| 1 | Fri Apr 6 | at Orioles | L2-4 | 0-1 | .000 | Camden Yards · Baltimore, MD |
| 2 | Sat Apr 7 | at Orioles | L2-8 | 0-2 | .000 | Camden Yards · Baltimore, MD |
| 3 | Sun Apr 8 | at Orioles | L1-3 | 0-3 | .000 | Camden Yards · Baltimore, MD |
| 4 | Mon Apr 9 | vs Angels | L1-5 | 0-4 | .000 | Target Field · Minneapolis, MN |
| 5 | Wed Apr 11 | vs Angels | W6-5 | 1-4 | .200 | Target Field · Minneapolis, MN |
| 6 | Thu Apr 12 | vs Angels | W10-9 | 2-4 | .333 | Target Field · Minneapolis, MN |
| 7 | Fri Apr 13 | vs Rangers | L1-4 | 2-5 | .286 | Target Field · Minneapolis, MN |
| 8 | Sat Apr 14 | vs Rangers | L2-6 | 2-6 | .250 | Target Field · Minneapolis, MN |
| 9 | Sun Apr 15 | vs Rangers | L3-4 | 2-7 | .222 | Target Field · Minneapolis, MN |
| 10 | Mon Apr 16 | at Yankees | W7-3 | 3-7 | .300 | Yankee Stadium · The Bronx, NY |
| 11 | Tue Apr 17 | at Yankees | L3-8 | 3-8 | .273 | Yankee Stadium · The Bronx, NY |
| 12 | Wed Apr 18 | at Yankees | W6-5 | 4-8 | .333 | Yankee Stadium · The Bronx, NY |
| 13 | Thu Apr 19 | at Yankees | L6-7 | 4-9 | .308 | Yankee Stadium · The Bronx, NY |
| 14 | Fri Apr 20 | at Rays | W5-4 | 5-9 | .357 | Tropicana Field · St. Petersburg, FL |
| 15 | Sat Apr 21 | at Rays | L1-4 | 5-10 | .333 | Tropicana Field · St. Petersburg, FL |
| 16 | Sun Apr 22 | at Rays | L2-6 | 5-11 | .313 | Tropicana Field · St. Petersburg, FL |
| 17 | Mon Apr 23 | vs Red Sox | L5-6 | 5-12 | .294 | Target Field · Minneapolis, MN |
| 18 | Tue Apr 24 | vs Red Sox | L2-11 | 5-13 | .278 | Target Field · Minneapolis, MN |
| 19 | Wed Apr 25 | vs Red Sox | L6-7 | 5-14 | .263 | Target Field · Minneapolis, MN |
| 20 | Fri Apr 27 | vs Royals | L6-7 | 5-15 | .250 | Target Field · Minneapolis, MN |
| 21 | Sun Apr 29 | vs Royals | W7-4 | 6-15 | .286 | Target Field · Minneapolis, MN |
| 22 | Mon Apr 30 | at Angels | L3-4 | 6-16 | .273 | Angel Stadium · Anaheim, CA |
| 23 | Tue May 1 | at Angels | L0-4 | 6-17 | .261 | Angel Stadium · Anaheim, CA |
| 24 | Wed May 2 | at Angels | L0-9 | 6-18 | .250 | Angel Stadium · Anaheim, CA |
| 25 | Fri May 4 | at Mariners | W3-2 | 7-18 | .280 | T-Mobile Park · Seattle, WA |
| 26 | Sat May 5 | at Mariners | L0-7 | 7-19 | .269 | T-Mobile Park · Seattle, WA |
| 27 | Sun May 6 | at Mariners | L2-5 | 7-20 | .259 | T-Mobile Park · Seattle, WA |
| 28 | Mon May 7 | vs Angels | L3-8 | 7-21 | .250 | Target Field · Minneapolis, MN |
| 29 | Tue May 8 | vs Angels | W5-0 | 8-21 | .276 | Target Field · Minneapolis, MN |
| 30 | Wed May 9 | vs Angels | L2-6 | 8-22 | .267 | Target Field · Minneapolis, MN |
| 31 | Thu May 10 | vs Blue Jays | L2-6 | 8-23 | .258 | Target Field · Minneapolis, MN |
| 32 | Fri May 11 | vs Blue Jays | W7-6 | 9-23 | .281 | Target Field · Minneapolis, MN |
| 33 | Sat May 12 | vs Blue Jays | L1-2 | 9-24 | .273 | Target Field · Minneapolis, MN |
| 34 | Sun May 13 | vs Blue Jays | W4-3 | 10-24 | .294 | Target Field · Minneapolis, MN |
| 35 | Mon May 14 | vs Guardians | L4-5 | 10-25 | .286 | Target Field · Minneapolis, MN |
| 36 | Tue May 15 | vs Guardians | L0-5 | 10-26 | .278 | Target Field · Minneapolis, MN |
| 37 | Wed May 16 | at Tigers | W11-7 | 11-26 | .297 | Comerica Park · Detroit, MI |
| 38 | Thu May 17 | at Tigers | W4-3 | 12-26 | .316 | Comerica Park · Detroit, MI |
| 39 | Fri May 18 | at Brewers | W11-3 | 13-26 | .333 | American Family Field · Milwaukee, WI |
| 40 | Sat May 19 | at Brewers | W5-4 (11) | 14-26 | .350 | American Family Field · Milwaukee, WI |
| 41 | Sun May 20 | at Brewers | L4-16 | 14-27 | .341 | American Family Field · Milwaukee, WI |
| 42 | Tue May 22 | at White Sox | W9-2 | 15-27 | .357 | Guaranteed Rate Field · Chicago, IL |
| 43 | Wed May 23 | at White Sox | L0-6 | 15-28 | .349 | Guaranteed Rate Field · Chicago, IL |
| 44 | Thu May 24 | at White Sox | L8-11 | 15-29 | .341 | Guaranteed Rate Field · Chicago, IL |
| 45 | Fri May 25 | vs Tigers | L6-10 | 15-30 | .333 | Target Field · Minneapolis, MN |
| 46 | Sat May 26 | vs Tigers | L3-6 | 15-31 | .326 | Target Field · Minneapolis, MN |
| 47 | Sun May 27 | vs Tigers | L3-4 | 15-32 | .319 | Target Field · Minneapolis, MN |
| 48 | Mon May 28 | vs Athletics | W5-4 | 16-32 | .333 | Target Field · Minneapolis, MN |
| 49 | Tue May 29 | vs Athletics | W3-2 | 17-32 | .347 | Target Field · Minneapolis, MN |
| 50 | Wed May 30 | vs Athletics | W4-0 | 18-32 | .360 | Target Field · Minneapolis, MN |
| 51 | Fri Jun 1 | at Guardians | L1-7 | 18-33 | .353 | Progressive Field · Cleveland, OH |
| 52 | Sat Jun 2 | at Guardians | W7-4 | 19-33 | .365 | Progressive Field · Cleveland, OH |
| 53 | Sun Jun 3 | at Guardians | W6-3 | 20-33 | .377 | Progressive Field · Cleveland, OH |
| 54 | Mon Jun 4 | at Royals | W10-7 | 21-33 | .389 | Kauffman Stadium · Kansas City, MO |
| 55 | Tue Jun 5 | at Royals | L0-1 | 21-34 | .382 | Kauffman Stadium · Kansas City, MO |
| 56 | Wed Jun 6 | at Royals | W4-2 | 22-34 | .393 | Kauffman Stadium · Kansas City, MO |
| 57 | Fri Jun 8 | vs Cubs | W8-7 (10) | 23-34 | .404 | Target Field · Minneapolis, MN |
| 58 | Sat Jun 9 | vs Cubs | W11-3 | 24-34 | .414 | Target Field · Minneapolis, MN |
| 59 | Sun Jun 10 | vs Cubs | L2-8 | 24-35 | .407 | Target Field · Minneapolis, MN |
| 60 | Tue Jun 12 | vs Phillies | W11-7 | 25-35 | .417 | Target Field · Minneapolis, MN |
| 61 | Wed Jun 13 | vs Phillies | L8-9 | 25-36 | .410 | Target Field · Minneapolis, MN |
| 62 | Thu Jun 14 | vs Phillies | L1-6 | 25-37 | .403 | Target Field · Minneapolis, MN |
| 63 | Fri Jun 15 | vs Brewers | L3-5 | 25-38 | .397 | Target Field · Minneapolis, MN |
| 64 | Sat Jun 16 | vs Brewers | L2-6 | 25-39 | .391 | Target Field · Minneapolis, MN |
| 65 | Sun Jun 17 | vs Brewers | W5-4 (15) | 26-39 | .400 | Target Field · Minneapolis, MN |
| 66 | Tue Jun 19 | at Pirates | L2-7 | 26-40 | .394 | PNC Park · Pittsburgh, PA |
| 67 | Wed Jun 20 | at Pirates | W2-1 | 27-40 | .403 | PNC Park · Pittsburgh, PA |
| 68 | Thu Jun 21 | at Pirates | L1-9 | 27-41 | .397 | PNC Park · Pittsburgh, PA |
| 69 | Fri Jun 22 | at Reds | W5-4 | 28-41 | .406 | Great American Ball Park · Cincinnati, OH |
| 70 | Sat Jun 23 | at Reds | L0-6 | 28-42 | .400 | Great American Ball Park · Cincinnati, OH |
| 71 | Sun Jun 24 | at Reds | W4-3 | 29-42 | .408 | Great American Ball Park · Cincinnati, OH |
| 72 | Mon Jun 25 | vs White Sox | W4-1 | 30-42 | .417 | Target Field · Minneapolis, MN |
| 73 | Tue Jun 26 | vs White Sox | L2-3 | 30-43 | .411 | Target Field · Minneapolis, MN |
| 74 | Wed Jun 27 | vs White Sox | L5-12 | 30-44 | .405 | Target Field · Minneapolis, MN |
| 75 | Fri Jun 29 | vs Royals | L3-4 | 30-45 | .400 | Target Field · Minneapolis, MN |
| 76 | Sat Jun 30 | vs Royals | W7-2 | 31-45 | .408 | Target Field · Minneapolis, MN |
| 77 | Sat Jun 30 | vs Royals | W5-1 | 32-45 | .416 | Target Field · Minneapolis, MN |
| 78 | Sun Jul 1 | vs Royals | W10-8 | 33-45 | .423 | Target Field · Minneapolis, MN |
| 79 | Mon Jul 2 | at Tigers | W6-4 | 34-45 | .430 | Comerica Park · Detroit, MI |
| 80 | Tue Jul 3 | at Tigers | W8-6 | 35-45 | .438 | Comerica Park · Detroit, MI |
| 81 | Wed Jul 4 | at Tigers | L1-5 | 35-46 | .432 | Comerica Park · Detroit, MI |
| 82 | Thu Jul 5 | at Tigers | L3-7 | 35-47 | .427 | Comerica Park · Detroit, MI |
| 83 | Fri Jul 6 | at Rangers | W5-1 | 36-47 | .434 | Globe Life Field · Arlington, TX |
| 84 | Sat Jul 7 | at Rangers | L3-4 (10) | 36-48 | .429 | Globe Life Field · Arlington, TX |
| 85 | Sun Jul 8 | at Rangers | L3-4 (13) | 36-49 | .424 | Globe Life Field · Arlington, TX |
| 86 | Fri Jul 13 | vs Athletics | L3-6 | 36-50 | .419 | Target Field · Minneapolis, MN |
| 87 | Sat Jul 14 | vs Athletics | L3-9 | 36-51 | .414 | Target Field · Minneapolis, MN |
| 88 | Sun Jul 15 | vs Athletics | L4-9 | 36-52 | .409 | Target Field · Minneapolis, MN |
| 89 | Mon Jul 16 | vs Orioles | W19-7 | 37-52 | .416 | Target Field · Minneapolis, MN |
| 90 | Tue Jul 17 | vs Orioles | W6-4 | 38-52 | .422 | Target Field · Minneapolis, MN |
| 91 | Wed Jul 18 | vs Orioles | L1-2 | 38-53 | .418 | Target Field · Minneapolis, MN |
| 92 | Thu Jul 19 | vs Orioles | L3-4 | 38-54 | .413 | Target Field · Minneapolis, MN |
| 93 | Fri Jul 20 | at Royals | W2-1 (11) | 39-54 | .419 | Kauffman Stadium · Kansas City, MO |
| 94 | Sat Jul 21 | at Royals | L3-7 | 39-55 | .415 | Kauffman Stadium · Kansas City, MO |
| 95 | Sun Jul 22 | at Royals | W7-5 | 40-55 | .421 | Kauffman Stadium · Kansas City, MO |
| 96 | Mon Jul 23 | at White Sox | L4-7 | 40-56 | .417 | Guaranteed Rate Field · Chicago, IL |
| 97 | Tue Jul 24 | at White Sox | L4-11 | 40-57 | .412 | Guaranteed Rate Field · Chicago, IL |
| 98 | Wed Jul 25 | at White Sox | L2-8 | 40-58 | .408 | Guaranteed Rate Field · Chicago, IL |
| 99 | Fri Jul 27 | vs Guardians | W11-0 | 41-58 | .414 | Target Field · Minneapolis, MN |
| 100 | Sat Jul 28 | vs Guardians | W12-5 | 42-58 | .420 | Target Field · Minneapolis, MN |
| 101 | Sun Jul 29 | vs Guardians | W5-1 | 43-58 | .426 | Target Field · Minneapolis, MN |
| 102 | Mon Jul 30 | vs White Sox | W7-6 | 44-58 | .431 | Target Field · Minneapolis, MN |
| 103 | Tue Jul 31 | vs White Sox | L3-4 | 44-59 | .427 | Target Field · Minneapolis, MN |
| 104 | Wed Aug 1 | vs White Sox | L2-3 | 44-60 | .423 | Target Field · Minneapolis, MN |
| 105 | Thu Aug 2 | at Red Sox | W5-0 | 45-60 | .429 | Fenway Park · Boston, MA |
| 106 | Fri Aug 3 | at Red Sox | W6-5 (10) | 46-60 | .434 | Fenway Park · Boston, MA |
| 107 | Sat Aug 4 | at Red Sox | W6-4 | 47-60 | .439 | Fenway Park · Boston, MA |
| 108 | Sun Aug 5 | at Red Sox | L4-6 | 47-61 | .435 | Fenway Park · Boston, MA |
| 109 | Mon Aug 6 | at Guardians | W14-3 | 48-61 | .440 | Progressive Field · Cleveland, OH |
| 110 | Tue Aug 7 | at Guardians | W7-5 | 49-61 | .445 | Progressive Field · Cleveland, OH |
| 111 | Wed Aug 8 | at Guardians | L2-6 | 49-62 | .441 | Progressive Field · Cleveland, OH |
| 112 | Fri Aug 10 | vs Rays | L6-12 | 49-63 | .438 | Target Field · Minneapolis, MN |
| 113 | Sat Aug 11 | vs Rays | L2-4 | 49-64 | .434 | Target Field · Minneapolis, MN |
| 114 | Sun Aug 12 | vs Rays | L3-7 (10) | 49-65 | .430 | Target Field · Minneapolis, MN |
| 115 | Mon Aug 13 | vs Tigers | W9-3 | 50-65 | .435 | Target Field · Minneapolis, MN |
| 116 | Tue Aug 14 | vs Tigers | L4-8 | 50-66 | .431 | Target Field · Minneapolis, MN |
| 117 | Wed Aug 15 | vs Tigers | L1-5 | 50-67 | .427 | Target Field · Minneapolis, MN |
| 118 | Fri Aug 17 | at Mariners | L3-5 | 50-68 | .424 | T-Mobile Park · Seattle, WA |
| 119 | Sat Aug 18 | at Mariners | L2-3 | 50-69 | .420 | T-Mobile Park · Seattle, WA |
| 120 | Sun Aug 19 | at Mariners | L1-5 | 50-70 | .417 | T-Mobile Park · Seattle, WA |
| 121 | Mon Aug 20 | at Athletics | W7-2 | 51-70 | .421 | RingCentral Coliseum · Oakland, CA |
| 122 | Tue Aug 21 | at Athletics | L1-4 | 51-71 | .418 | RingCentral Coliseum · Oakland, CA |
| 123 | Wed Aug 22 | at Athletics | L1-5 | 51-72 | .415 | RingCentral Coliseum · Oakland, CA |
| 124 | Thu Aug 23 | at Rangers | L6-10 | 51-73 | .411 | Globe Life Field · Arlington, TX |
| 125 | Fri Aug 24 | at Rangers | L0-8 | 51-74 | .408 | Globe Life Field · Arlington, TX |
| 126 | Sat Aug 25 | at Rangers | L3-9 | 51-75 | .405 | Globe Life Field · Arlington, TX |
| 127 | Sun Aug 26 | at Rangers | W6-5 | 52-75 | .409 | Globe Life Field · Arlington, TX |
| 128 | Mon Aug 27 | vs Mariners | L0-1 | 52-76 | .406 | Target Field · Minneapolis, MN |
| 129 | Tue Aug 28 | vs Mariners | L2-5 | 52-77 | .403 | Target Field · Minneapolis, MN |
| 130 | Wed Aug 29 | vs Mariners | W10-0 | 53-77 | .408 | Target Field · Minneapolis, MN |
| 131 | Thu Aug 30 | vs Mariners | L4-5 | 53-78 | .405 | Target Field · Minneapolis, MN |
| 132 | Sat Sep 1 | at Royals | W3-1 | 54-78 | .409 | Kauffman Stadium · Kansas City, MO |
| 133 | Sat Sep 1 | at Royals | W8-7 | 55-78 | .414 | Kauffman Stadium · Kansas City, MO |
| 134 | Sun Sep 2 | at Royals | L4-6 | 55-79 | .410 | Kauffman Stadium · Kansas City, MO |
| 135 | Mon Sep 3 | at White Sox | L2-4 | 55-80 | .407 | Guaranteed Rate Field · Chicago, IL |
| 136 | Tue Sep 4 | at White Sox | W18-9 | 56-80 | .412 | Guaranteed Rate Field · Chicago, IL |
| 137 | Wed Sep 5 | at White Sox | L2-6 | 56-81 | .409 | Guaranteed Rate Field · Chicago, IL |
| 138 | Fri Sep 7 | vs Guardians | L6-7 | 56-82 | .406 | Target Field · Minneapolis, MN |
| 139 | Sat Sep 8 | vs Guardians | W3-0 | 57-82 | .410 | Target Field · Minneapolis, MN |
| 140 | Sun Sep 9 | vs Guardians | W8-7 | 58-82 | .414 | Target Field · Minneapolis, MN |
| 141 | Mon Sep 10 | vs Guardians | W7-2 | 59-82 | .418 | Target Field · Minneapolis, MN |
| 142 | Tue Sep 11 | vs Royals | L1-9 | 59-83 | .415 | Target Field · Minneapolis, MN |
| 143 | Wed Sep 12 | vs Royals | L5-10 | 59-84 | .413 | Target Field · Minneapolis, MN |
| 144 | Thu Sep 13 | vs Royals | W4-3 (10) | 60-84 | .417 | Target Field · Minneapolis, MN |
| 145 | Fri Sep 14 | vs White Sox | L0-6 | 60-85 | .414 | Target Field · Minneapolis, MN |
| 146 | Sat Sep 15 | vs White Sox | L3-5 | 60-86 | .411 | Target Field · Minneapolis, MN |
| 147 | Sun Sep 16 | vs White Sox | L2-9 | 60-87 | .408 | Target Field · Minneapolis, MN |
| 148 | Tue Sep 18 | at Guardians | W6-5 (12) | 61-87 | .412 | Progressive Field · Cleveland, OH |
| 149 | Wed Sep 19 | at Guardians | W6-4 | 62-87 | .416 | Progressive Field · Cleveland, OH |
| 150 | Thu Sep 20 | at Guardians | L3-4 (10) | 62-88 | .413 | Progressive Field · Cleveland, OH |
| 151 | Sat Sep 22 | at Tigers | L0-8 | 62-89 | .411 | Comerica Park · Detroit, MI |
| 152 | Sun Sep 23 | at Tigers | W10-4 | 63-89 | .414 | Comerica Park · Detroit, MI |
| 153 | Sun Sep 23 | at Tigers | W2-1 (10) | 64-89 | .418 | Comerica Park · Detroit, MI |
| 154 | Mon Sep 24 | vs Yankees | L3-6 | 64-90 | .416 | Target Field · Minneapolis, MN |
| 155 | Tue Sep 25 | vs Yankees | W5-4 | 65-90 | .419 | Target Field · Minneapolis, MN |
| 156 | Wed Sep 26 | vs Yankees | L2-8 | 65-91 | .417 | Target Field · Minneapolis, MN |
| 157 | Fri Sep 28 | vs Tigers | W4-2 | 66-91 | .420 | Target Field · Minneapolis, MN |
| 158 | Sat Sep 29 | vs Tigers | L4-6 | 66-92 | .418 | Target Field · Minneapolis, MN |
| 159 | Sun Sep 30 | vs Tigers | L1-2 | 66-93 | .415 | Target Field · Minneapolis, MN |
| 160 | Mon Oct 1 | at Blue Jays | L5-6 (10) | 66-94 | .412 | Rogers Centre · Toronto, ON |
| 161 | Tue Oct 2 | at Blue Jays | L3-4 | 66-95 | .410 | Rogers Centre · Toronto, ON |
| 162 | Wed Oct 3 | at Blue Jays | L1-2 | 66-96 | .407 | Rogers Centre · Toronto, ON |