W6-2 | 39-32 | .549 | Target Field · Minneapolis, MN |
| 72 | Sun Jun 16 | vs Athletics | W8-7 | 40-32 | .556 | Target Field · Minneapolis, MN |
| 73 | Tue Jun 18 | vs Rays | W7-6 | 41-32 | .562 | Target Field · Minneapolis, MN |
| 74 | Wed Jun 19 | vs Rays | L2-3 (10) | 41-33 | .554 | Target Field · Minneapolis, MN |
| 75 | Thu Jun 20 | vs Rays | L6-7 (10) | 41-34 | .547 | Target Field · Minneapolis, MN |
| 76 | Fri Jun 21 | at Athletics | L5-6 | 41-35 | .539 | RingCentral Coliseum · Oakland, CA |
| 77 | Sat Jun 22 | at Athletics | W10-2 | 42-35 | .545 | RingCentral Coliseum · Oakland, CA |
| 78 | Sun Jun 23 | at Athletics | W3-0 | 43-35 | .551 | RingCentral Coliseum · Oakland, CA |
| 79 | Tue Jun 25 | at D-backs | L4-5 | 43-36 | .544 | Chase Field · Phoenix, AZ |
| 80 | Wed Jun 26 | at D-backs | W8-3 | 44-36 | .550 | Chase Field · Phoenix, AZ |
| 81 | Thu Jun 27 | at D-backs | W13-6 | 45-36 | .556 | Chase Field · Phoenix, AZ |
| 82 | Fri Jun 28 | at Mariners | L2-3 (10) | 45-37 | .549 | T-Mobile Park · Seattle, WA |
| 83 | Sat Jun 29 | at Mariners | W5-1 | 46-37 | .554 | T-Mobile Park · Seattle, WA |
| 84 | Sun Jun 30 | at Mariners | W5-3 | 47-37 | .560 | T-Mobile Park · Seattle, WA |
| 85 | Tue Jul 2 | vs Tigers | W5-3 | 48-37 | .565 | Target Field · Minneapolis, MN |
| 86 | Wed Jul 3 | vs Tigers | L2-9 | 48-38 | .558 | Target Field · Minneapolis, MN |
| 87 | Thu Jul 4 | vs Tigers | W12-3 | 49-38 | .563 | Target Field · Minneapolis, MN |
| 88 | Fri Jul 5 | vs Astros | L12-13 | 49-39 | .557 | Target Field · Minneapolis, MN |
| 89 | Sat Jul 6 | vs Astros | W9-3 | 50-39 | .562 | Target Field · Minneapolis, MN |
| 90 | Sun Jul 7 | vs Astros | W3-2 | 51-39 | .567 | Target Field · Minneapolis, MN |
| 91 | Mon Jul 8 | at White Sox | W8-6 (11) | 52-39 | .571 | Guaranteed Rate Field · Chicago, IL |
| 92 | Wed Jul 10 | at White Sox | L1-3 | 52-40 | .565 | Guaranteed Rate Field · Chicago, IL |
| 93 | Wed Jul 10 | at White Sox | W3-2 | 53-40 | .570 | Guaranteed Rate Field · Chicago, IL |
| 94 | Fri Jul 12 | at Giants | L1-7 | 53-41 | .564 | Oracle Park · San Francisco, CA |
| 95 | Sat Jul 13 | at Giants | W4-2 | 54-41 | .568 | Oracle Park · San Francisco, CA |
| 96 | Sun Jul 14 | at Giants | L2-3 | 54-42 | .563 | Oracle Park · San Francisco, CA |
| 97 | Sat Jul 20 | vs Brewers | L4-8 (12) | 54-43 | .557 | Target Field · Minneapolis, MN |
| 98 | Sun Jul 21 | vs Brewers | L7-8 | 54-44 | .551 | Target Field · Minneapolis, MN |
| 99 | Mon Jul 22 | vs Phillies | W7-2 | 55-44 | .556 | Target Field · Minneapolis, MN |
| 100 | Tue Jul 23 | vs Phillies | L0-3 | 55-45 | .550 | Target Field · Minneapolis, MN |
| 101 | Wed Jul 24 | vs Phillies | W5-4 | 56-45 | .554 | Target Field · Minneapolis, MN |
| 102 | Fri Jul 26 | at Tigers | W9-3 | 57-45 | .559 | Comerica Park · Detroit, MI |
| 103 | Sat Jul 27 | at Tigers | L2-7 | 57-46 | .553 | Comerica Park · Detroit, MI |
| 104 | Sun Jul 28 | at Tigers | W5-0 | 58-46 | .558 | Comerica Park · Detroit, MI |
| 105 | Mon Jul 29 | at Mets | L2-15 | 58-47 | .552 | Citi Field · Queens, NY |
| 106 | Tue Jul 30 | at Mets | L0-2 | 58-48 | .547 | Citi Field · Queens, NY |
| 107 | Wed Jul 31 | at Mets | W8-3 | 59-48 | .551 | Citi Field · Queens, NY |
| 108 | Fri Aug 2 | vs White Sox | W10-2 | 60-48 | .556 | Target Field · Minneapolis, MN |
| 109 | Sat Aug 3 | vs White Sox | W6-2 | 61-48 | .560 | Target Field · Minneapolis, MN |
| 110 | Sun Aug 4 | vs White Sox | W13-7 | 62-48 | .564 | Target Field · Minneapolis, MN |
| 111 | Mon Aug 5 | at Cubs | W3-0 | 63-48 | .568 | Wrigley Field · Chicago, IL |
| 112 | Tue Aug 6 | at Cubs | L3-7 | 63-49 | .563 | Wrigley Field · Chicago, IL |
| 113 | Wed Aug 7 | at Cubs | L2-8 | 63-50 | .558 | Wrigley Field · Chicago, IL |
| 114 | Fri Aug 9 | vs Guardians | W4-2 | 64-50 | .561 | Target Field · Minneapolis, MN |
| 115 | Fri Aug 9 | vs Guardians | W6-3 | 65-50 | .565 | Target Field · Minneapolis, MN |
| 116 | Sat Aug 10 | vs Guardians | L1-2 | 65-51 | .560 | Target Field · Minneapolis, MN |
| 117 | Sun Aug 11 | vs Guardians | L3-5 | 65-52 | .556 | Target Field · Minneapolis, MN |
| 118 | Mon Aug 12 | vs Royals | W8-3 | 66-52 | .559 | Target Field · Minneapolis, MN |
| 119 | Tue Aug 13 | vs Royals | W13-3 | 67-52 | .563 | Target Field · Minneapolis, MN |
| 120 | Wed Aug 14 | vs Royals | L1-4 | 67-53 | .558 | Target Field · Minneapolis, MN |
| 121 | Thu Aug 15 | at Rangers | W3-2 | 68-53 | .562 | Globe Life Field · Arlington, TX |
| 122 | Fri Aug 16 | at Rangers | W4-3 | 69-53 | .566 | Globe Life Field · Arlington, TX |
| 123 | Sat Aug 17 | at Rangers | W5-2 | 70-53 | .569 | Globe Life Field · Arlington, TX |
| 124 | Sun Aug 18 | at Rangers | L5-6 (10) | 70-54 | .565 | Globe Life Field · Arlington, TX |
| 125 | Mon Aug 19 | at Padres | L3-5 | 70-55 | .560 | Petco Park · San Diego, CA |
| 126 | Tue Aug 20 | at Padres | L5-7 | 70-56 | .556 | Petco Park · San Diego, CA |
| 127 | Wed Aug 21 | at Padres | W11-4 | 71-56 | .559 | Petco Park · San Diego, CA |
| 128 | Fri Aug 23 | vs Cardinals | L1-6 | 71-57 | .555 | Target Field · Minneapolis, MN |
| 129 | Sat Aug 24 | vs Cardinals | W6-0 | 72-57 | .558 | Target Field · Minneapolis, MN |
| 130 | Sun Aug 25 | vs Cardinals | L2-3 | 72-58 | .554 | Target Field · Minneapolis, MN |
| 131 | Mon Aug 26 | vs Braves | L6-10 | 72-59 | .550 | Target Field · Minneapolis, MN |
| 132 | Tue Aug 27 | vs Braves | L6-8 (10) | 72-60 | .545 | Target Field · Minneapolis, MN |
| 133 | Wed Aug 28 | vs Braves | L1-5 | 72-61 | .541 | Target Field · Minneapolis, MN |
| 134 | Fri Aug 30 | vs Blue Jays | W2-0 | 73-61 | .545 | Target Field · Minneapolis, MN |
| 135 | Sat Aug 31 | vs Blue Jays | L0-15 | 73-62 | .541 | Target Field · Minneapolis, MN |
| 136 | Sun Sep 1 | vs Blue Jays | W4-3 | 74-62 | .544 | Target Field · Minneapolis, MN |
| 137 | Mon Sep 2 | at Rays | W5-4 | 75-62 | .547 | Tropicana Field · St. Petersburg, FL |
| 138 | Tue Sep 3 | at Rays | L1-2 | 75-63 | .543 | Tropicana Field · St. Petersburg, FL |
| 139 | Wed Sep 4 | at Rays | L4-9 | 75-64 | .540 | Tropicana Field · St. Petersburg, FL |
| 140 | Thu Sep 5 | at Rays | W4-3 | 76-64 | .543 | Tropicana Field · St. Petersburg, FL |
| 141 | Fri Sep 6 | at Royals | L0-5 | 76-65 | .539 | Kauffman Stadium · Kansas City, MO |
| 142 | Sat Sep 7 | at Royals | L2-4 | 76-66 | .535 | Kauffman Stadium · Kansas City, MO |
| 143 | Sun Sep 8 | at Royals | L0-2 | 76-67 | .531 | Kauffman Stadium · Kansas City, MO |
| 144 | Mon Sep 9 | vs Angels | L2-6 | 76-68 | .528 | Target Field · Minneapolis, MN |
| 145 | Tue Sep 10 | vs Angels | W10-5 | 77-68 | .531 | Target Field · Minneapolis, MN |
| 146 | Wed Sep 11 | vs Angels | W6-4 | 78-68 | .534 | Target Field · Minneapolis, MN |
| 147 | Fri Sep 13 | vs Reds | L4-8 | 78-69 | .531 | Target Field · Minneapolis, MN |
| 148 | Sat Sep 14 | vs Reds | L1-11 | 78-70 | .527 | Target Field · Minneapolis, MN |
| 149 | Sun Sep 15 | vs Reds | W9-2 | 79-70 | .530 | Target Field · Minneapolis, MN |
| 150 | Mon Sep 16 | at Guardians | L3-4 | 79-71 | .527 | Progressive Field · Cleveland, OH |
| 151 | Tue Sep 17 | at Guardians | W4-1 | 80-71 | .530 | Progressive Field · Cleveland, OH |
| 152 | Wed Sep 18 | at Guardians | L4-5 (10) | 80-72 | .526 | Progressive Field · Cleveland, OH |
| 153 | Thu Sep 19 | at Guardians | L2-3 (10) | 80-73 | .523 | Progressive Field · Cleveland, OH |
| 154 | Fri Sep 20 | at Red Sox | W4-2 (12) | 81-73 | .526 | Fenway Park · Boston, MA |
| 155 | Sun Sep 22 | at Red Sox | L1-8 | 81-74 | .523 | Fenway Park · Boston, MA |
| 156 | Sun Sep 22 | at Red Sox | L3-9 | 81-75 | .519 | Fenway Park · Boston, MA |
| 157 | Tue Sep 24 | vs Marlins | L1-4 | 81-76 | .516 | Target Field · Minneapolis, MN |
| 158 | Wed Sep 25 | vs Marlins | W8-3 | 82-76 | .519 | Target Field · Minneapolis, MN |
| 159 | Thu Sep 26 | vs Marlins | L6-8 (13) | 82-77 | .516 | Target Field · Minneapolis, MN |
| 160 | Fri Sep 27 | vs Orioles | L2-7 | 82-78 | .512 | Target Field · Minneapolis, MN |
| 161 | Sat Sep 28 | vs Orioles | L2-9 | 82-79 | .509 | Target Field · Minneapolis, MN |
| 162 | Sun Sep 29 | vs Orioles | L2-6 | 82-80 | .506 | Target Field · Minneapolis, MN |