| 1 | Thu Mar 26 | at Orioles | L1-2 | 0-1 | .000 | Camden Yards · Baltimore, MD |
| 2 | Sat Mar 28 | at Orioles | W4-1 | 1-1 | .500 | Camden Yards · Baltimore, MD |
| 3 | Sun Mar 29 | at Orioles | L6-8 | 1-2 | .333 | Camden Yards · Baltimore, MD |
| 4 | Mon Mar 30 | at Royals | L1-3 | 1-3 | .250 | Kauffman Stadium · Kansas City, MO |
| 5 | Wed Apr 1 | at Royals | L9-13 | 1-4 | .200 | Kauffman Stadium · Kansas City, MO |
| 6 | Thu Apr 2 | at Royals | W5-1 | 2-4 | .333 | Kauffman Stadium · Kansas City, MO |
| 7 | Fri Apr 3 | vs Rays | W10-4 | 3-4 | .429 | Target Field · Minneapolis, MN |
| 8 | Sat Apr 4 | vs Rays | L1-7 | 3-5 | .375 | Target Field · Minneapolis, MN |
| 9 | Sun Apr 5 | vs Rays | L1-4 (10) | 3-6 | .333 | Target Field · Minneapolis, MN |
| 10 | Mon Apr 6 | vs Tigers | W7-3 | 4-6 | .400 | Target Field · Minneapolis, MN |
| 11 | Tue Apr 7 | vs Tigers | W4-2 | 5-6 | .455 | Target Field · Minneapolis, MN |
| 12 | Wed Apr 8 | vs Tigers | W8-6 | 6-6 | .500 | Target Field · Minneapolis, MN |
| 13 | Thu Apr 9 | vs Tigers | W3-1 | 7-6 | .538 | Target Field · Minneapolis, MN |
| 14 | Fri Apr 10 | at Blue Jays | L4-10 | 7-7 | .500 | Rogers Centre · Toronto, ON |
| 15 | Sat Apr 11 | at Blue Jays | W7-4 | 8-7 | .533 | Rogers Centre · Toronto, ON |
| 16 | Sun Apr 12 | at Blue Jays | W8-2 | 9-7 | .563 | Rogers Centre · Toronto, ON |
| 17 | Mon Apr 13 | vs Red Sox | W13-6 | 10-7 | .588 | Target Field · Minneapolis, MN |
| 18 | Tue Apr 14 | vs Red Sox | W6-0 | 11-7 | .611 | Target Field · Minneapolis, MN |
| 19 | Wed Apr 15 | vs Red Sox | L5-9 | 11-8 | .579 | Target Field · Minneapolis, MN |
| 20 | Fri Apr 17 | vs Reds | L1-2 | 11-9 | .550 | Target Field · Minneapolis, MN |
| 21 | Sat Apr 18 | vs Reds | L4-5 | 11-10 | .524 | Target Field · Minneapolis, MN |
| 22 | Sun Apr 19 | vs Reds | L4-7 (10) | 11-11 | .500 | Target Field · Minneapolis, MN |
| 23 | Tue Apr 21 | at Mets | W5-3 | 12-11 | .522 | Citi Field · Queens, NY |
| 24 | Wed Apr 22 | at Mets | L2-3 | 12-12 | .500 | Citi Field · Queens, NY |
| 25 | Thu Apr 23 | at Mets | L8-10 | 12-13 | .480 | Citi Field · Queens, NY |
| 26 | Fri Apr 24 | at Rays | L2-6 | 12-14 | .462 | Tropicana Field · St. Petersburg, FL |
| 27 | Sat Apr 25 | at Rays | L1-6 | 12-15 | .444 | Tropicana Field · St. Petersburg, FL |
| 28 | Sun Apr 26 | at Rays | L2-4 | 12-16 | .429 | Tropicana Field · St. Petersburg, FL |
| 29 | Mon Apr 27 | vs Mariners | W11-4 | 13-16 | .448 | Target Field · Minneapolis, MN |
| 30 | Tue Apr 28 | vs Mariners | L1-7 | 13-17 | .433 | Target Field · Minneapolis, MN |
| 31 | Wed Apr 29 | vs Mariners | L3-5 | 13-18 | .419 | Target Field · Minneapolis, MN |
| 32 | Thu Apr 30 | vs Blue Jays | W7-1 | 14-18 | .438 | Target Field · Minneapolis, MN |
| 33 | Fri May 1 | vs Blue Jays | L3-7 | 14-19 | .424 | Target Field · Minneapolis, MN |
| 34 | Sat May 2 | vs Blue Jays | L4-11 | 14-20 | .412 | Target Field · Minneapolis, MN |
| 35 | Sun May 3 | vs Blue Jays | W4-3 | 15-20 | .429 | Target Field · Minneapolis, MN |
| 36 | Tue May 5 | at Nationals | W11-3 | 16-20 | .444 | Nationals Park · Washington, D.C. |
| 37 | Wed May 6 | at Nationals | L2-15 | 16-21 | .432 | Nationals Park · Washington, D.C. |
| 38 | Thu May 7 | at Nationals | L5-7 | 16-22 | .421 | Nationals Park · Washington, D.C. |
| 39 | Fri May 8 | at Guardians | L4-6 | 16-23 | .410 | Progressive Field · Cleveland, OH |
| 40 | Sat May 9 | at Guardians | W2-1 (11) | 17-23 | .425 | Progressive Field · Cleveland, OH |
| 41 | Sun May 10 | at Guardians | W5-4 | 18-23 | .439 | Progressive Field · Cleveland, OH |
| 42 | Tue May 12 | vs Marlins | W3-0 | 19-23 | .452 | Target Field · Minneapolis, MN |
| 43 | Wed May 13 | vs Marlins | L5-9 | 19-24 | .442 | Target Field · Minneapolis, MN |
| 44 | Thu May 14 | vs Marlins | W9-1 | 20-24 | .455 | Target Field · Minneapolis, MN |
| 45 | Fri May 15 | vs Brewers | L2-3 | 20-25 | .444 | Target Field · Minneapolis, MN |
| 46 | Sat May 16 | vs Brewers | L1-2 | 20-26 | .435 | Target Field · Minneapolis, MN |
| 47 | Sun May 17 | vs Brewers | W5-4 | 21-26 | .447 | Target Field · Minneapolis, MN |
| 48 | Mon May 18 | vs Astros | W6-3 | 22-26 | .458 | Target Field · Minneapolis, MN |
| 49 | Tue May 19 | vs Astros | L1-2 | 22-27 | .449 | Target Field · Minneapolis, MN |
| 50 | Wed May 20 | vs Astros | W4-1 | 23-27 | .460 | Target Field · Minneapolis, MN |
| 51 | Fri May 22 | at Red Sox | W8-6 | 24-27 | .471 | Fenway Park · Boston, MA |
| 52 | Sat May 23 | at Red Sox | W4-2 | 25-27 | .481 | Fenway Park · Boston, MA |
| 53 | Sun May 24 | at Red Sox | W6-5 | 26-27 | .491 | Fenway Park · Boston, MA |
| 54 | Mon May 25 | at White Sox | L1-3 | 26-28 | .481 | Guaranteed Rate Field · Chicago, IL |
| 55 | Tue May 26 | at White Sox | W5-3 (11) | 27-28 | .491 | Guaranteed Rate Field · Chicago, IL |
| 56 | Wed May 27 | at White Sox | L2-15 | 27-29 | .482 | Guaranteed Rate Field · Chicago, IL |
| 57 | Thu May 28 | at White Sox | L2-6 | 27-30 | .474 | Guaranteed Rate Field · Chicago, IL |
| 58 | Fri May 29 | at Pirates | L5-6 | 27-31 | .466 | PNC Park · Pittsburgh, PA |
| 59 | Sat May 30 | at Pirates | L9-10 | 27-32 | .458 | PNC Park · Pittsburgh, PA |
| 60 | Sun May 31 | at Pirates | L3-9 | 27-33 | .450 | PNC Park · Pittsburgh, PA |
| 61 | Mon Jun 1 | vs White Sox | W9-6 | 28-33 | .459 | Target Field · Minneapolis, MN |
| 62 | Tue Jun 2 | vs White Sox | W6-4 | 29-33 | .468 | Target Field · Minneapolis, MN |
| 63 | Wed Jun 3 | vs White Sox | L0-8 | 29-34 | .460 | Target Field · Minneapolis, MN |
| 64 | Thu Jun 4 | vs Royals | L6-8 | 29-35 | .453 | Target Field · Minneapolis, MN |
| 65 | Fri Jun 5 | vs Royals | W5-3 | 30-35 | .462 | Target Field · Minneapolis, MN |
| 66 | Sat Jun 6 | vs Royals | L2-3 | 30-36 | .455 | Target Field · Minneapolis, MN |
| 67 | Sun Jun 7 | vs Royals | L5-6 | 30-37 | .448 | Target Field · Minneapolis, MN |
| 68 | Tue Jun 9 | at Tigers | L4-10 | 30-38 | .441 | Comerica Park · Detroit, MI |
| 69 | Wed Jun 10 | at Tigers | W6-4 | 31-38 | .449 | Comerica Park · Detroit, MI |
| 70 | Thu Jun 11 | at Tigers | L0-11 | 31-39 | .443 | Comerica Park · Detroit, MI |
| 71 | Fri Jun 12 | vs Cardinals | W9-8 | 32-39 | .451 | Target Field · Minneapolis, MN |
| 72 | Sat Jun 13 | vs Cardinals | L6-9 | 32-40 | .444 | Target Field · Minneapolis, MN |
| 73 | Sun Jun 14 | vs Cardinals | W5-4 | 33-40 | .452 | Target Field · Minneapolis, MN |
| 74 | Mon Jun 15 | at Rangers | W4-2 | 34-40 | .459 | Globe Life Field · Arlington, TX |
| 75 | Tue Jun 16 | at Rangers | W12-2 | 35-40 | .467 | Globe Life Field · Arlington, TX |
| 76 | Thu Jun 18 | at Rangers | W9-3 | 36-40 | .474 | Globe Life Field · Arlington, TX |
| 77 | Fri Jun 19 | at D-backs | L5-9 | 36-41 | .468 | Chase Field · Phoenix, AZ |
| 78 | Sat Jun 20 | at D-backs | W16-8 | 37-41 | .474 | Chase Field · Phoenix, AZ |
| 79 | Sun Jun 21 | at D-backs | W4-2 | 38-41 | .481 | Chase Field · Phoenix, AZ |
| 80 | Mon Jun 22 | vs Dodgers | L1-2 | 38-42 | .475 | Target Field · Minneapolis, MN |
| 81 | Tue Jun 23 | vs Dodgers | L3-12 | 38-43 | .469 | Target Field · Minneapolis, MN |
| 82 | Wed Jun 24 | vs Dodgers | L3-4 | 38-44 | .463 | Target Field · Minneapolis, MN |
| 83 | Fri Jun 26 | vs Rockies | W9-8 (10) | 39-44 | .470 | Target Field · Minneapolis, MN |
| 84 | Sat Jun 27 | vs Rockies | L5-8 | 39-45 | .464 | Target Field · Minneapolis, MN |
| 85 | Sun Jun 28 | vs Rockies | W3-2 | 40-45 | .471 | Target Field · Minneapolis, MN |
| 86 | Mon Jun 29 | at Astros | W5-4 | 41-45 | .477 | Minute Maid Park · Houston, TX |
| 87 | Tue Jun 30 | at Astros | L4-6 | 41-46 | .471 | Minute Maid Park · Houston, TX |
| 88 | Wed Jul 1 | at Astros | W8-3 | 42-46 | .477 | Minute Maid Park · Houston, TX |
| 89 | Fri Jul 3 | at Yankees | L2-5 | 42-47 | .472 | Yankee Stadium · The Bronx, NY |
| 90 | Sat Jul 4 | at Yankees | W11-4 | 43-47 | .478 | Yankee Stadium · The Bronx, NY |
| 91 | Sun Jul 5 | at Yankees | W6-1 | 44-47 | .484 | Yankee Stadium · The Bronx, NY |
| 92 | Tue Jul 7 | vs Guardians | W3-1 | 45-47 | .489 | Target Field · Minneapolis, MN |
| 93 | Wed Jul 8 | vs Guardians | W6-5 | 46-47 | .495 | Target Field · Minneapolis, MN |
| 94 | Thu Jul 9 | vs Guardians | L2-5 | 46-48 | .489 | Target Field · Minneapolis, MN |
| 95 | Fri Jul 10 | vs Angels | L3-4 | 46-49 | .484 | Target Field · Minneapolis, MN |
| 96 | Sat Jul 11 | vs Angels | W5-3 | 47-49 | .490 | Target Field · Minneapolis, MN |
| 97 | Sun Jul 12 | vs Angels | W4-2 | 48-49 | .495 | Target Field · Minneapolis, MN |